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1. 发明授权

US09610367B2 Particle and contrast agent having the particle 有权
公开(公告)号：US09610367B2
公开(公告)日：2017-04-04
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
IPC分类号： A61K9/00 , A61K49/00 , A61K9/51 , A61K49/22 , B82Y15/00 , B82Y30/00
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

2. 发明申请

US20130209367A1 PARTICLE AND CONTRAST AGENT HAVING THE PARTICLE 有权
标题翻译：具有颗粒的颗粒和对比剂
公开(公告)号：US20130209367A1
公开(公告)日：2013-08-15
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
IPC分类号： A61K49/00 , A61K49/22
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.
摘要翻译：提供了一种负载ICG的聚合物纳米颗粒，其动态稳定，防止所含ICG的泄漏和所得的变色，并具有高的摩尔吸光系数。该颗粒含有具有磺酸盐基团和疏水性聚合物的亲水性染料，并且该颗粒还含有具有带正电荷区域的脂质，烟酸衍生物和硫胺衍生物中的至少一种。

3. 发明授权

US08293782B2 Compound, probe containing the novel compound, and fluorescence-imaging contrast agent containing the novel compound or the probe 有权
标题翻译：含有新化合物的化合物，探针和含有新化合物或探针的荧光成像造影剂
公开(公告)号：US08293782B2
公开(公告)日：2012-10-23
申请号：US12696496
申请日：2010-01-29
申请人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
发明人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
IPC分类号： A61K31/403 , C07D209/10
CPC分类号： C07D209/30 , A61K49/0032 , C07D209/60
摘要： A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; R1 to R8 each independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and R9 to R12 each independently represent a substituted or unsubstituted C1-C3 alkyl group.
摘要翻译：由下式（1）表示的化合物，其中n为2或3; a为1〜4的整数，b为3〜5的整数，a为5，b为1〜10的整数。 R1至R8各自独立地表示氢原子或磺酸盐，其为磺酸钠，磺酸钾，磺酸铵，三乙基磺酸铵，吡啶磺酸盐，赖氨酸磺酸盐和精氨酸磺酸盐中的任一种; 且R 9至R 12各自独立地表示取代或未取代的C 1 -C 3烷基。

4. 发明申请

US20100197937A1 NOVEL COMPOUND, PROBE CONTAINING THE NOVEL COMPOUND, AND FLUORESCENCE-IMAGING CONTRAST AGENT CONTAINING THE NOVEL COMPOUND OR THE PROBE 有权
标题翻译：新化合物，含有新化合物的探针和含有新化合物或探针的荧光成像对比剂
公开(公告)号：US20100197937A1
公开(公告)日：2010-08-05
申请号：US12696496
申请日：2010-01-29
申请人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
发明人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
IPC分类号： C07D209/56 , C07D209/04
CPC分类号： C07D209/30 , A61K49/0032 , C07D209/60
摘要： A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; R1 to R8 each independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and R9 to R12 each independently represent a substituted or unsubstituted C1-C3 alkyl group.
摘要翻译：由下式（1）表示的化合物，其中n为2或3; a为1〜4的整数，b为3〜5的整数，a为5，b为1〜10的整数。 R1至R8各自独立地表示氢原子或磺酸盐，其为磺酸钠，磺酸钾，磺酸铵，三乙基磺酸铵，吡啶磺酸盐，赖氨酸磺酸盐和精氨酸磺酸盐中的任一种; 且R 9至R 12各自独立地表示取代或未取代的C 1 -C 3烷基。

5. 发明申请

US20120052017A1 METHOD FOR PRODUCING CONTRAST AGENT FOR OPTICAL IMAGING 审中-公开
标题翻译：生产光学成像对比剂的方法
公开(公告)号：US20120052017A1
公开(公告)日：2012-03-01
申请号：US13205233
申请日：2011-08-08
申请人： Kouichi Kato , Satoshi Yuasa , Tatsuki Fukui
发明人： Kouichi Kato , Satoshi Yuasa , Tatsuki Fukui
IPC分类号： A61K49/00 , A61P43/00
CPC分类号： A61K49/0034 , A61K49/0032 , A61K49/0071
摘要： A contrast agent for optical imaging is produced by preparing a composition containing a hydrophilic dye having a sulfonate group, a hydrophobic solvent, a lipid having a positively charged site, and a polymerizable monomer or a prepolymer, dispersing the composition into water, and polymerizing the polymerizable monomer or the prepolymer.
摘要翻译：用于光学成像的造影剂通过制备含有具有磺酸酯基的亲水性染料，疏水性溶剂，具有带正电荷位点的脂质和可聚合单体或预聚物的组合物来制备，将组合物分散在水中，可聚合单体或预聚物。

