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1. 发明授权

US07034292B1 Mass spectrometry with segmented RF multiple ion guides in various pressure regions 有权
公开(公告)号：US07034292B1
公开(公告)日：2006-04-25
申请号：US10448495
申请日：2003-05-30
申请人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins
发明人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/063
摘要： A mass spectrometer is configured with individual multipole ion guides, configured in an assembly in alignment along a common centerline wherein at least a portion of at least one multipole ion guide mounted in the assembly resides in a vacuum region with higher background pressure, and the other portion resides in a vacuum region with lower background pressure. Said multipole ion guides are operated in mass to charge selection and ion fragmentation modes, in either a high or low pressure region, said region being selected according to the optimum pressure or pressure gradient for the function performed. The diameter, lengths and applied frequencies and phases on these contiguous ion guides may be the same or may differ. A variety of MS and MS/MSn analysis functions can be achieved using a series of contiguous multipole ion guides operating in either higher background vacuum pressures, or along pressure gradients in the region where the pressure drops from high to low pressure, or in low pressure regions. Individual sets of RF, +/−DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multipole ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide. The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multipole ion guide into an adjacent ion guide. Alternatively ions can be fragmented in one or more multipole ion guides using resonant frequency excitation CID. A multiple multipole ion guide assembly can be configured as the primary mass analyzer in single or triple quadrupole mass analyzers with or without mass selective axial ejection. Alternatively, the multiple multipole ion guide linear assembly can be configured as part of a hybrid Time-Of-Flight, Magnetic Sector, Ion Trap or Fourier Transform mass analyzer.

2. 发明授权

US07786435B2 RF surfaces and RF ion guides 有权
标题翻译： RF表面和RF离子导向
公开(公告)号：US07786435B2
公开(公告)日：2010-08-31
申请号：US12111484
申请日：2008-04-29
申请人： Craig M. Whitehouse , David G. Welkie , Lisa Cousins
发明人： Craig M. Whitehouse , David G. Welkie , Lisa Cousins
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/062
摘要： Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides potential wells are formed near RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated over time in such wells During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage.
摘要翻译：提供了设备和方法，用于捕获，操纵和转移沿着RF和DC电势表面的离子，并通过RF离子引导，由于射频（RF）场和产生的静电场的重叠，在RF场产生表面附近形成势阱通过施加到周围电极的静电势。离子可以在这样的井中被约束和积累随着时间的推移在限制期间，离子可以经历各种过程，例如积累，碎裂，碰撞冷却，聚焦，质量 - 电荷过滤，空间分离离子迁移和化学相互作用，导致在后续处理和分析步骤中提高性能，如质量分析。或者，可以在限制期间更好地操作离子的运动，以提高其运送到特定位置的效率，例如从大气压进入真空的入口孔或进入随后的真空级。

3. 发明授权

US07858926B1 Mass spectrometry with segmented RF multiple ion guides in various pressure regions 有权
标题翻译：在各种压力区域分段RF多离子导向器的质谱
公开(公告)号：US07858926B1
公开(公告)日：2010-12-28
申请号：US11409169
申请日：2006-04-21
申请人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins
发明人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins
IPC分类号： H01J49/24 , H01J49/40
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/063
摘要： A mass spectrometer includes an ion source and at least one vacuum stage, a means for delivering ions from the ion source to the vacuum stage, a collision cell, a detector, at least two multipole ion guide segments, and independent RF frequency and DC voltage sources applied to the multipole ion guide segments, the RF frequency and DC voltage sources being controlled independently of each other.
摘要翻译：质谱仪包括离子源和至少一个真空级，用于将离子从离子源输送到真空级的装置，碰撞池，检测器，至少两个多极离子导向段以及独立的RF频率和DC电压施加到多极离子导向段的源，RF频率和DC电压源彼此独立地控制。

4. 发明申请

US20080296495A1 RF Surfaces and RF Ion Guides 有权
标题翻译：射频表面和射频离子指南
公开(公告)号：US20080296495A1
公开(公告)日：2008-12-04
申请号：US12111484
申请日：2008-04-29
申请人： Craig M. Whitehouse , David G. Welkie , Lisa Cousins
发明人： Craig M. Whitehouse , David G. Welkie , Lisa Cousins
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/062
摘要： Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides Potential wells are formed near RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated over time in such wells During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage.
摘要翻译：提供了设备和方法，用于沿着RF和DC电势表面捕获，操纵和转移离子，并通过RF离子导向器由于射频（RF）场和静电场的重叠而在RF场产生表面附近形成潜在的阱通过施加到周围电极的静电势。离子可以在这样的井中被约束和积累随着时间的推移在限制期间，离子可以经历各种过程，例如积累，碎裂，碰撞冷却，聚焦，质量 - 电荷过滤，空间分离离子迁移和化学相互作用，导致在后续处理和分析步骤中提高性能，如质量分析。或者，可以在限制期间更好地操作离子的运动，以提高其运送到特定位置的效率，例如从大气压进入真空的入口孔或进入随后的真空级。

