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1. 发明申请

US20200157545A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20200157545A1
公开(公告)日：2020-05-21
申请号：US16618010
申请日：2018-06-01
申请人： Chandra VARGEESE , Naoki IWAMOTO , David Charles Donnell BUTLER , Subramanian MARAPPAN , Genliang LU , Jason Jingxin ZHANG , Vinod VATHIPADIEKAL , Maria David FRANK-KAMENETSKY , Luciano Henrique APPONI , WAVE LIFE SCIENCES LTD.
发明人： Chandra Vargeese , Naoki Iwamoto , David Charles Donnell Butler , Subramanian Marappan , Genliang Lu , Jason Jingxin Zhang , Vinod Vathipadiekal , Maria David Frank-Kamenetsky , Luciano Henrique Apponi , Young Jin Cho
IPC分类号： C12N15/113 , A61K31/712
摘要： Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions, for example, in RNA interference and/or RNase H-mediated knockdown.

2. 发明授权

US09605019B2 Methods for the synthesis of functionalized nucleic acids 有权
公开(公告)号：US09605019B2
公开(公告)日：2017-03-28
申请号：US14233579
申请日：2012-07-13
申请人： Gregory L. Verdine , Meena , Naoki Iwamoto , David Charles Donnell Butler
发明人： Gregory L. Verdine , Meena , Naoki Iwamoto , David Charles Donnell Butler
IPC分类号： C07H21/02 , C07H21/04 , C07H21/00 , C07H11/00 , C07H13/12 , C07D265/30 , C07D295/00 , C07C69/96 , C07C315/00 , C07C317/00 , C07C331/00 , C07C381/00 , A61K31/66 , A61K31/70 , C07C309/66 , C07D295/108 , C07H13/04
CPC分类号： C07H21/04 , A61K31/66 , A61K31/70 , C07C309/66 , C07D295/108 , C07H13/04
摘要： The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.

3. 发明授权

US5945994A Kinematic-simulation apparatus and kinematic-simulation method with interference processing 失效
标题翻译：运动仿真装置和运动仿真方法与干扰处理
公开(公告)号：US5945994A
公开(公告)日：1999-08-31
申请号：US444358
申请日：1995-05-18
申请人： Kazuma Shimizu , Naoki Iwamoto , Mari Nomura
发明人： Kazuma Shimizu , Naoki Iwamoto , Mari Nomura
IPC分类号： G06F17/50 , G06F7/00
CPC分类号： G06F17/5086
摘要： Disclosed are a kinematic-simulation method and a kinematic-simulation apparatus which enable simulation of the behavior of a mechanism by using a CAD figure by a simple operation. The kinematic-simulation method includes an interference operational method according to which a translation is continued until the figure associated with the operation (the driver) comes into contact with the figure associated with interference (the stop). When defining the driver translation, an interference operation is defined, whereby a translation amount (an angle or a vector) can be calculated within a computer. Accordingly, an operator does not input a rotation angle for rotation or a vector for translation.
摘要翻译：公开了一种运动学仿真方法和运动学仿真装置，其能够通过简单的操作通过使用CAD图来模拟机构的行为。运动学仿真方法包括一种干涉操作方法，根据该方法，继续进行平移，直到与操作（驾驶员）相关联的图像与与干涉（停止）相关联的图形接触。当定义驱动程序翻译时，定义干涉操作，由此可以在计算机内计算平移量（角度或矢量）。因此，操作者不输入用于旋转的旋转角度或用于平移的矢量。

