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1. 发明授权

US06633771B1 Solid-state non-invasive thermal cycling spectrometer 失效
标题翻译：固态非侵入式热循环光谱仪
公开(公告)号：US06633771B1
公开(公告)日：2003-10-14
申请号：US09427178
申请日：1999-10-25
申请人： James R. Braig , Bernhard B. Sterling , Joan C. Godfrey , Julian M. Cortella , David J. Correia , Charles E. Kramer , Arthur M. Shulenberger
发明人： James R. Braig , Bernhard B. Sterling , Joan C. Godfrey , Julian M. Cortella , David J. Correia , Charles E. Kramer , Arthur M. Shulenberger
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/1491 , G01J3/02 , G01J3/0286 , G01J3/0291 , G01J3/42 , G01J5/061 , G01N21/35 , H01K7/00
摘要： A solid-state device for the non-invasive generation and capture of thermal gradient spectra from sample tissue. The device includes an infrared transmissive layered window assembly, a means for inducing a thermal gradient in sample tissues. Also provided is an infrared radiation detector for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the sample tissues. The sensor provides output signals proportional to the detected infrared emissions. A data capture means is provided for the sampling of output signals received from the infrared radiation detector as the induced temperature gradient progresses into the sample tissue.
摘要翻译：用于非侵入性生成和捕获来自样品组织的热梯度光谱的固态器件。该装置包括红外透射分层窗组件，用于诱导样品组织中的热梯度的装置。还提供了一种红外辐射检测器，用于当瞬态温度梯度进入样品组织时检测从组织发出的红外辐射。传感器提供与检测到的红外发射成比例的输出信号。提供数据捕获装置，用于随着感应温度梯度进入样品组织，从红外辐射检测器接收的输出信号的采样。

2. 发明授权

US07050157B2 Reagent-less whole-blood glucose meter 有权
公开(公告)号：US07050157B2
公开(公告)日：2006-05-23
申请号：US10200384
申请日：2002-07-19
申请人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
发明人： James R. Braig , Peter Rule , Robert D. Gaffney , Philip C. Hartstein , Julian M. Cortella , Kenneth I. Li , Bernhard B. Sterling , Peng Zheng , W. Dale Hall , Kenneth G. Witte , Mark D. Agostino , Daniel S. Goldberger
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/01 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150213 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150755 , A61B5/15087 , A61B5/151 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

3. 发明授权

US06958809B2 Reagent-less whole-blood glucose meter 有权
标题翻译：无试剂全血糖仪
公开(公告)号：US06958809B2
公开(公告)日：2005-10-25
申请号：US10055875
申请日：2002-01-21
申请人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
发明人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
IPC分类号： A61B5/00 , G01N21/35 , G01N33/48
CPC分类号： A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

4. 发明授权

US06678542B2 Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements 失效
标题翻译：配置用于非侵入性分析物浓度监测器并采用传统测量的校准器
公开(公告)号：US06678542B2
公开(公告)日：2004-01-13
申请号：US10015932
申请日：2001-11-02
申请人： James R. Braig , Peter Rule , Bernhard B. Sterling , Heidi M. Smith , Julian M. Cortella , Jennifer H. Gable
发明人： James R. Braig , Peter Rule , Bernhard B. Sterling , Heidi M. Smith , Julian M. Cortella , Jennifer H. Gable
IPC分类号： A61B500
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/1491
摘要： A method calibrates a monitor that comprises a non-invasive blood constituent monitor and a traditional measurement system. The non-invasive blood constituent monitor includes a thermal gradient inducing element an analyzer window. A traditional monitor output representing a property of a blood constituent is generated by the traditional measurement system. A non-invasive monitor output representing the property of the whole blood constituent is generated by the non-invasive constituent monitor. The traditional monitor output and the non-invasive monitor output are compared to estimate an amount of error. The non-invasive monitor output is corrected by the amount of error.
摘要翻译：一种校准包括非侵入性血液成分监测器和传统测量系统的监测器。非侵入性血液成分监测器包括热梯度诱导元件分析器窗口。由传统的测量系统产生代表血液成分属性的传统监视器输出。代表全血成分的性质的非侵入性监测输出是由非侵入性成分监测器产生的。将传统的监视器输出和非侵入式监视器输出进行比较，以估计误差量。非侵入性监视器输出由误差量校正。

