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1. 发明申请

US20150240245A1 Human optimized Bacillus anthracis protective antigen 审中-公开
标题翻译：人类优化炭疽芽孢杆菌保护性抗原
公开(公告)号：US20150240245A1
公开(公告)日：2015-08-27
申请号：US14190464
申请日：2014-02-26
申请人： Stanley Goldman , Mark Albrecht
发明人： Stanley Goldman , Mark Albrecht
IPC分类号： C12N15/64
CPC分类号： C12N15/64 , A61K39/07 , A61K2039/53 , A61K2039/55511 , C07K14/32
摘要： The invention relates to a humanized nucleic acid construct from Bacillus anthracis protective antigen (PA) gene and method of modifying the gene. The humanized gene, and method of producing it, improves the structural fidelity of expressed protein product, when produced in mammalian host cells, to native, bacterially produced protein. The construct is useful in nucleic acid based vaccine formulations against B. anthracis.
摘要翻译：本发明涉及来自炭疽芽孢杆菌保护性抗原（PA）基因的人源化核酸构建体和修饰该基因的方法。人源化基因及其生产方法提高了在哺乳动物宿主细胞中产生的表达蛋白质产物对天然的细菌产生的蛋白质的结构保真度。该构建体可用于针对炭疽杆菌的基于核酸的疫苗制剂。

2. 发明授权

US08125253B2 System and method for dynamically switching between low and high frequency reference clock to PLL and minimizing PLL output frequency changes 有权
标题翻译：用于在低频和高频参考时钟之间动态切换到PLL并最小化PLL输出频率变化的系统和方法
公开(公告)号：US08125253B2
公开(公告)日：2012-02-28
申请号：US12610438
申请日：2009-11-02
申请人： Stanley Goldman , Srinath Ramaswamy
发明人： Stanley Goldman , Srinath Ramaswamy
IPC分类号： H03L7/06
CPC分类号： H03L7/193 , H03L7/093
摘要： A circuit is provided for use with a clock having an input divider portion, a feedback divider portion, a phase detector portion, a loop compensation filter portion and a voltage controlled oscillator portion. The input divider portion receives a reference signal and outputs a divided reference signal. The feedback divider portion receives an output signal from the circuit and outputs a divided feedback signal. The phase detector portion outputs a phase detector signal based on the divided reference signal and the divided feedback signal. The loop compensation filter portion outputs a tuning signal based on the phase detector signal. The voltage controlled oscillator portion output the outputs a signal based on the tuning signal. The phase detector portion changes the phase detector signal based on the input divider portion receiving the control signal and the feedback divider portion receiving the control signal.
摘要翻译：提供了一种与具有输入分频器部分，反馈分频器部分，相位检测器部分，环路补偿滤波器部分和压控振荡器部分的时钟一起使用的电路。输入分频器部分接收参考信号并输出分频的参考信号。反馈分配器部分接收来自电路的输出信号并输出分频的反馈信号。相位检测器部分基于划分的参考信号和分离的反馈信号输出相位检测器信号。环路补偿滤波器部分基于相位检测器信号输出调谐信号。压控振荡器部分输出基于调谐信号的信号。相位检测器部分基于接收控制信号的输入分频器部分和接收控制信号的反馈分频器部分来改变相位检测器信号。

3. 发明申请

US20070085577A1 High frequency transmission gate buffer 审中-公开
标题翻译：高频传输门缓冲器
公开(公告)号：US20070085577A1
公开(公告)日：2007-04-19
申请号：US11253486
申请日：2005-10-18
申请人： Stanley Goldman
发明人： Stanley Goldman
IPC分类号： H03B1/00
CPC分类号： H03K5/151 , H03K19/018521 , H03K19/09429
摘要： An apparatus for providing a signal to a transmission medium. A first switching stage is connected in series between a source voltage and a transmission medium, and a second switching stage connected in series between the transmission medium and a reference line. The first and second switching stages each comprise at least one p channel transistor in parallel with at least one n channel transistor. The first and second switching stages are preferably configured to substantially symmetrically drive the transmission medium at a frequency of at least 4 gigahertz (GHz). The stages are further preferably characterized as variable resistance stages with lower resistance at the rails as compared to the midpoint of the input signal. Additional sets of stages can be provided to facilitate multiple outputs.
摘要翻译：一种用于向传输介质提供信号的装置。第一开关级串联连接在源电压和传输介质之间，第二开关级串联连接在传输介质和参考线之间。第一和第二开关级各自包括与至少一个n沟道晶体管并联的至少一个p沟道晶体管。第一和第二开关级优选地构造成以至少4千兆赫（GHz）的频率基本上对称地驱动传输介质。这些级进一步优选地被表征为与输入信号的中点相比在轨道处具有较低电阻的可变电阻级。可以提供额外的级级，以便于多个输出。

