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1. 发明授权

US06342634B2 Calixarenes and their use for sequestration of metals 失效
标题翻译：杯芳烃及其用于金属螯合的用途
公开(公告)号：US06342634B2
公开(公告)日：2002-01-29
申请号：US09880126
申请日：2001-06-14
申请人： Graeme P. Nicholson , Mark J. Kan , Gareth Williams , Michael G. Drew , Paul D. Beer
发明人： Graeme P. Nicholson , Mark J. Kan , Gareth Williams , Michael G. Drew , Paul D. Beer
IPC分类号： C07C23300
CPC分类号： C07C235/20 , C07C235/24 , C07C327/42 , C07C2603/92 , C07D273/00 , C22B3/002 , G01N27/3335 , Y02P10/234
摘要： Disclosed are “acid-amide” calixarenes of formula (I) wherein: L is [—CH2—] or [—O—CH2—O—] and may be the same or different between each aryl group R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R5 may be the same or different on each aryl group; R1 comprises an optionally protected carboxy group; two groups out of R2, R3, and R4, are H; the one group out of R2, R3, and R4 not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers
摘要翻译：公开了式（I）的“酸酰胺”杯芳烃，其中：L是[-CH 2 - ]或[-O-CH 2 -O-]，并且在每个芳基R5之间可以相同或不同，是H，卤素或 C 1 -C 10脂族烃基，C 6 -C 20芳基，其中任何一个可任选被一个或多个卤代或氧代基团取代或被一个或多个氧代基团间隔，并且R 5可以在每个芳基上相同或不同; R1包含任选保护的羧基; R2，R3和R4中的两个基团是H; R2，R3和R4不为H的一个基团包含酰胺基。酰胺基团可以与第二杯咖啡连接以形成二聚体。还公开了使用这种杯芳烃用于金属螯合的方法，特别是镧系元素和锕系元素的方法。还公开了本发明的杯芳烃的杯芳烃二聚体衍生物。还公开了制备杯芳烃和二聚体的方法

2. 发明授权

US06297395B1 Calixarenes and their use for sequestration of metals 失效
标题翻译：杯芳烃及其用于金属螯合的用途
公开(公告)号：US06297395B1
公开(公告)日：2001-10-02
申请号：US09460237
申请日：1999-12-13
申请人： Graeme P. Nicholson , Mark J. Kan , Gareth Williams , Michael G. Drew , Paul D. Beer
发明人： Graeme P. Nicholson , Mark J. Kan , Gareth Williams , Michael G. Drew , Paul D. Beer
IPC分类号： C07C22900
CPC分类号： C07C235/20 , C07C235/24 , C07C327/42 , C07C2603/92 , C07D273/00 , C22B3/002 , G01N27/3335 , Y02P10/234
摘要： Disclosed are “acid-amide” calixarenes of formula (I) wherein: L is [—CH2—] or [—O—CH2—O—] and may be the same or different between each aryl group; R5 is H, halogen, or C1-C10 aliphatic hydrocarbyl group, C6-C20 aryl group, C6-C10 hydrocarbyaryl group, any of which may optionally be substituted by one or more halo or oxo groups or interrupted by one or more oxo groups, and R5 may be the same or different on each aryl group; R1 comprises an optionally protected carboxy group; two groups out of R2, R3, and R4 are H; the one group out of R2, R3, and R4 not being H comprises an amide group. The amide group may be linked to a second calixarene to form a dimer. Also disclosed are methods of use of such calixarenes for the purposes of metal sequestration, especially of lanthanides and actinides. Also disclosed are calixarene dimer derivatives of the calixarenes of the invention. Also disclosed are processes for preparing the calixarenes and dimers.
摘要翻译：公开了式（I）的“酸酰胺”杯芳烃，其中：L是[-CH 2 - ]或[-O-CH 2 -O-]，并且在每个芳基之间可以相同或不同; R5是H，卤素或C1-C10脂族烃基，C6-C20芳基，C6-C10烃氧基，其中任何一个可以任选地被一个或多个卤代或氧代基取代或被一个或多个氧代基中断，并且R 5可以在每个芳基上相同或不同; R1包含任选保护的羧基; R2，R3和R4中的两个基团是H; R2，R3和R4不为H的一个基团包含酰胺基。酰胺基团可以与第二杯咖啡连接以形成二聚体。还公开了使用这种杯芳烃用于金属螯合的方法，特别是镧系元素和锕系元素的方法。还公开了本发明的杯芳烃的杯芳烃二聚体衍生物。还公开了制备杯芳烃和二聚体的方法。

