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1. 发明申请

US20170136450A1 POLYMER CONTAINING CARBOXYL GROUP, PREPARATION METHOD AND APPLICATION THEREOF, SUPPORTED CATALYST AND PREPARATION METHODS THEREOF AND PREPARATION METHODS OF PENEM ANTIBIOTIC INTERMEDIATE 审中-公开
公开(公告)号：US20170136450A1
公开(公告)日：2017-05-18
申请号：US15039189
申请日：2014-09-10
申请人： Asymchem Laboratories (Tianjin) Co., Ltd. , Asymchem Life Science (Tianjin) Co., Ltd. , Tianjin Asymchem Pharmaceutical Co., Ltd. , Asymchem Laboratories (Fuxin) Co., Ltd. , Jilin Asymchem Laboratories Co., Ltd.
发明人： Hao HONG , Jiuyuan LI , Changming DONG , Xin ZHANG , Gage JAMES
IPC分类号： B01J31/06 , B01J31/28 , C07D477/04 , C08J9/00 , C08J9/14 , C08F212/08
CPC分类号： B01J31/06 , B01J23/464 , B01J31/28 , C07D477/04 , C07D477/06 , C08F12/22 , C08F12/26 , C08F12/32 , C08F12/34 , C08F212/08 , C08F212/14 , C08J9/0061 , C08J9/141 , C08J9/142 , C08J9/145 , C08J9/149 , C08J2203/12 , C08J2203/14 , C08J2203/142 , C08J2325/08 , C08J2405/00 , C08J2429/04 , Y02P20/584 , C08F212/34 , C08F212/36 , C08F212/32
摘要： A polymer containing a carboxyl group, a preparation method and an application thereof, a supported catalyst and a preparation method thereof and preparation methods of penem antibiotic intermediate are disclosed. The polymer has high rigidity and hardness, thus the mechanical properties of the polymer is effectively improved. Meanwhile, in the polymer, the carboxyl group is used as a main functional group, and is used as a carrier to prepare, by means of a coordination reaction between the carboxyl group and a heavy metal, a supported metal catalyst which has better connection stability between the metal and the polymer. The above two factors can improve the stability of the supported metal catalyst, such that the catalyst can be recycled without losing the catalytic activity. Meanwhile, loss of a heavy metal active ingredient and production cost can be reduced.

2. 发明申请

US20160331774A1 IMMUNOMODULATING COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫调节组合物及其使用方法
公开(公告)号：US20160331774A1
公开(公告)日：2016-11-17
申请号：US15220153
申请日：2016-07-26
申请人： Whitehead Institute , Massachusetts Institute of Technology , Trustees of Boston University , The General Hospital Corporation d/b/a Massachusetts General Hospital
发明人： Ifat Rubin-Bejerano , Gerald R. Fink , Claudia Abeijon , Daniel S. Kohane , Jason E. Fuller , Robert S. Langer
IPC分类号： A61K31/716 , A61K39/35 , A61K39/00 , A61K47/48 , A61K39/39 , A61L31/16 , A61K45/06 , A61K36/064 , A61K36/09 , A61K9/16
CPC分类号： A61K31/716 , A61K9/1647 , A61K36/064 , A61K36/09 , A61K39/0011 , A61K39/385 , A61K39/39 , A61K45/06 , A61K47/61 , A61K47/6843 , A61K47/6921 , A61K2039/55583 , A61K2039/572 , C08B37/0024 , C08J3/126 , C08J3/128 , C08J2300/16 , C08J2325/06 , C08J2367/04 , C08J2400/16 , C08J2405/00
摘要： This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
摘要翻译：本发明涉及β-1-6-葡聚糖，包含其的组合物和装置及其在调节免疫应答中的用途。本发明某些实施方案的β-1-6-葡聚糖富含O-乙酰化基团和/或与固体支持物缀合或与靶向部分连接。

