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1. 发明申请

US20060142383A1 3D-Structure model of SARS coronavirus 3CL protease and anti-SARS drugs 失效
标题翻译： SARS冠状病毒3CL蛋白酶和抗SARS药物的3D结构模型
公开(公告)号：US20060142383A1
公开(公告)日：2006-06-29
申请号：US11293847
申请日：2005-12-02
申请人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
发明人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
IPC分类号： C12Q1/70 , G06F19/00 , C12N9/48 , A61K31/21 , A61K31/235 , A61K31/165
CPC分类号： C12N9/506 , A61K31/167
摘要： The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
摘要翻译：本发明公开了通过分子模拟获得的SARS-CoV病毒3CL蛋白酶的三维结构。使用3D结构作为筛选现有医学数据库CMC（Comprehensive Medicinal Chemistry，MDL Information System，Inc。）的药物靶点，并发现一组具有抑制SARS-CoV病毒3CL蛋白酶活性的化合物。在分子和病毒水平测试了Cinanserin，发现能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒。合成Cinanserin类似物并在分子和病毒水平进行测试，发现它们能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒，可用于治疗和/或预防SARS-CoV病毒感染。

2. 发明授权

US07662860B2 3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs 失效
标题翻译： SARS冠状病毒3CL蛋白酶和抗SARS药物的3D结构模型
公开(公告)号：US07662860B2
公开(公告)日：2010-02-16
申请号：US11293847
申请日：2005-12-02
申请人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
发明人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
IPC分类号： A61K31/165
CPC分类号： C12N9/506 , A61K31/167
摘要： The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
摘要翻译：本发明公开了通过分子模拟获得的SARS-CoV病毒3CL蛋白酶的三维结构。使用3D结构作为筛选现有医学数据库CMC（Comprehensive Medicinal Chemistry，MDL Information System，Inc。）的药物靶点，并发现一组具有抑制SARS-CoV病毒3CL蛋白酶活性的化合物。在分子和病毒水平测试了Cinanserin，发现能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒。合成Cinanserin类似物并在分子和病毒水平进行测试，发现它们能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒，可用于治疗和/或预防SARS-CoV病毒感染。

3. 发明申请

US20090182133A1 BENZOPYRANONE DERIVATIVES AND THEIR USE AS ANTI-VIRAL AGENTS 审中-公开
标题翻译：苯并噻吩衍生物及其用作反病毒剂
公开(公告)号：US20090182133A1
公开(公告)日：2009-07-16
申请号：US12159570
申请日：2006-12-15
申请人： Chum Mok Puah , Weiliang Zhu , Jian Li , Lili Chen , Cheng Luo , Gang Chen , Zhili Zuo , Xiaomin Luo , Xu Shen , Kaixian Chen , Hualiang Jiang
发明人： Chum Mok Puah , Weiliang Zhu , Jian Li , Lili Chen , Cheng Luo , Gang Chen , Zhili Zuo , Xiaomin Luo , Xu Shen , Kaixian Chen , Hualiang Jiang
IPC分类号： C07H17/06 , C07D319/08
CPC分类号： A61K31/35 , C07D311/30 , C07D407/04 , C07H17/06
摘要： The invention relates to pharmaceutical compositions comprising benzopyranone derivatives for the treatment of Severe Acute Respiratory Syndrome (SARS).
摘要翻译：本发明涉及包含用于治疗严重急性呼吸综合征（SARS）的苯并吡喃酮衍生物的药物组合物。

4. 发明申请

US20100113498A1 NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES 失效
标题翻译：新型VINBLASTINE衍生物，其制备，使用和药物组合物，包含该衍生物
公开(公告)号：US20100113498A1
公开(公告)日：2010-05-06
申请号：US12449180
申请日：2007-12-17
申请人： Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou
发明人： Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou
IPC分类号： A61K31/437 , C07D461/00 , A61P35/00
CPC分类号： C07D519/04
摘要： The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.
摘要翻译：本发明提供由下式1表示的长春花碱衍生物或其生理上可接受的盐，其制备，用途和包含所述衍生物的药物组合物。所述长春花碱衍生物显示对肿瘤细胞系的抑制活性，可用作治疗恶性肿瘤的药物。

