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1. 发明申请

US20180348139A1 METHOD OF DETECTING SINGLE MOLECULES 审中-公开
公开(公告)号：US20180348139A1
公开(公告)日：2018-12-06
申请号：US15990933
申请日：2018-05-29
申请人： Tsinghua University , HON HAI PRECISION INDUSTRY CO., LTD.
发明人： ZHEN-DONG ZHU , QUN-QING LI , SHOU-SHAN FAN
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B82Y15/00 , G01N2021/651
摘要： A method of detecting single molecule includes: providing a carrier, wherein the carrier includes a substrate, and a plurality of three-dimensional nanostructures are located on the substrate; disposing single molecule samples on the plurality of three-dimensional nanostructures; detecting the single molecule samples with a detector; wherein each three-dimensional nanostructure includes a first rectangular structure, a second rectangular structure, and a triangular prism structure; the first rectangular structure, the second rectangular structure, and the triangular prism structure are stacked in that order, a first width of a bottom surface of the triangular prism structure is equal to a second width of a first top surface of the second rectangular structure and greater than a third width of a second top surface of the first rectangular structure, and the first rectangular structure comprises a first metal and the triangular prism structure comprises a second metal.

2. 发明申请

US20180106725A1 PORTABLE WATER QUALITY INSTRUMENT 审中-公开
公开(公告)号：US20180106725A1
公开(公告)日：2018-04-19
申请号：US15792165
申请日：2017-10-24
申请人： OndaVia, Inc.
发明人： Mark C. Peterman , Merwan Benhabib , Samuel Kleinman
IPC分类号： G01N21/65 , G01J3/18 , G01J3/44 , G01N21/47 , G01N33/18 , G01N27/447 , B01L3/00 , G01N30/60 , G01N30/00
CPC分类号： G01N21/65 , B01L3/502761 , B01L2200/0652 , B01L2200/12 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2400/0418 , B01L2400/0421 , G01J3/18 , G01J3/44 , G01N21/47 , G01N21/4785 , G01N21/658 , G01N27/44704 , G01N27/44791 , G01N30/6065 , G01N30/6095 , G01N33/18 , G01N2021/651 , G01N2030/0095 , G01N2201/0221 , G01N2201/13
摘要： A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.

3. 发明授权

US09945775B2 Active chemical sensing using optical microcavity 有权
公开(公告)号：US09945775B2
公开(公告)日：2018-04-17
申请号：US14398752
申请日：2013-05-03
申请人： ISIS INNOVATION LIMITED
发明人： Jason Michael Smith , Claire Vallance
IPC分类号： G01N21/00 , G01N21/31 , G01N21/03 , G01N21/64 , G01N21/65 , G01N21/41
CPC分类号： G01N21/31 , G01N21/031 , G01N21/4133 , G01N21/64 , G01N21/65 , G01N2021/0346 , G01N2021/651 , G01N2201/06113
摘要： A sensor comprises a pair of mirrors (11, 12) opposed along an optical axis and shaped to provide an optical cavity with stable resonance in at least one mode and having a cavity length of at most 50 μm. An actuator system is arranged to move the mirrors relative to each other along the length of the optical cavity for tuning the wavelength of the mode of said cavity. A chemical sample is introduced inside the optical cavity using a sample introduction system (21). An EM radiation source (20) illuminates the cavity and a detector (25) detects the EM radiation emitted from, transmitted through, or reflected from the optical cavity.

4. 发明申请

US20180088027A1 OPTICAL MEASUREMENT DEVICE 审中-公开
公开(公告)号：US20180088027A1
公开(公告)日：2018-03-29
申请号：US15567695
申请日：2015-04-24
申请人： Shimadzu Corporation
发明人： Yusuke Nagai
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N21/031 , G01N2021/052 , G01N2021/6482 , G01N2021/651
摘要： Measurement light is cast from a light-casting unit into a flow cell. The light is repeatedly reflected at an outer surface of the flow cell. A detecting unit including a connecting element and a photodetector element is provided in contact with the outer surface of the flow cell. Since the connecting element is made of a material whose refractive index is higher than that of the wall of the flow cell, the light is extracted from the flow cell at the contact position of the connecting element, to be detected by the photodetector element. A shift of the attachment position of the detecting unit along the axis of the flow cell changes the optical path length of the measurement light. A high-sensitivity absorption measurement can be performed by controlling the optical path length by merely changing the attachment position of the detecting unit, without replacing the flow cell.

