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1. 发明授权

US07670290B2 Electric circuit for tuning a capacitive electrostatic transducer 有权
标题翻译：用于调谐电容式静电传感器的电路
公开(公告)号：US07670290B2
公开(公告)日：2010-03-02
申请号：US10803808
申请日：2004-03-17
申请人： John A. Hossack , Brett Bymaster , Igal Ladabaum , Paul A. Wagner , Christopher M. W. Daft
发明人： John A. Hossack , Brett Bymaster , Igal Ladabaum , Paul A. Wagner , Christopher M. W. Daft
IPC分类号： A61B8/00
CPC分类号： B06B1/0292 , A61B8/4483 , G01S7/52079
摘要： An electrostatic transducer circuit and method of tuning the same, in which a balancing circuit is inserted into the electrostatic transducer circuit, is described. The electrostatic transducer circuit generally includes transmit circuitry, receive circuitry, a capacitive electrostatic transducer and the balancing circuit. The balancing circuit can include, either singly or in combination, an inductance and a negative capacitance. The balancing inductance is tuned to counteract the negative reactance of the capacitive electrostatic transducer at a desired operating frequency and can be inserted into the transmit circuitry and/or the receive circuitry. The balancing negative capacitance is tuned to counteract the capacitance of the capacitive electrostatic transducer and can be inserted into the receive circuitry and/or the transmit circuitry. The transmit circuitry can be isolated from the receive circuitry, and vice versa, once the balancing circuit has been inserted. Isolation can be achieved by switching the electrostatic transducer circuit between transmit and receive modes of operation, or by providing separate transmit and receive electrode subsets.
摘要翻译：描述了一种静电换能器电路及其调谐方法，其中平衡电路插入到静电换能器电路中。静电换能器电路通常包括发射电路，接收电路，电容式静电变换器和平衡电路。平衡电路可以单独地或组合地包括电感和负电容。调整平衡电感以抵消在期望的工作频率下的电容式静电换能器的负电抗并且可以插入到发射电路和/或接收电路中。调整平衡负电容以抵消电容式静电变换器的电容，并可将其插入接收电路和/或发射电路。一旦平衡电路被插入，发射电路可以与接收电路隔离，反之亦然。可以通过在发射和接收工作模式之间切换静电转换器电路，或通过提供单独的发射和接收电极子集来实现隔离。

2. 发明申请

US20140142468A1 System for Treatment and Imaging Using Ultrasonic Energy and Microbubbles and Related Method Thereof 有权
标题翻译：超声波和微泡治疗和成像系统及其相关方法
公开(公告)号：US20140142468A1
公开(公告)日：2014-05-22
申请号：US14063830
申请日：2013-10-25
申请人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
发明人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
IPC分类号： A61K41/00 , A61N7/00 , A61K49/22
CPC分类号： A61N7/00 , A61B8/12 , A61B8/445 , A61B8/481 , A61B17/2202 , A61B2017/22088 , A61B2017/22089 , A61B2090/3782 , A61K41/0028 , A61K49/223 , A61M37/0092
摘要： A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.
摘要翻译：用于在受试者的一个或多个位置（例如脉管系统）向治疗部位提供治疗的方法和相关系统，例如狭窄或其它脉管系统疾病。该方法包括：将超声导管推进到受试者的治疗部位或其附近; 将微泡注入或接近治疗部位; 并从超声导管输送超声波能量。超声波能量可以适于：对治疗部位进行成像，将微泡翻译成治疗部位或其附近和/或破裂微泡。

3. 发明申请

US20140046186A1 BONE SURFACE IMAGE RECONSTRUCTION USING ULTRASOUND 审中-公开
标题翻译：使用超声波的骨表面图像重建
公开(公告)号：US20140046186A1
公开(公告)日：2014-02-13
申请号：US14113672
申请日：2012-04-25
申请人： F. William Mauldin, JR. , John A. Hossack , Kevin Owen
发明人： F. William Mauldin, JR. , John A. Hossack , Kevin Owen
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/0875 , A61B8/0841 , A61B8/4245 , A61B8/4254 , A61B8/4433 , A61B8/4455 , A61B8/4466 , A61B8/4483 , A61B8/466 , A61B8/483 , A61B34/20 , A61B2017/3413 , A61B2034/2048 , A61B2034/2051 , A61B2034/2055 , A61B2090/378 , A61B2090/3937 , G01S7/52073 , G01S7/5208 , G01S15/60 , G01S15/8915 , G01S15/899
摘要： An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4λ2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½λ, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.
摘要翻译：超声波换能器元件可以被配置为产生被引导到对象的组织中的超声能量，并且被配置为接收由位于组织内的目标反射的超声能量的一部分。超声波换能器可以包括被配置为提供或接收超声能量的表面，该表面包括大于或等于约4λ2的面积，或者超声波换能器元件可以被包括在具有至少两个相邻超声波之间的间隔的阵列中小于或等于约1/2的元件，并且该阵列包括在两个轴线上至少近似对称的孔。可以经由显示器呈现目标的至少一部分的位置，形状或取向中的一个或多个的三维表示。

