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1. 发明授权

US5777103A Process for producing cyclohexylazetidinone 失效
标题翻译：环己基氮杂环丁酮的制备方法
公开(公告)号：US5777103A
公开(公告)日：1998-07-07
申请号：US808270
申请日：1997-02-28
申请人： Takaji Matsumoto , Toshiyuki Murayama , Shigeru Mitsuhashi , Takashi Miura
发明人： Takaji Matsumoto , Toshiyuki Murayama , Shigeru Mitsuhashi , Takashi Miura
IPC分类号： C07D205/08 , C07F7/18 , C07B49/00
CPC分类号： C07F7/186 , C07D205/08 , Y02P20/55
摘要： A process for producing cyclohexylazetidinone expressed by the formula(IV) comprises condensing the magnesium enolate compound expressed by the formula (II) with acyloxyazetidinone expressed by the formula (III), wherein Me is a methyl group; R.sup.1 is a hydroxyl-protecting group, R.sup.2 is an acyl group, and X is a halogen atom. ##STR1##
摘要翻译：由式（IV）表示的环己基氮杂环丁酮的制备方法包括将由式（II）表示的烯醇镁化合物与由式（III）表示的酰氧基氮杂环丁酮缩合，其中Me为甲基; R1是羟基保护基，R2是酰基，X是卤素原子。（IMA）>（IV）

2. 发明授权

US5756863A Process for preparing optically active cyclohexanol derivatives 失效
标题翻译：光学活性环己醇衍生物的制备方法
公开(公告)号：US5756863A
公开(公告)日：1998-05-26
申请号：US730021
申请日：1996-10-11
申请人： Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
发明人： Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
IPC分类号： B01J31/22 , C07B61/00 , C07C29/145 , C07C35/08 , C07C41/26 , C07C43/196
CPC分类号： C07C41/26 , C07C29/145 , C07B2200/07 , C07C2101/14
摘要： A process for producing an optically active cyclohexanol derivative represented by formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms, a hydroxyl group, or a protected hydroxyl group, comprising asymmetrically hydrogenating a cyclohexanone derivative in the presence of a catalyst system composed of a transition metal compound (e.g., transition metal complex), a base (e.g., KOH), and a nitrogen compound (e.g., an amine compound).
摘要翻译：制备由式（I）表示的光学活性环己醇衍生物的方法：其中R 1表示具有1至4个碳原子的烷基，羟基或被保护的羟基，包括不对称地氢化环己酮在由过渡金属化合物（例如过渡金属络合物），碱（例如KOH）和氮化合物（例如胺化合物）组成的催化剂体系存在下的衍生物。

3. 发明授权

US08013193B2 Method for producing alcohol by hydrogenating lactone and carboxylic acid ester in liquid phase 有权
标题翻译：通过在液相中氢化内酯和羧酸酯来生产醇的方法
公开(公告)号：US08013193B2
公开(公告)日：2011-09-06
申请号：US12594577
申请日：2008-04-02
申请人： Hirofumi Maeda , Kenji Inoue , Takaji Matsumoto , Izuru Nagasaki , Ryoji Noyori , Susumu Saito
发明人： Hirofumi Maeda , Kenji Inoue , Takaji Matsumoto , Izuru Nagasaki , Ryoji Noyori , Susumu Saito
IPC分类号： C07C29/149
CPC分类号： C07B53/00 , C07B2200/07 , C07C29/157 , C07C213/00 , C07C231/12 , C07C269/06 , C07C31/20 , C07C33/20 , C07C31/207 , C07C31/22 , C07C31/205 , C07C33/22 , C07C33/26 , C07C215/28 , C07C233/73 , C07C271/16
摘要： Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic efficiency. This method also enables to produce an optically active alcohol from an optically active lactone or an optically active carboxylic acid ester. Specifically disclosed is a method for producing an alcohol by hydrogen reducing a lactone or a carboxylic acid ester in the presence of a catalyst containing ruthenium and a phosphine compound represented by the following general formula (1): wherein R1 represents a spacer; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group; and R8, R9, R10, R11, R12 and R13 independently represent an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group.
摘要翻译：公开了一种从内酯或羧酸酯制备醇的方法，其能够在相对温和的条件下以高产率和高催化效率从内酯或羧酸酯制备醇。该方法还能够从光学活性的内酯或光学活性的羧酸酯制备光学活性的醇。具体公开的是通过在含有钌的催化剂和由以下通式（1）表示的膦化合物的存在下氢还原内酯或羧酸酯来制备醇的方法：其中R1表示间隔基; R2，R3，R4，R5，R6和R7独立地表示氢原子，具有1-12个碳原子的烷基，芳基或杂环基; 并且R 8，R 9，R 10，R 11，R 12和R 13独立地表示具有1-12个碳原子的烷基，芳基或杂环基。

