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1. 再颁专利

USRE39571E1 Methods and apparatus for synthesizing labeled combinatorial chemistry libraries 失效
标题翻译：合成标记组合化学文库的方法和装置
公开(公告)号：USRE39571E1
公开(公告)日：2007-04-17
申请号：US10841421
申请日：2004-05-07
申请人： John Cargill
发明人： John Cargill
IPC分类号： G01N33/543 , C12Q1/68 , G08B13/14 , A61K38/00
摘要： The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.
摘要翻译：本发明提供了随机低聚物的标记的合成文库以及用于产生标记的合成低聚物文库的方法和装置。这种图书馆的每个成员都标有一个唯一的标识符标签，用于指定低聚物的结构或序列。在本发明的一个优选实施例中，标识符标签是一种微芯片，其在标识符标签被电磁辐射脉冲时被预先编码或可编码与信号相关的信息。

2. 再颁专利

USRE39545E1 Methods and apparatus for synthesizing labeled combinatorial chemistry libraries 失效
公开(公告)号：USRE39545E1
公开(公告)日：2007-04-03
申请号：US10841423
申请日：2004-05-07
申请人： John Cargill
发明人： John Cargill
IPC分类号： G01N33/543 , C12Q1/68 , G08B13/14 , A61K38/00
摘要： The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.

3. 发明申请

US20110308335A1 Sample Tube with Identification 审中-公开
标题翻译：样品管与鉴定
公开(公告)号：US20110308335A1
公开(公告)日：2011-12-22
申请号：US13061083
申请日：2009-08-11
申请人： Rosa Pink , Martin Berger
发明人： Rosa Pink , Martin Berger
IPC分类号： B01L3/14
CPC分类号： G06K1/126 , B01L3/5453 , B01L2300/021 , B01L2300/022 , B01L2300/0851 , B41M5/26 , B41M5/267
摘要： A sample tube (1) is provided with a top opening (2) that is surrounded by side walls (3) which merge into a bottom (4), the bottom (4) of the sample tube (1) comprising an essentially flat downside (5) that is arranged farther to the top opening (2), wherein the sample tube comprises an identification portion (6) located at the bottom side of the sample tube (1). The sample tube (1) according to the present invention is characterized in that the identification portion (6) is composed of an opaque material (7) with a first color and a transparent cover layer (8), wherein the transparent cover layer (8) comprises a laser sensitive filler that, upon irradiation with a laser marking beam, turns an irradiated area (9) of the transparent cover layer (8) into an opaque area with a second color that is contrasting from the first color.
摘要翻译：样品管（1）设置有由合并到底部（4）中的侧壁（3）围绕的顶部开口（2），样品管（1）的底部（4）包括基本平坦的下侧（5），其布置得更靠近顶部开口（2），其中样品管包括位于样品管（1）的底侧的识别部分（6）。根据本发明的样品管（1）的特征在于，识别部分（6）由具有第一颜色和透明覆盖层（8）的不透明材料（7）组成，其中透明覆盖层（8））包括激光敏感填料，其在用激光标记光束照射时，将透明覆盖层（8）的照射区域（9）转换成与第一颜色形成对比的第二颜色的不透明区域。

4. 发明授权

US07858044B2 Multi-well plate providing a high-density storage and assay platform 有权
标题翻译：多孔板提供高密度存储和测定平台
公开(公告)号：US07858044B2
公开(公告)日：2010-12-28
申请号：US10837219
申请日：2004-04-30
申请人： Peter J. Coassin , Todd Bennett , Brian Grot , David Nicol
发明人： Peter J. Coassin , Todd Bennett , Brian Grot , David Nicol
IPC分类号： B01L3/00
CPC分类号： B01L3/50851 , B01L9/523 , B01L2200/025 , B01L2200/142 , B01L2300/0829 , B01L2300/12
摘要： A dual-use, high density plate for storage and assays includes a frame including a matrix of wells. The matrix includes preferably 3456 wells with top portions being arranged preferably approximately flush with a plane of the frame. A solvent-resistant material such as cyclo-olefin polymer forms at least the bottom portions of the wells, and preferably the same solvent resistant material forms the frame, although varying from the bottoms of the wells by being rendered opaque. Evaporation control wells are preferably included at the periphery of the matrix for reducing effects of evaporation on edge wells.
摘要翻译：用于储存和测定的双重用途的高密度板包括包括孔的矩阵的框架。该基质优选包括3456个孔，顶部优选地与框架的平面大致齐平。耐溶剂材料如环烯烃聚合物至少形成孔的底部，并且优选地，相同的耐溶剂材料形成框架，尽管通过变得不透明而从孔的底部变化。蒸发控制孔优选包含在基质的周边，以减少边缘孔蒸发的影响。

