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1. 发明授权

US09610367B2 Particle and contrast agent having the particle 有权
公开(公告)号：US09610367B2
公开(公告)日：2017-04-04
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
IPC分类号： A61K9/00 , A61K49/00 , A61K9/51 , A61K49/22 , B82Y15/00 , B82Y30/00
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

2. 发明申请

US20130209367A1 PARTICLE AND CONTRAST AGENT HAVING THE PARTICLE 有权
标题翻译：具有颗粒的颗粒和对比剂
公开(公告)号：US20130209367A1
公开(公告)日：2013-08-15
申请号：US13817711
申请日：2011-08-23
申请人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
发明人： Shinzaburo Ito , Masato Minami , Tatsuki Fukui , Kouichi Kato , Fumio Yamauchi , Yoshinori Tomida , Satoshi Yuasa , Tetsuya Yano , Satoshi Ogawa , Kengo Kanazaki , Atsushi Takahashi , Daisuke Sasaguri , Hiroyuki Aoki
IPC分类号： A61K49/00 , A61K49/22
CPC分类号： A61K49/0093 , A61K9/5153 , A61K49/0034 , A61K49/0052 , A61K49/225 , B82Y15/00 , B82Y30/00
摘要： There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.
摘要翻译：提供了一种负载ICG的聚合物纳米颗粒，其动态稳定，防止所含ICG的泄漏和所得的变色，并具有高的摩尔吸光系数。该颗粒含有具有磺酸盐基团和疏水性聚合物的亲水性染料，并且该颗粒还含有具有带正电荷区域的脂质，烟酸衍生物和硫胺衍生物中的至少一种。

3. 发明授权

US08293782B2 Compound, probe containing the novel compound, and fluorescence-imaging contrast agent containing the novel compound or the probe 有权
标题翻译：含有新化合物的化合物，探针和含有新化合物或探针的荧光成像造影剂
公开(公告)号：US08293782B2
公开(公告)日：2012-10-23
申请号：US12696496
申请日：2010-01-29
申请人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
发明人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
IPC分类号： A61K31/403 , C07D209/10
CPC分类号： C07D209/30 , A61K49/0032 , C07D209/60
摘要： A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; R1 to R8 each independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and R9 to R12 each independently represent a substituted or unsubstituted C1-C3 alkyl group.
摘要翻译：由下式（1）表示的化合物，其中n为2或3; a为1〜4的整数，b为3〜5的整数，a为5，b为1〜10的整数。 R1至R8各自独立地表示氢原子或磺酸盐，其为磺酸钠，磺酸钾，磺酸铵，三乙基磺酸铵，吡啶磺酸盐，赖氨酸磺酸盐和精氨酸磺酸盐中的任一种; 且R 9至R 12各自独立地表示取代或未取代的C 1 -C 3烷基。

4. 发明申请

US20100197937A1 NOVEL COMPOUND, PROBE CONTAINING THE NOVEL COMPOUND, AND FLUORESCENCE-IMAGING CONTRAST AGENT CONTAINING THE NOVEL COMPOUND OR THE PROBE 有权
标题翻译：新化合物，含有新化合物的探针和含有新化合物或探针的荧光成像对比剂
公开(公告)号：US20100197937A1
公开(公告)日：2010-08-05
申请号：US12696496
申请日：2010-01-29
申请人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
发明人： Masato Minami , Yoshinori Tomida , Atsushi Takahashi , Kouichi Kato , Fumiko Tomatsu , Sachiko Inoue
IPC分类号： C07D209/56 , C07D209/04
CPC分类号： C07D209/30 , A61K49/0032 , C07D209/60
摘要： A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; R1 to R8 each independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and R9 to R12 each independently represent a substituted or unsubstituted C1-C3 alkyl group.
摘要翻译：由下式（1）表示的化合物，其中n为2或3; a为1〜4的整数，b为3〜5的整数，a为5，b为1〜10的整数。 R1至R8各自独立地表示氢原子或磺酸盐，其为磺酸钠，磺酸钾，磺酸铵，三乙基磺酸铵，吡啶磺酸盐，赖氨酸磺酸盐和精氨酸磺酸盐中的任一种; 且R 9至R 12各自独立地表示取代或未取代的C 1 -C 3烷基。