5. 发明授权

US06959211B2 Device for capturing thermal spectra from tissue 失效
标题翻译：用于从组织中捕获热谱的装置
公开(公告)号：US06959211B2
公开(公告)日：2005-10-25
申请号：US10213730
申请日：2002-08-06
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
IPC分类号： A61B5/00 , G01N21/01 , G01N21/03 , G01N21/35
CPC分类号： A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/6824 , G01J3/0286 , G01J3/0291 , G01N21/01 , G01N21/35 , G01N2021/0389 , G01N2201/021 , G01N2201/0245
摘要： A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

6. 发明授权

US06645142B2 Glucose monitoring instrument having network connectivity 失效
公开(公告)号：US06645142B2
公开(公告)日：2003-11-11
申请号：US09728743
申请日：2000-12-01
申请人： James R. Braig , Gary E. Hewett , Michael A. Munrow , Julian M. Cortella , Kamrava Azizi , Daniel S. Goldberger
发明人： James R. Braig , Gary E. Hewett , Michael A. Munrow , Julian M. Cortella , Kamrava Azizi , Daniel S. Goldberger
IPC分类号： A61B500
CPC分类号： G06F19/3418 , A61B5/0002 , A61B5/14532 , G06F19/00 , G16H40/40 , Y10S128/903 , Y10S128/904
摘要： A glucose monitoring instrument having network-based communication features which provide a link between patient and practitioner. The glucose monitoring instrument comprises circuitry for communicating data with one or more destination sites on the network which are configured to transmit and receive information to and from the instrument. Instrument measurements are transmitted over the link in addition to information and guidance, to provide increased accuracy, improved program compliance, and patient guidance from a supervisory authority or medical practitioner. In addition, a set of calibration features encourage calibration compliance.

7. 发明授权

US06931328B2 Analyte detection system with software download capabilities 有权
标题翻译：具有软件下载功能的分析物检测系统
公开(公告)号：US06931328B2
公开(公告)日：2005-08-16
申请号：US10291908
申请日：2002-11-08
申请人： James R. Braig , Gary E. Hewett , Michael A. Munrow , Julian M. Cortella , Kamrava Azizi , Daniel S. Goldberger
发明人： James R. Braig , Gary E. Hewett , Michael A. Munrow , Julian M. Cortella , Kamrava Azizi , Daniel S. Goldberger
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14532 , A61B5/1455 , A61B2560/0271 , A61B2562/0295 , G06F19/00 , G06F19/3418 , G16H40/40 , G16H40/63 , Y10S707/99945
摘要： An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection system has a processor that calculates analyte concentration in accordance with software executable by the processor. Under certain conditions, the software needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.
摘要翻译：分析物浓度监测系统，其具有基于网络的通信特征，其提供分析物检测系统和集中式计算机之间的连接。分析物检测系统具有根据可由处理器执行的软件计算分析物浓度的处理器。在某些条件下，软件需要更新。因此，当分析物检测系统连接到集中式计算机时，集中式计算机确定是否需要软件更新。如果需要软件更新，则集中式计算机可方便地向分析物检测系统提供软件更新，而无需用户干预。