4. 发明授权

US08622911B2 System for treatment and imaging using ultrasonic energy and microbubbles and related method thereof 有权
标题翻译：使用超声波能量和微泡进行治疗和成像的系统及其相关方法
公开(公告)号：US08622911B2
公开(公告)日：2014-01-07
申请号：US12739128
申请日：2008-10-24
申请人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
发明人： John A. Hossack , Brian R. Wamhoff , Alexander L. Klibanov
IPC分类号： A61B8/00 , A61M31/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/445 , A61B8/481 , A61B17/2202 , A61B2017/22088 , A61B2017/22089 , A61B2090/3782 , A61K41/0028 , A61K49/223 , A61M37/0092
摘要： A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.
摘要翻译：用于在受试者的一个或多个位置（例如脉管系统）向治疗部位提供治疗的方法和相关系统，例如狭窄或其它脉管系统疾病。该方法包括：将超声导管推进到受试者的治疗部位或其附近; 将微泡注入或接近治疗部位; 并从超声导管输送超声波能量。超声波能量可以适于：对治疗部位进行成像，将微泡翻译成治疗部位或其附近和/或破裂微泡。

5. 发明授权

US07756304B2 Medical diagnostic ultrasonic imaging method and system for displaying multi-phase, multi-frame images 有权
标题翻译：医学诊断超声成像方法和显示多相，多帧图像的系统
公开(公告)号：US07756304B2
公开(公告)日：2010-07-13
申请号：US09369510
申请日：1999-08-06
申请人： John A. Hossack , Linyong Pang , Thilaka S. Sumanaweera
发明人： John A. Hossack , Linyong Pang , Thilaka S. Sumanaweera
IPC分类号： G06K9/00
CPC分类号： A61B8/08 , A61B8/0883 , A61B8/483 , A61B8/543 , G01S7/52034 , G01S7/52065 , G01S7/52087 , G01S15/8993 , G06F19/00 , G06F19/321 , G16H40/63 , G16H50/50 , Y10S128/922
摘要： A medical diagnostic ultrasonic imaging system acquires image data for at least two frames at each of multiple positions, each frame identified with a respective phase of a physiological cycle. A multiphase 3-D or extended field of view data set is constructed from the image data. Then a plurality of images are generated from the multiphase data set. Each image is associated with a respective phase of the physiological cycle, and these images are displayed in sequence to a user.
摘要翻译：医疗诊断超声成像系统在多个位置的每一个处获取至少两帧的图像数据，每个帧用生理周期的相应相位标识。从图像数据构建多相3-D或扩展视场数据集。然后，从多相数据集生成多个图像。每个图像与生理周期的相应相关联，并且这些图像依次显示给用户。

6. 发明申请

US20100063399A1 FRONT END CIRCUITRY FOR IMAGING SYSTEMS AND METHODS OF USE 有权
标题翻译：成像系统的前端电路及其使用方法
公开(公告)号：US20100063399A1
公开(公告)日：2010-03-11
申请号：US12543452
申请日：2009-08-18
申请人： William F. Walker , Michael I Fuller , Karthik Ranganathan , John A. Hossack , Travis N. Blalock
发明人： William F. Walker , Michael I Fuller , Karthik Ranganathan , John A. Hossack , Travis N. Blalock
IPC分类号： A61B8/00 , G01N29/36 , G06K9/00
CPC分类号： G01N29/0654 , A61B8/00 , A61B8/4483 , G01N2291/02475 , G01S7/52026 , G01S7/52046 , G01S7/52079 , G01S15/8959
摘要： Pulse-echo imaging systems and methods are provided, including a transmit code sequencer and a pulse generation circuit, The transmit code sequencer is configured to input a transmit code sequence to the pulse generation circuit. A transducer is configured to receive electrical signals provided as pulses using coded excitation according to the transmit code sequence, and to transduce the electrical signals to pulses of energy other than electrical signals. The transducer is further configured to receive echoes of the pulses of energy other than electrical signals and convert the echoes to received electrical signals generate using coded excitation. A receive circuit is configured to receive the received electrical signals generate using coded excitation, perform analog sampling of the received electrical signals generate using coded excitation, and provide a weighted, summed digital signal by processing the analog samples. At least one example of a pulse imaging system described is configured for ultrasonic pulse-echoes. At least one example of a pulse imaging system described is a medical diagnostic imaging system.
摘要翻译：提供脉冲回波成像系统和方法，包括发射码序列器和脉冲发生电路。发送码序列器被配置为向脉冲发生电路输入发射码序列。传感器被配置为接收根据发射码序列使用编码激励的脉冲提供的电信号，并将电信号转换成电信号以外的能量脉冲。换能器还被配置为接收除电信号之外的能量脉冲的回波，并将回波转换成使用编码激励产生的接收电信号。接收电路被配置为接收使用编码激励产生的接收电信号，对使用编码激励产生的接收电信号进行模拟采样，并通过处理模拟采样来提供加权的相加的数字信号。所描述的脉冲成像系统的至少一个示例被配置用于超声脉冲回波。所描述的脉冲成像系统的至少一个示例是医学诊断成像系统。