3. 发明授权

US07807823B2 Method of forming polysaccharide structures 有权
标题翻译：形成多糖结构的方法
公开(公告)号：US07807823B2
公开(公告)日：2010-10-05
申请号：US11050003
申请日：2005-02-03
申请人： Wilson Moya , Neil P. Soice , Volkmar Thom
发明人： Wilson Moya , Neil P. Soice , Volkmar Thom
IPC分类号： C07B37/02 , C07H1/00
CPC分类号： C08J3/075 , B01J20/24 , B01J20/26 , B01J20/262 , B01J20/267 , B01J20/28033 , B01J20/285 , B01J2220/4825 , C08J9/365 , C08J2305/12 , C08J2405/00 , C09D105/12 , D06M15/03 , G01N27/44747
摘要： A process for forming polysaccharide structures such as beads, gel films and porous coatings on porous substrates by forming a room temperature gel-inhibited solution of a polysaccharide, one or more gel-inhibiting agent(s) and a solvent such as water, heating the mixture until all the components are dissolved, cooling the mixture as a solution to about room temperature, forming a three dimensional structure with the solution and adding the structure to a gelling agent to form a polysaccharide gel. Optionally, the solution can be added to a porous structure such as a non-woven fabric or a porous membrane and the solution is allowed to dry before being subjected to the gelling agent. Porous structures having a polysaccharide coating and being capable of convective flow through the pores of the structure and diffusive flow through the coating can be formed.
摘要翻译：通过形成多糖，一种或多种凝胶抑制剂和溶剂如水的室温凝胶抑制溶液，在多孔基材上形成多糖结构如珠，凝胶膜和多孔涂层的方法，加热混合物直到所有组分溶解，将溶液冷却至约室温，用溶液形成三维结构，并将结构加入胶凝剂中以形成多糖凝胶。任选地，可以将溶液加入到诸如无纺布或多孔膜的多孔结构中，并使溶液在经受胶凝剂之前干燥。可以形成具有多糖涂层并且能够对流流过结构的孔和通过涂层的扩散流的多孔结构。

4. 发明授权

US07446138B2 Wood particle filled polyvinyl chloride composites and their foams 失效
标题翻译：木颗粒填充聚氯乙烯复合材料及其泡沫
公开(公告)号：US07446138B2
公开(公告)日：2008-11-04
申请号：US11408779
申请日：2006-04-21
申请人： Laurent M. Matuana , Patricia A. Heiden , Bhavesh L. Shah
发明人： Laurent M. Matuana , Patricia A. Heiden , Bhavesh L. Shah
IPC分类号： B29C47/00 , B29C43/22 , B29C47/60 , B32B5/16 , B29D7/00 , C08J9/00 , C08J9/10 , D01D5/12
CPC分类号： C08J9/0085 , B27N3/005 , B27N3/28 , B29C43/003 , B29C47/0004 , B29C47/0019 , B29C47/0038 , B29C47/40 , B29C2791/001 , B29K2027/06 , B29K2105/0097 , B29K2105/04 , B29K2105/06 , B29K2311/10 , B29K2311/14 , B29K2711/00 , B29K2711/14 , B29L2007/002 , C08J9/0061 , C08J2201/03 , C08J2327/06 , C08J2405/00 , Y10T428/25 , Y10T428/253
摘要： Extruded composite compositions of PVC and wood particles containing chitosan or chitin as a coupling agent are described. The composite compositions have improved physical and mechanical properties.
摘要翻译：描述了含有壳聚糖或壳多糖作为偶联剂的PVC和木材颗粒的挤出复合组合物。复合组合物具有改善的物理和机械性能。