4. 发明申请

US20110102030A1 SYSTEM AND METHOD FOR DYNAMICALLY SWITCHING BETWEEN LOW AND HIGH FREQUENCY REFERENCE CLOCK TO PLL AND MINIMIZING PLL OUTPUT FREQUENCY CHANGES 有权
标题翻译：低频和高频参考时钟之间的动态切换到PLL和最小化PLL输出频率变化的系统和方法
公开(公告)号：US20110102030A1
公开(公告)日：2011-05-05
申请号：US12610438
申请日：2009-11-02
申请人： Stanley Goldman , Srinath Ramaswamy
发明人： Stanley Goldman , Srinath Ramaswamy
IPC分类号： H03L7/06
CPC分类号： H03L7/193 , H03L7/093
摘要： A circuit is provided for use with a clock signal having a plurality of clock pulses, each clock pulse having a rising edge and a falling edge. The circuit is operable to receive a reference signal and to output an output signal. The circuit includes an input divider portion, a feedback divider portion, a phase detector portion, a loop compensation filter portion and a voltage controlled oscillator portion. The input divider portion is arranged to receive the reference signal and is operable to output a divided reference signal. The feedback divider portion is arranged to receive the output signal and is operable to output a divided feedback signal. The phase detector portion is operable to output a phase detector signal based on the divided reference signal and the divided feedback signal. The loop compensation filter portion is operable to output a tuning signal based on the phase detector signal. The voltage controlled oscillator portion is operable to output the output signal based on the tuning signal. The phase detector portion is further operable to change the phase detector signal based on the input divider portion receiving the control signal and the feedback divider portion receiving the control signal, and further based on the control signal and a rising edge of a clock pulse.
摘要翻译：提供电路用于具有多个时钟脉冲的时钟信号，每个时钟脉冲具有上升沿和下降沿。电路可操作以接收参考信号并输出输出信号。电路包括输入分频器部分，反馈分频器部分，相位检测器部分，环路补偿滤波器部分和压控振荡器部分。输入分频器部分被布置成接收参考信号并且可操作以输出分频的参考信号。反馈分配器部分被布置成接收输出信号并且可操作以输出分离的反馈信号。相位检测器部分可操作以基于划分的参考信号和分频反馈信号输出相位检测器信号。环路补偿滤波器部分可操作以基于相位检测器信号输出调谐信号。压控振荡器部分可操作以基于调谐信号输出输出信号。相位检测器部分还可操作以基于接收控制信号的输入分频器部分和接收控制信号的反馈分频器部分，并且还基于控制信号和时钟脉冲的上升沿来改变相位检测器信号。

5. 发明授权

US09382547B2 Human optimized Bacillus anthracis protective antigen 有权
公开(公告)号：US09382547B2
公开(公告)日：2016-07-05
申请号：US14190464
申请日：2014-02-26
申请人： Stanley Goldman , Mark Albrecht
发明人： Stanley Goldman , Mark Albrecht
IPC分类号： C12N15/64 , A61K39/07 , C07K14/32 , A61K39/00
CPC分类号： C12N15/64 , A61K39/07 , A61K2039/53 , A61K2039/55511 , C07K14/32
摘要： The invention relates to a humanized nucleic acid construct from Bacillus anthracis protective antigen (PA) gene and method of modifying the gene. The humanized gene, and method of producing it, improves the structural fidelity of expressed protein product, when produced in mammalian host cells, to native, bacterially produced protein. The construct is useful in nucleic acid based vaccine formulations against B. anthracis.

6. 发明申请

US20060012414A1 Circuit and method for generating a polyphase clock signal and system incorporating the same 审中-公开
标题翻译：用于产生多相时钟信号的电路和方法及其结合的系统
公开(公告)号：US20060012414A1
公开(公告)日：2006-01-19
申请号：US10891651
申请日：2004-07-15
申请人： Stanley Goldman
发明人： Stanley Goldman
IPC分类号： G06F1/04
CPC分类号： H03K3/0315 , G06F1/04
摘要： A circuit for, and method of, generating a polyphase clock signal and a synchronous data processing system incorporating the circuit or the method. In one embodiment, the circuit includes: (1) R-S latch delay elements connected in a ring and configured to generate a circulating sequence of logic signals and (2) phase taps, coupled to points between ones of the R-S latch delay elements and configured to tap the circulating sequence to provide the polyphase clock signal.
摘要翻译：用于产生多相时钟信号的电路和方法，以及结合该电路或方法的同步数据处理系统。在一个实施例中，电路包括：（1）连接在环中并被配置为产生逻辑信号的循环序列的RS锁存延迟元件和（2）耦合到RS锁存延迟元件之间的点的相位抽头，并被配置为点击循环序列以提供多相时钟信号。

