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1. 发明授权

US07858385B2 Method for detecting binding events using micro-X-ray fluorescence spectrometry 有权
标题翻译：使用微X射线荧光光谱法检测结合事件的方法
公开(公告)号：US07858385B2
公开(公告)日：2010-12-28
申请号：US09859701
申请日：2001-05-16
申请人： Benjamin P. Warner , George J. Havrilla , Grace Mann
发明人： Benjamin P. Warner , George J. Havrilla , Grace Mann
IPC分类号： G01N21/76 , G01N33/543 , G01N33/00
CPC分类号： G01N33/582 , G01N33/54373 , Y10S430/167 , Y10T436/16 , Y10T436/18 , Y10T436/19
摘要： Method for detecting binding events using micro-X-ray fluorescence spectrometry. Receptors are exposed to at least one potential binder and arrayed on a substrate support. Each member of the array is exposed to X-ray radiation. The magnitude of a detectable X-ray fluorescence signal for at least one element can be used to determine whether a binding event between a binder and a receptor has occurred, and can provide information related to the extent of binding between the binder and receptor.
摘要翻译：使用微X射线荧光光谱法检测结合事件的方法。受体暴露于至少一种潜在的粘合剂并排列在基底支架上。阵列的每个成员暴露于X射线辐射。可以使用至少一种元素的可检测X射线荧光信号的大小来确定粘合剂和受体之间的结合事件是否已经发生，并且可以提供与粘合剂和受体之间的结合程度相关的信息。

2. 发明授权

US06858148B2 Method and apparatus for detecting chemical binding 有权
标题翻译：检测化学结合的方法和装置
公开(公告)号：US06858148B2
公开(公告)日：2005-02-22
申请号：US10621825
申请日：2003-07-16
申请人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cyndi A. Wells
发明人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cyndi A. Wells
IPC分类号： G01N23/223 , G01N33/53 , B01D15/08
CPC分类号： G01N23/223 , G01N33/5306 , G01N2223/076 , Y10T436/13
摘要： The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.
摘要翻译：用于筛选目标粘合剂和潜在的药物化学药物之间的结合的方法包括将目标粘合剂的溶液（优选水溶液）通过导管送到尺寸排阻过滤器，目标粘合剂太大而不能通过尺寸排阻过滤器，然后在将目标粘合剂收集在过滤器上之后，将一种或多种潜在的药物化学品（优选水溶液）的溶液通过相同的导管送到尺寸排阻过滤器。潜在的药物化学品足够小以通过过滤器。之后，将x射线从x射线源发送到尺寸排阻滤光片，如果潜在的药物化学品与靶结合物形成复合物，则复合物产生具有指示复合物的强度的X射线荧光信号已形成。

3. 发明授权

US07929662B2 Flow method and apparatus for screening chemicals using micro x-ray fluorescence 有权
标题翻译：使用微X射线荧光筛选化学品的流动方法和装置
公开(公告)号：US07929662B2
公开(公告)日：2011-04-19
申请号：US12396592
申请日：2009-03-03
申请人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cris Lewis , Cynthia A. Mahan , Cyndi A. Wells
发明人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cris Lewis , Cynthia A. Mahan , Cyndi A. Wells
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , G01N2223/076
摘要： Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.
摘要翻译：使用微X射线荧光筛选化学品的方法和设备。用于筛选与至少一种目标粘合剂结合的潜在药物化合物的混合物的方法包括将化学品和靶粘合剂溶液分离成分离的组分，将其暴露于X射线激发光束中，从其中检测X射线荧光信号并且根据信号确定是否发生了化学和目标粘合剂之间的结合事件。

4. 发明授权

US07519145B2 Flow method and apparatus for screening chemicals using micro x-ray fluorescence 有权
标题翻译：使用微X射线荧光筛选化学品的流动方法和装置
公开(公告)号：US07519145B2
公开(公告)日：2009-04-14
申请号：US11444660
申请日：2006-05-31
申请人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cris Lewis , Cynthia A. Mahan , Cyndi A. Wells
发明人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cris Lewis , Cynthia A. Mahan , Cyndi A. Wells
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , G01N2223/076
摘要： Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow-separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.
摘要翻译：使用微X射线荧光筛选化学品的方法和设备。用于筛选用于结合至少一种靶粘合剂的潜在药物化学品混合物的方法包括将化学品和靶粘合剂的溶液流分离成分离的组分，将其暴露于x射线激发光束，检测X射线荧光信号并且根据信号确定是否发生了化学和目标粘合剂之间的结合事件。

5. 发明授权

US07241381B2 Method and apparatus for detecting chemical binding 有权
标题翻译：检测化学结合的方法和装置
公开(公告)号：US07241381B2
公开(公告)日：2007-07-10
申请号：US10986519
申请日：2004-11-10
申请人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cyndi A. Wells
发明人： Benjamin P. Warner , George J. Havrilla , Thomasin C. Miller , Cyndi A. Wells
IPC分类号： B01D15/08
CPC分类号： G01N23/223 , G01N33/5306 , G01N2223/076 , Y10T436/13
摘要： The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.
摘要翻译：用于筛选目标粘合剂和潜在的药物化学药物之间的结合的方法包括将目标粘合剂的溶液（优选水溶液）通过导管送到尺寸排阻过滤器，目标粘合剂太大而不能通过尺寸排阻过滤器，然后在将目标粘合剂收集在过滤器上之后，将一种或多种潜在的药物化学品（优选水溶液）的溶液通过相同的导管送至尺寸排阻过滤器。潜在的药物化学品足够小以通过过滤器。之后，将x射线从x射线源发送到尺寸排阻滤光片，如果潜在的药物化学品与靶结合物形成复合物，则复合物产生具有指示复合物的强度的X射线荧光信号已形成。

