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1. 发明授权

US07732559B2 Method of making halophthalic acids and halophthalic anhydrides 有权
标题翻译：制备卤代邻苯二甲酸和卤代邻苯二甲酸酐的方法
公开(公告)号：US07732559B2
公开(公告)日：2010-06-08
申请号：US12175502
申请日：2008-07-18
申请人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , Karl Ernst Mack , Prashant Anil Tatake , Uptal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
发明人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , Karl Ernst Mack , Prashant Anil Tatake , Uptal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
IPC分类号： C08G73/33
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.
摘要翻译：公开了一种制备卤代邻苯二甲酸的方法，其包括以下步骤：在液相反应混合物中使至少一种卤素取代的邻二甲苯与氧和乙酸在约120℃至约220℃的温度下接触在催化剂体系的存在下，产生包含小于10％的卤素取代的邻二甲苯原料，卤代邻苯二甲酸产物和小于约10,000ppm的卤代苯甲酸和小于约1000ppm的卤代苯甲酸副产物的产物混合物，基于产物混合物中存在的卤代邻苯二甲酸的总量的产物。另外还公开了制备卤代邻苯二甲酸酐的方法，以及在制备卤代邻苯二甲酸期间产生的包含HCl的乙酸水溶液中回收高纯度乙酸。

2. 发明申请

US20080275211A1 METHOD OF MAKING HALOPHTHALIC ACIDS AND HALOPHTHALIC ANHYDRIDES 有权
标题翻译：制备半胱氨酸和半胱氨酸的方法
公开(公告)号：US20080275211A1
公开(公告)日：2008-11-06
申请号：US12175502
申请日：2008-07-18
申请人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , Karl Ernst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
发明人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , Karl Ernst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
IPC分类号： C08G73/10 , C07D307/77
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.
摘要翻译：公开了一种制备卤代邻苯二甲酸的方法，其包括以下步骤：在液相反应混合物中使至少一种卤素取代的邻二甲苯与氧和乙酸在约120℃至约220℃的温度下接触在催化剂体系的存在下，产生包含小于10％的卤素取代的邻二甲苯原料，卤代邻苯二甲酸产物和小于约10,000ppm的卤代苯甲酸和小于约1000ppm的卤代苯甲酸副产物的产物混合物，基于产物混合物中存在的卤代邻苯二甲酸的总量的产物。另外还公开了制备卤代邻苯二甲酸酐的方法，以及在制备卤代邻苯二甲酸期间产生的包含HCl的乙酸水溶液中回收高纯度乙酸。

3. 发明授权

US07541489B2 Method of making halophthalic acids and halophthalic anhydrides 有权
标题翻译：制备卤代邻苯二甲酸和卤代邻苯二甲酸酐的方法
公开(公告)号：US07541489B2
公开(公告)日：2009-06-02
申请号：US11170708
申请日：2005-06-29
申请人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , KarlErnst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
发明人： Robert Edgar Colborn , David Bruce Hall , Peter Alois Koch , Bernd Volker Demuth , Thomas Wessel , KarlErnst Mack , Prashant Anil Tatake , Utpal Mahendra Vakil , Shyamal Bhaskar Gondkar , John Edward Pace , Kwang Woong Won
IPC分类号： C07C51/16
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.
摘要翻译：公开了一种制备卤代邻苯二甲酸的方法，其包括以下步骤：在液相反应混合物中使至少一种卤素取代的邻二甲苯与氧和乙酸在约120℃至约220℃的温度下接触在催化剂体系的存在下，产生包含小于10％的卤素取代的邻二甲苯原料，卤代邻苯二甲酸产物和小于约10,000ppm的卤代苯甲酸和小于约1000ppm的卤代苯甲酸副产物的产物混合物，基于产物混合物中存在的卤代邻苯二甲酸的总量的产物。另外还公开了制备卤代邻苯二甲酸酐的方法，以及在制备卤代邻苯二甲酸期间产生的包含HCl的乙酸水溶液中回收高纯度乙酸。

4. 发明申请

US20100280038A1 METHODS OF TREATMENT OF CHRONIC PAIN USING ESZOPICLONE 有权
标题翻译：使用兴奋剂治疗慢性疼痛的方法
公开(公告)号：US20100280038A1
公开(公告)日：2010-11-04
申请号：US12838554
申请日：2010-07-19
申请人： Thomas Wessel , Judy Caron
发明人： Thomas Wessel , Judy Caron
IPC分类号： A61K31/4985 , A61P29/00
CPC分类号： A61K31/4985 , Y02A50/401
摘要： The invention relates to the use of eszopiclone for the treatment of low-level, chronic pain and fatigue associated with pain.
摘要翻译：本发明涉及使用依佐唑隆治疗与疼痛相关的低水平，慢性疼痛和疲劳。

