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1. 发明申请

US20200147298A1 SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS 审中-公开
公开(公告)号：US20200147298A1
公开(公告)日：2020-05-14
申请号：US16613766
申请日：2018-05-17
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61M5/142 , A61M37/00 , A61B10/02 , A61N1/36 , A61N1/32 , A61B5/145
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

2. 发明申请

US20230050912A1 SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS 有权
公开(公告)号：US20230050912A1
公开(公告)日：2023-02-16
申请号：US17826799
申请日：2022-05-27
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61K9/48 , A61J3/07 , A61N1/36 , A61K9/00 , A61N1/32 , A61M5/32 , A61B5/145 , A61B10/02 , A61M5/20 , A61M31/00 , A61M5/142 , A61M5/158 , A61M37/00 , A61K38/28 , A61N1/05
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

3. 发明授权

US12036324B2 Self-righting systems and related components and methods 有权
公开(公告)号：US12036324B2
公开(公告)日：2024-07-16
申请号：US17826799
申请日：2022-05-27
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61K9/48 , A61B5/145 , A61B10/02 , A61J3/07 , A61K9/00 , A61K38/28 , A61M5/142 , A61M5/145 , A61M5/158 , A61M5/20 , A61M5/32 , A61M31/00 , A61M37/00 , A61N1/32 , A61N1/36 , A61B10/06 , A61N1/05
CPC分类号： A61K9/4808 , A61B5/14503 , A61B5/14539 , A61B10/02 , A61J3/07 , A61K9/0002 , A61K9/0012 , A61K9/0021 , A61K9/0065 , A61K9/0092 , A61K9/4866 , A61K38/28 , A61M5/14276 , A61M5/1454 , A61M5/158 , A61M5/2033 , A61M5/329 , A61M5/3295 , A61M31/002 , A61M37/0015 , A61M37/0069 , A61N1/325 , A61N1/36007 , A61B2010/0208 , A61B10/0233 , A61B10/06 , A61M2005/14284 , A61M2005/1581 , A61M2005/1585 , A61M2037/0023 , A61M2037/0053 , A61M2205/0238 , A61M2205/21 , A61M2210/1053 , A61M2210/106 , A61N1/0509
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

4. 发明授权

US11771829B2 Systems and methods for liquid injection 有权
公开(公告)号：US11771829B2
公开(公告)日：2023-10-03
申请号：US16778152
申请日：2020-01-31
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Robert S. Langer , Carlo Giovanni Traverso , Alex G. Abramson , Morten Revsgaard Frederiksen , Mikkel Oliver Jespersen , Brian Mouridsen , Jesper Windum , Mette Poulsen , Brian Jensen , Jorrit Jeroen Water , Mikkel Wennemoes Hvitfeld Ley , Xiaoya Lu , Andreas Vegge
IPC分类号： A61M5/20 , A61K9/00 , A61M5/30
CPC分类号： A61M5/2033 , A61K9/0024 , A61M5/30 , A61M2005/202 , A61M2202/0007 , A61M2202/30 , A61M2210/1042
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

5. 发明授权

US11607390B2 Self-righting systems and related components and methods 有权
公开(公告)号：US11607390B2
公开(公告)日：2023-03-21
申请号：US16691579
申请日：2019-11-21
申请人： Massachusetts Institute of Technology , Novo Nordisk A/S , The Brigham and Women's Hospital, Inc.
发明人： Alex G. Abramson , Morten Revsgaard Frederiksen , Brian Jensen , Mikkel Oliver Jespersen , Carlo Giovanni Traverso
IPC分类号： A61K9/48 , A61K9/00 , A61M5/142 , A61M37/00 , A61N1/36 , A61M31/00 , A61M5/158 , A61J3/07 , A61B5/145 , A61B10/02 , A61N1/32 , A61M5/20 , A61M5/32 , A61K38/28 , A61N1/05
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage with a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components.

6. 发明授权

US11369574B2 Self-righting systems and related components and methods 有权
公开(公告)号：US11369574B2
公开(公告)日：2022-06-28
申请号：US16613766
申请日：2018-05-17
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , Novo Nordisk A/S
发明人： Carlo Giovanni Traverso , Alex G. Abramson , Ester Caffarel Salvador , Niclas Roxhed , Minsoo Khang , Taylor Bensel , Robert S. Langer , Jorrit Jeroen Water , Morten Revsgaard Frederiksen , Bo Uldall Kristiansen , Mikkel Oliver Jespersen , Mette Poulsen , Peter Herskind , Brian Jensen
IPC分类号： A61K9/48 , A61J3/07 , A61K9/00 , A61M5/142 , A61M37/00 , A61M5/20 , A61M5/32 , A61M31/00 , A61M5/158 , A61B5/145 , A61B10/02 , A61N1/32 , A61N1/36 , A61K38/28 , A61N1/05
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

7. 发明申请

US20200246545A1 SYSTEMS AND METHODS FOR LIQUID INJECTION 审中-公开
公开(公告)号：US20200246545A1
公开(公告)日：2020-08-06
申请号：US16778152
申请日：2020-01-31
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital Inc. , Novo Nordisk A/S
发明人： Robert S. Langer , Carlo Giovanni Traverso , Alex G. Abramson , Morten Revsgaard Frederiksen , Mikkel Oliver Jespersen , Brian Mouridsen , Jesper Windum , Mette Poulsen , Brian Jensen , Jorrit Jeroen Water , Mikkel Wennemoes Hvitfeld Ley , Xiaoya Lu
IPC分类号： A61M5/20 , A61M5/30 , A61K9/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article.

