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1. 发明授权

US09039935B2 Photoelectric conversion material containing fullerene derivative 有权
标题翻译：含有富勒烯衍生物的光电转换材料
公开(公告)号：US09039935B2
公开(公告)日：2015-05-26
申请号：US12299898
申请日：2007-05-02
申请人： Eiichi Nakamura , Yutaka Matsuo , Katsuhiko Kanaizuka
发明人： Eiichi Nakamura , Yutaka Matsuo , Katsuhiko Kanaizuka
IPC分类号： H01B1/00 , H01B1/12 , H01B1/04 , H01L31/00 , C07C63/49 , B82Y10/00 , H01L51/00 , H01L31/04 , H01L51/42
CPC分类号： C07C63/49 , B82Y10/00 , H01B1/04 , H01L31/04 , H01L51/0047 , H01L51/42 , Y02E10/50 , Y02E10/549 , Y10S977/738 , Y10S977/948
摘要： The present invention provides a photoelectric conversion material comprising a fullerene derivative represented by the formula C60(R1)5(R2), wherein each R1 independently represents an organic group having a substituent; and R2 represents a hydrogen atom or a substituted or unsubstituted C1-C30 hydrocarbon group. Further, the present invention also provides a photoelectric conversion device having a self-assembled monomolecular film of the photoelectric conversion material, and a solar cell having the photoelectric conversion device.
摘要翻译：本发明提供一种光电转换材料，其包含由式C60（R1）5（R2）表示的富勒烯衍生物，其中每个R 1独立地表示具有取代基的有机基团。并且R 2表示氢原子或取代或未取代的C 1 -C 30烃基。此外，本发明还提供一种具有光电转换材料的自组装单分子膜的光电转换装置和具有光电转换装置的太阳能电池。

2. 发明申请

US20140213552A1 CYCLOHEXYLAMINES 有权
标题翻译：环辛基胺
公开(公告)号：US20140213552A1
公开(公告)日：2014-07-31
申请号：US14220381
申请日：2014-03-20
申请人： Endo Pharmaceuticals Inc.
发明人： Scott Kevin Thompson , Roger Astbury Smith , Sandeep Gupta , Tony Priestley , Nicholas James Laping , Ashis K. Saha , Sonali Rudra
IPC分类号： A61K31/40 , A61K31/381 , A61K31/24 , C07D207/34 , A61K45/06 , C07D333/38 , C07D309/14 , C07C65/26 , C07C63/49 , A61K31/351 , C07D333/72
CPC分类号： A61K31/40 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/381 , A61K45/06 , C07C63/49 , C07C65/26 , C07C219/12 , C07C219/14 , C07C2601/14 , C07D207/34 , C07D309/14 , C07D333/38 , C07D333/40 , C07D333/70 , C07D333/72 , A61K2300/00
摘要： The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.
摘要翻译：本申请提供了用于制备和使用这些化合物的新型化合物和方法。这些化合物可用于通过向患者施用一种或多种化合物来治疗患者的疼痛，瘙痒，膀胱过度活动和/或间质性膀胱炎。所述方法包括施用式（I）化合物和TRPV1受体激活剂。在一个实施方案中，TRPV1受体激活剂是利多卡因。

3. 发明申请

US20130101667A1 Cyclohexylamines 有权
公开(公告)号：US20130101667A1
公开(公告)日：2013-04-25
申请号：US13659694
申请日：2012-10-24
申请人： Endo Pharmaceuticals, Inc.
发明人： Scott Kevin Thompson , Roger Astbury Smith , Sandeep Gupta , Tony Priestley , Nicholas James Laping , Ashis K. Saha , Sonali Rudra
IPC分类号： C07C219/14 , A61K31/24 , C07D309/14 , A61K31/351 , C07C219/12 , A61K31/215 , C07D333/70 , A61K31/381 , C07D333/38 , C07D207/34 , A61K31/40 , A61K9/00 , A61K9/127 , A61P29/00 , A61P17/04 , A61P25/00 , A61P13/10 , A61K31/235
CPC分类号： A61K31/40 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/351 , A61K31/381 , A61K45/06 , C07C63/49 , C07C65/26 , C07C219/12 , C07C219/14 , C07C2601/14 , C07D207/34 , C07D309/14 , C07D333/38 , C07D333/40 , C07D333/70 , C07D333/72 , A61K2300/00
摘要： The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.