4. 发明授权

US06340751B1 Process for the preparation of 4-substituted azetidinone derivatives 失效
标题翻译：制备4-取代的氮杂环丁酮衍生物的方法
公开(公告)号：US06340751B1
公开(公告)日：2002-01-22
申请号：US09357153
申请日：1999-07-19
申请人： Takao Saito , Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
发明人： Takao Saito , Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
IPC分类号： C07F718
CPC分类号： C07D413/06 , C07D205/08 , Y02P20/55
摘要： Disclosed is a process for the preparation of a 4-substituted azetidinone derivative, which comprises reacting an azetidinone derivative and an amide compound in the presence of a magnesium compound such as those represented by the following formulas (II): and (IV): represented by the following formula (III): MgR5R6 (III) wherein R5 represents a C1-12 alkyl group, a C2-5 alkenyl group, a 5- to 8-membered alicyclic group which may be substituted by a lower C1-4 alkyl group, a phenyl group which may be substituted by a lower C1-4 alkyl group, a lower C1-4 alkoxy group or a halogen atom or a benzyl group which may be substituted by a lower C1-4 alkyl group, a lower C1-4 alkoxy group or a halogen atom, and R6 represents a halogen atom, a methanesulfonyloxy group, a benzenesulfonyloxy group, a p-toluenesulfonyloxy group, a trifluoromethanesulfonyloxy group, an acetoxy group which may be substituted by a halogen atom or a cyano group or an OR7 group (R7 representing a lower C1-4 alkyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted benzyl group). The process provides an industrially excellent process for the preparation of a 4-substituted azetidinone derivative which permits the selective preparation of an intermediate for the synthesis of a carbapenem antibacterial agent having a desired 1-&bgr;′ configuration.
摘要翻译：公开了制备4-取代的氮杂环丁酮衍生物的方法，该方法包括在镁化合物如下式（II）和（IV）所示的那些镁化合物存在下使氮杂环丁酮衍生物与酰胺化合物反应：代表通过下式（III）表示：其中R5表示C1-12烷基，C2-5烯基，可被低级C1-4烷基取代的5至8元脂环基，苯基可以被低级C 1-4烷基，低级C 1-4烷氧基或卤素原子取代的苯基，或可以被低级C 1-4烷基取代的苄基，低级C 1-4烷氧基或卤原子，R6表示卤原子，甲磺酰氧基，苯磺酰氧基，对甲苯磺酰氧基，三氟甲磺酰氧基，可被卤素原子或氰基取代的乙酰氧基或OR7基（R7表示低级C 1-4烷基，取代的o R未取代的苯基或取代或未取代的苄基）。该方法提供了制备4-取代的氮杂环丁酮衍生物的工业上优异的方法，其允许选择性制备用于合成具有所需1-β'构型的碳青霉烯类抗菌剂的中间体。