5. 发明授权

US07635246B2 Device and method for retrieving or replacing a tray within a storage compartment 有权
标题翻译：用于检索或更换储藏室内的托盘的装置和方法
公开(公告)号：US07635246B2
公开(公告)日：2009-12-22
申请号：US11925912
申请日：2007-10-27
申请人： Robert K. Neeper , Rhett L Affleck , John E. Lillig
发明人： Robert K. Neeper , Rhett L Affleck , John E. Lillig
IPC分类号： B65G1/00 , B65G65/00
CPC分类号： G01N35/0099 , G01N35/00732 , G01N2035/00752 , Y10T436/11 , Y10T436/113332 , Y10T436/114165
摘要： An automated storage system for storing large quantities of samples in trays includes a storage compartment, a tray shuttle compartment abutting the storage compartment on one side and a plurality of independent modules on the other side. The modules perform processing of samples that are retrieved from the storage compartment by a tray shuttle, including extraction of selected samples from retrieved source trays and transfer of the selected samples into a separate, destination tray that can be further processed or removed from the system for use. The independent operation of the modules permits handling and processing to be performed simultaneously by different modules while the tray shuttle accesses additional samples within the storage compartment. In one embodiment, a vertical carousel is used to vertically align a desired tray with the tray shuttle, while the tray shuttle operates within a horizontal plane.
摘要翻译：用于将大量样品储存在托盘中的自动存储系统包括储存室，在一侧邻接储藏室的托盘穿梭隔室和另一侧上的多个独立模块。模块执行通过托盘穿梭从储存室取出的样品的处理，包括从检索的源托盘提取所选样品并将所选样品转移到单独的目的地托盘中，所述目的托盘可以进一步处理或从系统中移除使用。模块的独立操作允许不同模块同时执行处理和处理，而托盘穿梭器访问存储隔间内的附加样品。在一个实施例中，垂直转盘用于将期望的托盘垂直地对准托盘梭，而托盘梭在水平面内运行。

6. 发明授权

US07596251B2 Automated sample analysis system and method 有权
标题翻译：自动样本分析系统和方法
公开(公告)号：US07596251B2
公开(公告)日：2009-09-29
申请号：US10769462
申请日：2004-01-30
申请人： Rhett L. Affleck , Mike Bodnar , Robert K. Levin , John E. Lillig , Robert K. Neeper
发明人： Rhett L. Affleck , Mike Bodnar , Robert K. Levin , John E. Lillig , Robert K. Neeper
IPC分类号： G06K9/00 , A61B19/02 , A61C19/02 , B01L9/02 , A47B88/06
CPC分类号： C30B29/58 , B01L9/523 , C30B7/00 , G01N15/1475 , G01N21/253 , G01N35/0099 , G01N35/028 , G01N2001/4027 , G01N2015/1493 , G01N2035/00356 , G01N2035/00455 , G01N2035/00881 , G01N2035/042 , G01N2035/0425 , G01N2035/0463 , G02B21/0016
摘要： An automated biological sample analysis system and method for use in incubating and analyzing multiple samples for protein crystallization. A temperature controlled cabinet houses sample storage, sample transport, and sample imaging systems. The operation of the system is automated and can be controlled by software, which can be reconfigured remotely. An array of storage shelves includes multiple shelf columns arranged around a core. Multiple banks of removable shelves arranged as magazines are accessed through a door on the cabinet. Each shelf stores a multi-well plate and different sizes can be stored in different shelves. The core houses a sample transport system that includes a multi-axis robot that rotates about a vertical axis to access the shelves in the shelf array. The transport system retrieves and replaces the multi-well plates in the shelves and can move plates from the shelves to an imaging system where each sample can be automatically imaged.
摘要翻译：一种用于孵化和分析多个样品进行蛋白质结晶的自动化生物样品分析系统和方法。温度控制柜包含样品储存，样品运输和样品成像系统。系统的操作是自动化的，可以通过软件进行控制，可以远程重新配置。一组存储架包括围绕一个核心布置的多个搁架列。可以通过柜子上的门访问多个排列成杂志的可移动货架。每个货架存储多孔板，不同的尺寸可以存放在不同的货架上。核心包含一个样品输送系统，其中包括一个绕垂直轴旋转的多轴机器人，以便进入架子阵列中的货架。运输系统检索和取代货架中的多孔板，并可将板从搁板移动到成像系统，每个样品可自动成像。