7. 发明申请

US20060009184A1 Hybrid control of phase locked loops 有权
标题翻译：锁相环的混合控制
公开(公告)号：US20060009184A1
公开(公告)日：2006-01-12
申请号：US10885909
申请日：2004-07-07
申请人： Stanley Goldman
发明人： Stanley Goldman
IPC分类号： H04B17/00
CPC分类号： H03L7/093 , H03L7/0995 , H03L7/18 , H03L2207/06
摘要： A hybrid digital and analog phase locked loop. A voltage controlled oscillator is provided, having a fine tune input, a coarse tune input and an output. A frequency divider has an input connected to receive a signal provided by the output of the voltage controlled oscillator, and has an output for providing a signal having a frequency that is divided with respect to a signal provided to its input. A phase detector is connected to receive a reference input signal having a reference frequency at a first input thereof and is connected to receive the signal provided by the output of the frequency divider. The phase detector has an output for providing a phase error signal. An analog is circuit configured as a proportional filter and is connected to receive the phase error signal and to provide a fine tune signal at the fine tune input of the voltage controlled oscillator. A digital integrator is connected to receive the phase error signal and to provide a coarse tune signal at the coarse tune input of the voltage controlled oscillator.
摘要翻译：混合数字和模拟锁相环。提供压控振荡器，具有微调输入，粗调输入和输出。分频器具有连接的输入端以接收由压控振荡器的输出提供的信号，并且具有用于提供具有相对于提供给其输入的信号被分频的频率的信号的输出。相位检测器被连接以在其第一输入处接收具有参考频率的参考输入信号，并被连接以接收由分频器的输出提供的信号。相位检测器具有用于提供相位误差信号的输出。模拟电路被配置为比例滤波器，并被连接以接收相位误差信号并且在压控振荡器的微调输入处提供微调信号。连接数字积分器以接收相位误差信号，并在压控振荡器的粗调输入端提供粗调信号。

8. 发明申请

US20110110968A1 Human optimized Bacillus anthracis protective antigen 审中-公开
标题翻译：人类优化炭疽芽孢杆菌保护性抗原
公开(公告)号：US20110110968A1
公开(公告)日：2011-05-12
申请号：US12916889
申请日：2010-11-01
申请人： Stanley Goldman , Mark Albrecht
发明人： Stanley Goldman , Mark Albrecht
IPC分类号： A61K39/07 , C07H21/04 , A61P37/04 , A61P31/04
CPC分类号： C12N15/64 , A61K39/07 , A61K2039/53 , A61K2039/55511 , C07K14/32
摘要： The invention relates to a humanized nucleic acid construct from Bacillus anthracis protective antigen (PA) gene and method of modifying the gene. The humanized gene, and method of producing it, improves the structural fidelity of expressed protein product, when produced in mammalian host cells, to native, bacterially produced protein. The construct is useful in nucleic acid based vaccine formulations against B. anthracis.
摘要翻译：本发明涉及来自炭疽芽孢杆菌保护性抗原（PA）基因的人源化核酸构建体和修饰该基因的方法。人源化基因及其生产方法提高了在哺乳动物宿主细胞中产生的表达蛋白质产物对天然的细菌产生的蛋白质的结构保真度。该构建体可用于针对炭疽杆菌的基于核酸的疫苗制剂。

9. 发明申请

US20080015116A1 Integrated Systems and Methods for Diversity Generation and Screening 有权
标题翻译：用于多样性生成和筛选的综合系统和方法
公开(公告)号：US20080015116A1
公开(公告)日：2008-01-17
申请号：US11677505
申请日：2007-02-21
申请人： Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
发明人： Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
IPC分类号： C40B60/04
CPC分类号： C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
摘要： Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
摘要翻译：提供了用于多样化生成和筛选的集成系统和方法。该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。

10. 发明授权

US08014961B2 Integrated systems and methods for diversity generation and screening 有权
标题翻译：用于多样化生成和筛选的综合系统和方法
公开(公告)号：US08014961B2
公开(公告)日：2011-09-06
申请号：US11677505
申请日：2007-02-21
申请人： Steven H. Bass , Simon Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy S. Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephan J. Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
发明人： Steven H. Bass , Simon Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy S. Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephan J. Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
IPC分类号： G01N33/48
CPC分类号： C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
摘要： Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
摘要翻译：提供了用于多样化生成和筛选的集成系统和方法。该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。

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