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1. 发明申请

US20110028732A1 NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE 有权
标题翻译：硝酸盐，衍生物及其制造方法
公开(公告)号：US20110028732A1
公开(公告)日：2011-02-03
申请号：US12934817
申请日：2009-04-08
申请人： Daniel M. Trauth , George D. Green , Raymond J. Swedo , Richard L. James , Ian A. Tomlinson
发明人： Daniel M. Trauth , George D. Green , Raymond J. Swedo , Richard L. James , Ian A. Tomlinson
IPC分类号： C07D263/04 , C07C205/05 , C07C205/01 , C07C205/06 , C07C215/02 , C07C239/08
CPC分类号： C07D498/10 , A01N43/76 , A01N43/90 , C07C201/08 , C07C201/12 , C07C205/02 , C07C205/04 , C07C205/05 , C07C205/06 , C07C205/15 , C07C205/16 , C07C205/18 , C07C215/08 , C07C215/20 , C07C215/28 , C07C215/42 , C07C239/10 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D263/04 , C07D263/52 , C07D498/04 , C08G18/3271 , Y02P20/582
摘要： Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.
摘要翻译：提供了通过用稀硝酸硝化烃化合物形成硝化化合物的方法。还提供了用于制备硝化化合物的工业上有用的下游衍生物的方法，以及新颖的硝化化合物和衍生物，以及在各种应用中使用衍生物的方法。

2. 发明授权

US07399885B2 Method for preparing hydroxylamine 有权
标题翻译：制备羟胺的方法
公开(公告)号：US07399885B2
公开(公告)日：2008-07-15
申请号：US11712690
申请日：2007-02-28
申请人： Pin-To Yao , Cheng-Fa Hsieh , Ren-Hao Hsu
发明人： Pin-To Yao , Cheng-Fa Hsieh , Ren-Hao Hsu
IPC分类号： C07C239/08
CPC分类号： C01B21/1418
摘要： A method for preparing hydroxylamine, comprising the steps of: (i) pretreating the acidic buffer solution with the compounds having a functional group represented by formula (I), thereby removing metal impurities from the acidic buffer solution; and (ii) reducing nitrate ions in the acidic buffer solution with hydrogen to give hydroxylamine in the presence of catalysts, According to the present invention the selectivity for reducing nitrate ions to give hydroxylamine can be significantly enhanced.
摘要翻译：一种制备羟胺的方法，包括以下步骤：（i）用具有由式（I）表示的官能团的化合物预处理酸性缓冲溶液，从而从酸性缓冲溶液中除去金属杂质; 和（ii）用氢还原酸性缓冲溶液中的硝酸根离子，在催化剂存在下得到羟胺。根据本发明，可显着提高还原硝酸根离子以产生羟胺的选择性。

3. 发明授权

US07309802B2 Preparation of isoxazolin-3-ylacylbenzene 有权
标题翻译：异恶唑啉-3-基酰基苯的制备
公开(公告)号：US07309802B2
公开(公告)日：2007-12-18
申请号：US10417083
申请日：2003-04-17
申请人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Baumann
发明人： Joachim Rheinheimer , Wolfgang von Deyn , Joachim Gebhardt , Michael Rack , Rene Lochtman , Norbert Götz , Michael Keil , Matthias Witschel , Helmut Hagen , Ulf Misslitz , Ernst Baumann
IPC分类号： C07C239/08
CPC分类号： C07C249/06 , C07C201/10 , C07C201/12 , C07C205/44 , C07C209/62 , C07C251/48 , C07C253/00 , C07C255/50 , C07C315/04 , C07C319/14 , C07D261/04 , C07D413/10 , C07C323/09 , C07C317/24 , C07C317/32 , C07C205/06 , C07C211/52
摘要： A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.
摘要翻译：描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6 - - 烷基，R 2是C 1 -C 6 - 烷基，R 3，R 4， R 5是氢，C 1 -C 6 - 烷基或R 4和/或 R 5一起形成键，R 6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体并描述了制备中间体的新方法。