8. 发明授权

US06277096B1 Digital fluid delivery and aspiration apparatus with mechanical de-amplifier 有权
标题翻译：具有机械去放大器的数字流体输送和抽吸装置
公开(公告)号：US06277096B1
公开(公告)日：2001-08-21
申请号：US09592642
申请日：2000-06-13
申请人： Julian M. Cortella , Carl C.T. Wang
发明人： Julian M. Cortella , Carl C.T. Wang
IPC分类号： A61M3700
CPC分类号： A61M1/0062 , A61B2017/00553 , A61B2017/320044 , A61F9/00 , A61M1/0068
摘要： A digital fluid delivery and aspiration apparatus with a mechanical de-amplifier for the delivery or removal of discrete volumes of fluidic material from a surgical site. The apparatus has a syringe with a plunger designed to be powered by a pneumatic air supply system. A ratcheting mechanism attached to a pneumatic piston by a mechanical linkage causes the plunger of the syringe to inject discrete doses of the fluidic material into the surgical site or remove discrete amounts of fluidic material from the surgical site. The mechanical linkage increases the force provided to the plunger by the movement of the piston and also de-amplifies the movement of the piston into a lesser movement of the plunger. Adjusting the waveform of the pneumatic air supply, coupled with the mechanical de-amplification of the movement of the pneumatic piston, reduces the jetting of the fluidic material being delivered, and allows the delivery or removal of precise volumes of fluidic material from the surgical site at precise rates without damaging the tissue into which or from which the fluidic material is being delivered or removed. The irrigation and aspiration features may be incorporated into one device.
摘要翻译：具有用于从外科手术部位输送或移除离散体积的流体材料的机械去放大器的数字流体输送和抽吸装置。该装置具有注射器，其具有设计成由气动空气供应系统供电的柱塞。通过机械连接件附接到气动活塞的棘轮机构使得注射器的柱塞将离散剂量的流体材料注射到外科手术部位或从手术部位移除离散量的流体材料。机械联动通过活塞的移动增加了提供给柱塞的力，并且还将活塞的移动减小到柱塞较小的运动。调整气动空气供应的波形，加上气动活塞的运动的机械去放大，减少了被输送的流体材料的喷射，并允许从手术部位输送或移除精确体积的流体材料以精确的速率，而不损害流体材料被输送或移除的组织。灌溉和抽吸特征可并入一个装置中。

9. 发明授权

US6102895A Digital fluid delivery and aspiration apparatus with mechanical de-amplifier 失效
标题翻译：具有机械去放大器的数字流体输送和抽吸装置
公开(公告)号：US6102895A
公开(公告)日：2000-08-15
申请号：US940189
申请日：1997-09-30
申请人： Julian M. Cortella , Carl C. T. Wang
发明人： Julian M. Cortella , Carl C. T. Wang
IPC分类号： A61B17/00 , A61B17/32 , A61F9/00 , A61M1/00 , A61M5/00
CPC分类号： A61M1/0062 , A61M1/0068 , A61B2017/00553 , A61B2017/320044 , A61F9/00
摘要： A digital fluid delivery and aspiration apparatus with a mechanical de-amplifier for the delivery or removal of discrete volumes of fluidic material from a surgical site. The apparatus has a syringe with a plunger designed to be powered by a pneumatic air supply system. A ratcheting mechanism attached to a pneumatic piston by a mechanical linkage causes the plunger of the syringe to inject discrete doses of the fluidic material into the surgical site or remove discrete amounts of fluidic material from the surgical site. The mechanical linkage increases the force provided to the plunger by the movement of the piston and also de-amplifies the movement of the piston into a lesser movement of the plunger. Adjusting the waveform of the pneumatic air supply, coupled with the mechanical de-amplification of the movement of the pneumatic piston, reduces the jetting of the fluidic material being delivered, and allows the delivery or removal of precise volumes of fluidic material from the surgical site at precise rates without damaging the tissue into which or from which the fluidic material is being delivered or removed. The irrigation and aspiration features may be incorporated into one device.
摘要翻译：具有用于从外科手术部位输送或移除离散体积的流体材料的机械去放大器的数字流体输送和抽吸装置。该装置具有注射器，其具有设计成由气动空气供应系统供电的柱塞。通过机械连接件附接到气动活塞的棘轮机构使得注射器的柱塞将离散剂量的流体材料注射到外科手术部位或从手术部位移除离散量的流体材料。机械联动通过活塞的移动增加了提供给柱塞的力，并且还将活塞的移动减小到柱塞较小的运动。调整气动空气供应的波形，加上气动活塞的运动的机械去放大，减少了被输送的流体材料的喷射，并允许从手术部位输送或移除精确体积的流体材料以精确的速率，而不损害流体材料被输送或移除的组织。灌溉和抽吸特征可并入一个装置中。

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