5. 发明申请

US20100021986A1 APPARATUS AND METHOD FOR INTRODUCING SUBSTANCE INTO CELLS 有权
标题翻译：将物质引入细胞的装置和方法
公开(公告)号：US20100021986A1
公开(公告)日：2010-01-28
申请号：US12522041
申请日：2008-01-17
申请人： Kouichi Kato , Atsushi Takahashi
发明人： Kouichi Kato , Atsushi Takahashi
IPC分类号： C12N11/18 , C12M1/00
CPC分类号： C12M25/06 , C12M35/00
摘要： Provided is a cell chip for exposing to a portion of each of cells microdroplets dispensed with an inkjet printer or the like in a screening test of the effect of a substance on cells by using an apparatus for introducing the substance into cells including: a cell-immobilizing support including a substrate having through-holes penetrating from one side to the other side of the substrate and including cells immobilized in the through-holes so as to block up the through-holes; a liquid phase region present in contact with one side of the support and including a medium of the cells; and a mechanism present so as to face the other side of the support and imparting a microdroplet to a portion of each of the cells exposed in the openings on the other side.
摘要翻译：提供一种细胞芯片，用于通过使用将物质引入细胞的装置进行细胞的影响的筛选试验中，暴露于分配有喷墨打印机等的每个细胞微滴的一部分，细胞芯片包括：固定支撑体，其包括具有从基板的一侧贯穿到另一侧的通孔的基板，并且包括固定在通孔中的细胞以阻挡通孔; 存在与载体的一侧接触并且包括电池的介质的液相区域; 以及以与所述支撑体的另一侧相对的方式存在的机构，并且在另一侧的所述开口中露出的每个所述单元的一部分上产生微滴。

6. 发明授权

US08247215B2 Apparatus for introducing substance into cells 有权
标题翻译：将物质引入细胞的装置
公开(公告)号：US08247215B2
公开(公告)日：2012-08-21
申请号：US12522041
申请日：2008-01-17
申请人： Kouichi Kato , Atsushi Takahashi
发明人： Kouichi Kato , Atsushi Takahashi
IPC分类号： C12M1/00
CPC分类号： C12M25/06 , C12M35/00
摘要： Provided is a cell chip for exposing to a portion of each of cells microdroplets dispensed with an inkjet printer or the like in a screening test of the effect of a substance on cells by using an apparatus for introducing the substance into cells including: a cell-immobilizing support including a substrate having through-holes penetrating from one side to the other side of the substrate and including cells immobilized in the through-holes so as to block up the through-holes; a liquid phase region present in contact with one side of the support and including a medium of the cells; and a mechanism present so as to face the other side of the support and imparting a microdroplet to a portion of each of the cells exposed in the openings on the other side.
摘要翻译：提供一种细胞芯片，用于通过使用将物质引入细胞的装置进行细胞的影响的筛选试验中，暴露于分配有喷墨打印机等的每个细胞微滴的一部分，细胞芯片包括：固定支撑体，其包括具有从基板的一侧贯穿到另一侧的通孔的基板，并且包括固定在通孔中的细胞以阻挡通孔; 存在与载体的一侧接触并且包括电池的介质的液相区域; 以及以与所述支撑体的另一侧相对的方式存在的机构，并且在另一侧的所述开口中露出的每个所述单元的一部分上产生微滴。

7. 发明申请

US20100003745A1 CELL CULTURE VESSEL 审中-公开
标题翻译：细胞培养基
公开(公告)号：US20100003745A1
公开(公告)日：2010-01-07
申请号：US12493242
申请日：2009-06-29
申请人： Atsushi Takahashi , Mamoru Tsukada , Kouichi Kato
发明人： Atsushi Takahashi , Mamoru Tsukada , Kouichi Kato
IPC分类号： C12M1/00
CPC分类号： C12M25/06 , C12M23/04 , C12M23/58 , C12M29/10
摘要： A cell culture vessel for culturing adherent cells includes a channel allowing liquid to flow therethrough; a culture surface disposed on a wall of the channel, the culture surface allowing the adherent cells to adhere thereto; an inlet for introducing the liquid into the channel; an outlet for draining the liquid from the channel; a connecting portion communicating with the channel; and a connection receiving portion communicating with the channel. The cell culture vessel is capable of being connected to another cell culture vessel using the connecting portion or the connection receiving portion. When the connecting portion of the cell culture vessel is connected to a connection receiving portion of the other cell culture vessel, the culture surface of the cell culture vessel and a culture surface of the other cell culture vessel form a continuous culture surface.
摘要翻译：用于培养粘附细胞的细胞培养容器包括允许液体流过的通道; 设置在通道的壁上的培养表面，培养表面允许粘附细胞粘附于其上; 用于将液体引入通道的入口; 用于从通道排出液体的出口; 与通道连通的连接部分; 以及与所述通道通信的连接接收部。细胞培养容器能够使用连接部分或连接接收部分连接到另一个细胞培养容器。当细胞培养容器的连接部分连接到另一个细胞培养容器的连接部分时，细胞培养容器的培养表面和另一细胞培养容器的培养表面形成连续的培养表面。