3. 发明申请

US20110104375A1 Biocide composition comprising pyrithione and pyrrole derivatives 有权
公开(公告)号：US20110104375A1
公开(公告)日：2011-05-05
申请号：US12928983
申请日：2010-12-22
申请人： Craig Waldron , Robert Martin , Gareth Williams , Tina Williams
发明人： Craig Waldron , Robert Martin , Gareth Williams , Tina Williams
IPC分类号： B05D3/00
CPC分类号： C09D5/1625 , A01N43/36 , C09D5/14 , Y10T428/31678 , Y10T428/31699 , Y10T428/31855 , Y10T428/31906 , Y10T428/31935 , Y10T428/31989 , A01N43/40 , A01N59/16 , A01N59/20 , A01N2300/00
摘要： The present invention is directed to a biocidal composition comprising a blend of one or more pyrithione compounds, and one or more pyrrole compounds of Formula I wherein said biocidal composition is copper free or low copper content.

4. 发明授权

US07893047B2 Biocide composition comprising pyrithione and pyrrole derivatives 有权
公开(公告)号：US07893047B2
公开(公告)日：2011-02-22
申请号：US11368244
申请日：2006-03-03
申请人： Craig Waldron , Robert Martin , Gareth Williams , Tina Williams, legal representative
发明人： Craig Waldron , Robert Martin , Gareth Williams
IPC分类号： A01N55/02 , A61K31/555
CPC分类号： C09D5/1625 , A01N43/36 , C09D5/14 , Y10T428/31678 , Y10T428/31699 , Y10T428/31855 , Y10T428/31906 , Y10T428/31935 , Y10T428/31989 , A01N43/40 , A01N59/16 , A01N59/20 , A01N2300/00
摘要： The present invention is directed to a biocidal composition comprising a blend of one or more pyrithione compounds, and one or more pyrrole compounds of Formula I wherein said biocidal composition is copper free or low copper content.

5. 发明申请

US20080069935A1 COHESIVE NON-FREE FLOWING SWEETENER COMPOSITIONS INCLUDING LOW-DENSITY INGREDIENTS 审中-公开
标题翻译：包含低密度成分的非自由流动感应器组合物
公开(公告)号：US20080069935A1
公开(公告)日：2008-03-20
申请号：US11532698
申请日：2006-09-18
申请人： Renny Ison , Melanie Loades , Gareth Williams
发明人： Renny Ison , Melanie Loades , Gareth Williams
IPC分类号： A23L1/236 , A23L1/0534 , A23L1/09 , A23L1/305 , A23L1/221 , A23L1/222
CPC分类号： A23L33/175 , A23L5/00 , A23L27/30 , A23L27/33 , A23L29/244 , A23L29/30 , A23L29/35 , A23L33/125 , A23P10/20
摘要： Cohesive non-free flowing sweetener compositions, e.g., sweetener cubes, useful for adding sweetness to liquid foodstuffs, for example, beverages, having a reduced caloric burden as compared to conventional sucrose cubes, are provided. More particularly, a cohesive non-free flowing sweetener composition containing a high intensity sweetener and a low-density bulking agent, wherein a sweetener cube formed from the cohesive non-free flowing sweetener composition having the same dimensions as a conventional sucrose cube has a lower caloric burden and an equivalent sweetness. Methods of making such cohesive non-free flowing sweetener compositions are also provided.
摘要翻译：提供了与常规蔗糖立方体相比具有降低热量负担的液体食品例如饮料中的甜味剂的粘性非自由流动甜味剂组合物，例如增甜剂立方体。更具体地，含有高强度甜味剂和低密度填充剂的粘性非自由流动甜味剂组合物，其中由具有与常规蔗糖立方体相同尺寸的内聚非自由流动甜味剂组合物形成的甜味剂立方体具有较低的热量负担和相当的甜度。还提供制备这种内聚非自由流动甜味剂组合物的方法。