7. 发明申请

US20090226891A2 ENCODED SOLID SUPPORTS FOR BIOLOGICAL PROCESSING AND ASSAYS USING SAME 失效
标题翻译：用于生物加工的编码固体支持和使用相同的测定
公开(公告)号：US20090226891A2
公开(公告)日：2009-09-10
申请号：US11011452
申请日：2004-12-14
申请人： Michael Nova , Andrew Senyei , Zahra Parandoosh , Gary David , Xiao-Yi Xiao
发明人： Michael Nova , Andrew Senyei , Zahra Parandoosh , Gary David , Xiao-Yi Xiao
IPC分类号： C12Q1/68 , G01N33/53 , G06F19/00 , C12M3/00
CPC分类号： C40B30/04 , B01J19/0046 , B01J2219/00295 , B01J2219/00299 , B01J2219/00308 , B01J2219/00333 , B01J2219/00344 , B01J2219/00461 , B01J2219/00463 , B01J2219/005 , B01J2219/00502 , B01J2219/0054 , B01J2219/00542 , B01J2219/00547 , B01J2219/00549 , B01J2219/00551 , B01J2219/0056 , B01J2219/00563 , B01J2219/00567 , B01J2219/00569 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , B01L3/502707 , B01L2300/0609 , B82Y10/00 , C07K1/00 , C07K1/04 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/08 , C40B60/14 , C40B70/00 , G01N35/00732 , G01N35/00871 , G01N2015/149 , G01N2035/00782 , G11C13/0014 , G11C13/0019 , G11C13/025
摘要： Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, scintillation proximity assays, non-radioactive proximity assays, and other methods are also provided.
摘要翻译：提供了具有包含至少一个数据存储单元的具有可远程寻址或远程可编程记录设备的矩阵材料的具有存储器的组合。基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。数据存储单元是非易失性反熔丝存储器或易失性存储器，例如EEPROMS，DRAMS或闪存。通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如噬菌体和病毒颗粒和细胞，并且可以通过检索存储的信息。还提供了基质材料，记忆和连接分子和生物材料的组合。这些组合具有多种应用，包括组合化学，目标大分子的分离和纯化，用于分析目的的大分子的捕获和检测，污染物的选择性去除，酶催化，细胞分选，药物递送，化学修饰和其它用途。还提供了用于电子标记分子，生物颗粒和基质支持材料的方法，免疫测定，受体结合测定，闪烁亲近测定，非放射性邻近测定和其它方法。