5. 发明授权

US09012690B2 Method for producing alcohol and/or amine from amide compound 有权
标题翻译：从酰胺化合物制备醇和/或胺的方法
公开(公告)号：US09012690B2
公开(公告)日：2015-04-21
申请号：US13825449
申请日：2011-09-01
申请人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
发明人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
IPC分类号： C07C209/00 , C07C209/50 , C07B41/02 , C07B43/04 , C07C29/149 , C07C209/62 , C07D295/18 , C07C29/36 , C07D295/02
CPC分类号： C07C209/50 , B01J31/1805 , B01J31/189 , B01J31/20 , B01J31/24 , B01J2231/643 , B01J2531/821 , C07B41/02 , C07B43/04 , C07C29/149 , C07C29/36 , C07C209/62 , C07D295/02 , C07D295/18 , C07C211/04 , C07C211/46 , C07C211/48 , C07C211/55 , C07C31/125 , C07C33/22
摘要： Disclosed herein is a method for producing an alcohol and an amine from an amide under an atmosphere of hydrogen with the use of, as a catalyst, a ruthenium complex that is easily prepared, easy to handle, and relatively cheaply obtained. Specifically, the method is a method for producing an alcohol and/or an amine from an amide compound under an atmosphere of hydrogen with the use of as a catalyst, a ruthenium carbonyl complex represented by the following general formula (1): RuXY(CO)(L) (1) wherein X and Y may be the same or different from each other and each represents an anionic ligand and L represents a tridentate aminodiphosphine ligand containing two phosphino groups and a —NH— group.
摘要翻译：本文公开了一种在氢气氛下由酰胺制备醇和胺的方法，其中使用易于制备，易于处理和相对便宜地获得的钌络合物作为催化剂。具体地说，该方法是使用作为催化剂的氢气气氛下的酰胺化合物制备醇和/或胺的方法，由以下通式（1）表示的羰基钌络合物：RuXY（CO ）（L）（1）其中X和Y可以相同或不同，各自表示阴离子配体，L表示含有两个膦基和-NH-基团的三齿氨基二膦配体。

6. 发明申请

US20130172619A1 METHOD FOR PRODUCING ALCOHOL AND/OR AMINE FROM AMIDE COMPOUND 有权
标题翻译：从酰胺化合物生产醇和/或胺的方法
公开(公告)号：US20130172619A1
公开(公告)日：2013-07-04
申请号：US13825449
申请日：2011-09-01
申请人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
发明人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
IPC分类号： C07C209/50 , C07C29/36
CPC分类号： C07C209/50 , B01J31/1805 , B01J31/189 , B01J31/20 , B01J31/24 , B01J2231/643 , B01J2531/821 , C07B41/02 , C07B43/04 , C07C29/149 , C07C29/36 , C07C209/62 , C07D295/02 , C07D295/18 , C07C211/04 , C07C211/46 , C07C211/48 , C07C211/55 , C07C31/125 , C07C33/22
摘要： Disclosed herein is a method for producing an alcohol and an amine from an amide under an atmosphere of hydrogen with the use of, as a catalyst, a ruthenium complex that is easily prepared, easy to handle, and relatively cheaply obtained. Specifically, the method is a method for producing an alcohol and/or an amine from an amide compound under an atmosphere of hydrogen with the use of as a catalyst, a ruthenium carbonyl complex represented by the following general formula (1): RuXY(CO)(L) (1) wherein X and Y may be the same or different from each other and each represents an anionic ligand and L represents a tridentate aminodiphosphine ligand containing two phosphino groups and a —NH— group.
摘要翻译：本文公开了一种在氢气氛下由酰胺制备醇和胺的方法，其中使用易于制备，易于处理和相对便宜地获得的钌络合物作为催化剂。具体地说，该方法是使用作为催化剂的氢气气氛下的酰胺化合物制备醇和/或胺的方法，由以下通式（1）表示的羰基钌络合物：RuXY（CO ）（L）（1）其中X和Y可以相同或不同，各自表示阴离子配体，L表示含有两个膦基和-NH-基团的三齿氨基二膦配体。