5. 发明授权

US07365317B2 RF surfaces and RF ion guides 有权
标题翻译： RF表面和RF离子导向
公开(公告)号：US07365317B2
公开(公告)日：2008-04-29
申请号：US11133724
申请日：2005-05-20
申请人： Craig M. Whitehouse , David G. Welkie , Lisa Cousins
发明人： Craig M. Whitehouse , David G. Welkie , Lisa Cousins
IPC分类号： H01J49/42
CPC分类号： H01J49/42 , H01J49/062
摘要： Apparatus and methods are provided for trapping, manipulation and transferring ions along RF and DC potential surfaces and through RF ion guides. Potential wells are formed near RF-field generating surfaces due to the overlap of the radio-frequency (RF) fields and electrostatic fields created by static potentials applied to surrounding electrodes. Ions can be constrained and accumulated over time in such wells. During confinement, ions may be subjected to various processes, such as accumulation, fragmentation, collisional cooling, focusing, mass-to-charge filtering, spatial separation ion mobility and chemical interactions, leading to improved performance in subsequent processing and analysis steps, such as mass analysis. Alternatively, the motion of ions may be better manipulated during confinement to improve the efficiency of their transport to specific locations, such as an entrance aperture into vacuum from atmospheric pressure or into a subsequent vacuum stage.
摘要翻译：提供了设备和方法，用于沿着RF和DC电势表面以及通过RF离子导向器捕获，操纵和转移离子。由于射频（RF）场和施加到周围电极的静电势产生的静电场的重叠，在RF场产生表面附近形成潜在的阱。这些井中的离子可以随着时间的推移而受到约束和积累。在限制期间，离子可以经历各种过程，例如累积，碎裂，碰撞冷却，聚焦，质量 - 电荷过滤，空间分离离子迁移和化学相互作用，导致后续处理和分析步骤中的改进的性能，例如质量分析。或者，可以在限制期间更好地操作离子的运动，以提高其运送到特定位置的效率，例如从大气压进入真空的入口孔或进入随后的真空级。

6. 发明授权

US08334507B1 Fragmentation methods for mass spectrometry 有权
标题翻译：质谱分离方法
公开(公告)号：US08334507B1
公开(公告)日：2012-12-18
申请号：US11435034
申请日：2006-05-16
申请人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins , Sergey Rakov
发明人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins , Sergey Rakov
IPC分类号： H01J49/42 , H01J49/26 , B01D59/44
CPC分类号： H01J49/147 , H01J49/0054
摘要： Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.
摘要翻译：提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。

7. 发明授权

US07049584B1 Fragmentation methods for mass spectrometry 有权
标题翻译：质谱分离方法
公开(公告)号：US07049584B1
公开(公告)日：2006-05-23
申请号：US11184387
申请日：2005-07-19
申请人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins , Sergey Rakov
发明人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins , Sergey Rakov
IPC分类号： H01J49/26
CPC分类号： H01J49/147 , H01J49/0054
摘要： Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.
摘要翻译：提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。

8. 发明授权

US06919562B1 Fragmentation methods for mass spectrometry 有权
标题翻译：质谱分离方法
公开(公告)号：US06919562B1
公开(公告)日：2005-07-19
申请号：US10448477
申请日：2003-05-30
申请人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins , Sergey Rakov
发明人： Craig M. Whitehouse , David G. Welkie , Gholamreza Javahery , Lisa Cousins , Sergey Rakov
IPC分类号： H01J49/26
CPC分类号： H01J49/147 , H01J49/0054
摘要： Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.
摘要翻译：提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。

9. 发明授权

US08507850B2 Multipole ion guide interface for reduced background noise in mass spectrometry 有权
公开(公告)号：US08507850B2
公开(公告)日：2013-08-13
申请号：US11809349
申请日：2007-05-31
申请人： Craig M. Whitehouse , David G. Welkie
发明人： Craig M. Whitehouse , David G. Welkie
IPC分类号： H01J49/00
CPC分类号： H01J49/04 , H01J49/063
摘要： Ions that are transported from an ion source to a mass spectrometer for mass analysis are often accompanied by background particles such as photons, neutral species, and cluster or aerosol ions which originate in the ion source. Background particles are also produced by scattering and neutralization of ions during collisions with background gas molecules in higher pressure regions with line-of-sight to the mass spectrometer detector. In either case, such background particles produce noise in mass spectra. Apparatus and methods are provided in which a multipole ion guide is configured to efficiently transport ions through multiple vacuum stages, while preventing background particles, produced both in the ion source and along the ion transport pathway, from reaching the detector, thereby improving signal-to-noise in mass spectra.

10. 发明授权

US06872941B1 Charged particle trapping in near-surface potential wells 有权
标题翻译：在近地表潜势井中带电粒子捕获
公开(公告)号：US06872941B1
公开(公告)日：2005-03-29
申请号：US10719330
申请日：2003-11-20
申请人： Craig M. Whitehouse , David G. Welkie
发明人： Craig M. Whitehouse , David G. Welkie
IPC分类号： H01J49/40 , H01J49/42 , H01J49/16
CPC分类号： H01J49/40 , B82Y30/00 , H01J49/0068
摘要： A Time-Of-Flight mass spectrometer is configured with a pulsing region and electronic controls that generate a potential well for ions in the pulsing region, due to the repelling effect of a high-frequency electric field that is created in the space immediately proximate to a surface, and an additional static electric field that accelerates ions toward the surface. Ions can be constrained and accumulated over time in the potential well prior to acceleration into the Time-Of-Flight tube for mass analysis. Ions can also be directed to collide with the surface with high energy to cause Surface Induced Dissociation (SID) fragmentation, or with low energy to effect collisional cooling, hence, better spatial focusing, prior to mass analysis. The apparatus and method described in the invention result in refined control of ion fragmentation energy and improved Time-Of-Flight mass analysis performance.
摘要翻译：飞行时间质谱仪配置有脉冲区域和电子控制器，由于在紧邻的空间中产生的高频电场的排斥效应，脉冲区域中的离子产生潜在的阱一个表面和一个额外的静电场，可以将离子加速到表面。在加速进入飞行时间管以进行质量分析之前，离子可以在潜在的时间内受到约束和积累。离子也可以被引导与高能量的表面碰撞以引起表面诱导解离（SID）碎裂，或者以低能量来实现碰撞冷却，因此在质量分析之前更好地进行空间聚焦。本发明描述的装置和方法可以精确控制离子碎片能量，提高飞行时间质量分析性能。

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