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1. 发明授权

US10941394B2 Device for manipulating magnetic particles and method for manipulating magnetic particles 有权
公开(公告)号：US10941394B2
公开(公告)日：2021-03-09
申请号：US15543425
申请日：2015-01-15
申请人： SHIMADZU CORPORATION
发明人： Masaki Kanai , Tetsuo Ohashi , Takahiro Nishimoto
IPC分类号： B01L3/00 , C12N15/10 , B03C1/30 , B03C1/01 , B03C1/033 , B03C1/28 , C07K1/14 , C07K16/00
摘要： A device for manipulating magnetic particles includes a gelled medium layer and liquid layers alternately stacked in a tubular container along a longitudinal direction of the container. A magnetic particle movement portion for moving magnetic particles exists along an inner wall surface of the container, and the magnetic particle movement portion extends along the longitudinal direction of the container. At a portion where the gelled medium layer is loaded, the cross-sectional shape of the container inner wall in a plane perpendicular to the longitudinal direction of the container is non-circular, and the shape of the magnetic particle movement portion in the cross section is a curved shape or an angular shape.

2. 发明申请

US20150268201A1 GAS CHROMATOGRAPH DEVICE 审中-公开
标题翻译：气体色谱装置
公开(公告)号：US20150268201A1
公开(公告)日：2015-09-24
申请号：US14437863
申请日：2012-10-25
申请人： SHIMADZU CORPORATION
发明人： Masaki Kanai , Satoshi Matsuoka , Masanori Nishino , Takahiro Nishimoto
IPC分类号： G01N30/30 , G01N30/16
CPC分类号： G01N30/30 , G01N30/16 , G01N30/54 , G01N30/60 , G01N2030/3084
摘要： A gas chromatograph includes a column module for independently adjusting the temperature of a separation column. The column module is held by an oven with the separation column being horizontal. The column module includes the separation column for separating a sample gas into components, a column accommodating member accommodating inside the separation column while surrounding the separation column by a heat insulating member, and including a gap between the separation column and the heat insulating member for air to flow along the separation column, and a heater, provided inside the column accommodating member, for heating the separation column by being in direct or indirect contact with the separation column. The column accommodating member includes an air inlet port for introducing external air into the gap between the separation column and the heat insulating member, and an air outlet port for exhausting air in the gap.
摘要翻译：气相色谱仪包括用于独立调节分离塔的温度的色谱柱模块。柱模块由烘箱保持，分离柱是水平的。柱模块包括用于将样品气体分离成组分的分离塔，容纳在分离塔内部的塔容纳构件，同时通过绝热构件围绕分离塔，并且在分离塔和用于空气的隔热构件之间包括间隙沿着分离柱流动，以及设置在塔容纳构件内部的加热器，用于通过与分离塔直接或间接接触来加热分离塔。塔容纳构件包括用于将外部空气引入分离柱和绝热构件之间的间隙的空气入口端口和用于排出间隙中的空气的空气出口。

3. 发明申请

US20150042354A1 ANALYSIS DEVICE PROVIDED WITH DISCHARGE IONIZATION CURRENT DETECTOR 有权
标题翻译：具有放电电流检测器的分析装置
公开(公告)号：US20150042354A1
公开(公告)日：2015-02-12
申请号：US14384049
申请日：2013-02-20
申请人： SHIMADZU CORPORATION
发明人： Kei Shinada , Shigeyoshi Horiike , Takahiro Nishimoto
IPC分类号： G01N30/64 , G01N27/70
CPC分类号： G01N30/64 , G01N27/70 , G01N2030/645 , G01N2030/8813
摘要： An analysis device comprising a discharge ionization current detector, a plasma gas supply section, a sample gas supply section, a flow rate setting condition holding section and a gas flow rate setting means controller. The flow rate setting condition holding section holds, as a flow rate setting condition, a relationship between a sample gas supply flow rate from the sample gas supply section and a supply flow rate of plasma gas to be set with respect to the sample gas supply flow rate and the gas flow rate controller is configured to set a plasma gas supply flow rate from the plasma gas supply section to a flow rate according to the sample gas supply flow rate, based on the flow rate setting condition held in the flow rate setting condition holding section.
摘要翻译：一种分析装置，包括放电电离电流检测器，等离子体气体供给部，样品气体供给部，流量设定条件保持部和气体流量设定装置控制部。流量设定条件保持部将作为流量设定条件的样品气体供给部的样品气体供给流量与对样品气体供给流量设定的等离子体气体的供给流量的关系进行保持速率和气体流量控制器被配置为基于保持在流量设定条件下的流量设定条件，将等离子体气体供给部的等离子体气体供给流量设定为根据取样气体供给流量的流量持有部分。

4. 发明授权

US10391483B2 Dispensing device 有权
公开(公告)号：US10391483B2
公开(公告)日：2019-08-27
申请号：US14088226
申请日：2013-11-22
申请人： SHIMADZU CORPORATION
发明人： Masaki Kanai , Takahiro Nishimoto , Masakazu Akechi , Nobuhiro Hanafusa
IPC分类号： B01L99/00 , G01N35/10 , B01L3/02 , B01L3/00
摘要： A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and a sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel, flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.

