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1. 发明授权

US11662329B2 Outer membrane compositions for creatinine/creatine sensors 有权
公开(公告)号：US11662329B2
公开(公告)日：2023-05-30
申请号：US16430057
申请日：2019-06-03
申请人： Instrumentation Laboratory Company
发明人： Xiaoxian Xu
IPC分类号： G01N27/327 , C12Q1/00 , G01N27/333 , G01N33/70 , G01N33/96 , G01N27/30 , C12Q1/54 , G01N33/53 , G16H10/40 , G16B25/30 , G06F17/18 , C12Q1/58 , G01N33/543 , G06F30/331
CPC分类号： G01N27/3275 , C12Q1/002 , C12Q1/003 , C12Q1/005 , C12Q1/54 , G01N27/308 , G01N27/3272 , G01N27/3276 , G01N27/3335 , G01N33/5308 , G01N33/70 , G01N33/96 , G06F17/18 , G16B25/30 , G16H10/40 , C12Q1/58 , G01N27/3274 , G01N33/5438 , G06F30/331
摘要： Disclosed herein are compositions for permeable outer diffusion control membranes for creatinine and creatine sensors and methods of making such membranes.

2. 发明申请

US20170224879A1 METHOD FOR MANUFACTURING A CONDUCTIVE FILM FROM AN ELECTROCHEMICAL BIOREACTOR 审中-公开
公开(公告)号：US20170224879A1
公开(公告)日：2017-08-10
申请号：US15503392
申请日：2015-07-30
申请人： UNIVERSITE GRENOBLE ALPES
发明人： COSNIER Serge , HADDAD Raoudha
IPC分类号： A61L31/04 , A61F2/82 , A61L31/14 , H01M8/16 , C23F13/10
CPC分类号： A61L31/047 , A61F2/82 , A61L31/14 , B82Y30/00 , C12N11/08 , C12N11/14 , C12Q1/002 , C12Q1/003 , C23F13/10 , C23F2213/30 , H01M4/90 , H01M8/16 , H01M2250/30 , Y02B90/18 , Y02E60/527 , Y02P70/56
摘要： The invention relates to a device that is to be implanted in vivo and includes a stent (46) surrounded, at least partially, by at least one flexible conductive film (54, 56) containing chains of a linear polymer, each of which has carbon nanotubes connected thereto via pi-pi interactions. Said film is functionalized by enzymatic grafting so as to form an electrochemical bioreactor element.

3. 发明授权

US09700851B2 Phenol crosslink for sensor membrane 有权
公开(公告)号：US09700851B2
公开(公告)日：2017-07-11
申请号：US13107816
申请日：2011-05-13
申请人： Yuan Wang , Raeanne Gifford
发明人： Yuan Wang , Raeanne Gifford
IPC分类号： C08G65/40 , C25D11/00 , B01D71/72 , B01D67/00 , C12Q1/00 , G01N27/327 , A61B5/145 , G01N27/40
CPC分类号： B01D71/72 , A61B5/14532 , A61B2562/12 , B01D67/0006 , B01D2323/30 , C12Q1/003 , G01N27/3274 , G01N27/40
摘要： Embodiments herein provide a membrane that is a product of a phenol crosslinked with one or more compounds containing an allyl group. The phenol may be electropolymerized with the allyl-containing compounds to form the crosslinked polymer. Suitable allyl-containing compounds include allylphenol, allylalcohol, allylamine, and allylcarbamide. A membrane may have one type of allyl-containing compound, or, alternatively, two or more types of compounds. As used in an analyte sensing device, a membrane formed from a crosslinked phenol may provide improved interference exclusion, peroxide response, stability, and/or solvent resistance.

4. 发明授权

US09388503B2 Cross-linked enzyme matrix and uses thereof 有权
标题翻译：交联酶基质及其用途
公开(公告)号：US09388503B2
公开(公告)日：2016-07-12
申请号：US13858501
申请日：2013-04-08
申请人： Instrumentation Laboratory Company
发明人： Prasad Pamidi , Sohrab Mansouri , Melanie Shin , Vasile Cosofret , Clarke Xu
IPC分类号： G01N27/327 , C25D9/02 , C12Q1/00
CPC分类号： C25D9/02 , C12Q1/002 , C12Q1/003 , C12Q1/005 , Y10S435/817
摘要： An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors.
摘要翻译：一种电化学传感器系统及其膜及其方法，用于提高电化学和酶传感器的精度和有效寿命。

5. 发明授权

US09365882B2 Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same 有权
公开(公告)号：US09365882B2
公开(公告)日：2016-06-14
申请号：US12394975
申请日：2009-02-27
申请人： Atsushi Sato , Tokuji Ikeda , Kenji Kano
发明人： Atsushi Sato , Tokuji Ikeda , Kenji Kano
IPC分类号： C12N11/00 , C12Q1/00 , H01M8/16 , H01M4/86
CPC分类号： C12Q1/003 , H01M4/86 , H01M8/16 , Y02E60/527 , Y10S435/817
摘要： An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously to an electrode. For example, here are used diaphorase as the enzyme and 2-amino-3-carboxy-1,4-naphthoquinone (ACNQ) as the electron acceptor compound.