8. 发明授权

US09515277B2 Organic electroluminescent element, organic EL display device and organic EL illumination 有权
标题翻译：有机电致发光元件，有机EL显示装置和有机EL照明
公开(公告)号：US09515277B2
公开(公告)日：2016-12-06
申请号：US12935416
申请日：2009-08-12
申请人： Kazuki Okabe , Atsushi Takahashi , Tomohiro Abe , Yasuyuki Tsurutani , Hideki Sato
发明人： Kazuki Okabe , Atsushi Takahashi , Tomohiro Abe , Yasuyuki Tsurutani , Hideki Sato
IPC分类号： H01L51/50 , C08G61/12 , C08G73/02 , C08L65/00 , C08L79/02 , C09K11/06 , H05B33/14 , H01L51/00
CPC分类号： H01L51/5012 , C08G61/12 , C08G73/026 , C08G2261/135 , C08G2261/141 , C08G2261/1424 , C08G2261/3162 , C08L65/00 , C08L79/02 , C09K11/06 , C09K2211/1433 , H01L51/0035 , H01L51/0043 , H01L51/0058 , H01L51/006 , H01L51/0067 , H01L51/008 , H01L51/0081 , H01L51/5048 , H05B33/14
摘要： To provide an organic electroluminescent element having a low driving voltage, high current efficiency and high voltage efficiency.An organic electroluminescent element comprising an anode, a cathode and an organic layer disposed between the anode and the cathode, wherein the organic layer comprises a mixed layer containing a light-emitting low molecular compound and/or a charge-transporting low molecular compound in a film containing an insolubilized polymer obtained by insolubilizing an insolubilizing polymer, and, adjacent to the mixed layer, a layer containing a light-emitting low molecular compound and a charge-transporting low molecular compound and not containing an insolubilized polymer.
摘要翻译：一种有机电致发光元件，包括阳极，阴极和设置在阳极和阴极之间的有机层，其中有机层包括含有发光低分子化合物和/或电荷输送低分子化合物的混合层，含有通过使不溶性聚合物不溶化而得到的不溶性聚合物和与混合层相邻的含有发光低分子化合物和电荷输送性低分子化合物并且不含不溶性聚合物的层的膜。

9. 发明授权

US09009519B2 Timing control device and control method thereof 有权
标题翻译：定时控制装置及其控制方法
公开(公告)号：US09009519B2
公开(公告)日：2015-04-14
申请号：US13569378
申请日：2012-08-08
申请人： Atsushi Takahashi
发明人： Atsushi Takahashi
IPC分类号： G06F1/14 , F02D41/28 , F02D41/24
CPC分类号： H03K3/017 , F02D41/2403 , F02D41/28 , F02D2250/14 , G06F1/14
摘要： Provided is a timing control device including: a storage unit that stores multiple pieces of timing control information including identification information and expected value data; a first selector that selectively outputs any of the multiple pieces of timing control information; a second selector that selectively outputs any of data items output from data output devices based on the identification information; a reference data generation unit that generates reference data based on expected value data and a data item output from the second selector in synchronization with a switching of the timing control information; a comparator that compares the reference data with the data item output from the second selector and outputs a coincidence signal when the reference data and the data item coincide with each other; and an output control unit that outputs a timing signal according to the coincidence signal.
摘要翻译：提供了一种定时控制装置，包括：存储单元，存储包括识别信息和期望值数据的多个定时控制信息; 第一选择器，其选择性地输出所述多个定时控制信息中的任何一个; 第二选择器，其基于所述识别信息选择性地输出从数据输出设备输出的任何数据项; 参考数据生成单元，其与定时控制信息的切换同步地基于期望值数据和从第二选择器输出的数据项生成参考数据; 比较器，当参考数据和数据项彼此一致时，比较参考数据和从第二选择器输出的数据项，并输出一致信号; 以及输出控制单元，其根据所述一致信号输出定时信号。

10. 发明授权

US08912145B2 Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease 有权
标题翻译：用于预防和/或治疗阿尔茨海默病的疫苗组合物
公开(公告)号：US08912145B2
公开(公告)日：2014-12-16
申请号：US13290960
申请日：2011-11-07
申请人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
发明人： Teruhiko Terakawa , Hisakazu Hasegawa , Yasushi Shimada , Atsushi Takahashi , Takeshi Kawarabayashi , Mikio Shoji
IPC分类号： C12N15/62 , C12N15/82 , A61P25/28 , A61K38/00 , A61K38/08 , A61K36/48 , C07K7/06 , C12N15/12 , C12N15/29 , A61K39/00 , C07K14/415 , C07K14/47
CPC分类号： A61K39/0007 , A61K2039/55516 , A61K2039/6031 , C07K14/415 , C07K14/4711 , C12N15/62 , C12N15/8257 , C12N15/8258
摘要： A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β antigenic peptide having 5 to 15 continuous amino acid residues derived from the N-terminus of amyloid β peptide into a wild type seed storage protein.
摘要翻译：一种用于预防和/或治疗阿尔茨海默氏病的疫苗组合物，其包含通过插入单个或串联重复的多个淀粉样蛋白复合物制备的融合蛋白; 具有衍生自淀粉样蛋白N末端的5至15个连续氨基酸残基的抗原肽; 肽成野生型种子储存蛋白。

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