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1. 发明公开

US20240197462A1 SAMPLE CONTAINER WITH PEELABLE SEAL AND ACCESS PORT 审中-公开
公开(公告)号：US20240197462A1
公开(公告)日：2024-06-20
申请号：US18591836
申请日：2024-02-29
申请人： Instant Systems, Inc.
发明人： Madeline C. ALDEN , Kimber L. BURLEY , Tara C. RAMSEY
IPC分类号： A61F2/00 , A01N1/02 , B65B5/04 , B65B51/10 , B65D65/42 , B65D75/58
CPC分类号： A61F2/0095 , A01N1/0273 , B65B5/04 , B65B51/10 , B65D65/42 , B65D75/5855
摘要： An apparatus includes a flexible container and a port. The container includes a first layer coupled to a second layer to define a storage volume within which a tissue specimen can be contained. The first layer has a first stiffness and the second layer has a second stiffness. An edge of the first layer is spaced apart from an edge of the second layer to define an opening into the storage volume. The edges of the first and second layer form a peelable seal that hermetically seals the storage volume such that the first layer can be peeled away from the second layer to expose the storage volume. The port is coupled to the flexible container and allows fluid communication between the storage volume and an external volume.

2. 发明公开

US20230348831A1 INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS 审中-公开
公开(公告)号：US20230348831A1
公开(公告)日：2023-11-02
申请号：US18346165
申请日：2023-06-30
申请人： President and Fellows of Harvard College
发明人： Donald E. Ingber , Anthony M. Bahinski , Robert Cunningham , Josue A. Goss , Geraldine A. Hamilton , Christopher David Hinojosa , Daniel Levner , Kevin Kit Parker
IPC分类号： C12M3/06 , A01N1/02 , C12M1/34 , G01N33/50 , B01L3/00 , B01L9/00 , C12M3/00 , C12M1/00 , C12M1/42
CPC分类号： C12M23/16 , A01N1/02 , C12M41/00 , G01N33/5082 , B01L3/502715 , B01L9/52 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , G01N33/5088 , A01N1/0247 , G01N33/5005 , A01N1/0273 , A01N1/021 , B01L3/5027 , C12M41/46 , C12M41/12 , B01L2300/0877 , B01L2300/0867 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644
摘要： The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

3. 发明授权

US11703275B2 Systems and methods for remotely monitoring the cryogenic processing of samples 有权
公开(公告)号：US11703275B2
公开(公告)日：2023-07-18
申请号：US16689175
申请日：2019-11-20
申请人： Asymptote Ltd.
发明人： Alexander Nancekievill , Rupert Rutledge
IPC分类号： B01L7/02 , F25D29/00 , G06F9/451 , G06F16/23 , A01N1/02 , B01L7/00 , H04L67/125
CPC分类号： F25D29/001 , A01N1/0257 , A01N1/0273 , A01N1/0284 , B01L7/02 , B01L7/50 , F25D29/008 , G06F9/451 , G06F16/2379 , H04L67/125 , B01L2200/18 , B01L2300/023 , B01L2300/0663 , F25D2600/06
摘要： A remote system for monitoring and controlling one or more devices for use in the cryogenic processing of a sample is provided. A remote server capable of transmitting freezing profile data to one or more freezers, transmitting transportation profile data to one or more transportation devices, and transmitting thawing profile data to one or more thawing devices. The remote server is also capable of receiving detected data from the one or more freezers relating to the freezing of a sample in accordance with the freezing profile data, receiving detected data from the one or more transportation devices relating to the transportation of a sample in accordance with the transportation profile data, and receiving detected data from the one or more thawing machines relating to the thawing of a sample in accordance with the thawing profile data.

4. 发明授权

US11642208B2 Sample container with peelable seal and access port 有权
公开(公告)号：US11642208B2
公开(公告)日：2023-05-09
申请号：US17345900
申请日：2021-06-11
申请人： Instant Systems, Inc.
发明人： Madeline C. Alden , Kimber L. Burley , Tara C. Ramsey
IPC分类号： A61F2/00 , B65D75/58 , A01N1/02 , B65B5/04 , B65B51/10 , B65D65/42
CPC分类号： A61F2/0095 , A01N1/0273 , B65B5/04 , B65B51/10 , B65D65/42 , B65D75/5855
摘要： An apparatus includes a flexible container, a port, and a support structure. The container includes a first layer coupled to a second layer to define a storage volume within which a tissue specimen can be contained. The first layer is characterized by a first stiffness and the second layer characterized by a second stiffness. An edge of the first layer is spaced apart from an edge of the second layer to define an opening into the storage volume. The edge of the first layer and the edge of the second layer are configured to form a peelable seal that hermetically seals the storage volume such that the first layer can be peeled away from the second layer to expose the storage volume. The port is coupled to the flexible container and allows fluid communication between the storage volume and an external volume. The support structure is configured to support the tissue specimen within the storage volume and is characterized by a third stiffness. The third stiffness is greater than the first stiffness and the second stiffness.