4. 发明授权

US07318964B2 Fluorene compounds containing various functional groups, polymers thereof and EL element using the same 失效
标题翻译：含有各种官能团的芴化合物，其聚合物和使用其的EL元件
公开(公告)号：US07318964B2
公开(公告)日：2008-01-15
申请号：US10135728
申请日：2002-05-01
申请人： Hyun-Nam Cho , Sung Hyun Jung , Sang Won Son
发明人： Hyun-Nam Cho , Sung Hyun Jung , Sang Won Son
IPC分类号： C09B27/00 , C09B31/00 , C07C321/00 , C07C323/00 , H01L1/62
CPC分类号： C07C69/76 , C07C22/04 , C07C25/22 , C07C25/24 , C07C33/36 , C07C43/21 , C07C47/546 , C07C47/575 , C07C63/49 , C07C65/26 , C07C205/06 , C07C205/22 , C07C205/35 , C07C205/38 , C07C211/50 , C07C255/34 , C07C255/51 , C07C261/02 , C07C2603/18 , C07F5/025 , C09B11/02 , C09B23/141 , C09B69/10
摘要： The present invention relates to fluorene compounds and polymers thereof, having various structures and functional groups, and capable of being used as a luminescent material for organic and polymer-based electro-luminescence (EL) element and other optical element, and to an EL element using the same as a luminescent material.
摘要翻译：本发明涉及具有各种结构和官能团的芴化合物及其聚合物，并且能够用作有机和基于聚合物的电致发光（EL）元件和其它光学元件的发光材料，以及EL元件使用相同的发光材料。

5. 发明申请

US20070135392A1 Apoptosis promoters 有权
标题翻译：凋亡启动子
公开(公告)号：US20070135392A1
公开(公告)日：2007-06-14
申请号：US11482458
申请日：2006-07-07
申请人： Michael Wendt , Hong Ding , Sheela Thomas , Steven Elmore , Wang Shen , Daniel Dickman , David Augeri
发明人： Michael Wendt , Hong Ding , Sheela Thomas , Steven Elmore , Wang Shen , Daniel Dickman , David Augeri
IPC分类号： A61K31/655 , A61K31/44 , C07D213/53 , C07D207/30
CPC分类号： C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
摘要翻译：公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其表达为Mcl-1蛋白。

6. 发明授权

US06380445B1 Poly(9,9'-spirobisfluorenes), their production and their use 失效
标题翻译：聚（9,9'-spirobisfluorenes），它们的生产和使用
公开(公告)号：US06380445B1
公开(公告)日：2002-04-30
申请号：US09567348
申请日：2000-05-09
申请人： Ralf-Roman Rietz , Wolfgang Wernet
发明人： Ralf-Roman Rietz , Wolfgang Wernet
IPC分类号： C07C2522
CPC分类号： C09K11/06 , C07C17/12 , C07C25/22 , C07C49/792 , C07C49/813 , C07C63/49 , C08G61/00 , Y10S428/917
摘要： Soluble poly(bis-9,9′-fluorenes) comprise identical or different structural repeating units of the formula I, where the two R1s are, independently of one another, H, C1-C18alkyl, C6-C14aryl, C7-C15aralkyl, C1-C18alkoxy, R2—(O—CnH2n)m—O—, C1-C18alkylthio, C1-C18dialkylamino, —C(O)OH, —C(O)O—C1-C18alkyl, —C(O)—N(C1-C18alkyl)2, —SO3H, —SO3—C1-C18alkyl, —SO2—N(C1-C18alkyl)2, C1-C17alkyl-C(O)—O— or C1-C17alkyl-C(O)—, R2 is H or C1-C12alkyl, n is from 2 to 6 and m is from 1 to 12. The polymers can be used either alone or in admixture with at least one additional fluorophore whose absorption band overlaps the emission band (fluorescent emission) of the polymer of the formula I as active radiative layer for light-emitting diodes, VDUs and display elements.
摘要翻译：可溶性聚（双-9,9'-芴）包含相同或不同的式I结构重复单元，其中两个R 1彼此独立地为H，C 1 -C 18烷基，C 6 -C 14芳基，C 7 -C 15芳烷基，C 1 -C 18烷基，（O-C n H 2n）m O - ，C 1 -C 18烷硫基，C 1 -C 18二烷基氨基，-C（O）OH，-C（O）O-C 1 -C 18烷基，-C（O） 2，-SO 3 H，-SO 3 -C 1 -C 18烷基，-SO 2 -N（C 1 -C 18烷基）2，C 1 -C 17烷基-C（O）-O-或C 1 -C 17烷基-C（O） - ，R 2为H或C 1 -C 12烷基，n为2-6，m为1至12.聚合物可单独使用或与至少一种另外的荧光团混合使用，其吸收带与式（I）的聚合物的发射带（荧光发射）重叠我作为发光二极管，VDU和显示元件的有源辐射层。

