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1. 发明申请

US20130253447A1 NEEDLE PLACEMENT SYSTEM 审中-公开
标题翻译：针头放置系统
公开(公告)号：US20130253447A1
公开(公告)日：2013-09-26
申请号：US13426045
申请日：2012-03-21
申请人： Brian W. Ball , Keith A. Miesel , Mary M. Morris , Luis E. Fesser , Jonathan P. Bogott
发明人： Brian W. Ball , Keith A. Miesel , Mary M. Morris , Luis E. Fesser , Jonathan P. Bogott
IPC分类号： A61M5/00
CPC分类号： A61M5/427 , A61M5/14276 , A61M5/46 , A61M2005/1588
摘要： A needle and needle system that aids in determining needle position with respect to an implanted device. The system determines needle position by detecting changes in electrical characteristics and the system further may generate a cue to indicate proper needle placement within an implanted device. Methods for detecting needle position with respect to an implanted infusion device are also disclosed.
摘要翻译：针和针系统，其有助于相对于植入装置确定针位置。该系统通过检测电特性的变化来确定针位置，并且该系统还可以产生一个提示，以指示植入装置内适当的针位置。还公开了相对于植入的输注装置检测针位置的方法。

2. 发明授权

US08731656B2 Closed-loop therapy adjustment 有权
公开(公告)号：US08731656B2
公开(公告)日：2014-05-20
申请号：US13154309
申请日：2011-06-06
申请人： Duane L. Bourget , Keith A. Miesel
发明人： Duane L. Bourget , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/37211 , A61N1/36071 , A61N1/37247 , A61N1/37252 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.

3. 发明授权

US08554325B2 Therapy control based on a patient movement state 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US08554325B2
公开(公告)日：2013-10-08
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

4. 发明授权

US08308661B2 Collecting activity and sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集活动和睡眠质量信息
公开(公告)号：US08308661B2
公开(公告)日：2012-11-13
申请号：US11691425
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/103 , A61B5/117 , A61B5/04
CPC分类号： A61B5/4815 , A61B5/1116 , A61B5/1118 , A61B5/6814 , A61B5/6823 , A61B5/6825 , A61B5/686 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06F19/3481 , G06Q50/22 , G16H40/63
摘要： A device, such as an implantable medical device (IMD), programming device, or other computing device determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by a medical device.
摘要翻译：诸如可植入医疗设备（IMD），编程设备或其他计算设备的设备确定患者何时尝试睡眠。当设备确定患者正在尝试睡眠时，设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。当设备确定患者没有尝试睡眠时，设备周期性地确定患者的活动水平。活动度量值可以基于所确定的活动水平来确定。临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息，以例如评估由医疗设备递送给患者的治疗的有效性。

5. 发明申请

US20120108998A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20120108998A1
公开(公告)日：2012-05-03
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/048 , A61B5/0482
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

6. 发明申请

US20120053514A1 DRUG INFUSION DEVICE WITH CONTROLLABLE VALVE 有权
标题翻译：具有可控阀的药物输注装置
公开(公告)号：US20120053514A1
公开(公告)日：2012-03-01
申请号：US13217981
申请日：2011-08-25
申请人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
发明人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
IPC分类号： A61M5/168 , A61M5/158 , A61M39/22
CPC分类号： A61M5/16827 , A61M5/14276 , A61M5/1684 , A61M39/223 , A61M2205/3523 , A61M2205/3569 , A61M2210/1003
摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the value to open and close the first fluid pathway and to open and close the second fluid pathway.
摘要翻译：通常描述包括至少一个可控阀的治疗流体输送装置。在一个示例中，可植入治疗流体递送系统包括构造成输送第一治疗流体的第一流体通路和构造成输送第二治疗流体的第二流体通路，第二流体通路与第一流体通路分离。治疗流体递送系统包括连接到第一流体通路和第二流体通路的阀，以及配置成控制该值的致动以打开和关闭第一流体通路并打开和关闭第二流体通路的处理器。

7. 发明申请

US20120022340A1 DETECTING SLEEP TO EVALUATE THERAPY 有权
标题翻译：检测睡眠以评估治疗
公开(公告)号：US20120022340A1
公开(公告)日：2012-01-26
申请号：US13249862
申请日：2011-09-30
申请人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/0476 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/0476 , A61B5/4809 , A61B5/4815 , A61B5/4818 , A61M5/14276 , A61M2005/1726 , A61M2210/0693 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36067 , A61N1/36082 , A61N1/36135 , A61N1/36585 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep. In addition, an electroencephalogram signal may be used to identify sleep states of the patient.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。此外，可以使用脑波信号来识别患者的睡眠状态。