6. 发明申请

US20150192538A1 NOVEL CHEMISTRY USED IN BIOSENSORS 审中-公开
标题翻译：生物传感器中使用的新化学物质
公开(公告)号：US20150192538A1
公开(公告)日：2015-07-09
申请号：US14593318
申请日：2015-01-09
申请人： OHMX CORPORATION
发明人： MICHAEL J. AHRENS , PAUL A. BERTIN , HARRY B. GRAY , THOMAS J. MEADE
IPC分类号： G01N27/327 , C07F15/00
CPC分类号： G01N27/327 , C07F15/002 , C12Q1/003 , G01N33/54353 , G01N33/5438 , Y10T29/49117 , Y10T29/49204
摘要： The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
摘要翻译：本发明涉及可用于合成标记蛋白质，核酸和用于电极修饰的二取代联吡啶锇络合物的新组合物。

7. 发明申请

US20150005180A9 Biochip 审中-公开
标题翻译：生物芯片
公开(公告)号：US20150005180A9
公开(公告)日：2015-01-01
申请号：US10572332
申请日：2004-09-17
申请人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
发明人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
IPC分类号： C40B30/04 , C40B60/12 , C40B40/08 , C40B40/12 , C40B50/18 , C40B99/00 , C40B40/10
CPC分类号： C12Q1/003
摘要： A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.
摘要翻译：提供一种生物芯片，其抑制检测对象物质的非特异性吸附或结合而不用吸附抑制剂涂覆并且具有优异的检测灵敏度。其结构是在生物芯片基板的基板表面上具有含有磷酰胆碱基和活性酯基的大分子物质。

8. 发明申请

US20150001074A1 Enzyme Immobilization by Crosslinking 有权
标题翻译：通过交联酶固定
公开(公告)号：US20150001074A1
公开(公告)日：2015-01-01
申请号：US13930890
申请日：2013-06-28
申请人： Google Inc.
发明人： Zenghe Liu
IPC分类号： G01N27/40
CPC分类号： C12Q1/002 , C12Q1/003 , C12Q1/006 , G01N27/40
摘要： An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes an electrode, a sensing layer in contact with a surface of the electrode, and a protective membrane. The sensing layer is a crosslinked, hydrophilic copolymer including poly(alkylene oxide) and poly(vinyl pyridine), and an analyte sensing component is immobilized within the crosslinked, hydrophilic copolymer. The protective membrane is a crosslinked, hydrophilic copolymer including alkylene oxide, vinyl pyridine and styrene units. The method involves the formation of a sensing layer on a surface of an electrode, followed by the formation of a protective membrane on a surface of the sensing layer.
摘要翻译：公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。在一个方面，分析物传感器包括电极，与电极的表面接触的感测层和保护膜。感测层是包括聚（环氧烷）和聚（乙烯基吡啶）的交联的亲水共聚物，并且分析物感测组分固定在交联的亲水共聚物内。保护膜是包括环氧烷，乙烯基吡啶和苯乙烯单元的交联的亲水共聚物。该方法涉及在电极表面上形成感测层，随后在感测层的表面上形成保护膜。

9. 发明申请

US20130112558A1 FORMATION OF IMMOBILIZED BIOLOGICAL LAYERS FOR SENSING 审中-公开
公开(公告)号：US20130112558A1
公开(公告)日：2013-05-09
申请号：US13711886
申请日：2012-12-12
申请人： Abbott Point of Care Inc.
发明人： Gordon Bruce Collier , Jason Andrew Macleod , Anjulia Wong , Attila Csaba Nemeth
IPC分类号： B05C9/12 , C12Q1/00
CPC分类号： C12Q1/003 , B05C5/0291 , B05C9/12 , B05C11/1034 , C12Q1/00 , C12Q1/005 , C12Q1/006 , C12Q1/26 , C12Q1/28 , C12Q1/42 , C12Q1/58
摘要： The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.

10. 发明申请

US20120270756A1 FORMATION OF IMMOBILIZED BIOLOGICAL LAYERS FOR SENSING 有权
标题翻译：形成用于感测的固定生物层
公开(公告)号：US20120270756A1
公开(公告)日：2012-10-25
申请号：US13478260
申请日：2012-05-23
申请人： Gordon Bruce Collier , Jason Andrew Macleod , Anjulia Wong , Attila Csaba Nemeth
发明人： Gordon Bruce Collier , Jason Andrew Macleod , Anjulia Wong , Attila Csaba Nemeth
IPC分类号： C12N11/14 , C40B60/14 , C40B50/18 , C12M1/42
CPC分类号： C12Q1/003 , B05C5/0291 , B05C9/12 , B05C11/1034 , C12Q1/00 , C12Q1/005 , C12Q1/006 , C12Q1/26 , C12Q1/28 , C12Q1/42 , C12Q1/58
摘要： The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.
摘要翻译：本发明涉及酶固定组合物，其包含：在基本上均匀的含水混合物中的一种或多种酶，湿润剂，丙烯酸类单体，水溶性有机光引发剂和水溶性丙烯酸类交联剂。本发明还涉及用于形成包含这种组合物的传感器的方法，并且通过将这样的组合物分配到基底上来设置在传感器阵列上形成固定化层的阵列。

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