5. 发明授权

US08168647B2 Vinblastine derivatives, their preparation, use and pharmaceutical compositions comprising the said derivatives 失效
标题翻译：长春花碱衍生物，它们的制备，用途和包含所述衍生物的药物组合物
公开(公告)号：US08168647B2
公开(公告)日：2012-05-01
申请号：US12449180
申请日：2007-12-17
申请人： Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou , Hong Ding , Yong Shao , Hankun Zhang
发明人： Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou , Hong Ding , Yong Shao , Hankun Zhang
IPC分类号： C07D519/04 , A61K31/475 , A61P35/00
CPC分类号： C07D519/04
摘要： The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.
摘要翻译：本发明提供由下式1表示的长春花碱衍生物或其生理上可接受的盐，其制备，用途和包含所述衍生物的药物组合物。所述长春花碱衍生物显示对肿瘤细胞系的抑制活性，可用作治疗恶性肿瘤的药物。

6. 发明授权

US09165724B2 Change-over structure between moving contact and static contact of tap selector 有权
标题翻译：分接选择器的移动触点和静触点之间的切换结构
公开(公告)号：US09165724B2
公开(公告)日：2015-10-20
申请号：US13793781
申请日：2013-03-11
申请人： Xu Shen
发明人： Xu Shen
IPC分类号： H01H67/14 , H01H9/00 , H01H1/06 , H01F29/04
CPC分类号： H01H9/0016 , H01F29/04 , H01H1/06
摘要： A change-over structure disposed between a moving contact and a static contact of a tap selector includes an insulation changer base plate, static contacts which are fixed on the insulation changer base plate in at least one column at intervals, the inner ends of the static contacts are electrically connected to respective tap windings of a transformer, rotation shafts, each comprising moving contacts that are evenly distributed on each of the rotation shafts and are electrically connected to each other, and arc-shaped conductors corresponding to the static contacts in at least one column. Each of the arc-shaped conductors and outer ends of the static contacts are disposed at the same circumference with a center of one of the rotation shafts as a circle center. When one of the moving contacts is changed over between the two static contacts, another moving contact is electrically connected to the arc-shaped conductor.
摘要翻译：设置在分接选择器的移动触点和静触点之间的转换结构包括绝缘改变器基板，静态触点间隔地固定在至少一列的绝缘变换器基板上，静态触点的内端触点电连接到变压器的各个抽头绕组，旋转轴各自包括均匀分布在每个旋转轴上并且彼此电连接的移动触点，并且至少在静电触点对应的弧形导体一列。每个弧形导体和静触头的外端都以与其中一个旋转轴的中心为圆心相同的圆周设置。当其中一个移动触点在两个静触头之间转换时，另一个移动触点与弧形导体电连接。

7. 发明授权

US09728327B2 External on-load tap changer 有权
公开(公告)号：US09728327B2
公开(公告)日：2017-08-08
申请号：US14078067
申请日：2013-11-12
申请人： Xu Shen , Riming Xiao
发明人： Xu Shen , Riming Xiao
IPC分类号： H01H9/02 , H01F29/04 , H01H9/00
CPC分类号： H01F29/04 , H01H9/0027 , H01H9/0044
摘要： Disclosed is a suspensible external combined on-load tap changer, including: a switch box, a switch body and a motor mechanism, a top box wall of the switch box being opened with a top opening, a top box cover being mounted on the top opening, wherein the switch body is detachably mounted in the switch box and is entirely lifted in and lifted out by the top opening; and the motor mechanism is connected with the switch body in a driving manner. The switch body in the present invention uses a hoisting structure, and the top box wall of the switch box is opened with a top opening with a size large enough, so that the switch body is directly lifted in and lifted out of the switch box from the top opening, and installation and maintenance are easier.

8. 发明申请

US20130000563A1 Animal toy and related method of fabrication 审中-公开
标题翻译：动物玩具及相关制造方法
公开(公告)号：US20130000563A1
公开(公告)日：2013-01-03
申请号：US13273101
申请日：2011-10-13
申请人： Xu Shen
发明人： Xu Shen
IPC分类号： A01K29/00 , B32B5/20
CPC分类号： B32B5/022 , A01K15/025 , B32B3/04 , B32B5/245 , B32B5/26 , B32B25/042 , B32B2307/5825
摘要： The purpose of the present invention is to provide an animal toy and its manufacturing process. The animal is not easily destroyed when bitten by an animal, and its light weight reduces the risk of harm to an animal when the toy is thrown.
摘要翻译：本发明的目的是提供一种动物玩具及其制造方法。当被动物咬伤时，动物不容易被破坏，并且其轻量化减少了当玩具被投掷时对动物造成伤害的风险。

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