5. 发明授权

US07465729B2 Methods of treatment of menopause and perimenopause using eszopiclone 有权
标题翻译：使用左前列酮治疗绝经和围绝经期的方法
公开(公告)号：US07465729B2
公开(公告)日：2008-12-16
申请号：US11099155
申请日：2005-04-05
申请人： Thomas Wessel , Judy Caron
发明人： Thomas Wessel , Judy Caron
IPC分类号： A61K31/495
CPC分类号： A61K31/498
摘要： The invention relates to the use of eszopiclone for the treatment of symptoms accompanying perimenopause or menopause.
摘要翻译：本发明涉及依曲普洛酮用于治疗伴随围绝经期或更年期的症状的用途。

6. 发明申请

US20080293726A1 Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders 审中-公开
标题翻译：依佐匹克隆和反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基）-1,2,3， 4-四氢-1-萘胺，以及更年期和心情，焦虑和认知障碍的治疗方法
公开(公告)号：US20080293726A1
公开(公告)日：2008-11-27
申请号：US11994644
申请日：2006-07-06
申请人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
发明人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Steve Han , Stefan G. Koenig
IPC分类号： A61K31/498 , C07C209/22 , A61P25/00
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） 2,3,4-四氢-1-萘胺。本发明还涉及一种治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

7. 发明授权

US07274844B2 Light-emitting textile structure, in particular for medical purposes, and use thereof 有权
标题翻译：特别是用于医疗目的的发光织物结构及其用途
公开(公告)号：US07274844B2
公开(公告)日：2007-09-25
申请号：US11126843
申请日：2005-05-11
申请人： Heinrich Walt , Bärbel Selm , Thomas Wessel
发明人： Heinrich Walt , Bärbel Selm , Thomas Wessel
IPC分类号： G02B6/26 , F21V21/08
CPC分类号： G02B6/001 , A61B5/0059 , A61B5/6804 , A61N5/0616 , A61N5/062 , A61N5/0621 , A61N5/0624 , A61N2005/063 , A61N2005/0645
摘要： A light-emitting textile structure, which in particular is useful for medical purposes, comprises a flat support (2) and a plurality of light-emitting elements (4) fixed thereto. Each light-emitting element comprises a light-supplying optical fiber (6), to each optical fiber (6) there being associated exactly one light-emitting element (4), which comprises at least one output zone formed by a local curvature of the optical fiber. The local curvature is selected in such a way that a lateral exit of light from the optical fiber occurs due to the absence of total reflection.
摘要翻译：特别是用于医疗目的的发光纺织品结构包括平坦支撑件（2）和固定到其上的多个发光元件（4）。每个发光元件包括供给光纤（6），其中每个光纤（6）与正好相关联的一个发光元件（4）相关联，该发光元件包括至少一个输出区域，该输出区域由光纤。选择局部曲率，使得由于不存在全反射而发生来自光纤的光的侧向出射。

8. 发明授权

US06407029B1 Mixtures comprising tetrakis(pyrrolidino/piperdino)phosphonium salts 有权
标题翻译：包含四（吡咯烷子基/哌啶子）鏻盐的混合物
公开(公告)号：US06407029B1
公开(公告)日：2002-06-18
申请号：US09617470
申请日：2000-07-17
申请人： Berthold Schiemenz , Thomas Wessel , Ralf Pfirmann , Andreas Beck , Walter Hahn
发明人： Berthold Schiemenz , Thomas Wessel , Ralf Pfirmann , Andreas Beck , Walter Hahn
IPC分类号： B01J2714
CPC分类号： C07C45/63 , C07B39/00 , C07F9/572 , C07F9/59 , C07C47/55
摘要： The present invention relates to mixtures comprising from 70 to 99.5% by weight of a compound of the formula (R)4P+X− (1) and from 30 to 0.5% by weight of a compound of the formula (R)3P═O (2), where R is in each case a radical and X− is an inorganic or organic anion or the equivalent of a multiply charged inorganic or organic anion, also to a process for preparing the mixtures by reacting a phosphorus pentahalide with pyrrolidine or piperidine in the molar ratio 1:6 to 1:50 in the presence of an inert solvent initially at −20 to 80° C., subsequently continuing the reaction at 90 to 180° C., treating the resulting reaction product at 0 to 80° C. with aqueous alkali at a pH of 7 to 15, and separating aqueous and organic phase from one another, and to the use of the mixtures as catalyst and cocatalyst for phase-transfer reactions, nucleophilic substitution reactions or halogen-fluorine exchange reactions.
摘要翻译：本发明涉及包含70-99.5重量％的式（R）4P + X-（1）的化合物和30至0.5重量％的式（R）化合物3P = O的混合物（2），其中R在每种情况下是基团，X是无机或有机阴离子或相当于多电荷无机或有机阴离子，也是通过使五卤化磷与吡咯烷或哌啶反应制备混合物的方法摩尔比1:6至1:50，最初在-20至80℃的惰性溶剂存在下，随后在90至180℃下继续反应，在0至80℃下处理所得反应产物与碱水溶液在pH为7至15，并分离水相和有机相，并将混合物用作催化剂和助催化剂用于相转移反应，亲核取代反应或卤素 - 氟交换反应。