8. 发明申请

US20220105330A1 MEDICAL DEVICE WITH ACTUATION MECHANISM 有权
公开(公告)号：US20220105330A1
公开(公告)日：2022-04-07
申请号：US17426848
申请日：2020-01-31
申请人： Novo Nordisk A/S
发明人： Brian Jensen , Morten Revsgaard Frederiksen , Brian Mouridsen , Jacob Pyung Hwa Jepsen
IPC分类号： A61M37/00 , A61M31/00
摘要： A medical delivery device suitable for insertion into a lumen of a patient, the medical device (100, 200) comprising a capsule (110, 120, 210, 220) sized to be inserted into the lumen, the capsule comprising a base member, and an actuation mechanism comprising an actuation member (150, 250, 350) configured for movement relative to the base member along an axis, and an energy source (140, 240, 340) associated with the actuation member for powering the actuation member to move relative to the base member along the axis. The base member and the actuation member define a latch assembly comprising: a) a dissolvable firing member (160, 260, 360), the dissolvable firing member being at least partially dissolvable when subjected to a biological fluid, b) a retainer portion (113, 213, 313) comprised by one of the base member and the actuation member, and c) a movable latch (152, 252, 352) configured for lateral movement relative to the axis, the movable latch defining a first surface with a blocking portion (153, 253, 353), and a second surface (152a, 252a, 352a) configured for interacting with the dissolvable firing member (160, 260, 360). In a pre-firing configuration, the blocking portion (153, 253, 353) of the movable latch engages the retainer portion (113, 213, 313) in a latching engagement, and the second surface (152a, 252a, 352a) of the movable latch interacts with the dissolvable firing member to restrict lateral movement of the movable latch thereby preventing release of the latching engagement. In a firing configuration where the dissolvable firing member (160, 260) has become at least partially dissolved, the movable latch is allowed to move laterally thereby releasing the latching engagement.

9. 发明申请

US20210030966A1 Flow Communication Unit With Unconnected and Connected Configuration 有权
公开(公告)号：US20210030966A1
公开(公告)日：2021-02-04
申请号：US17045708
申请日：2019-01-10
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Brian Jensen , Bo Kvolsbjerg
IPC分类号： A61M5/24 , A61M39/24
摘要： A flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) for establishing flow communication from a multi-use drug delivery device adapted for extended use, to a flow conducting device, wherein the drug delivery device comprises a reservoir comprising multiple doses of a liquid drug formulation, wherein the reservoir is adapted to pressurize the liquid drug formulation, wherein the flow conducting device (230) is adapted for conducting the drug to the subcutaneous tissue of a subject, wherein the flow communication unit is adapted for being in an unconnected and a connected configuration, whereby the flow communication unit (240, 540, 640, 740, 840, 940, 1040, 1140, 1240) is adapted to enable the extended use of the multi-use drug delivery device.

10. 发明申请

US20220265560A1 CAPSULE DEVICE HAVING IMPROVED SELF-RIGHTING ABILITY 有权
公开(公告)号：US20220265560A1
公开(公告)日：2022-08-25
申请号：US17627226
申请日：2020-07-22
申请人： Novo Nordisk A/S
发明人： Mikkel Wennemoes Hvitfeld Ley , Morten Revsgaard Frederiksen , Brian Jensen
IPC分类号： A61K9/48 , A61M31/00 , A61B5/00 , A61M5/20
摘要： A capsule device suitable for insertion into a lumen of a patient, the lumen having a lumen wall, wherein the capsule device (100, 200, 300, 400, 500) comprises a) a capsule housing (110, 120, 210, 220) having an outside shape formed as a rounded object and defining an exterior surface, and b) a tissue interfacing component (130, 230) disposed relative to the capsule housing (110, 120, 210, 220), the tissue interfacing component (130, 230) configured to interact with the lumen wall at a target location, wherein the capsule device is configured as a self-righting capsule having a geometric center and a center of mass offset from the geometric center along a first axis, wherein when the capsule device (100, 200, 300, 400, 500) is supported by the tissue of the lumen wall while being oriented so that the centre of mass is offset laterally from the geometric center the capsule device experiences an externally applied torque due to gravity acting to orient the capsule device with the first axis oriented along the direction of gravity to enable the tissue interfacing component (130, 230) to interact with the lumen wall at the target location, wherein at least a portion of the exterior surface of the capsule device (100, 200, 300, 400, 500) has a surface property exhibiting one or more surface properties selected from the group consisting of a surface coating, a surface roughness, a surface geometry, and a surface micro-geometry, and wherein said surface property is selected to provide low friction, such as low static friction, ensuring slipping movement of the capsule device relative to the tissue of the lumen wall when said externally applied torque due to gravity acts on the capsule device.

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