5. 发明授权

US10241092B2 Gas chromatograph device 有权
公开(公告)号：US10241092B2
公开(公告)日：2019-03-26
申请号：US14437863
申请日：2012-10-25
申请人： SHIMADZU CORPORATION
发明人： Masaki Kanai , Satoshi Matsuoka , Masanori Nishino , Takahiro Nishimoto
IPC分类号： G01N30/30 , G01N30/54 , G01N30/16 , G01N30/60
摘要： A gas chromatograph includes a column module for independently adjusting the temperature of a separation column. The column module is held by an oven with the separation column being horizontal. The column module includes the separation column for separating a sample gas into components, a column accommodating member accommodating inside the separation column while surrounding the separation column by a heat insulating member, and including a gap between the separation column and the heat insulating member for air to flow along the separation column, and a heater, provided inside the column accommodating member, for heating the separation column by being in direct or indirect contact with the separation column. The column accommodating member includes an air inlet port for introducing external air into the gap between the separation column and the heat insulating member, and an air outlet port for exhausting air in the gap.

6. 发明授权

US09366656B2 Analysis device provided with discharge ionization current detector 有权
标题翻译：分析装置配有放电电离电流检测器
公开(公告)号：US09366656B2
公开(公告)日：2016-06-14
申请号：US14384049
申请日：2013-02-20
申请人： SHIMADZU CORPORATION
发明人： Kei Shinada , Shigeyoshi Horiike , Takahiro Nishimoto
IPC分类号： G01N27/62 , G01N30/64 , G01N27/70 , G01N30/88
CPC分类号： G01N30/64 , G01N27/70 , G01N2030/645 , G01N2030/8813
摘要： An analysis device comprising a discharge ionization current detector, a plasma gas supply section, a sample gas supply section, a flow rate setting condition holding section and a gas flow rate setting means controller. The flow rate setting condition holding section holds, as a flow rate setting condition, a relationship between a sample gas supply flow rate from the sample gas supply section and a supply flow rate of plasma gas to be set with respect to the sample gas supply flow rate and the gas flow rate controller is configured to set a plasma gas supply flow rate from the plasma gas supply section to a flow rate according to the sample gas supply flow rate, based on the flow rate setting condition held in the flow rate setting condition holding section.
摘要翻译：一种分析装置，包括放电电离电流检测器，等离子体气体供给部，样品气体供给部，流量设定条件保持部和气体流量设定装置控制部。流量设定条件保持部将作为流量设定条件的样品气体供给部的样品气体供给流量与对样品气体供给流量设定的等离子体气体的供给流量的关系进行保持速率和气体流量控制器被配置为基于保持在流量设定条件下的流量设定条件，将等离子体气体供给部的等离子体气体供给流量设定为根据取样气体供给流量的流量持有部分。

7. 发明申请

US20140079603A1 DISPENSING DEVICE 审中-公开
标题翻译：分配设备
公开(公告)号：US20140079603A1
公开(公告)日：2014-03-20
申请号：US14088226
申请日：2013-11-22
申请人： Shimadzu Corporation
发明人： Masaki Kanai , Takahiro Nishimoto , Masakazu Akechi , Nobuhiro Hanafusa
IPC分类号： B01L3/02
CPC分类号： B01L3/0293 , B01L3/502723 , B01L3/502738 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , B01L2400/0688 , G01N35/1016 , G01N2035/1039 , G01N2035/1062
摘要： A dispensing device for reducing the dead volume of a liquid sample includes a main channel connected to a sample inlet and a sample outlet, and branch channels connected to the main channel. Each branch channel is connected to a different liquid reservoir. High inflow-withstanding pressure sections are provided in the main channel between the branch channels and between the branch channel and the sample outlet. Each high inflow-withstanding pressure section has a channel inner wall forming a contact angle of 90° or larger with a liquid sample. A liquid sample enters the main channel through the sample inlet, reaches a branch point between the first branch channel and the main channel, flows into the first branch channel and the liquid reservoir, and then passes through the high inflow-withstanding pressure section to a branch point between the next branch channel and the main channel.
摘要翻译：用于减少液体样品的死体积的分配装置包括连接到样品入口和样品出口的主通道以及连接到主通道的分支通道。每个分支通道连接到不同的液体储存器。在分支通道之间和分支通道与样品出口之间的主通道中设有高流入耐压部分。每个高流入耐压部分具有与液体样品形成90°或更大接触角的通道内壁。液体样品通过样品入口进入主通道，到达第一分支通道和主通道之间的分支点，流入第一分支通道和液体储存器，然后通过高流入耐压段进入下一个分支通道和主通道之间的分支点。