6. 发明申请

US20120052011A1 COMPOSITION AND A METHOD FOR PRODUCING CONTRAST AGENT USING THE COMPOSITION 审中-公开
标题翻译：组合物和使用该组合物生产对比剂的方法
公开(公告)号：US20120052011A1
公开(公告)日：2012-03-01
申请号：US13205246
申请日：2011-08-08
申请人： Tatsuki Fukui , Satoshi Yuasa , Kouichi Kato
发明人： Tatsuki Fukui , Satoshi Yuasa , Kouichi Kato
IPC分类号： A61K49/00 , A61P43/00
CPC分类号： A61K49/0034 , A61K49/0032
摘要： A composition including a hydrophilic dye having a sulfonate group and a hydrophobic solvent, wherein the composition includes at least one of a nicotinic acid derivative and a tiamine derivative, can form densely accumulated particles and the like since the composition includes a hydrophilic dye that is likely to dissolve in a hydrophobic solvent.
摘要翻译：包含具有磺酸盐基团和疏水性溶剂的亲水性染料的组合物，其中所述组合物包含烟酸衍生物和硫胺素衍生物中的至少一种可以形成致密聚集的颗粒等，因为该组合物包含可能的亲水性染料溶解在疏水性溶剂中。

7. 发明授权

US08247215B2 Apparatus for introducing substance into cells 有权
标题翻译：将物质引入细胞的装置
公开(公告)号：US08247215B2
公开(公告)日：2012-08-21
申请号：US12522041
申请日：2008-01-17
申请人： Kouichi Kato , Atsushi Takahashi
发明人： Kouichi Kato , Atsushi Takahashi
IPC分类号： C12M1/00
CPC分类号： C12M25/06 , C12M35/00
摘要： Provided is a cell chip for exposing to a portion of each of cells microdroplets dispensed with an inkjet printer or the like in a screening test of the effect of a substance on cells by using an apparatus for introducing the substance into cells including: a cell-immobilizing support including a substrate having through-holes penetrating from one side to the other side of the substrate and including cells immobilized in the through-holes so as to block up the through-holes; a liquid phase region present in contact with one side of the support and including a medium of the cells; and a mechanism present so as to face the other side of the support and imparting a microdroplet to a portion of each of the cells exposed in the openings on the other side.
摘要翻译：提供一种细胞芯片，用于通过使用将物质引入细胞的装置进行细胞的影响的筛选试验中，暴露于分配有喷墨打印机等的每个细胞微滴的一部分，细胞芯片包括：固定支撑体，其包括具有从基板的一侧贯穿到另一侧的通孔的基板，并且包括固定在通孔中的细胞以阻挡通孔; 存在与载体的一侧接触并且包括电池的介质的液相区域; 以及以与所述支撑体的另一侧相对的方式存在的机构，并且在另一侧的所述开口中露出的每个所述单元的一部分上产生微滴。

8. 发明申请

US20100021986A1 APPARATUS AND METHOD FOR INTRODUCING SUBSTANCE INTO CELLS 有权
标题翻译：将物质引入细胞的装置和方法
公开(公告)号：US20100021986A1
公开(公告)日：2010-01-28
申请号：US12522041
申请日：2008-01-17
申请人： Kouichi Kato , Atsushi Takahashi
发明人： Kouichi Kato , Atsushi Takahashi
IPC分类号： C12N11/18 , C12M1/00
CPC分类号： C12M25/06 , C12M35/00
摘要： Provided is a cell chip for exposing to a portion of each of cells microdroplets dispensed with an inkjet printer or the like in a screening test of the effect of a substance on cells by using an apparatus for introducing the substance into cells including: a cell-immobilizing support including a substrate having through-holes penetrating from one side to the other side of the substrate and including cells immobilized in the through-holes so as to block up the through-holes; a liquid phase region present in contact with one side of the support and including a medium of the cells; and a mechanism present so as to face the other side of the support and imparting a microdroplet to a portion of each of the cells exposed in the openings on the other side.
摘要翻译：提供一种细胞芯片，用于通过使用将物质引入细胞的装置进行细胞的影响的筛选试验中，暴露于分配有喷墨打印机等的每个细胞微滴的一部分，细胞芯片包括：固定支撑体，其包括具有从基板的一侧贯穿到另一侧的通孔的基板，并且包括固定在通孔中的细胞以阻挡通孔; 存在与载体的一侧接触并且包括电池的介质的液相区域; 以及以与所述支撑体的另一侧相对的方式存在的机构，并且在另一侧的所述开口中露出的每个所述单元的一部分上产生微滴。