7. 发明申请

US20090048519A1 Hybrid Dual Layer Diagnostic Ultrasound Transducer Array 有权
标题翻译：混合双层诊断超声波传感器阵列
公开(公告)号：US20090048519A1
公开(公告)日：2009-02-19
申请号：US11840079
申请日：2007-08-16
申请人： John A. Hossack , Travis N. Blalock , William F. Walker
发明人： John A. Hossack , Travis N. Blalock , William F. Walker
IPC分类号： A61B8/00
CPC分类号： B06B1/0629 , A61B8/4483 , A61B8/483 , G01S15/8913 , G01S15/8915 , G10K11/004
摘要： An ultrasound transducer array having a transmit transducer element comprising a transmit transducer material interposed between a transmit electrode and a reference electrode, wherein voltages applied across the transmit electrode and reference electrode induce an acoustic wave to emanate from the transmit transducer material; and a plurality of receive transducer elements positioned in an array on the transmit transducer element, each of the plurality of the receive transducer elements comprising a receive electrode and a receive transducer material interposed between the receive electrode and the reference electrode, and wherein acoustic waves applied to the plurality of receive transducer elements induces receive voltage signals on the receive electrodes with respect to the reference electrode.
摘要翻译：一种具有发射换能器元件的超声换能器阵列，其包括插入在发射电极和参考电极之间的发射换能器材料，其中施加在所述发射电极和参考电极两端的电压引起从所述发射换能器材料发出的声波; 以及多个接收换能器元件，其定位在所述发射换能器元件上的阵列中，所述多个所述接收换能器元件中的每一个包括插入在所述接收电极和所述参考电极之间的接收电极和接收换能器材料，并且其中施加声波到多个接收换能器元件相对于参考电极在接收电极上感应出接收电压信号。

8. 发明授权

US06511426B1 Medical diagnostic ultrasound system and method for versatile processing 有权
公开(公告)号：US06511426B1
公开(公告)日：2003-01-28
申请号：US09328113
申请日：1999-06-08
申请人： John A. Hossack , Jeffrey S. Hastings , Jeffrey M. Greenberg , Samuel H. Maslak
发明人： John A. Hossack , Jeffrey S. Hastings , Jeffrey M. Greenberg , Samuel H. Maslak
IPC分类号： A61B800
CPC分类号： G01S15/899 , A61B8/483 , A61B8/5276 , G01S7/52034 , G01S7/52077 , G01S15/8981 , G01S15/8993 , G01S15/8995
摘要： A method and system for reducing speckle for two and three-dimensional images is disclosed. For two-dimensional imaging, a one and a half or a two-dimensional transducer is used to obtain sequential, parallel or related frames of elevation spaced data. The frames are compounded to derive a two-dimensional image. For three-dimensional imaging, various pluralities of two-dimensional frames of data spaced in elevation are compounded into one plurality of spaced two-dimensional frames of data. The frames of data are then used to derive a three dimensional set of data, such as by interpolation. Alternatively, the various pluralities are used to derive a three-dimensional set of data. An anisotropic filter is applied to the set of data. The anisotropic filter filters at least along the elevation dimension. In either situation, various displays may be generated from the final three-dimensional set of data. A method and system for adjustably generating two and three-dimensional representations is also disclosed. For three-dimensional imaging, at least two sets of three-dimensional data corresponding respectively to two types of Doppler or B-mode data are generated. The sets of data are then combined. An image or a quantity may be obtained from the combined data. By combining after generating the three-dimensional sets of data, the same data (sets of data) may be combined multiple times pursuant to different relationships. Thus, a user may optimize the image or quantity. Likewise, frames of data may be combined pursuant to different persistence parameters, such as different finite impulse response filter size and coefficients. The frames of data may then be re-combined pursuant to different persistence parameters. Original ultrasound data may also be used to re-generate an imaging using the same ultrasound image processes as used for a previous image.