5. 发明申请

US20170108439A1 WAVEGUIDE-ENHANCED RAMAN SCATTERING SPECTROSCOPY OF ANALYTES USING SORBENTS 审中-公开
公开(公告)号：US20170108439A1
公开(公告)日：2017-04-20
申请号：US15293394
申请日：2016-10-14
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY
发明人： Todd H. Stievater , Jacob B. Khurgin , Dmitry A. Kozak , Scott A. Holmstrom , R. Andrew McGill
IPC分类号： G01N21/65 , G02B6/124 , G02B21/02
CPC分类号： G01N21/658 , G01N2021/651 , G01N2021/773 , G02B6/00 , G02B6/124 , G02B21/02
摘要： A system and method for detecting an analyte includes a waveguide configured to receive a narrow-band laser signal; and a sorbent material covering an analyte detection region of the waveguide, wherein the sorbent material is configured to sorb the analyte and bring the analyte to an evanescent field of the waveguide, and wherein Raman scattering is produced by an interaction of the evanescent field and the analyte sorbed in the sorbent material along the analyte detection region of the waveguide, and the waveguide is further configured to collect the Raman scattering along the analyte detection region of the waveguide, wherein the collected Raman scattering indicates a type of the analyte.

6. 发明申请

US20170045453A1 PORTABLE WATER QUALITY INSTRUMENT 审中-公开
标题翻译：便携式水质仪器
公开(公告)号：US20170045453A1
公开(公告)日：2017-02-16
申请号：US15239153
申请日：2016-08-17
申请人： OndaVia, Inc.
发明人： Mark C. PETERMAN , Merwan BENHABIB , Samuel KLEINMAN
IPC分类号： G01N21/65 , B01L3/00 , G01N21/47 , G01N33/18 , G01N21/49
CPC分类号： G01N21/65 , B01L3/502761 , B01L2200/0652 , B01L2200/12 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2400/0418 , B01L2400/0421 , G01J3/18 , G01J3/44 , G01N21/47 , G01N21/4785 , G01N21/658 , G01N27/44704 , G01N27/44791 , G01N30/6065 , G01N30/6095 , G01N33/18 , G01N2021/651 , G01N2030/0095 , G01N2201/0221 , G01N2201/13
摘要： A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.
摘要翻译：提供了一种手持微流体测试装置，其包括具有盒接收端口的壳体，用于输入到具有样品输入和通道的盒接收端口的盒，其中该通道包括拉曼散射纳米颗粒的混合物和校准解决方案，其中校准溶液包括能够与待测试输入的样品与拉曼散射纳米颗粒相互作用的化合物和壳体中的光学检测系统，其中光学检测系统能够提供照明电场，其中照明电场能够用于具有拉曼散射纳米颗粒的拉曼光谱和校准溶液以分析被测试的输入到盒的样品。

7. 发明申请

US20160018557A1 METHODS AND DEVICES FOR INSPECTING LIQUID 有权
标题翻译：检测液体的方法和装置
公开(公告)号：US20160018557A1
公开(公告)日：2016-01-21
申请号：US14804087
申请日：2015-07-20
申请人： NUCTECH COMPANY LIMITED
发明人： Yumin Yi , Li Zhang , Hongqiu Wang , Huacheng Feng , Jianhong Zhang
IPC分类号： G01V5/00 , G01N23/087 , G01N23/04 , G01N21/65
CPC分类号： G01V5/0033 , G01N21/65 , G01N23/046 , G01N23/087 , G01N2021/651 , G01N2201/0612 , G01V5/0008
摘要： Methods and devices for inspecting liquid are disclosed. According to the method, it is firstly determined whether the package of the liquid is transparent, semi-transparent, or opaque; in a case that the package of the liquid is transparent or semi-transparent, Raman spectrum analysis is implemented by a Raman spectrum module on the inspected liquid to judge whether the inspected liquid is dangerous or is suspected; and in a case that the package of the inspected liquid is opaque, the inspected liquid are inspected by using an X-ray dual-energy scanning technology to judge whether the inspected liquid is dangerous or is suspected. The above solution has advantages that the inspection speed is high, the material can be recognized, it is suitable for various packing materials with various shapes, the accuracy of the inspection result is high or the like. Therefore, the solution is suitable for security inspection in public places with high security inspection requirements, complicated inspected liquids, high personnel flow rate or the like.
摘要翻译：公开了用于检查液体的方法和装置。根据该方法，首先确定液体的包装是透明的，半透明的还是不透明的; 在液体的包装是透明或半透明的情况下，拉曼光谱分析由检查液体上的拉曼光谱模块进行，以判断被检液体是否是危险的或被怀疑的; 并且在被检查液体的包装不透明的情况下，通过使用X射线双能扫描技术来检查被检查液体，以判断被检查液体是否是危险的或被怀疑的。上述解决方案具有检测速度高，材料可以识别的优点，适用于各种形状的各种包装材料，检验结果准确度高等优点。因此，该解决方案适用于公安场所的安全检查，具有较高的安全检查要求，复杂的检查液体，高人流量等。