4. 发明授权

US6001347A Compounds and compositions for delivering active agents 失效
标题翻译：用于递送活性剂的化合物和组合物
公开(公告)号：US6001347A
公开(公告)日：1999-12-14
申请号：US798031
申请日：1997-02-06
申请人： Andrea Leone-Bay , Koc-Kan Ho , Donald J. Sarubbi , Sam J. Milstein
发明人： Andrea Leone-Bay , Koc-Kan Ho , Donald J. Sarubbi , Sam J. Milstein
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/715 , C07C229/34
CPC分类号： C07D333/38 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/0019 , A61K9/1617 , A61K9/4858 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopolysaccharide, carbohydrate, or a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.
摘要翻译：提供了可用于递送活性剂的载体化合物，组合物和剂量单位形式。本发明提供具有下式的化合物或其盐，其中所述化合物可以组合物或剂量单位形式用于递送至少一种活性剂，包括肽，粘多糖，碳水化合物或脂质。还提供了本发明化合物和组合物的施用和制备方法，包括口服给药。此外，本发明的组合物可以通过混合至少一种活性剂，至少一种载体化合物和任选的给药载体来制备。

5. 发明授权

US5965121A Compounds and compositions for delivering active agents 失效
标题翻译：用于递送活性剂的化合物和组合物
公开(公告)号：US5965121A
公开(公告)日：1999-10-12
申请号：US798023
申请日：1997-02-06
申请人： Andrea Leone-Bay , Koc-Kan Ho , Donald J. Sarubbi , Sam J. Milstein
发明人： Andrea Leone-Bay , Koc-Kan Ho , Donald J. Sarubbi , Sam J. Milstein
IPC分类号： C07D295/20 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/197 , A61K31/198 , A61K31/40 , A61K31/44 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/48 , C07C53/126 , C07C53/134 , C07C229/08 , C07C229/10 , C07C229/42 , C07C231/12 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/62 , C07C235/64 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C239/06 , C07C239/08 , C07C259/06 , C07C271/22 , C07C303/22 , C07C303/40 , C07C309/59 , C07C311/19 , C07D207/34 , C07D207/416 , C07D213/75 , C07D213/81 , C07D295/215 , C07D317/68 , C07D333/38 , A61K31/725
CPC分类号： C07D333/38 , A61K38/212 , A61K38/23 , A61K38/27 , A61K38/29 , A61K47/18 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/4803 , A61K9/0019 , A61K9/1617 , A61K9/4858 , C07C233/34 , C07C233/47 , C07C233/48 , C07C233/51 , C07C233/52 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/81 , C07C233/83 , C07C233/84 , C07C233/87 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/40 , C07C235/52 , C07C235/60 , C07C235/64 , C07C235/82 , C07C237/22 , C07C237/40 , C07C237/42 , C07C259/06 , C07C271/22 , C07C309/59 , C07C311/19 , C07D207/34 , C07D213/81 , C07D295/215 , C07D317/68 , A61K9/0043 , A61K9/0056 , C07C2101/14 , C07C2101/18 , C07C2103/74
摘要： Carrier compounds, compositions, and dosage unit forms therefor which are useful in the delivery of active agents are provided. The present invention provides a compound having the formula: ##STR1## or a salt thereof, wherein the compound may be used in a composition or dosage unit form for delivery of at least one active agent, including a peptide, mucopoly-saccharide, carbohydrate, of a lipid. Methods of administration and preparation of the compounds and compositions of the invention are provided as well, including oral administration. Further, the compositions of the invention may be prepared by mixing at least one active agent, at least one carrier compound, and, optionally, a dosing vehicle.
摘要翻译：提供了可用于递送活性剂的载体化合物，组合物和剂量单位形式。本发明提供具有下式的化合物或其盐，其中该化合物可以组合物或剂量单位形式用于递送至少一种活性剂，包括脂质的肽，粘多糖，碳水化合物。还提供了本发明化合物和组合物的施用和制备方法，包括口服给药。此外，本发明的组合物可以通过混合至少一种活性剂，至少一种载体化合物和任选的给药载体来制备。