9. 发明授权

US06436046B1 Diagnostic ultrasound imaging method and system with improved frame rate 有权
标题翻译：诊断超声成像方法和系统，帧率提高
公开(公告)号：US06436046B1
公开(公告)日：2002-08-20
申请号：US09698995
申请日：2000-10-27
申请人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
发明人： David J. Napolitano , Christopher R. Cole , Gregory L. Holley , John A. Hossack , Charles E. Bradley , Patrick Phillips
IPC分类号： A61B800
CPC分类号： G01S15/8963 , A61B8/00 , G01S7/52039 , G01S7/52046 , G01S7/52085 , G01S7/52095 , G01S15/8927 , G01S15/8959 , G01S15/8977
摘要： A medical diagnostic ultrasonic imaging system acquires receive beams from spatially distinct transmit beams. The receive beams alternate in type between at least first and second types across the region being imaged. The first and second types of receive beams differ in at least one scan parameter other than transmit and receive line geometry, and can for example differ in transmit phase, transmit or receive aperture, system frequency, transmit focus, complex phase angle, transmit code or transmit gain. Receive beams associated with spatially distinct ones of the transmit beams (including at least one beam of the first type and at least one beam of the second type) are then combined. In this way, many two-pulse techniques, including, for example, phase inversion techniques, synthetic aperture techniques, synthetic frequency techniques, and synthetic focus techniques, can be used while substantially reducing the frame rate penalty normally associated with such techniques.
摘要翻译：医疗诊断超声成像系统从空间上不同的发射波束获取接收波束。接收波束在被成像的区域之间在至少第一和第二类型之间交替类型。第一和第二类型的接收波束在除发射和接收线几何之外的至少一个扫描参数不同，并且例如可以在发射相位，发射或接收孔径，系统频率，发射焦点，复相位角，发射码或传输增益。然后组合与空间上不同的发射波束（包括第一类型的至少一个波束和第二类型的至少一个波束）相关联的接收波束。以这种方式，可以使用许多双脉冲技术，包括例如相位反转技术，合成孔径技术，合成频率技术和合成焦点技术，同时显着降低通常与这种技术相关联的帧速率损失。

10. 发明授权

US6122222A Ultrasonic transmit and receive system 有权
标题翻译：超声波发射和接收系统
公开(公告)号：US6122222A
公开(公告)日：2000-09-19
申请号：US307491
申请日：1999-05-07
申请人： John A. Hossack , Jian-Hua Mo
发明人： John A. Hossack , Jian-Hua Mo
IPC分类号： G01N29/24 , G01N29/26 , G01N29/34 , G01N29/40 , G01N29/42 , G01N29/46 , G01S7/52 , G01S15/89 , G10K11/34 , G03B42/06
CPC分类号： G01N29/343 , G01N29/2456 , G01N29/2462 , G01N29/262 , G01N29/348 , G01N29/40 , G01N29/42 , G01N29/46 , G01S15/8909 , G01S15/895 , G01S7/52034 , G01S7/52036 , G01S7/52038 , G01S7/52039 , G01S7/52046 , G01S7/52047 , G10K11/341 , G10K11/343 , G01N2291/012 , G01N2291/015 , G01N2291/106
摘要： A transmit beamformer includes multiple transducers, each responsive to a respective transmit waveform to produce a respective transducer waveform. A transmit waveform generator generates the transmit waveforms, and the transmit waveforms each include multiple frequency components. Progressively higher frequency components of the transmit waveforms are timed to cause corresponding progressively higher frequency components of the transducer waveforms to focus along a line at progressively shorter ranges. In this way, a frequency dependent line focus is achieved.
摘要翻译：发射波束形成器包括多个换能器，每个换能器响应相应的发射波形以产生相应的换能器波形。发送波形发生器产生发送波形，并且发送波形各自包括多个频率分量。发射波形的逐渐更高的频率分量被定时，以使得相应的逐渐更高的频率分量的换能器波形在逐渐更短的范围内沿着一条线聚焦。以这种方式，实现了频率相关的线焦点。

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