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1. 发明授权

US08543214B2 Configuring and testing treatment therapy parameters for a medical device system 有权
标题翻译：配置和测试医疗器械系统的治疗治疗参数
公开(公告)号：US08543214B2
公开(公告)日：2013-09-24
申请号：US10687135
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Randy M. Jensen
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Randy M. Jensen
IPC分类号： A61N1/00
CPC分类号： A61N1/36132 , A61N1/08
摘要： Apparatus and method support the configuration and testing of therapy parameters for a medical device system in the treatment of nervous system disorders. With the embodiment, the medical device system operates in a manual treatment therapy mode, in which the medical device system evaluates a set of information that is indicative of a system configuration. The medical device system determines if the set of information is acceptable. During the manual treatment therapy mode, the medical device system applies therapeutic treatment to a patient in accordance with the set of information. If the patient cannot tolerate the therapeutic treatment, the user indicates so through a user interface. The medical device system may associate the patient's intolerance to therapeutic treatments that equal or exceed the patient's level of tolerance. Moreover, the medical device system may use this information to prevent a delivery of therapeutic treatment that exceeds the patient's level of tolerance during a run mode.
摘要翻译：装置和方法支持用于治疗神经系统疾病的医疗装置系统的治疗参数的配置和测试。在该实施例中，医疗设备系统以手动治疗治疗模式操作，其中医疗设备系统评估指示系统配置的一组信息。医疗设备系统确定该组信息是否可接受。在手动治疗治疗模式期间，医疗装置系统根据该组信息向患者施加治疗。如果患者不能耐受治疗，则用户通过用户界面来表示。医疗装置系统可以将患者的不耐受性与等于或超过患者的耐受水平的治疗性治疗联系起来。此外，医疗装置系统可以使用该信息来防止在运行模式期间超过患者的容忍度的治疗性治疗的递送。

2. 发明授权

US07079977B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07079977B2
公开(公告)日：2006-07-18
申请号：US10687566
申请日：2003-10-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G04F1/00 , A61B5/00 , A61B1/36
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, includes a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

3. 发明授权

US07321837B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07321837B2
公开(公告)日：2008-01-22
申请号：US11355784
申请日：2006-02-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G01R35/00 , G04F10/00 , G04G15/00
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

4. 发明授权

US08579786B2 Screening techniques for management of a nervous system disorder 有权
标题翻译：用于管理神经系统疾病的筛查技术
公开(公告)号：US08579786B2
公开(公告)日：2013-11-12
申请号：US10687344
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Nina M. Graves , Scott F. Schaffner , Jonathon E. Giftakis , Mark T. Rise , Jonathan C. Werder
IPC分类号： A61N2/00
CPC分类号： A61N1/08 , A61B5/0476 , A61B5/4094 , A61B5/7275 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/37217
摘要： Apparatus and method support a neurological event screening for a medical device. The medical device assists a user in determining a configuration of the medical device for delivering an effective treatment for a nervous system disorder. The medical device detects a neurological event, such as a seizure, and reports a neurological event focus location and a neurological event spread to the user. The user may use the information to provide a configuration of a therapeutic delivery unit and associated therapy parameters. Therapeutic treatment is delivered to the patient, and the medical device is provided an indication of the patient's acceptance to the treatment. The user may modify the configuration and therapy parameters in order to achieve efficacy and acceptance. Depending upon the patient's acceptance, therapy is applied in either an open loop mode or a closed loop mode. The medical device determines whether the treatment is successful in accordance with a criterion.
摘要翻译：装置和方法支持用于医疗装置的神经事件筛查。医疗装置帮助用户确定医疗装置的配置以递送用于神经系统障碍的有效治疗。医疗装置检测诸如癫痫发作的神经系统事件，并向用户报告神经系统事件焦点位置和神经系统事件。用户可以使用该信息来提供治疗递送单元的配置和相关联的治疗参数。向患者传送治疗性治疗，并且向患者提供患者接受治疗的指示。用户可以修改配置和治疗参数，以达到功效和验收。根据患者的接受程度，治疗以开环模式或闭环模式应用。医疗设备根据标准确定治疗是否成功。

5. 发明授权

US07624293B2 Synchronization and calibration of clocks for a medical device and calibrated clock 有权
标题翻译：用于医疗设备和校准时钟的时钟的同步和校准
公开(公告)号：US07624293B2
公开(公告)日：2009-11-24
申请号：US11355489
申请日：2006-02-15
申请人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
发明人： Ivan Osorio , Naresh C. Bhavaraju , Thomas E. Peters , Mark G. Frei , Jonathan C. Werder
IPC分类号： G06F1/12 , G06F1/14 , G06F1/04
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/048 , A61B5/4094 , A61N1/025 , A61N1/36025 , A61N1/36082 , A61N1/37 , A61N1/372 , G04G7/00 , G06F19/00
摘要： Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, comprises a first clock and a second clock. The second clock may be synchronized to a first clock by disabling a run mode operation and setting the second clock to a selected time. When a reference time of the first clock approximately equals the selected time, the second clock enables the run mode operation. Additionally, a drift time that is indicative of a time difference between the first clock and the second clock is determined. If the drift time is greater than a predetermined amount, an indication to resynchronize the first and second clocks is provided.
摘要翻译：装置和方法支持医疗装置系统中的多个时钟的同步和校准，其可以向神经系统障碍的患者提供治疗。可以位于医疗装置系统的不同部件的多个时钟包括第一时钟和第二时钟。第二时钟可以通过禁用运行模式操作并将第二时钟设置到所选择的时间来同步到第一时钟。当第一个时钟的参考时间大致等于所选择的时间时，第二个时钟使能运行模式操作。此外，确定指示第一时钟和第二时钟之间的时间差的漂移时间。如果漂移时间大于预定量，则提供重新同步第一和第二时钟的指示。