5. 发明授权

US09781920B2 Suspendable organ transplant system and method of use 有权
公开(公告)号：US09781920B2
公开(公告)日：2017-10-10
申请号：US14681837
申请日：2015-04-08
申请人： Paul Jeffrey Campsen
发明人： Paul Jeffrey Campsen
IPC分类号： A61F2/00 , A01N1/02 , A61F7/02 , A61F7/10
CPC分类号： A01N1/0247 , A01N1/0263 , A01N1/0273 , A61F2007/023 , A61F2007/101
摘要： The present invention relates to organ transplant systems used to keep organs chilled and viable as they are moved between patients. More specifically, the present invention both contains the organ and holds it in position during transplant surgery. Thus, there is no need for a member of the implant surgical team to hold the organ while it is being sewn into place.

6. 发明申请

US20170223950A1 APPARATUS FOR MAINTENANCE OF HARVESTED HEARTS FOR TRANSPLANTING 审中-公开
公开(公告)号：US20170223950A1
公开(公告)日：2017-08-10
申请号：US15128634
申请日：2015-03-18
申请人： Darren Freed
发明人： Darren FREED
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0252 , A01N1/0273 , A61B5/0402 , A61N1/3622 , A61N1/3625 , A61N1/3968
摘要： An apparatus, a system, and methods for maintaining and monitoring an excised donor heart. The apparatus comprises a first component for receiving and submerging therein an excised heart in a constantly circulating perfusate solution and a second component comprising equipment for adjusting the temperature and oxygen content of the perfusate solution. The first component comprises an integral pair of defibrillating pads. A first conduit infrastructure interconnects the first module, the second module and an aorta of the excised donor heart pushing a perfusion solution from the first module through the second module into the aorta. The second conduit infrastructure connects the first module with the right atrium and the left atrium for pushing the perfusion solution from the first module into the atria. The third conduit infrastructure connects the first module with the pulmonary artery and provides an after pressure to the flow of the perfusion solution from the pulmonary artery.

7. 发明申请

US20170188572A1 SPECIMEN CONTAINER FOR BIOLOGICAL MATERIALS 审中-公开
公开(公告)号：US20170188572A1
公开(公告)日：2017-07-06
申请号：US15463771
申请日：2017-03-20
申请人： Francesca Dagny TEKULA
发明人： Francesca Dagny TEKULA
IPC分类号： A01N1/02 , A61B10/00 , B01L3/00
CPC分类号： A01N1/0263 , A01N1/0273 , A61B10/0096 , B01F13/0023 , B01L3/502 , B01L3/561 , B01L3/563 , B01L3/565 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0689 , B01L2200/087 , B01L2200/18 , B01L2300/028 , B01L2300/042 , B01L2300/0832 , B01L2300/087 , B01L2400/0478
摘要： A specimen container for use with biological specimens that includes at least one cylindrical housing, wherein the at least one cylindrical housing is open on one or both ends thereof; at least one cap for sealing the open ends of the at least one cylindrical housing; a syringe plunger adapted for insertion into the at least one cylindrical housing, wherein the syringe plunger is operative to move a biological specimen into the at least one cylindrical housing when the syringe plunger is depressed; and optionally, a linking cuff, wherein the linking cuff is operative to join multiple cylindrical housings to one another and permit mixing of the contents thereof.