5. 发明授权

US07446131B1 Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making 失效
标题翻译：由天然聚合物和合成聚合物制成的多孔聚合物基质和任选的至少一种阳离子和制备方法
公开(公告)号：US07446131B1
公开(公告)日：2008-11-04
申请号：US11058034
申请日：2005-02-15
申请人： LinShu Liu , Marshall L. Fishman , Kevin B. Hicks
发明人： LinShu Liu , Marshall L. Fishman , Kevin B. Hicks
IPC分类号： C08B37/00
CPC分类号： C08B37/0045 , A61L27/26 , A61L27/56 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/05 , C08J2367/04 , C08J2405/00 , C08L5/06 , C08L67/04 , C08L5/04 , C08L2666/18 , C08L2666/26
摘要： A porous polymeric matrix containing at least one natural polymer and at least one synthetic polymer and optionally at least one cation. Furthermore, a method of making a porous polymeric matrix involving mixing at least one natural polymer and inorganic salts with a solution comprising at least one solvent and at least one synthetic polymer to form a slurry, casting the slurry in a mold and removing the solvent to form solid matrices, immersing the solid matrices in deionized water to allow natural polymer cross-linking and pore creation to occur simultaneously, and drying the matrices to create a porous polymeric matrix; wherein the matrix contains a cation. Also, a method of making a porous polymeric matrix, involving mixing at least one natural polymer in an aqueous solvent and mixing at least one synthetic polymer in an organic solvent, combining the mixtures and casting in a mold, and separately removing said aqueous solvent and said organic solvent to form a porous polymeric matrix; wherein the porous polymeric matrix does not contain a cation.
摘要翻译：含有至少一种天然聚合物和至少一种合成聚合物和任选的至少一种阳离子的多孔聚合物基质。此外，制备多孔聚合物基质的方法包括将至少一种天然聚合物和无机盐与包含至少一种溶剂和至少一种合成聚合物的溶液混合以形成浆料，将浆料浇铸到模具中并除去溶剂形成固体基质，将固体基质浸入去离子水中以允许天然聚合物交联和孔产生同时发生，并干燥基质以产生多孔聚合物基质; 其中所述基质含有阳离子。而且，制备多孔聚合物基质的方法，包括在水性溶剂中混合至少一种天然聚合物并在有机溶剂中混合至少一种合成聚合物，将该混合物和铸件混合在模具中，并分别除去所述水性溶剂和所述有机溶剂形成多孔聚合物基质; 其中所述多孔聚合物基质不含阳离子。

6. 发明授权

US6007876A Method for producing polymer articles with a modified surface 失效
标题翻译：具有改性表面的聚合物制品的制造方法
公开(公告)号：US6007876A
公开(公告)日：1999-12-28
申请号：US46632
申请日：1998-03-24
申请人： Hiroyuki Niino
发明人： Hiroyuki Niino
IPC分类号： A61L27/00 , A61L27/34 , C08F2/48 , C08J7/00 , C08J7/04 , C08J7/12
CPC分类号： C08J7/047 , A61L27/34 , C08J2400/14 , C08J2405/00 , C08J2489/00
摘要： There is disclosed a method for producing polymer articles having highly functionalized surfaces excellent in biocompatibility, by irradiating the surfaces of a polymer article with an ultraviolet laser beam in a solution containing a biopolymer. According to this method, a polymer article that has surfaces with biocompatibility, can be produced.
摘要翻译：公开了通过在含有生物聚合物的溶液中用紫外线激光束照射聚合物制品的表面，制造具有生物相容性优异的高官能化表面的聚合物制品的方法。根据该方法，可以制造具有生物相容性的表面的聚合物制品。

7. 发明授权

US09457047B2 Immunomodulating compositions and methods of use thereof 有权
标题翻译：免疫调节组合物及其使用方法
公开(公告)号：US09457047B2
公开(公告)日：2016-10-04
申请号：US14037420
申请日：2013-09-26
申请人： Whitehead Institute , Massachusetts Institute of Technology , Boston University , The General Hospital Corporation
发明人： Ifat Rubin-Bejerano , Gerald R. Fink , Claudia Abeijon , Daniel S. Kohane , Jason E Fuller , Robert S. Langer
IPC分类号： A61K39/395 , A61K31/716 , A61K45/06 , A61K36/09 , C08B37/00 , A61K36/064 , A61K47/48 , C08J3/12
CPC分类号： A61K31/716 , A61K9/1647 , A61K36/064 , A61K36/09 , A61K39/0011 , A61K39/385 , A61K39/39 , A61K45/06 , A61K47/61 , A61K47/6843 , A61K47/6921 , A61K2039/55583 , A61K2039/572 , C08B37/0024 , C08J3/126 , C08J3/128 , C08J2300/16 , C08J2325/06 , C08J2367/04 , C08J2400/16 , C08J2405/00
摘要： This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
摘要翻译：本发明涉及β-1-6-葡聚糖，包含其的组合物和装置及其在调节免疫应答中的用途。本发明某些实施方案的β-1-6-葡聚糖富含O-乙酰化基团和/或与固体支持物缀合或与靶向部分连接。

