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1. 发明申请

US20220134012A1 DRUG DELIVERY DEVICE WITH MEANS FOR DETERMINING EXPELLED DOSE 有权
公开(公告)号：US20220134012A1
公开(公告)日：2022-05-05
申请号：US17433479
申请日：2020-02-27
申请人： Novo Nordisk A/S
发明人： Henrik Bengtsson , Nikolaj Eusebius Jacobsen , Ebbe Kiilerich , Per Einar Pontus Holm
IPC分类号： A61M5/315
摘要： The present invention provides a drug delivery device (1) of the type in which a piston rod (10, 110) extends along a reference axis and is forced to rotate in an expelling direction about the reference axis during a dose expelling event to cause an expelling of drug from a drug reservoir (30, 130), and a resilient ratchet element (12) is operatively coupled with the piston rod (10, 110) and undergoes a deflecting motion comprising elastic deformation and recovery in response to an expelling of a predetermined dose increment, which deflecting motion occasions a velocity fluctuation of the piston rod (10, 110), comprising: a rotator module (50, 150) operatively coupled with the piston rod (10, 110) and configured to rotate about the reference axis against a rotation resisting force in response to a rotation of the piston rod (10, 110) in the expelling direction, the rotator module (50, 150) comprising a sensor system (70, 71; 170, 183; 270, 183) for monitoring a torque transferred by the piston rod (10, 110) during the dose expelling event, wherein the sensor system (70, 71; 170, 183; 270, 183) is configured to, from the monitored torque, identify occurrences of velocity fluctuation of the piston rod (10, 110) attributable to the deflecting motion of the resilient ratchet element 15 (12).

2. 发明申请

US20170290988A1 An Injection Device Adapted to Detect Air in a Cartridge 审中-公开
公开(公告)号：US20170290988A1
公开(公告)日：2017-10-12
申请号：US15507861
申请日：2015-09-01
申请人： Novo Nordisk A/S
发明人： Michael Monrad , Jens Aage Munk , Per Einar Pontus Holm , Dan Noertoft Soerensen
IPC分类号： A61M5/315 , A61M5/24 , A61M5/31 , A61M5/20
CPC分类号： A61M5/31565 , A61M5/14 , A61M5/20 , A61M5/24 , A61M5/31 , A61M5/3146 , A61M5/31515 , A61M5/31573 , A61M5/365 , A61M2005/31588 , A61M2205/33 , A61M2205/332
摘要： A drug delivery device (100) for estimating the amount of free air in a cartridge (1) comprising a cartridge receiving portion (not shown) adapted to receive a cartridge (1), the cartridge (1) comprising a body portion (6), an axially displaceable piston (5), and a distal outlet portion (4), an expelling assembly comprising an axially displaceable piston drive member (10) adapted to interface with the proximal piston (5) portion of a received cartridge (1), the piston drive member (10) is adapted to be moveable in a distal direction, and to thereby pressurize the drug in a received cartridge. The drug delivery device further comprises means for measuring and acquiring a property relating to a fluid pres-sure of the drug in a received cartridge (1), and where the property depends on the amount of free air (7) contained in the cartridge (1). The drug delivery device further comprises means (20) for measuring and acquiring the position of the piston rod drive member (10), and means (40) for measuring and acquiring the time. The drug delivery device further comprises means (30) for storing, and means (31) for processing the acquired measurements. The processing means are configured for estimating the amount of air (7) in the cartridge (1).

3. 发明申请

US20210042429A1 Data Transmission Safety Feature 有权
公开(公告)号：US20210042429A1
公开(公告)日：2021-02-11
申请号：US17044665
申请日：2019-04-03
申请人： Novo Nordisk A/S
发明人： Per Einar Pontus Holm
IPC分类号： G06F21/60
摘要： The invention provides a method and corresponding devices for wireless pairing of two devices for subsequent secure transmission of data. Each device comprises impact sensor circuitry for detecting an impact event made to the device, and is adapted to determine a unique time related value based on the detected impact event, respectively a corresponding time related value based on the detected impact event. The transmitting device is adapted to calculate a hint H for a key K based on the unique time related value, and the receiving device is adapted to calculate the key K based on the hint H and the corresponding time related value.