7. 发明授权

US06608214B2 Process for producing optically active &ggr;-butyrolactone 失效
标题翻译：光学活性γ-丁内酯的制备方法
公开(公告)号：US06608214B2
公开(公告)日：2003-08-19
申请号：US10199136
申请日：2002-07-19
申请人： Tsukasa Sotoguchi , Takaji Matsumoto , Motonobu Takenaka , Takashi Miura
发明人： Tsukasa Sotoguchi , Takaji Matsumoto , Motonobu Takenaka , Takashi Miura
IPC分类号： C07D30733
CPC分类号： C07D307/33 , C07B2200/07 , C07C67/31 , Y02P20/55 , C07C69/734
摘要： This invention provides a novel process for producing optically active 3-hydroxy-&ggr;-butyrolactone in a short step, which is superior economically and in efficiency and industrially suitable by using a starting material which is inexpensive and easily available and reagents easy to handle. This invention relates to a process for producing optically active 3-hydroxy-&ggr;-butyrolactone represented by formula I: wherein the symbol * means an asymmetric carbon atom, which comprises hydrogenating an optically active 4-substituted oxy-3-hydroxybutyrate represented by formula II: wherein R1 represents a C1-4 lower alkyl group, R2 represents a protective group for a hydroxyl group deprotected by hydrogenation with a heterogeneous hydrogenation catalyst, and the symbol * has the same meaning as defined above, in the presence of a heterogeneous hydrogenation catalyst and an acidic substance followed by deprotection and simultaneous ring closure thereof.
摘要翻译：本发明提供了一种在短时间内制备光学活性3-羟基-γ-丁内酯的新方法，其经济性和效率都优异，在工业上适用于便宜且易于获得的试剂和易于处理的试剂。本发明涉及一种由式I表示的光学活性3-羟基-γ-丁内酯的制备方法：其中符号*表示不对称碳原子，其包括将由式II表示的光学活性的4-取代的氧基-3-羟基丁酸：其中R1表示C1-4低级烷基，R2表示通过异相氢化催化剂氢化脱保护的羟基的保护基，符号*具有与上述相同的含义，在非均相加氢催化剂存在下和酸性物质，然后脱保护并同时闭环。

8. 发明授权

US08471048B2 Ruthenium carbonyl complex having tridentate ligand, its production method and use 有权
标题翻译：具有三齿配体的钌羰基络合物，其制备方法和用途
公开(公告)号：US08471048B2
公开(公告)日：2013-06-25
申请号：US13121990
申请日：2010-06-30
申请人： Wataru Kuriyama , Takaji Matsumoto , Yasunori Ino , Osamu Ogata
发明人： Wataru Kuriyama , Takaji Matsumoto , Yasunori Ino , Osamu Ogata
IPC分类号： C07F5/02 , C07F15/00 , C07C209/00 , C07C29/00
CPC分类号： C07B53/00 , C07B2200/07 , C07C29/145 , C07C29/149 , C07C29/177 , C07C41/26 , C07C213/08 , C07C269/06 , C07F9/5022 , C07F15/0046 , C07F15/0053 , C07C33/22 , C07C31/205 , C07C31/20 , C07C43/13 , C07C43/1782 , C07C271/16 , C07C215/16
摘要： The present invention relates to a ruthenium carbonyl complex that is represented by the following Formula (1): RuXY(CO)(L) (1) (in the Formula (1), X and Y, which may be the same or different from each other, represent an anionic ligand and L represents a tridentate aminodiphosphine ligand which has two phosphino groups and a —NH— group), its production method, and a method for production of alcohols by hydrogenation-reduction of ketones, esters, and lactones using the complex as a catalyst.The ruthenium carbonyl complex of the invention has a high catalytic activity and it can be easily prepared and handled.
摘要翻译：本发明涉及由下式（1）表示的羰基钌羰基络合物：RuXY（CO）（L）（1）（在式（1）中，X和Y可以相同或不同彼此表示阴离子配体，L表示具有两个膦基和-NH-基团的三齿氨基二膦配体），其制备方法和通过酮，酯和内酯的氢化还原来制备醇的方法，其使用该复合物作为催化剂。本发明的羰基钌络合物具有很高的催化活性，可以容易地制备和处理。