8. 发明授权

US09309436B2 Composite maillard-resole binders 有权
公开(公告)号：US09309436B2
公开(公告)日：2016-04-12
申请号：US14041015
申请日：2013-09-30
申请人： Knauf Insulation, Inc. , Knauf Insulation SPRL
发明人： Brian L. Swift
IPC分类号： C09D161/34 , C09D161/06 , C08J5/04 , D04H1/587 , D04H1/64 , C08L3/02 , C08H1/00 , C08L97/02 , C09J161/34 , C08L61/34 , C08K7/14
CPC分类号： C08L61/06 , B27N3/002 , C08H1/00 , C08J5/04 , C08J2301/02 , C08J2361/06 , C08J2405/00 , C08K7/14 , C08L3/02 , C08L61/34 , C08L97/02 , C08L2205/16 , C09D161/06 , C09J161/34 , D04H1/587 , D04H1/64 , D04H1/641 , C08L89/00
摘要： Composite Maillard-resole binders to produce or promote cohesion in non-assembled or loosely assembled matter.

9. 发明申请

US20140088225A1 COMPOSITE MAILLARD-RESOLE BINDERS 有权
标题翻译：复合材料MAILARD-RESOLE BINDERS
公开(公告)号：US20140088225A1
公开(公告)日：2014-03-27
申请号：US14041015
申请日：2013-09-30
申请人： Knauf Insulation GmbH
发明人： Brian L. Swift
IPC分类号： C09D161/06
CPC分类号： C08L61/06 , B27N3/002 , C08H1/00 , C08J5/04 , C08J2301/02 , C08J2361/06 , C08J2405/00 , C08K7/14 , C08L3/02 , C08L61/34 , C08L97/02 , C08L2205/16 , C09D161/06 , C09J161/34 , D04H1/587 , D04H1/64 , D04H1/641 , C08L89/00
摘要： Composite Maillard-resole binders to produce or promote cohesion in non-assembled or loosely assembled matter.
摘要翻译：复合美拉德 - 固体粘合剂，用于生产或促进非组装或松散组装的物质的内聚力。

10. 发明申请

US20140030277A1 IMMUNOMODULATING COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：免疫调节组合物及其使用方法
公开(公告)号：US20140030277A1
公开(公告)日：2014-01-30
申请号：US14037420
申请日：2013-09-26
申请人： Whitehead Institute , The General Hospital Corporation d/b/a Massachusetts General Hospital , Boston University , Massachusetts Institute of Technology
发明人： Ifat Rubin-Bejerano , Gerald R. Fink , Claudia Abeijon , Daniel S. Kohane , Jason E. Fuller , Robert S. Langer
IPC分类号： A61K31/716 , A61K45/06
CPC分类号： A61K31/716 , A61K9/1647 , A61K36/064 , A61K36/09 , A61K39/0011 , A61K39/385 , A61K39/39 , A61K45/06 , A61K47/61 , A61K47/6843 , A61K47/6921 , A61K2039/55583 , A61K2039/572 , C08B37/0024 , C08J3/126 , C08J3/128 , C08J2300/16 , C08J2325/06 , C08J2367/04 , C08J2400/16 , C08J2405/00
摘要： This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
摘要翻译：本发明涉及β-1-6-葡聚糖，包含其的组合物和装置及其在调节免疫应答中的用途。本发明的某些实施方案的β-1-6-葡聚糖富含O-乙酰化基团和/或与固体支持物缀合或连接至靶向部分。

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