4. 发明申请

US20170151388A1 Motorized Drug Delivery Device 审中-公开
公开(公告)号：US20170151388A1
公开(公告)日：2017-06-01
申请号：US15324559
申请日：2015-07-08
申请人： Novo Nordisk A/S
发明人： Michael Monrad , Per Einar Pontus Holm , Jens Aage Munk
IPC分类号： A61M5/20 , A61M5/315
CPC分类号： A61M5/20 , A61M5/31546 , A61M5/31578 , A61M2005/3126 , A61M2005/31588 , A61M2205/3306 , A61M2205/332 , A61M2205/3368 , A61M2205/50 , A61M2205/60 , A61M2205/8206
摘要： A drug delivery device comprising a piston rod adapted to engage and axially move a cartridge piston to thereby expel an amount of drug from a loaded cartridge corresponding to a set dose amount, the device comprising a motor for moving the drive member from an initial position, through a start-of-dose position, to an end-of-dose position, as well as position detection means adapted to generate output data indicative of the drive member's position relative to the piston of a loaded cartridge. An electronic controller adapted is adapted operate the motor to continuously move the drive member from the initial position, based on output data from the position detection means determine that the drive member is in engagement with the cartridge piston corresponding to the start-of-dose position, and operate the motor to move the drive member from the start-of-dose position to the an end-of-dose position corresponding to the set dose.

5. 发明申请

US20210023308A1 TRANSMISSION PROTOCOL FOR MEDICAL DEVICE WITH LOGGING FEATURE 有权
公开(公告)号：US20210023308A1
公开(公告)日：2021-01-28
申请号：US16977409
申请日：2019-03-07
申请人： Novo Nordisk A/S
发明人： Per Einar Pontus Holm
IPC分类号： A61M5/315 , G16H20/17 , G16H40/67
摘要： The invention provides a method for wirelessly communicating a dynamic data log from a data generating device using a transmit-only protocol is provided, the dynamic data log comprising at least one latest data entry, and a plurality of previous data entries. The method comprises the steps of continuously or intermittently transmitting the dynamic data log as a plurality of data packets, wherein the data packets comprise a prioritised packet populated by the at least one latest data entry, and a plurality of regular segment packets, each being populated with a subset of the plurality of previous data entries. The prioritised packet is transmitted more frequently than at least one of the regular segment packets.

6. 发明申请

US20190117899A1 ACCESSORY DEVICE WITH ZERO POSITION ADJUSTMENT FEATURE 审中-公开
公开(公告)号：US20190117899A1
公开(公告)日：2019-04-25
申请号：US16095100
申请日：2017-04-27
申请人： Novo Nordisk A/S
发明人： Nikolai Byskov , Michael Ejstrup Hansen , Per Einar Pontus Holm
IPC分类号： A61M5/315 , A61M5/24
摘要： An add-on device configured to be releasably attached to a drug delivery device comprising a housing with a reference marker and a scale drum with a zero identifier and an initial marker. The add-on device comprises a memory and a camera adapted to capture an image of the housing reference marker and the initial marker when the scale drum is in a (near) initial position. The add-on device is adapted to perform a reference offset value determination, comprising: capture an image, perform an image analysis to determine if the captured image comprises the zero identifier, if so, determine a reference offset value based on the distance between the housing reference marker and the initial marker, the reference off-set value representing the initial rotational position, and if no reference offset value is stored in the memory or if the determined reference offset value corresponds to a smaller set dose amount than a currently stored value, store in the memory the determined reference offset value.

7. 发明申请

US20150088092A1 Drug Delivery Device and Method for Detection of End-Of-Dose Condition 审中-公开
标题翻译：药物输送装置和用于检测剂量结束条件的方法
公开(公告)号：US20150088092A1
公开(公告)日：2015-03-26
申请号：US14395976
申请日：2013-04-24
申请人： Novo Nordisk A/S
发明人： Per Einar Pontus Holm , Jens A. Munk
IPC分类号： A61M5/50
CPC分类号： A61M5/5086 , A61M5/16831 , A61M5/31535 , A61M5/3159 , A61M2205/18 , A61M2205/3306
摘要： Method for detecting an end-of-dose condition in a pressurized system, comprising the steps of (a) providing a system having a fluid-filled variable volume reservoir comprising an elastically deformable portion and an outlet, pressurizing means, and means for detecting a property of the elastically deformable portion which varies with the internal pressure in the reservoir, (b) pressurizing the reservoir to expel a desired amount of fluid by applying a force, thereby deforming the elastically deformable portion, (c) measuring, after the actuating step, a property related to the elastically deformable portion as it regains its initial configuration, (d) comparing a value for the measured property with one or more threshold values, and (e) providing a user with an indication when a given threshold value has been reached, and/or when a given threshold value has not been reached within a given period of time.
摘要翻译：一种用于检测加压系统中的剂量结束状况的方法，包括以下步骤：（a）提供具有流体填充的可变体积贮存器的系统，其包括可弹性变形的部分和出口，加压装置，以及用于检测弹性变形部分的特性随储存器内部压力而变化，（b）通过施加力来加压贮存器以排出所需量的流体，从而使可弹性变形部分变形，（c）在致动步骤之后测量（d）将所测量的属性的值与一个或多个阈值进行比较，以及（e）当给定的阈值已经被提供给用户时，向用户提供指示和/或当给定的时间段内没有达到给定的阈值时。

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