6. 发明申请

US20130034205A1 Well Plate 有权
标题翻译：井板
公开(公告)号：US20130034205A1
公开(公告)日：2013-02-07
申请号：US13567613
申请日：2012-08-06
申请人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L.E. Miller
发明人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L.E. Miller
IPC分类号： G01N1/28 , G01N23/223
CPC分类号： G01N23/2202 , G01N23/2204 , G01N23/223 , G01N2223/074 , G01N2223/076 , G01N2223/309 , G01N2223/64 , G03B42/02
摘要： An apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. A plate has one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays.
摘要翻译：通过X射线荧光光谱法制备用于测量的样品的装置。板有一个或多个孔穿过板。孔被板的一侧的薄膜覆盖。在膜覆盖孔的一个维度上，孔小于500微米。这部电影对于x射线是半透明的。

7. 发明申请

US20150023467A1 Well Plate 有权
公开(公告)号：US20150023467A1
公开(公告)日：2015-01-22
申请号：US14508322
申请日：2014-10-07
申请人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L.E. Miller
发明人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L.E. Miller
IPC分类号： G01N23/223 , G01N23/22
CPC分类号： G01N23/2202 , G01N23/2204 , G01N23/223 , G01N2223/074 , G01N2223/076 , G01N2223/309 , G01N2223/64 , G03B42/02
摘要： The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium. The holes are less than about 500 micrometers across in one dimension where the cover covers the holes. The present invention also includes a method for preparing samples for measurement by x-ray fluorescence spectrometry. The method comprises providing a solution of with less than 10 micromolar solute and a volume of between about 2 microliters and about 2 milliliters. The solution is concentrated and analyzed using x-ray fluorescence spectrometry.

8. 发明申请

US20090087919A1 Method and Apparatus for Measuring Protein Post-Translational Modification 审中-公开
公开(公告)号：US20090087919A1
公开(公告)日：2009-04-02
申请号：US12239459
申请日：2008-09-26
申请人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Lori J. Peterson-Court , Michael N. Harris , Rebecca L.E. Miller
发明人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Lori J. Peterson-Court , Michael N. Harris , Rebecca L.E. Miller
IPC分类号： G01N33/00 , G01N21/64
CPC分类号： C12Q1/485 , C12Q1/37 , G01N21/75 , G01N23/223 , G01N33/20 , G01N33/6842 , G01N2223/076 , G01N2333/91215 , G01N2333/96441 , Y10T436/17 , Y10T436/200833
摘要： The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The donor chemical includes a functional group selected from ester, anhydride, imide, acyl halide, and amide. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Yet another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. An additional analytical method is also used to measure either the acceptor product or the donor chemical.

9. 发明申请

US20080220441A1 Advanced drug development and manufacturing 审中-公开
标题翻译：先进的药物开发和制造
公开(公告)号：US20080220441A1
公开(公告)日：2008-09-11
申请号：US11974156
申请日：2007-10-10
申请人： Eva R. Birnbaum , Andrew T. Koppisch , Sharon M. Baldwin , Benjamin P. Warner , T. Mark McCleskey , Jeffrey Joseph Stewart , Jennifer A. Berger , Michael N. Harris , Anthony K. Burrell
发明人： Eva R. Birnbaum , Andrew T. Koppisch , Sharon M. Baldwin , Benjamin P. Warner , T. Mark McCleskey , Jeffrey Joseph Stewart , Jennifer A. Berger , Michael N. Harris , Anthony K. Burrell
IPC分类号： G01N33/53 , G01N21/76 , G01N33/68 , G01N23/223
CPC分类号： G01N33/566 , G01N2500/04
摘要： X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
摘要翻译：已经使用X射线荧光（XRF）光谱法检测结合事件并测量化学物质和受体之间的结合选择性。 XRF还可用于估计化学品的治疗指数，用于估计化学品与化学类似物的结合选择性，用于测量蛋白质的翻译后修饰和药物制造。

10. 发明授权

US07119937B2 Durable electrooptic devices comprising ionic liquids 失效
标题翻译：包含离子液体的耐用电光装置
公开(公告)号：US07119937B2
公开(公告)日：2006-10-10
申请号：US11041069
申请日：2005-01-20
申请人： Benjamin P. Warner , T. Mark McCleskey , Anthony K. Burrell
发明人： Benjamin P. Warner , T. Mark McCleskey , Anthony K. Burrell
IPC分类号： G02F1/153 , G02F1/07 , G02F1/68 , G03G17/04
CPC分类号： C09K9/02 , B60R1/088 , C09K2211/1029 , G02F1/1521 , G02F1/157 , G02F2202/36
摘要： Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3−), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N−), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N−) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C−). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes.
摘要翻译：使用廉价，低导电性的导体制备电致变色器件如后视镜和低漏电流的显示器的电解液。优选的电解质包括双功能氧化还原染料和熔融盐溶剂，对紫外线辐射具有增强的稳定性。溶剂包括锂或季铵阳离子，和全氟磺酰亚胺阴离子，选自三氟甲基磺酸酯（CF 3 SO 3 SO 2），双（三氟甲基磺酰基）酰亚胺（（CF 3 SO 2）2 N - ），双（全氟乙基磺酰基）酰亚胺（（CF _{3（三氟甲基磺酰基）甲基化（（3,3-二甲基-2- （CF 3 SO 2）3） - （CH 3）3）。具有纳米结构电极的电致发光，电致变色和光电致变色装置包括具有双功能氧化还原染料的离子液体。}

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