6. 发明授权

US5777163A Preparation of hydroxylamines from ammonia or the corresponding amines, hydrogen and oxygen 失效
标题翻译：由氨或相应的胺，氢和氧制备羟胺
公开(公告)号：US5777163A
公开(公告)日：1998-07-07
申请号：US809709
申请日：1997-04-04
申请人： Ulrich Muller , Daniel Heineke
发明人： Ulrich Muller , Daniel Heineke
IPC分类号： B01J29/04 , B01J29/89 , C01B21/14 , C07C239/00 , C07C239/08
CPC分类号： B01J29/04 , B01J29/89 , C01B21/1409
摘要： Hydroxylamines are prepared from ammonia or the corresponding amines, hydrogen and oxygen by a process in which the starting materials are reacted under heterogeneous catalysis using an oxidation catalyst based on a titanium or vanadium silicalite having a zeolite structure and containing from 0.01 to 20% by weight of one or more platinum metals selected from the group consisting of ruthenium, rhodium, palladium, osmium, iridium and platinum, the platinum metals each being present in at least two different bond energy states.
摘要翻译： PCT No.PCT / EP95 / 03771 Sec。 371日期1997年04月4日 102（e）日期1997年4月4日PCT提交1995年9月23日PCT公布。出版物WO96 / 10535 日期1996年4月11日羟胺通过以下方法由氨或相应的胺，氢和氧制备，其中起始材料在非均相催化下使用基于具有沸石结构的钛或钒硅沸石的氧化催化剂反应，并含有0.01 至20重量％的选自钌，铑，钯，锇，铱和铂的一种或多种铂金属，铂金属各自以至少两种不同的键能态存在。

7. 发明授权

US5663368A Synthesis of acid addition salts of hydroxylamines 失效
标题翻译：羟胺的酸加成盐的合成
公开(公告)号：US5663368A
公开(公告)日：1997-09-02
申请号：US581562
申请日：1996-04-11
申请人： Joseph R. Flisak , Stephen Torey Ross
发明人： Joseph R. Flisak , Stephen Torey Ross
IPC分类号： C07C239/08 , C07D209/40 , C07D307/82 , C07D333/58 , C07D333/66 , C07D209/88 , C07D311/58
CPC分类号： C07D307/82 , C07C239/08 , C07D333/58
摘要： This invention relates to novel diastereomeric acid addition salts of homochiral hydroxylamines, to processes for obtaining such, to processes for the conversion thereof to the corresponding homochiral hydroxylamines, to certain novel homochiral hydroxylamines and the processes for using these as intermediates.
摘要翻译： PCT No.PCT / US94 / 08117 Sec。 371日期：1996年4月11日 102（e）日期1996年4月11日PCT 1994年7月14日PCT公布。出版物WO95 / 02574 日期1995年1月26日本发明涉及同基因羟胺的新型非对映异构酸加成盐，其获得方法，将其转化为相应的同基因羟基胺的方法，以及某些新型的同型双羟胺，以及使用它们作为中间体的方法。

8. 发明授权

US5412082A Conversion of amines to hydroxylamines 失效
标题翻译：胺转化为羟胺
公开(公告)号：US5412082A
公开(公告)日：1995-05-02
申请号：US114601
申请日：1993-08-31
申请人： Mark D. Wittman , Samuel J. Danishefsky , Randall L. Halcomb
发明人： Mark D. Wittman , Samuel J. Danishefsky , Randall L. Halcomb
IPC分类号： C07B43/00 , C07C239/08 , C07C239/18 , C07H1/00 , C07H5/06 , C07H9/04 , C07H13/00 , C07H19/02 , C07C239/00
CPC分类号： C07C239/18
摘要： Oxidation of primary amines to primary hydroxylamines using a dialkyl dioxirane is described. This new method is utilized to prepare aliphatic non-axial hydroxylamines from corresponding primary amino-substituted sugar derivatives and hydroxylamino acid derivatives.
摘要翻译：描述了使用二烷基二环氧烷将伯胺氧化为伯羟胺。该新方法用于从相应的伯氨基取代的糖衍生物和羟基氨基酸衍生物制备脂族非轴羟胺。