7. 发明授权

US06316404B1 Treating NIDDM with RXR agonists 有权
标题翻译：用RXR激动剂治疗NIDDM
公开(公告)号：US06316404B1
公开(公告)日：2001-11-13
申请号：US09745681
申请日：2000-12-22
申请人： Richard A. Heyman , Rosemary Cesario , Ranjan Mukherjee
发明人： Richard A. Heyman , Rosemary Cesario , Ranjan Mukherjee
IPC分类号： A61K3828
CPC分类号： G01N33/5044 , A61K31/00 , A61K31/192 , A61K31/425 , A61K31/44 , A61K31/4418 , A61K38/28 , A61K45/06 , C07C57/50 , C07C59/72 , C07C63/49 , C07C63/66 , C07C65/28 , C07C65/36 , C07C251/48 , C07C2602/10 , C07C2603/24 , C07D221/08 , C07D265/34 , C07D311/92 , C07D317/30 , G01N33/5008 , G01N33/502 , G01N33/5038 , G01N33/5073 , G01N2500/00 , A61K2300/00
摘要： This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPAR&ggr; agonist such as a thiazolidinedione compound.
摘要翻译：本发明涉及使用单独的RXR激动剂或与PPARγ激动剂如噻唑烷二酮化合物组合治疗非胰岛素依赖性糖尿病的方法和组合物。

8. 发明授权

US06228862B1 Treating NIDDM with RXR agonists 有权
公开(公告)号：US06228862B1
公开(公告)日：2001-05-08
申请号：US09309370
申请日：1999-05-11
申请人： Richard A. Heyman , Rosemary Cesario , Ranjan Mukherjee
发明人： Richard A. Heyman , Rosemary Cesario , Ranjan Mukherjee
IPC分类号： A61K31435
CPC分类号： G01N33/5044 , A61K31/00 , A61K31/192 , A61K31/425 , A61K31/44 , A61K31/4418 , A61K38/28 , A61K45/06 , C07C57/50 , C07C59/72 , C07C63/49 , C07C63/66 , C07C65/28 , C07C65/36 , C07C251/48 , C07C2602/10 , C07C2603/24 , C07D221/08 , C07D265/34 , C07D311/92 , C07D317/30 , G01N33/5008 , G01N33/502 , G01N33/5038 , G01N33/5073 , G01N2500/00 , A61K2300/00
摘要： This invention relates to methods and compositions for the treatment of non-insulin-dependent diabetes mellitus using an RXR agonist alone or in combination with a PPAR&ggr; agonist such as a thiazolidinedione compound.