6. 发明申请

US20080069934A1 COHESIVE NON-FREE FLOWING SWEETENER COMPOSITIONS CONTAINING DISINTEGRANT 审中-公开
标题翻译：含有消毒剂的非自由流动感应器组合物
公开(公告)号：US20080069934A1
公开(公告)日：2008-03-20
申请号：US11532687
申请日：2006-09-18
申请人： Renny Ison , Melanie Loades , Gareth Williams
发明人： Renny Ison , Melanie Loades , Gareth Williams
IPC分类号： A23L1/236
CPC分类号： A23L27/33 , A23L27/30 , A23L27/31 , A23L27/32
摘要： Cohesive non-free flowing compositions for adding sweetness to liquid foodstuffs, for example, beverages, having a reduced caloric burden as compared to conventional sucrose cubes, are provided. More particularly, a low calorie Cohesive non-free flowing compositions containing a high intensity sweetener, a bulking agent, and a disintegrant, wherein a sweetener cube formed from the cohesive non-free flowing sweetener composition having about the same dimensions as a convention sucrose cube has a lower caloric burden and an equivalent sweetness is disclosed. Also provided are cohesive non-free flowing compositions containing sucralose, carboxymethyl cellulose, polydextrose, trehalose, and erythritol, wherein a sweetener cube formed from the cohesive non-free flowing composition having about the same dimension as a conventional sucrose cube has a lower caloric burden and a equivalent sweetness. Methods of making such sweetener cubes are also provided.
摘要翻译：提供了与常规蔗糖立方体相比具有降低热量负担的液体食品例如饮料的甜味的粘性非自由流动性组合物。更具体地，含有高强度甜味剂，填充剂和崩解剂的低热量粘性非自由流动组合物，其中由内聚非自由流动甜味剂组合物形成的甜味剂立方体具有与常规蔗糖立方体大致相同的尺寸具有较低的热量负担，并且公开了相当的甜度。还提供了含有三氯蔗糖，羧甲基纤维素，聚右旋糖，海藻糖和赤藓糖醇的内聚非自由流动组合物，其中由具有与常规蔗糖立方体相同尺寸的内聚非自由流动组合物形成的甜味剂立方体具有较低的热量负担和相当的甜度。还提供了制备这种甜味剂立方体的方法。

7. 发明申请

US20170037030A1 AUTOTAXIN INHIBITORS 审中-公开
标题翻译：维生素抑制剂
公开(公告)号：US20170037030A1
公开(公告)日：2017-02-09
申请号：US15305602
申请日：2015-04-21
申请人： Vikki FURMINGER , Owen HUGHES , Darren LEGRAND , Emily STANLEY , Christopher THOMSON , Gareth WILLIAMS
发明人： Vikki Furminger , Owen Rhys Hughes , Darren Mark Legrand , Emily Stanley , Christopher Thomson , Gareth Williams
IPC分类号： C07D401/12 , A61K31/454
CPC分类号： C07D401/12 , A61K31/454 , A61K45/06 , C07D211/26 , C07D211/34 , C07D211/58 , C07D249/04 , C07D263/38 , C07D265/30 , C07D401/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04 , A61K2300/00
摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of an ATX-dependent or ATX-mediated disease or condition.
摘要翻译：本发明涉及自体吸收素抑制剂的新化合物，其制备方法，药物组合物和含有它们的药物及其在治疗ATX依赖性或ATX介导的疾病或病症中的用途。