8. 发明申请

US20160342941A1 Biologic Stability, Delivery Logistics and Administration of Time and/or Temperature Sensitive Biologic Based Materials 有权
标题翻译：生物稳定性，运输物流和时间和/或温度敏感生物基材料的管理
公开(公告)号：US20160342941A1
公开(公告)日：2016-11-24
申请号：US15158700
申请日：2016-05-19
申请人： Biologistex CCM, LLC
发明人： Michael Rice , Bruce McCormick
IPC分类号： G06Q10/08 , B65D43/02 , B65D81/38 , A01N1/02 , H04Q9/00
CPC分类号： G01N33/483 , A01N1/0273 , A61J1/00 , A61J1/03 , A61J2200/44 , A61J2200/50 , A61J2200/72 , A61J2205/60 , B65D43/02 , B65D81/3813 , B65D2201/00 , B65D2203/10 , G06Q10/0832 , H04Q9/00 , H04Q2209/40 , H04Q2209/43 , H04Q2209/823
摘要： In some embodiments, alerts are sent to appropriate parties if an insulated container is not properly packed out to insure the approximate safe temperature of the materials. In other embodiments, a countdown timer is used to keep track of the time that the biologic has been in transit, and ensure that the amount of time does not exceed the known shelf life of the biologic. In still other embodiments, the payload container is equipped with its own sensors, such as temperature sensors, and communications devices, such as a close range communication device, capable of transmitting information regarding a range of parameters, including, but not limited to, temperature, humidity, location and time, from the payload container to an end user. In other embodiments, shielding and/or radiation sensors are included in insulated shipping or storage containers, or payload containers, to shield and monitor the radiation exposure of the payload.
摘要翻译：在一些实施例中，如果隔热容器没有被适当地包装以确保材料的近似安全温度，则将警报发送给适当的方。在其他实施例中，倒数计时器用于跟踪生物体已经在运输的时间，并确保时间量不超过生物体的已知保质期。在其他实施例中，有效载荷容器配备有其自己的传感器，例如温度传感器，以及能够发送关于参数范围的信息的通信设备，例如近距离通信设备，包括但不限于温度，湿度，位置和时间，从有效载荷容器到最终用户。在其他实施例中，屏蔽和/或辐射传感器包括在绝缘运输或存储容器或有效载荷容器中，以屏蔽和监测有效负载的辐射暴露。

9. 发明申请

US20160338344A1 ORGAN TRANSPORT APPARATUS WITH SAMPLE COMPARTMENTS 审中-公开
标题翻译：机关运输装置
公开(公告)号：US20160338344A1
公开(公告)日：2016-11-24
申请号：US15163088
申请日：2016-05-24
申请人： LIFELINE SCIENTIFIC, INC.
发明人： David Kravitz , Christopher P. Steinman , David Pettinato , Mathew Copithorne , Brian Otts , Robert J. Allen , Frank P. Nanna , Peter Demuylder
IPC分类号： A01N1/02
CPC分类号： A01N1/0252 , A01N1/0247 , A01N1/0273
摘要： An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.
摘要翻译：用于器官或组织的储存，处理，评估和运输中的至少一个的装置包括构造成冷却器官或组织的冷却容器，构造成灌注器官或组织的灌注回路，以及用于保持生物样品。优选的装置在装置的第一盖（盖）下方具有包括冷却剂容器和样品室的第一内部隔室。该装置可以包括设备的第二盖（盖）下的第二内部隔室，第二内部隔室包括至少部分灌注回路和样品室。

10. 发明申请

US20160309707A1 METHOD, DEVICE AND FLUID FOR TREATMENT OF A HEART AFTER HARVESTING 审中-公开
标题翻译：方法，设备和流体用于治疗心脏后收集
公开(公告)号：US20160309707A1
公开(公告)日：2016-10-27
申请号：US15202655
申请日：2016-07-06
申请人： VIVOLINE MEDICAL AB
发明人： Stig Steen , Audrius Paskevicius
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0226 , A01N1/0273
摘要： Method and device for treatment of a heart after harvesting and before transplantation. The device comprises a container intended to comprise the heart; a first line for connection to an aorta of the heart; a fluid circuit comprising an oxygenator for oxygenating said fluid and a heater/cooler for regulating the temperature of said fluid; and a pump for perfusion of said fluid through the coronary blood vessels of the heart. The fluid comprises an oncotic agent exerting an oncotic pressure larger than about 30 mmHg and is cardioplegic by comprising a potassium concentration between 15 mM and 30 mM. A control device is arranged for controlling the pump to perform said perfusion intermittently, whereby the perfusion time is less than half of the cycle time. The perfusion is performed at a pressure of at least 15 mmHg and at least 15 mmHg lower than said oncotic pressure.
摘要翻译：收集后和移植前治疗心脏的方法和装置。该装置包括旨在包括心脏的容器; 与心脏主动脉连接的第一条线流体回路，包括用于使所述流体充氧的氧合器和用于调节所述流体的温度的加热器/冷却器; 以及用于通过心脏的冠状动脉血液灌注所述流体的泵。流体包含施用大于约30mmHg的肿瘤压力的肿瘤剂，并且通过包含15mM至30mM的钾浓度而引起心脏停搏。控制装置被布置成用于控制泵间歇地执行所述灌注，由此灌注时间小于循环时间的一半。灌注在至少15mmHg的压力和低于所述肿瘤压力的至少15mmHg的压力下进行。

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