8. 发明申请

US20150233834A1 SENSOR CHIP AND METHOD FOR STORING SENSOR CHIP 审中-公开
标题翻译：传感器芯片和存储传感器芯片的方法
公开(公告)号：US20150233834A1
公开(公告)日：2015-08-20
申请号：US14429745
申请日：2013-09-12
申请人： KONICA MINOLTA, INC.
发明人： Takeshi Wada , Masataka Matsuo , Naoki Hikage , Masanori Tsukagoshi
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , G01N21/553 , G01N21/648 , G01N2021/6482 , G01N2021/651
摘要： A sensor chip includes: a transparent support; a metal thin film formed on one surface of the transparent support; and a reaction section in which a ligand is immobilized on an other surface of the metal thin film that is not in contact with the transparent support, wherein the sensor chip also includes a closed space-forming member which forms a closed space such that at least the reaction section is housed in the closed space, and water content in the closed space is adjusted to satisfy: X/Y
摘要翻译：传感器芯片包括：透明支架; 形成在所述透明支撑体的一个表面上的金属薄膜; 以及其中配体固定在与透明支撑体不接触的金属薄膜的另一表面上的反应部分，其中传感器芯片还包括形成封闭空间的封闭空间形成部件，使得至少将反应部容纳在封闭空间内，将封闭空间的含水量调整为满足：X / Y <10（μg/ mm2）（其中，X表示封闭空间中的水分含量，Y表示封闭空间中金属薄膜的面积）。

9. 发明申请

US20150233833A1 SURFACE-ENHANCED RAMAN SCATTERING ELEMENT 有权
标题翻译：表面增强拉曼散射元件
公开(公告)号：US20150233833A1
公开(公告)日：2015-08-20
申请号：US14420556
申请日：2013-08-09
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Katsumi Shibayama , Yoshihiro Maruyama , Masashi Ito
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B82Y40/00 , G01N2021/651
摘要： A SERS element comprises a substrate; a fine structure part formed on a front face of the substrate and having a plurality of pillars; and a conductor layer formed on the fine structure part and constituting an optical function part for generating surface-enhanced Raman scattering. The pillars have respective side faces provided with grooves. A plurality of gaps are formed in the conductor layer by entering the grooves.
摘要翻译： SERS元件包括基底; 形成在所述基板的正面上并且具有多个支柱的精细结构部件; 以及形成在微细结构部分上并构成用于产生表面增强拉曼散射的光学功能部分的导体层。支柱具有设置有凹槽的相应侧面。通过进入沟槽在导体层中形成多个间隙。

10. 发明申请

US20150219562A1 SURFACE-ENHANCED RAMAN SCATTERING ELEMENT, AND METHOD FOR PRODUCING SAME 有权
标题翻译：表面增强拉曼散射元件及其制造方法
公开(公告)号：US20150219562A1
公开(公告)日：2015-08-06
申请号：US14420510
申请日：2013-08-09
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Katsumi Shibayama , Masashi Ito , Takafumi Yokino , Masaki Hirose , Anna Yoshida , Kazuto Ofuji , Yoshihiro Maruyama , Takashi Kasahara , Toshimitsu Kawai , Toru Hirohata , Hiroki Kamei , Hiroki Oyama
IPC分类号： G01N21/65 , G01N21/03
CPC分类号： G01N21/658 , B82Y40/00 , G01N21/03 , G01N2021/651
摘要： A SERS element comprises a substrate having a front face; a fine structure part formed on the front face and having a plurality of pillars; and a conductor layer formed on the fine structure part and constituting an optical function part for generating surface-enhanced Raman scattering. The conductor layer has a base part formed along the front face and a plurality of protrusions protruding from the base part at respective positions corresponding to the pillars. The base part has a thickness greater than the height of the pillars.
摘要翻译： SERS元件包括具有正面的基板; 形成在前表面上并具有多个支柱的精细结构部分; 以及形成在微细结构部分上并构成用于产生表面增强拉曼散射的光学功能部分的导体层。导体层具有沿着前表面形成的基部和在与支柱对应的各个位置处从基部突出的多个突起。基部的厚度大于支柱的高度。

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