9. 发明授权

US5124449A Azaporphyrin derivatives 失效
标题翻译：氨基吡啶衍生物
公开(公告)号：US5124449A
公开(公告)日：1992-06-23
申请号：US748867
申请日：1991-08-23
申请人： Burchard Franck , Hartmann Koenig , Christian Eickmeier , Michael Voelker , Thomas Wessel
发明人： Burchard Franck , Hartmann Koenig , Christian Eickmeier , Michael Voelker , Thomas Wessel
IPC分类号： C07D207/32 , C07D207/335 , C07D209/44 , C07D487/22
CPC分类号： C07D207/335
摘要： Azaporphyrin derivatives of the formula ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, hydrogen, unsubstituted or substituted C.sub.1 -C.sub.20 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl or unsubstituted or substituted phenyl, or two adjacent R.sup.1 radicals form, together with the carbon atoms to which they are bonded, an unsaturated or aromatic 5- to 7-membered carbocyclic ring,X are each hydrogen or C.sub.1 -C.sub.4 -alkyl andp are each 1 or 2, andbiladienes of the formula ##STR2## where R.sup.1, R.sup.2, X and p each have the abovementioned meanings, m and n are each 0 or 1 and An.sup..crclbar. is an anion, as intermediates therefor, are used for preparing vinylogous porphyrin derivatives.
摘要翻译：其中R 1和R 2各自独立地为氢，未取代或取代的C 1 -C 20 - 烷基，C 5 -C 7 - 环烷基或未取代或取代的苯基或两个相邻的R 1基团一起形成的式与它们所键合的碳原子，不饱和或芳族5-至7-元碳环，X各自为氢或C 1 -C 4烷基，p各自为1或2，并且式“IMAGE”的双二烯，其中 R1，R2，X和p各自具有上述含义，m和n各自为0或1，并且An（ - ）为阴离子，作为其中间体，用于制备血液卟啉衍生物。

10. 发明授权

US08097625B2 Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression 有权
标题翻译：镇静剂和神经递质调节剂的组合，以及改善睡眠质量和治疗抑郁症的方法
公开(公告)号：US08097625B2
公开(公告)日：2012-01-17
申请号：US11761235
申请日：2007-06-11
申请人： Karim Lalji , Timothy J. Barberich , Judy Caron , Thomas Wessel
发明人： Karim Lalji , Timothy J. Barberich , Judy Caron , Thomas Wessel
IPC分类号： A01N43/58 , A01N43/40 , A61K31/50 , A61K31/497 , A61K31/435
CPC分类号： A61K31/4985 , A61K31/137 , A61K31/138 , A61K31/495 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT2A modulator or DRI.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，当它们一起被用于治疗，例如失眠和/或抑郁症时。药物组合物的第一组分是调节GABA受体的化合物。药物组合物的第二组分是5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-HT2A调节剂或多巴胺再摄取抑制剂。在某些实施方案中，药物组合物包含依佐匹克。在优选的实施方案中，药物组合物包含依佐匹克和氟西汀。本发明还涉及一种治疗睡眠异常，治疗失眠，治疗抑郁症，增强抗抑郁药治疗，引发剂量保留作用，减少抑郁症复发，改善抗抑郁治疗疗效或提高抗抑郁治疗耐受性的方法，包括向有需要的患者共同施用GABA受体调节化合物; 和SRI，NRI，5-HT2A调节剂或DRI。

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