4. 发明申请

US20220306573A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF 有权
公开(公告)号：US20220306573A1
公开(公告)日：2022-09-29
申请号：US17046752
申请日：2019-04-11
申请人： Jason Jingxi ZHANG , Chandra VARGEESE , Naoki IWAMOTO , Chikdu Shakti SHIVALILA , Nayantara KOTHARI , Ann Fiegen DURBIN , Selvi RAMASAMY , Pachamuthu KANDASAMY , Jayakanthan KUMARASAMY , Gopal Reddy BOMMINENI , Subramanian MARAPPAN , Sethumadhavan DIVAKARAMENON , David Charles Donnel BUTLER , Genliang LU , Hailin YANG , Mamoru SHIMIZU , Prashant MONIAN , WAVE LIFE SCIENCES LTD.
发明人： Jason Jingxin Zhang , Chandra Vargeese , Naoki Iwamoto , Chikdu Shakti Shivalila , Nayantara Kothari , Ann Fiegen Durbin , Selvi Ramasamy , Pachamuthu Kandasamy , Jayakanthan Kumarasamy , Gopal Reddy Bommineni , Subramanian Marappan , Sethumadhavan Divakaramenon , David Charles Donnell Butler , Genliang Lu , Hailin Yang , Mamoru Shimizu , Prashant Monian
IPC分类号： C07C317/28 , C07H21/02 , C07H21/04 , C12N15/113
摘要： Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods of use thereof. In some embodiments, the present disclosure provides technologies useful for reducing levels of transcripts. In some embodiments, the present disclosure provides technologies useful for modulating transcript splicing. In some embodiments, provided technologies can alter splicing of a dystrophin (DMD) transcript. In some embodiments, the present disclosure provides methods for treating diseases, such as Duchenne muscular dystrophy, Becker's muscular dystrophy, etc.

5. 发明授权

US09982898B2 Indoor unit of air conditioner and air conditioner including a heat exchanger on a downstream side of a blower 有权
公开(公告)号：US09982898B2
公开(公告)日：2018-05-29
申请号：US13144220
申请日：2009-10-02
申请人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
发明人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
IPC分类号： F24F13/24 , F24F1/00 , F24F13/30 , F28D20/00
CPC分类号： F24F1/0007 , F24F1/0029 , F24F1/0059 , F24F13/24 , F24F13/30 , F24F2013/247 , F28D2020/0013
摘要： An indoor unit includes a casing having a suction port formed in an upper part and a blow-out port formed on a lower side at a front face part, an axial-flow or diagonal-flow fan provided on the downstream side of the suction port in the casing, and a heat exchanger provided on the downstream side of the fan and on the upstream side of the blow-out port in the casing, in which air blown out of the fan and refrigerant are heat-exchanged.

6. 发明申请

US20120018117A1 INDOOR UNIT OF AIR CONDITIONER AND AIR CONDITIONER 有权
标题翻译：空调和空调室内单元
公开(公告)号：US20120018117A1
公开(公告)日：2012-01-26
申请号：US13144220
申请日：2009-10-02
申请人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
发明人： Shoji Yamada , Kenichi Sakoda , Masao Akiyoshi , Akira Takamori , Nobuaki Uehara , Tomoya Fukui , Seiji Nakashima , Naoki Iwamoto , Satoshi Michihata , Isao Otsuka , Masayuki Tsuji
IPC分类号： F28F27/00 , F28D15/00
CPC分类号： F24F1/0007 , F24F1/0029 , F24F1/0059 , F24F13/24 , F24F13/30 , F24F2013/247 , F28D2020/0013
摘要： An indoor unit includes a casing having a suction port formed in an upper part and a blow-out port formed on a lower side at a front face part, an axial-flow or diagonal-flow fan provided on the downstream side of the suction port in the casing, and a heat exchanger provided on the downstream side of the fan and on the upstream side of the blow-out port in the casing, in which air blown out of the fan and refrigerant are heat-exchanged.
摘要翻译：室内机包括：上部形成有吸入口的壳体和形成在前面部的下侧的吹出口，设置在吸入口的下游侧的轴流或斜流风扇并且设置在风扇的下游侧和壳体内的吹出口的上游侧的热交换器，其中从风扇吹出的空气和制冷剂被热交换。