8. 发明申请

US20120077863A1 GUANIDINO-SUBSTITUTED BI-AND POLYPHENYLS AS SMALL MOLECULE CARRIERS 审中-公开
标题翻译：作为小分子载体的甘氨酸取代的双 - 聚双环
公开(公告)号：US20120077863A1
公开(公告)日：2012-03-29
申请号：US13203667
申请日：2010-03-01
申请人： David Selwood , Roberta Worthington , Anne-Sophie Rebstock , Michela Simone , Matt Gooding , Henry Dube , Kai Stoeber , Slavica Tudzarova , Christoffer Boshoff , Gareth Williams , Sarah Kingsbury , Dimitrios Lagos , Juan Manuel Funes Quesada
发明人： David Selwood , Roberta Worthington , Anne-Sophie Rebstock , Michela Simone , Matt Gooding , Henry Dube , Kai Stoeber , Slavica Tudzarova , Christoffer Boshoff , Gareth Williams , Sarah Kingsbury , Dimitrios Lagos , Juan Manuel Funes Quesada
IPC分类号： A61K31/713 , C12N5/071 , A61K31/155 , C07C279/08 , C07H21/02
CPC分类号： C07D277/18 , C07C279/08 , C07C279/24 , C07C323/60 , Y02P20/55
摘要： A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein —X1, X2 and X3 are each independently where Y is an alkylene, alkenylene or alkynylene group, each of which may be optionally substituted with one or more substituents selected from alkyl, halo, CF3, OH, alkoxy, NH2, CN, NO2 and COOH; W is absent or is O, S or NH; R1, R2, R3 and R4 are each independently selected from H, alkyl, aryl and a protecting group Pi; R7, R8 and R9 are each independently selected from H, alkyl, halo, CF3, OH, alkoxy, CN, NO2 and COOH; —q is 1, 2, 3 or 4; q′ is 0, 1, 2 or 3, where q+q′ equals 4; p and r are each independently 1, 2, 3, 4 or 5; p′ and r′ are each independently 0, 1, 2, 3 or 4, where p+p′ and r+r′ each equal 5; and —n is 0, 1, 2, 3, 4, 5 or 6.
摘要翻译：式I化合物或其药学上可接受的盐，其中-X1，X2和X3各自独立地为Y为亚烷基，亚烯基或亚炔基，其各自可以任选地被一个或多个选自烷基，卤素，CF 3，OH，烷氧基，NH 2，CN，NO 2和COOH; W不存在或是O，S或NH; R1，R2，R3和R4各自独立地选自H，烷基，芳基和保护基团Pi; R 7，R 8和R 9各自独立地选自H，烷基，卤素，CF 3，OH，烷氧基，CN，NO 2和COOH; -q为1,2,3或4; q'为0,1,2或3，其中q + q'等于4; p和r各自独立地为1,2,3,4或5; p'和r'各自独立地为0,1,2,3或4，其中p + p'和r + r'各自等于5; 和-n是0，1，2，3，4，5或6。

9. 发明申请

US20060160791A1 Wood preservative formulations 审中-公开
标题翻译：木材防腐剂配方
公开(公告)号：US20060160791A1
公开(公告)日：2006-07-20
申请号：US11284527
申请日：2005-11-21
申请人： Gareth Williams , Michael Bacon
发明人： Gareth Williams , Michael Bacon
IPC分类号： B32B21/02 , A01N33/12 , B32B21/10 , A01N43/50
CPC分类号： A01N43/653 , A01N43/88 , Y10T428/249925 , A01N33/12 , A01N2300/00
摘要： The invention provides a preservative composition comprising, in synergistic proportions, an oxathiazine compound plus one or more of a quaternary ammonium compound and a triazole compound as well as methods of treating wood and other material with said compositions.
摘要翻译：本发明提供一种防腐组合物，其包含协同比例的恶噻嗪化合物加上一种或多种季铵化合物和三唑化合物，以及用所述组合物处理木材和其它材料的方法。

10. 再颁专利

USRE36798E Preservatives for wood and other cellulosic materials 有权
标题翻译：防腐剂用于木材和其他纤维素材料
公开(公告)号：USRE36798E
公开(公告)日：2000-08-01
申请号：US190109
申请日：1998-11-12
申请人： Gareth Williams , Judith A. Cornfield , Janet Brown , Neil P. Ryan
发明人： Gareth Williams , Judith A. Cornfield , Janet Brown , Neil P. Ryan
IPC分类号： A01N20060101 , A01N43/647 , A01N43/653 , A01N59/00 , A01N59/06 , A01N59/16 , B27K20060101 , B27K3/00 , B27K3/50 , B27K3/52
CPC分类号： A01N59/20 , A01N43/653 , B27K3/20 , B27K3/22 , B27K3/343 , B27K3/40 , B27K3/52
摘要： The instant invention concerns a wood preservative composition comprising a synergistically effective amount of (a) a cuprammonium compound and (b) tebuconazole to preserve wood.
摘要翻译： PCT No.PCT / GB92 / 01427 371日期1994年04月4日 102（e）日期1994年4月4日PCT提交1992年8月3日PCT公布。公开号WO93 / 02557 日期：1993年2月18日本发明涉及木质防腐剂组合物，其包含协同有效量的（a）一种铜铵化合物和（b）戊唑醇来保存木材。

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