9. 发明申请

US20100003745A1 CELL CULTURE VESSEL 审中-公开
标题翻译：细胞培养基
公开(公告)号：US20100003745A1
公开(公告)日：2010-01-07
申请号：US12493242
申请日：2009-06-29
申请人： Atsushi Takahashi , Mamoru Tsukada , Kouichi Kato
发明人： Atsushi Takahashi , Mamoru Tsukada , Kouichi Kato
IPC分类号： C12M1/00
CPC分类号： C12M25/06 , C12M23/04 , C12M23/58 , C12M29/10
摘要： A cell culture vessel for culturing adherent cells includes a channel allowing liquid to flow therethrough; a culture surface disposed on a wall of the channel, the culture surface allowing the adherent cells to adhere thereto; an inlet for introducing the liquid into the channel; an outlet for draining the liquid from the channel; a connecting portion communicating with the channel; and a connection receiving portion communicating with the channel. The cell culture vessel is capable of being connected to another cell culture vessel using the connecting portion or the connection receiving portion. When the connecting portion of the cell culture vessel is connected to a connection receiving portion of the other cell culture vessel, the culture surface of the cell culture vessel and a culture surface of the other cell culture vessel form a continuous culture surface.
摘要翻译：用于培养粘附细胞的细胞培养容器包括允许液体流过的通道; 设置在通道的壁上的培养表面，培养表面允许粘附细胞粘附于其上; 用于将液体引入通道的入口; 用于从通道排出液体的出口; 与通道连通的连接部分; 以及与所述通道通信的连接接收部。细胞培养容器能够使用连接部分或连接接收部分连接到另一个细胞培养容器。当细胞培养容器的连接部分连接到另一个细胞培养容器的连接部分时，细胞培养容器的培养表面和另一细胞培养容器的培养表面形成连续的培养表面。

10. 发明申请

US20090000085A1 Fastener 有权
标题翻译：紧固件
公开(公告)号：US20090000085A1
公开(公告)日：2009-01-01
申请号：US12213965
申请日：2008-06-26
申请人： Shigeo Okada , Kouichi Kato
发明人： Shigeo Okada , Kouichi Kato
IPC分类号： A44B21/00
CPC分类号： F16B19/1081 , Y10T24/309 , Y10T24/42
摘要： According to an aspect of the present invention, there is provided a fastener including: a fastener body including: a cylindrical portion having an insertion hole formed therethrough; and a locking portion protruding outward from the cylindrical portion; and an unlocking member inserted into the insertion hole, wherein the locking portion is inserted into an attachment hole of an attachment object from a front side thereof, and exposed from a rear side of the attachment hole, wherein the locking portion has an elastic claw locked to an edge of the attachment hole at the rear side, wherein the elastic claw is elastically reducible in diameter, wherein the unlocking member is movable in a position rearward of the elastic claw, and wherein the locking portion is reduced in diameter when the unlocking member is pushed.
摘要翻译：根据本发明的一个方面，提供了一种紧固件，其包括：紧固件主体，包括：圆筒部，其具有穿过其形成的插入孔; 以及从所述圆筒部向外突出的卡定部。以及插入到所述插入孔中的解锁构件，其中，所述锁定部从其前侧插入到附着物的安装孔中，并且从所述安装孔的后侧露出，其中，所述锁定部具有锁定的弹性爪在所述后侧的所述安装孔的边缘处，其中所述弹性爪可弹性地减径，其中所述解锁构件可在所述弹性爪的后方的位置移动，并且其中所述锁定部在所述解锁构件被推

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