9. 发明授权

US5328927A Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them 失效
标题翻译：异环化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5328927A
公开(公告)日：1994-07-12
申请号：US021826
申请日：1993-02-24
申请人： Richard T. Lewis , Kevin J. Merchant , Angus M. MacLeod
发明人： Richard T. Lewis , Kevin J. Merchant , Angus M. MacLeod
IPC分类号： C07D333/60 , A61K31/34 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61P43/00 , C07C237/22 , C07C239/08 , C07C251/40 , C07C255/24 , C07C255/30 , C07C317/28 , C07C323/24 , C07D209/14 , C07D209/16 , C07D307/81 , C07D333/58 , C07K1/113 , C07K5/02 , A61K31/405 , C07D209/10
CPC分类号： C07D333/58 , C07D209/16
摘要： Compounds of formula (I), and salts and prodrugs thereof ##STR1## wherein Q.sup.1 is halo substituted phenyl; naphthyl; indolyl; benzthiophenyl; benzofuranyl; benzyl; or fluorenyl; . . is an optional covalent bond;one of X and Y is H and the other is hydroxy or C.sub.1-6 alkoxy, or X and Y are together .dbd.0 or .dbd.NOR.sup.5 ;R.sup.1 and R.sup.2 are H; C.sub.1-6 alkyl optionally substituted by hydroxy, cyano, COR.sup.c, CO.sub.2 R.sup.c, CONR.sup.c R.sup.d, or NR.sup.c R.sup.d (where R.sup.c and R.sup.d are H, C.sub.1-6 alkyl or phenyl(C.sub.0-4 alkyl) optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halo and trifluoromethyl); phenyl(C.sub.1-4 alkyl) (optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halo or trifluoromethyl); COR.sup.c ; CO.sub.2 R.sup.c ; CONR.sup.c R.sup.d ; COC.sub.1-6 alkylNR.sup.c R.sup.d ; CONR.sup.c COOR.sup.d ; or SO.sub.2 R.sup.c ;R.sup.3 is H, C.sub.1-6 alkyl or C.sub.2-6 alkenyl; andR.sup.4 is phenyl optionally substituted by C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, OR.sup.a, SR.sup.a, SOR.sup.a, NR.sup.a R.sup.b, NR.sup.a COR.sup.b, NR.sup.a CO.sub.2 R.sup.b, CO.sub.2 R.sup.a or CONR.sup.a R.sup.b, where R.sup.a and R.sup.b are H, C.sub.1-6 alkyl, phenyl or trifluoromethyl; are tachykinin antagonists.
摘要翻译：式（I）化合物及其盐和前药其中Q 1是卤素取代的苯基; 萘基; 吲哚基苯硫酚苯并呋喃基苄基; 或芴基; 。。。是可选的共价键; X和Y之一是H，另一个是羟基或C 1-6烷氧基，或X和Y一起= 0或= NOR5; R1和R2是H; 任选被羟基，氰基，CORc，CO2Rc，CONRcRd或NRcRd取代的C 1-6烷基（其中R c和R d为H，任选被C 1-6烷基，C 1-6烷氧基，卤素和三氟甲基取代的C 1-6烷基或苯基（C 0-4烷基））; 苯基（C 1-4烷基）（任选被C 1-6烷基，C 1-6烷氧基，卤素或三氟甲基取代）; CORC; CO2Rc; CONRcRd; COC 1-6烷基NR c R d; CONRcCOORd; 或SO2Rc; R3是H，C1-6烷基或C2-6烯基; R4是任选被C 1-6烷基，C 2-6烯基，C 2-6炔基，卤素，氰基，硝基，三氟甲基，三甲基甲硅烷基，OR a，SR a，SOR a，NR a R b，NR a COR b，NR a CO 2 R b，CO 2 R a或CONR a R b任意取代的苯基，其中R a和R b是 H，C 1-6烷基，苯基或三氟甲基; 速激肽拮抗剂。

10. 发明授权

US5288907A Hydrogenation of nitroalkanes to hydroxylamines 失效
标题翻译：硝基烷烃氢化成羟胺
公开(公告)号：US5288907A
公开(公告)日：1994-02-22
申请号：US784850
申请日：1991-10-30
申请人： Martin B. Sherwin , Puvin Pichaichanarong
发明人： Martin B. Sherwin , Puvin Pichaichanarong
IPC分类号： C02F1/20 , C07C239/10 , C23F11/14 , C07C239/08
CPC分类号： C23F11/147 , C02F1/20 , C07C239/10
摘要： Catalytic hydrogenation of nitroalkane to N-alkylhydroxylamine free base in the absence of transition metal ions, and omission of acid and the resultant free base is storage stable, permitting shipment and storage of 15% aqueous solution for use as oxygen scavenger in boiler feed water treatment.
摘要翻译：在不存在过渡金属离子的情况下将硝基烷烃催化氢化为N-烷基羟胺游离碱，省略酸和得到的游离碱保存稳定，允许运输和储存15％水溶液，用作锅炉给水处理中的除氧剂。

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