8. 发明申请

US20080216955A1 DEVICE AND METHOD FOR REMOVING A PEELABLE SEAL 有权
标题翻译：用于去除可剥离密封件的装置和方法
公开(公告)号：US20080216955A1
公开(公告)日：2008-09-11
申请号：US12045644
申请日：2008-03-10
申请人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
发明人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
IPC分类号： B32B38/10
CPC分类号： B01L9/00 , B01L99/00 , B29C63/0013 , B32B38/10 , B32B43/006 , B67B7/00 , Y10T156/1168 , Y10T156/1174 , Y10T156/19 , Y10T156/195 , Y10T156/1956 , Y10T156/1978 , Y10T156/1989
摘要： A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.
摘要翻译：用可剥离密封件密封的容器或容器阵列通过输送机沿着处理路径被输送到一个吸引站，在该站处，具有基本上等于或大于密封件的宽度的宽度的粘合剂表面被压紧可剥离密封件的上表面。收集杆在粘合剂表面上施加向下的压力，当压板随着输送机移动时，将其压靠在密封件上并将容器或容器阵列保持在输送机上的适当位置。当密封的前缘通过收集杆时，粘合剂表面向上滚动，远离密封件的平面，在密封件的前缘上拉起，以将其与容器或容器阵列分开，同时容器或容器阵列被滚筒压住。然后将去除的密封件丢弃。

9. 发明授权

US07157285B2 Automated method for treatment of samples on solid supports 失效
标题翻译：固体支架上样品处理的自动化方法
公开(公告)号：US07157285B2
公开(公告)日：2007-01-02
申请号：US10058462
申请日：2002-01-28
申请人： Rob Neeper , John Lillig
发明人： Rob Neeper , John Lillig
IPC分类号： G01N33/48
CPC分类号： G01N35/02 , B01L3/0293 , G01N35/028 , G01N35/1074 , G01N2035/00504 , Y10T436/11 , Y10T436/111666 , Y10T436/114998 , Y10T436/25375
摘要： The automated sample-on-solid-support processing system of the present invention comprises a computer-based control unit and a main unit comprising a variable-speed centrifuge having an openable vacuum-tight chamber and a centrifuge rotor with a plurality of multi-sample holding positions, a liquid solvent supply subsystem which feeds solvent to a plurality of dispensing stations in the centrifuge chamber, a temperature control subsystem, and a vacuum subsystem. A sample/collection container includes a plurality of wells, each for separating a sample from its solid support when solvent is dispensed into the wells and the centrifuge is activated at a low speed. Operation of the centrifuge at high speed concentrates the cleaved sample in collection wells. In the preferred embodiment bar code reader or other identification means, preferably a non-contact reader, can be included in the chamber to allow sample carriers to be identified.
摘要翻译：本发明的自动化样本固体支持处理系统包括基于计算机的控制单元和主单元，其包括具有可打开的真空密封室的可变速离心机和具有多个多样品的离心机转子保持位置，将溶剂供给到离心机室中的多个分配站的液体溶剂供应子系统，温度控制子系统和真空子系统。样品/收集容器包括多个孔，每个孔用于当将溶剂分配到孔中并且离心机以低速启动时，将样品与其固体支持物分离。离心机高速运转将切割的样品集中在收集井中。在优选实施例中，条形码读取器或其他识别装置，优选地非接触式读取器可以包括在腔室中以允许识别样品载体。

10. 发明授权

US07975746B2 Device and method for removing a peelable seal 有权
公开(公告)号：US07975746B2
公开(公告)日：2011-07-12
申请号：US12637597
申请日：2009-12-14
申请人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
发明人： Robert K. Neeper , Rhett L. Affleck , Roger Howard
IPC分类号： B29C63/00 , B32B38/10
CPC分类号： B01L9/00 , B01L99/00 , B29C63/0013 , B32B38/10 , B32B43/006 , B67B7/00 , Y10T156/1168 , Y10T156/1174 , Y10T156/19 , Y10T156/195 , Y10T156/1956 , Y10T156/1978 , Y10T156/1989
摘要： A container or array of containers that is are sealed with a peelable seal is transported via a conveyor along a processing path toward a desealing station at which an adhesive surface having a width substantially the same as or greater than the width of the seal is pressed against the upper surface of the peelable seal. A collection rod applies a downward pressure on the adhesive surface, pressing it against the seal and keeping the container or container array in position on the conveyor as the plate moves with the conveyor. As the leading edge of the seal passes the collection rod, the adhesive surface is rolled upward, away from the plane of the seal, pulling up on the leading edge of the seal to separate it from the container or container array while the container or container array is held down by the roller. The removed seal is then discarded.

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