7. 发明申请

US20190249173A1 METHODS AND COMPOSITIONS OF BIOLOGICALLY ACTIVE AGENTS 审中-公开
公开(公告)号：US20190249173A1
公开(公告)日：2019-08-15
申请号：US16098658
申请日：2017-05-03
申请人： Chandra VARGEESE , Jason Jingxin ZHANG , Sethumadhavan DIVAKARAMENON , David Charles Donnell BUTLER , Genliang LU , Naoki IWAMOTO , Hailin YANG , Maria David FRANK-KAMENETSKY , Subramanian MARAPPAN , WAVE LIFE SCIENCES LTD.
发明人： Chandra Vargeese , Jason Jingxin Zhang , Sethumadhavan Divakaramenon , David Charles Donnell Butler , Genliang Lu , Naoki Iwamoto , Hailin Yang , Maria David Frank-Kamenetsky , Subramanian Marappan
IPC分类号： C12N15/11 , A61K31/7088 , A61K47/54
CPC分类号： C12N15/111 , A61K31/7088 , A61K47/542 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/16 , C12N2310/20 , C12N2310/315 , C12N2310/3515 , C12N2320/32
摘要： In some embodiments, the present disclosure pertains to compositions and methods related to delivery of a biologically active agent, wherein the compositions comprise a biologically active agent and a lipid. In various embodiments, the lipid is selected from: lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, docosa-hexaenoic acid (cis-DHA), turbinaric acid and dilinoleyl. In some embodiments, a composition and method are useful for delivery of a biologically active agent to a particular cell or tissue, e.g., a muscle cell or tissue.

8. 发明授权

US09744183B2 Nucleic acid prodrugs and methods of use thereof 有权
公开(公告)号：US09744183B2
公开(公告)日：2017-08-29
申请号：US13381323
申请日：2010-07-06
申请人： Gregory L. Verdine , Meena . , Naoki Iwamoto
发明人： Gregory L. Verdine , Meena . , Naoki Iwamoto
IPC分类号： A61K31/70 , C07F9/655 , C07H21/00
CPC分类号： A61K31/70 , C07F9/65515 , C07H21/00
摘要： Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.

9. 发明申请

US20120316224A1 NOVEL NUCLEIC ACID PRODRUGS AND METHODS OF USE THEREOF 有权
标题翻译：新型核酸产品及其使用方法
公开(公告)号：US20120316224A1
公开(公告)日：2012-12-13
申请号：US13381323
申请日：2010-07-06
申请人： Gregory L. Verdine , Meena Meena , Naoki Iwamoto
发明人： Gregory L. Verdine , Meena Meena , Naoki Iwamoto
IPC分类号： A61K31/7084 , A61K31/711 , A61P35/00 , C07H21/04
CPC分类号： A61K31/70 , C07F9/65515 , C07H21/00
摘要： Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.
摘要翻译：本文描述的是包含手性磷部分的核酸前药和核酸前药。本文还描述了制备和使用包含手性磷部分的核酸前药和核酸前药的方法。

10. 发明授权

US5621865A Graphics processing apparatus using grid and a method thereof 失效
标题翻译：使用网格的图形处理装置及其方法
公开(公告)号：US5621865A
公开(公告)日：1997-04-15
申请号：US688217
申请日：1996-07-29
申请人： Naoki Iwamoto , Toshio Abe , Hiroyuki Sakai
发明人： Naoki Iwamoto , Toshio Abe , Hiroyuki Sakai
IPC分类号： G06F17/50 , G06T19/20 , G06F15/00
CPC分类号： G06T19/20 , G06T2219/2016
摘要： The present invention relates to a graphics processing apparatus for plotting three-dimensional graphics by using a grid, and to a method of use of the apparatus. An arbitrary plane grid is displayed on a display screen, the displayed grid is variously changed and the three-dimensional graphic is plotted using the changed grid. The possible changes of the grid include a grid translation, a grid spacing change, a grid rotation, the selection of a grid display/non-display mode, coincidence/non-coincidence of the reference points of the graphic with the grid, and the like. Also, the apparatus executes a corner processing, including arc processing and straight line processing. In the arc processing, the corner processing is executed by selecting two straight lines and inputting a radius to define a corner joining the two lines; and in the straight line processing, the corner processing is executed by selecting two straight lines and inputting the length and angle of a line segment to join them.
摘要翻译：本发明涉及一种用于通过使用网格绘制三维图形的图形处理装置以及该装置的使用方法。任意平面网格显示在显示屏幕上，显示的网格被不同地改变，并且使用改变的网格来绘制三维图形。网格的可能变化包括网格平移，网格间距变化，网格旋转，网格显示/非显示模式的选择，图形与网格的参考点的重合/非重合，以及喜欢。此外，该装置执行包括电弧处理和直线处理的拐角处理。在电弧处理中，通过选择两条直线并输入半径来定义连接两条线的拐角来执行拐角处理; 并且在直线处理中，通过选择两条直线并输入线段的长度和角度来连接它们来执行拐角处理。

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