6. 发明授权

US08515538B1 Medical device failure detection and warning system 有权
标题翻译：医疗器械故障检测和警告系统
公开(公告)号：US08515538B1
公开(公告)日：2013-08-20
申请号：US12157955
申请日：2008-06-13
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/08
CPC分类号： A61B5/7221 , A61B5/0022 , A61B5/01 , A61B5/04005 , A61B5/4094 , A61B5/686 , A61B5/746 , A61B7/00 , A61N1/36142 , A61N1/3706 , A61N1/37258 , G16H40/63
摘要： A failure detection and warning system for monitoring a medical device wherein the system includes means structured to passively or actively detect faults occurring in the medical device being monitored, and wherein the fault includes an unprogrammed and/or undesired shut off of the medical device being monitored or an unprogrammed and/or undesired shut-off of the output of the medical device being monitored by the system.
摘要翻译：一种用于监测医疗装置的故障检测和警告系统，其中所述系统包括构造成被动地或主动地检测正被监视的医疗装置中发生的故障的装置，并且其中所述故障包括被监视的医疗装置的未编程和/或不期望的切断或者由系统监视的未编程和/或非期望的关闭医疗设备的输出。

7. 发明授权

US07856272B2 Implantable interface for a medical device system 有权
标题翻译：用于医疗设备系统的可植入界面
公开(公告)号：US07856272B2
公开(公告)日：2010-12-21
申请号：US11414736
申请日：2006-04-28
申请人： Alexei V. Nikitin , Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Alexei V. Nikitin , Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/375
CPC分类号： A61N1/0529 , A61M5/14276 , A61M5/16827 , A61M5/16881 , A61M2205/054 , A61M2205/3507 , A61M2210/0693 , A61N1/36082
摘要： An implantable interface system for a medical device system providing selective interconnectivity between conduits and therapy elements. The interface system contains connecting elements that each provide a robust connection between a selected conduit and a selected therapy element. The interface system enables the use of a surplus of therapy elements so that treatment to the same site (in the case of electrode migration or failure), or to different sites but within the spatial domain of the interface's elements may be delivered through the spare/excess therapy elements without the need for additional major surgical procedures.
摘要翻译：一种用于医疗装置系统的可植入界面系统，其提供导管和治疗元件之间的选择性互连。接口系统包含连接元件，每个连接元件在所选导管和选定的治疗元件之间提供牢固的连接。接口系统使得能够使用多余的治疗元件，使得可以通过备用/非接触式的治疗单元向相同部位（在电极迁移或失效的情况下）或不同部位但在界面元件的空间域内进行治疗，多余的治疗元素，而不需要额外的主要外科手术。

8. 发明授权

US07389144B1 Medical device failure detection and warning system 有权
标题翻译：医疗器械故障检测和警告系统
公开(公告)号：US07389144B1
公开(公告)日：2008-06-17
申请号：US10982748
申请日：2004-11-05
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/00
CPC分类号： A61B5/7221 , A61B5/0022 , A61B5/01 , A61B5/04005 , A61B5/4094 , A61B5/686 , A61B5/746 , A61B7/00 , A61N1/36142 , A61N1/3706 , A61N1/37258 , G16H40/63
摘要： A failure detection and warning system for monitoring a medical device wherein the system includes means structured to passively or actively detect faults occurring in the medical device being monitored, and wherein the fault includes an unprogrammed and/or undesired shut off of the medical device being monitored or an unprogrammed and/or undesired shut-off of the output of the medical device being monitored by the system.
摘要翻译：一种用于监测医疗设备的故障检测和警告系统，其中所述系统包括构造成被动地或主动地检测正被监视的医疗设备中发生的故障的装置，并且其中所述故障包括被监视的所述医疗设备的未编程和/或不期望的切断或者由系统监视的未编程和/或非期望的关闭医疗设备的输出。

9. 发明授权

US06768969B1 Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes 有权
标题翻译：方法，计算机程序和用于信号变化的检测，量化和预测的自动化实时信号分析系统
公开(公告)号：US06768969B1
公开(公告)日：2004-07-27
申请号：US09824946
申请日：2001-04-03
申请人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio
发明人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio
IPC分类号： G01L2100
CPC分类号： G06K9/00536 , G06F17/10 , G06F17/18 , G06F19/24 , G16H50/20 , G16H50/50
摘要： A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.
摘要翻译：一种用于实时信号分析的方法，计算机程序和系统，通过跟踪顺序统计滤波器的输出（也称为百分位数，分位数）来提供移动时间窗口中的任意类型信号的时间演化密度和信号特征分布的表征或等级阶滤波器）。给定任意类型，原点或尺度的原始输入信号，本发明能够自动量化和检测该信号随时间发生的任何一组可量化特征的分布变化。此外，本发明快速准确地检测输入信号的某些特征的变化的能力还可以在与未来信号的可能性增加相关联的检测到的变化的情况下进行预测。

10. 发明授权

US09659216B2 Method, computer program, and system for automated real-time signal analysis for detection, quanitification, and prediction of signal changes 有权
公开(公告)号：US09659216B2
公开(公告)日：2017-05-23
申请号：US13608551
申请日：2012-09-10
申请人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio , Ruslan L. Davidchack
发明人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio , Ruslan L. Davidchack
IPC分类号： G01N33/48 , G01N33/50 , G06K9/00 , G06F17/10 , G06F17/18 , G06F19/24 , G06F19/00
CPC分类号： G06K9/00536 , G06F17/10 , G06F17/18 , G06F19/24 , G16H50/20 , G16H50/50
摘要： A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.

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