9. 发明申请

US20110237814A1 NOVEL RUTHENIUM CARBONYL COMPLEX HAVING TRIDENTATE LIGAND, ITS PRODUCTION METHOD AND USE 有权
标题翻译：具有三齿配子的新型亚麻烃复合物及其生产方法和用途
公开(公告)号：US20110237814A1
公开(公告)日：2011-09-29
申请号：US13121990
申请日：2010-06-30
申请人： Wataru Kuriyama , Takaji Matsumoto , Yasunori Ino , Osamu Ogata
发明人： Wataru Kuriyama , Takaji Matsumoto , Yasunori Ino , Osamu Ogata
IPC分类号： C07F19/00 , C07C29/149 , C07C269/06 , C07C41/18 , C07C209/68 , C07F7/18 , C07C29/145
CPC分类号： C07B53/00 , C07B2200/07 , C07C29/145 , C07C29/149 , C07C29/177 , C07C41/26 , C07C213/08 , C07C269/06 , C07F9/5022 , C07F15/0046 , C07F15/0053 , C07C33/22 , C07C31/205 , C07C31/20 , C07C43/13 , C07C43/1782 , C07C271/16 , C07C215/16
摘要： The present invention relates to a ruthenium carbonyl complex that is represented by the following Formula (1): RuXY(CO)(L) (1) (in the Formula (1), X and Y, which may be the same or different from each other, represent an anionic ligand and L represents a tridentate aminodiphosphine ligand which has two phosphino groups and a —NH— group), its production method, and a method for production of alcohols by hydrogenation-reduction of ketones, esters, and lactones using the complex as a catalyst. The ruthenium carbonyl complex of the invention has a high catalytic activity and it can be easily prepared and handled.
摘要翻译：本发明涉及由下式（1）表示的羰基钌羰基络合物：RuXY（CO）（L）（1）（在式（1）中，X和Y可以相同或不同彼此表示阴离子配体，L表示具有两个膦基和-NH-基团的三齿氨基二膦配体），其制备方法和通过酮，酯和内酯的氢化还原来制备醇的方法，其使用该复合物作为催化剂。本发明的羰基钌络合物具有很高的催化活性，可以容易地制备和处理。

10. 发明申请

US20100113842A1 METHOD FOR PRODUCING ALCOHOL BY HYDROGENATING LACTONE AND CARBOXYLIC ACID ESTER IN LIQUID PHASE 有权
标题翻译：通过在液相中氢化柠檬酸和羧酸酯生产醇的方法
公开(公告)号：US20100113842A1
公开(公告)日：2010-05-06
申请号：US12594577
申请日：2008-04-02
申请人： Hirofumi Maeda , Kenji Inoue , Takaji Matsumoto , Izuru Nagasaki , Ryoji Noyori , Susumu Saito
发明人： Hirofumi Maeda , Kenji Inoue , Takaji Matsumoto , Izuru Nagasaki , Ryoji Noyori , Susumu Saito
IPC分类号： C07C31/18 , C07C27/04
CPC分类号： C07B53/00 , C07B2200/07 , C07C29/157 , C07C213/00 , C07C231/12 , C07C269/06 , C07C31/20 , C07C33/20 , C07C31/207 , C07C31/22 , C07C31/205 , C07C33/22 , C07C33/26 , C07C215/28 , C07C233/73 , C07C271/16
摘要： Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic efficiency. This method also enables to produce an optically active alcohol from an optically active lactone or an optically active carboxylic acid ester. Specifically disclosed is a method for producing an alcohol by hydrogen reducing a lactone or a carboxylic acid ester in the presence of a catalyst containing ruthenium and a phosphine compound represented by the following general formula (1): wherein R1 represents a spacer; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group; and R8, R9, R10, R11, R12 and R13 independently represent an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group.
摘要翻译：公开了一种从内酯或羧酸酯制备醇的方法，其能够在相对温和的条件下以高产率和高催化效率从内酯或羧酸酯制备醇。该方法还能够从光学活性的内酯或光学活性的羧酸酯制备光学活性的醇。具体公开的是通过在含有钌的催化剂和由以下通式（1）表示的膦化合物的存在下氢还原内酯或羧酸酯来制备醇的方法：其中R1表示间隔基; R2，R3，R4，R5，R6和R7独立地表示氢原子，具有1-12个碳原子的烷基，芳基或杂环基; 并且R 8，R 9，R 10，R 11，R 12和R 13独立地表示具有1-12个碳原子的烷基，芳基或杂环基。

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