8. 发明申请

US20140051160A1 MICRO DROPLET OPERATION DEVICE AND REACTION PROCESSING METHOD USING THE SAME 审中-公开
标题翻译： MICRO DROPLET OPERING DEVICE AND REACTION PROCESSING METHOD WITH THE SAME
公开(公告)号：US20140051160A1
公开(公告)日：2014-02-20
申请号：US14052299
申请日：2013-10-11
申请人： SHIMADZU CORPORATION
发明人： Masakazu Akechi , Masaki Kanai , Takahiro Nishimoto , Nobuhiro Hanafusa
IPC分类号： C12M1/32
CPC分类号： B01L3/502715 , B01L3/5027 , B01L3/502723 , B01L3/502738 , B01L3/502746 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/04 , B01L2300/046 , B01L2300/0816 , B01L2300/0858 , B01L2300/0861 , B01L2300/0864 , B01L2300/0887 , B01L2400/0622 , B01L2400/0644 , B01L2400/084 , C12M23/12 , G01N2035/00158 , G01N2035/1034
摘要： Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).
摘要翻译：微滴精确地放置在反应井中。反应井（5）形成在井底（3）的一个表面中。通道底座（11）放置在井底（3）上。通道底座11在其表面上与井底（3）连接，具有液体引入通道（12a）和反应井排气通道（18a）。通道底座（11）还具有与反应槽（5）相对形成并从液体导入通道（12a）的上表面向上凹陷的凹部（27）。当从上方观察时，凹部（27）的肩部（26）放置在反应槽（5）和液体导入通道（12a）之间的连接部分附近，并且更靠近反应槽（5）的中心）比反应井（5）的肩部（16）。

9. 发明授权

US12050231B2 Micro flow path device, testing method using micro flow path device, and testing apparatus using micro flow path device 有权
公开(公告)号：US12050231B2
公开(公告)日：2024-07-30
申请号：US17615893
申请日：2020-05-25
申请人： Shimadzu Corporation
发明人： Hiroshi Iwata , Hiroomi Goto , Shigehiko Zoda , Eiichi Ozeki , Takahiro Nishimoto , Aline Rotzetter , Yasuko Yoneda , Ippei Takeuchi
IPC分类号： G01N35/08 , G02B21/36
CPC分类号： G01N35/085 , G02B21/365
摘要： A testing method using a micro flow path device configured for a test liquid containing a specimen to be brought into contact with a drug therein and for a test on an action of the drug on the specimen includes: preparing the micro flow path device including: a plurality of micro flow paths, first and second openings which are disposed at both ends of each of the plurality of micro flow paths and communicate with an outside, a storage unit which is provided in each of the plurality of micro flow paths and stores the drug, and a gas-permeable membrane covering the first opening; applying a fluid pressure higher than an external pressure to the test liquid through the second opening from a syringe pump connected to the second opening to pressure-feed the test liquid to the storage unit; and observing a target region set in the micro flow path.

10. 发明授权

US09839932B2 Surface chemical treatment apparatus for drawing predetermined pattern by carrying out a chemical treatment 有权
公开(公告)号：US09839932B2
公开(公告)日：2017-12-12
申请号：US14766494
申请日：2013-02-14
申请人： SHIMADZU CORPORATION , TOKYO METROPOLITAN UNIVERSITY , WASEDA UNIVERSITY
发明人： Katsumi Uchiyama , Hizuru Nakajima , Ming Yang , Hulie Zeng , Yoshiyuki Sugahara , Takahiro Nishimoto
IPC分类号： C23F1/08 , B05B15/04 , B05C9/06 , B05B7/06 , B05C3/20 , B01J19/00 , B05C5/02 , B05B7/14 , C23F1/00
CPC分类号： B05B15/0431 , B01J19/00 , B05B7/06 , B05B7/14 , B05B12/18 , B05B14/10 , B05C3/20 , B05C5/02 , B05C9/06 , C03C15/00 , C03C25/68 , C23F1/00 , C23F1/08
摘要： A surface chemical treatment apparatus provided with: a first conduit having an opening at one end and communicating with a liquid supply means at the other end; a second conduit having at one end an opening that surrounds the opening of the first conduit and communicating with a liquid suction means at the other end; and a moving mechanism for moving the openings of the first and second conduits relative to the solid phase surface, so as to make a surface chemical treatment possible in a fine pattern by allowing the patterning solution to be dispensed through the opening of the first conduit while allowing the solution to be suctioned up together with the surrounding liquid phase or gas phase medium through the opening of the second conduit that surrounds the opening of the first conduit and, thus, preventing seepage of the solution in all directions.

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