8. 发明申请

US20110257593A1 DEVICES AND METHODS FOR DETECTING CATHETER COMPLICATIONS 有权
标题翻译：用于检测导管连接的装置和方法
公开(公告)号：US20110257593A1
公开(公告)日：2011-10-20
申请号：US13169092
申请日：2011-06-27
申请人： Scott L. Kalpin , Lucien Bell Solefack , Keith A. Miesel
发明人： Scott L. Kalpin , Lucien Bell Solefack , Keith A. Miesel
IPC分类号： A61M25/00
CPC分类号： A61M5/14276 , A61M5/16854 , A61M5/16859 , A61M5/1723 , A61M27/006 , A61M2005/1726 , A61M2025/0003 , A61M2202/0464 , A61M2205/3331 , A61M2205/3344 , A61M2205/3355 , A61M2210/0693 , A61M2230/005 , A61M2230/04 , A61M2230/06 , A61M2230/40 , A61M2230/42 , A61M2230/63
摘要： A method for determining status of an implanted catheter includes acquiring raw pressure data from a pressure sensor of in an implantable infusion device. The pressure sensor is in communication with a lumen of the catheter operably coupled to the infusion device. The catheter has a delivery region, in communication with the lumen, intended to be positioned in a fluid-filled target location of a patient. The method further includes filtering the raw pressure data to remove the DC component, leaving the AC component within a relevant physiological frequency range; rectifying the AC component to produce a rectified pressure signal; calculating a mean magnitude of the rectified signal; and determining whether the mean magnitude is below a predetermined threshold. If the mean magnitude is below the threshold, the catheter is determined to be in a state other than a normal state.
摘要翻译：用于确定植入导管的状态的方法包括从可植入输注装置中的压力传感器获取原始压力数据。压力传感器与可操作地连接到输注装置的导管的内腔连通。导管具有与内腔连通的输送区域，用于定位在患者的流体填充的目标位置。该方法还包括过滤原始压力数据以去除DC分量，将AC分量留在相关的生理频率范围内; 整流交流分量以产生整流压力信号; 计算整流信号的平均幅度; 以及确定平均幅度是否低于预定阈值。如果平均值低于阈值，则确定导管处于正常状态以外的状态。

9. 发明申请

US20110208163A1 Pressure Sensing in Implantable Medical Devices 审中-公开
标题翻译：植入式医疗器械中的压力感应
公开(公告)号：US20110208163A1
公开(公告)日：2011-08-25
申请号：US13096590
申请日：2011-04-28
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61M25/00
CPC分类号： A61M5/14276 , A61M5/16854 , A61M2205/3355 , A61M2205/3523
摘要： An implantable medical device for delivering a therapeutic substance to a delivery site in a patient. A reservoir holds a supply of the fluid therapeutic substance. A catheter has a proximal end, a delivery region and a lumen extending from the proximal end to the delivery region. The proximal end of the catheter is operatively coupled to the reservoir. The delivery region of the catheter is adapted to be placed proximate the delivery site in the patient. The therapeutic substance is adapted to be delivered through the lumen to the patient. A sensing device is operatively coupled with the lumen of the catheter being capable of detecting a pressure of the therapeutic substance in the lumen. A controller is operatively coupled to the sensing device, the controller being capable of taking an action in response to the pressure in the lumen.
摘要翻译：一种用于将治疗物质输送到患者的输送部位的可植入医疗装置。储存器容纳流体治疗物质的供应。导管具有近端，输送区域和从近端延伸到输送区域的内腔。导管的近端可操作地联接到储存器。导管的输送区域适于放置在患者体内的输送部位附近。治疗物质适于通过内腔输送给患者。感测装置与导管的内腔可操作地耦合，能够检测内腔中的治疗物质的压力。控制器可操作地耦合到感测装置，所述控制器能够响应于内腔中的压力而采取动作。

10. 发明授权

US07908013B2 Collecting activity information to evaluate therapy 有权
标题翻译：收集活动信息以评估治疗
公开(公告)号：US07908013B2
公开(公告)日：2011-03-15
申请号：US12017918
申请日：2008-01-22
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61N1/37
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/02055 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/1455 , A61B5/6814 , A61B5/6826 , A61B5/6831 , A61B5/6838 , A61B2562/0219 , A61M5/14276 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗设备可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

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