9. 发明授权

US5877207A Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities 失效
公开(公告)号：US5877207A
公开(公告)日：1999-03-02
申请号：US880823
申请日：1997-06-24
申请人： Elliott S. Klein , Alan T. Johnson , Andrew M. Standeven , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Sunil Nagpal , Vidyasagar Vuligonda , Min Teng , Roshantha A. Chandraratna
发明人： Elliott S. Klein , Alan T. Johnson , Andrew M. Standeven , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Sunil Nagpal , Vidyasagar Vuligonda , Min Teng , Roshantha A. Chandraratna
IPC分类号： C07D333/24 , A61K31/245 , A61K31/353 , A61K31/381 , A61P3/10 , A61P17/16 , A61P19/08 , A61P39/02 , A61P43/00 , C07C57/50 , C07C63/33 , C07C63/49 , C07C63/66 , C07C63/72 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38 , C07C69/618 , C07C69/76 , C07C69/90 , C07C69/94 , C07C233/81 , C07C233/87 , C07C245/10 , C07C327/48 , C07D213/55 , C07D277/30 , C07D307/54 , C07D311/58 , C07D335/06 , C07F7/08 , C07F7/18 , A61K31/35 , C07D311/04
CPC分类号： C07C57/50 , C07C233/81 , C07C233/87 , C07C245/10 , C07C327/48 , C07C63/33 , C07C63/49 , C07C63/66 , C07C63/72 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38 , C07C69/618 , C07C69/76 , C07C69/90 , C07C69/94 , C07D213/55 , C07D277/30 , C07D307/54 , C07D311/58 , C07D333/24 , C07D335/06 , C07F7/0818 , C07C2102/10 , C07C2102/28
摘要： Aryl-substituted and aryl and (3-oxo-1-propenly)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists can be administered to mammals, including humans, for the purpose of preventing or diminishing action of RAR agonists on the bound receptor sites. Specifically, the RAR agonists are administered or coadministered with retinoid drugs to prevent or ameliorate toxicity or side effects caused by retinoids or vitamin A or vitamin A precursors. The retinoid negative hormones can be used to potentiate the activities of other retinoids and nuclear receptor agonists. For example, the retinoid negative hormone called AGN 193109 effectively increased the effectiveness of other retinoids and steroid hormones in in vitro transactivation assays. Additionally, transactivation assays can be used to identify compounds having negative hormone activity. These assays are based on the ability of negative hormones to down-regulate the activity of chimeric retinoid receptors engineered to possess a constitutive transcription activator domain.

10. 发明授权

US5770763A Difunctional bitricyclodecatriene monomers 失效
公开(公告)号：US5770763A
公开(公告)日：1998-06-23
申请号：US705630
申请日：1996-08-30
申请人： David C. Martin , Jeffrey S. Moore , Larry J. Markoski , Kenneth A. Walker , Gary E. Spilman
发明人： David C. Martin , Jeffrey S. Moore , Larry J. Markoski , Kenneth A. Walker , Gary E. Spilman
IPC分类号： C07C37/055 , C07C39/17 , C07C63/38 , C07C63/49 , C07C63/72 , C07C211/61 , C07C233/65 , C07C265/14 , C08G65/40 , C08G69/26 , C08G69/32 , C07C205/12
CPC分类号： C08G69/32 , C07C211/61 , C07C233/65 , C07C265/14 , C07C29/147 , C07C37/00 , C07C63/38 , C07C63/49 , C07C63/72 , C08G65/4012 , C08G69/26 , C07C2102/06 , C07C2103/08
摘要： Novel difunctionalized cyclobutabenzene monomers of the general formula: ##STR1## wherein Z can be hydrogens or a cyclobutane ring; and X and Y are carboxyl, amino, alcohol, isocyanate, acid halide, or bis-acyl halide groups. Exemplary difunctional bitricyclodecatriene monomers are �2,2'-bidicyclo�2.4.0!octa-1,3,5-triene!-5,5'-dicarboxylic acid (BXTA) and �2,2'-bitricyclo�6.2.0.0!deca-1,3,(6),7-triene!-7,7'-dicarboxylic acid (QXTA). The difunctionalized bitricyclodecatriene monomers can form part of a polymer backbone chain in which the multiple butane ring functionalities can be easily opened to produce strong, three-dimensional covalent bond crosslinking between polymer chains. The crosslinking can be induced simply by heating the polymer to a temperature in excess of 250.degree. C.

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