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1. 发明授权

US11261153B2 Organic amine salt compounds having CO2-donating anions and their use as foaming agent 有权
公开(公告)号：US11261153B2
公开(公告)日：2022-03-01
申请号：US16063889
申请日：2017-05-11
申请人： SHANDONG UNIVERSITY OF TECHNOLOGY
发明人： Gehua Bi , Yusui Bi
IPC分类号： C07C213/04 , C08J9/08 , C07C271/02 , C08G18/16 , C08G18/48 , C08G18/20 , C07C211/14 , C08G18/24 , C07C269/06 , C08G18/40 , C08G18/42 , C08G18/76
摘要： An organic amine salt compounds of general formula An−[Bm+]p (I) is disclosed, wherein An− is a CO2-donating anion with a valence of −n, wherein n=1, 2 or 3; each Bm+ comprises: ammonium ion, hydrazinium ion and/or organic amine B cation; wherein m = 1 ⁢ - ⁢ 10 ; 0

2. 发明授权

US09914743B2 Organic silver complexes, their preparation methods and their methods for forming thin layers 有权
公开(公告)号：US09914743B2
公开(公告)日：2018-03-13
申请号：US15071593
申请日：2016-03-16
申请人： Inktec Co., Ltd.
发明人： Kwang-Choon Chung , Hyun-Nam Cho , Myoung-Seon Gong , Yi-Sup Han , Jeong-Bin Park , Dong-Hun Nam , Seong-Yong Uhm , Young-Kwan Seo
IPC分类号： C23C18/08 , C07F1/00 , C07C271/02 , C07C211/65 , C09D5/24 , C09D11/30 , C09D11/52 , C25D3/46 , H05K3/10
CPC分类号： C07F1/00 , C07C211/65 , C07C271/02 , C07F1/005 , C09D5/24 , C09D11/30 , C09D11/52 , C23C18/08 , C25D3/46 , H05K3/105
摘要： Provided herein is a method for preparing a silver complex. The method includes reacting a silver oxide with a mixture of ammonium carbamate and isopropyl amine at room temperature in the presence of methanol.

3. 发明授权

US09624164B2 Phenyl carbamate compounds for use in preventing or treating epilepsy 有权
公开(公告)号：US09624164B2
公开(公告)日：2017-04-18
申请号：US13727654
申请日：2012-12-27
申请人： Bio-Pharm Solutions Co., Ltd.
发明人： Yong Moon Choi
IPC分类号： A61K31/27 , A01N47/10 , C07C271/02 , A61K31/165 , A61K31/047 , A61K31/164 , C07C33/26 , C07C271/12 , C07C271/24 , C07F7/18 , C07C271/28 , C07C271/16 , A61K31/325 , C07C33/36
CPC分类号： C07C271/02 , A61K31/047 , A61K31/164 , A61K31/165 , A61K31/325 , C07C33/26 , C07C33/36 , C07C271/12 , C07C271/16 , C07C271/24 , C07C271/28 , C07C2601/02 , C07C2601/14 , C07C2602/42 , C07F7/1804
摘要： A method for treatment or prevention epilepsy comprising administering a phenyl carbamate compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of epilepsy is provided.

4. 发明申请

US20170029366A1 INHIBITORS OF HISTONE LYSINE SPECIFIC DEMETHYLASE (LSD1) AND HISTONE DEACETYLASES (HDACS) 审中-公开
标题翻译：胶原蛋白特异性脱乙酰酶（LSD1）和组蛋白脱乙酰酶（HDACS）的抑制剂
公开(公告)号：US20170029366A1
公开(公告)日：2017-02-02
申请号：US15124208
申请日：2015-03-09
申请人： THE JOHNS HOPKINS UNIVERSITY , INTONATION RESEARCH LABORATORIES
发明人： PHILIP COLE , SHONOI MING , POLINA PRUSEVICH , JAY KALIN , RAMAN BAKSHI
IPC分类号： C07C243/18 , A61K31/167 , C07C309/66 , A61K31/325 , C07D209/18 , A61K31/405 , C07C271/02 , A61K45/06 , A61K31/255
CPC分类号： C07C243/18 , A61K31/137 , A61K31/167 , A61K31/255 , A61K31/325 , A61K31/405 , A61K45/06 , C07C233/29 , C07C259/06 , C07C271/02 , C07C309/66 , C07C2602/02 , C07D209/18 , A61K2300/00
摘要： A series of phenelzine analogs comprising a phenelzine scaffold linked to an aromatic moiety and their use as inhibitors of lysine-specific demethylase 1 (LSD1) and/or one or more histone deacetylases (HDACs) is provided. The presently disclosed phenelzine analogs exhibit potency and selectivity for LSD1 versus MAO and LSD2 enzymes and exhibit bulk, as well as, gene specific histone methylation changes, anti-proliferative activity in several cancer cell lines, and neuroprotection in response to oxidative stress. Accordingly, the presently disclosed phenelzine analogs can be used to treat diseases, conditions, or disorders related to LSD1 and/or HDACs, including, but not limited to, cancers and neurodegenerative diseases.
摘要翻译：提供了一系列苯乙烯类似物，其包含与芳族部分连接的苯乙烯支架及其作为赖氨酸特异性脱甲基酶1（LSD1）和/或一种或多种组蛋白脱乙酰酶（HDAC）的抑制剂的用途。目前公开的苯乙肼类似物显示对LSD1与MAO和LSD2酶的效力和选择性，并且显示出大量，以及基因特异性组蛋白甲基化变化，几种癌细胞系中的抗增殖活性和对氧化应激的神经保护作用。因此，目前公开的苯乙嗪类似物可用于治疗与LSD1和/或HDAC相关的疾病，病症或障碍，包括但不限于癌症和神经变性疾病。

5. 发明授权

US09067875B2 Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use 有权
标题翻译：通过醚键和氨基甲酸酯键的四取代的NDGA衍生物及其合成和药物用途
公开(公告)号：US09067875B2
公开(公告)日：2015-06-30
申请号：US13470779
申请日：2012-05-14
申请人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
发明人： Qingqi Chen , Rocio Alejandra Lopez , Jonathan Daniel Heller , Amanda Jean Morris
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/445 , A61K31/426 , A61K31/27 , A61K31/135 , A61K31/075 , C07D265/30 , C07D241/04 , C07D211/06 , C07D277/02 , C07C271/02 , C07C215/00 , C07C43/02 , C07C43/225 , C07C43/23 , C07C217/20 , C07D277/24 , C07D295/088 , C07D295/13 , C07D307/52 , C07C217/64 , C07C271/52 , C07D211/14 , C07D295/15 , C07D307/54
CPC分类号： A61K31/5377 , A61K31/09 , A61K31/138 , A61K31/325 , A61K31/341 , A61K31/427 , A61K31/4545 , A61K31/496 , C07C43/225 , C07C43/23 , C07C217/20 , C07C217/64 , C07C271/52 , C07C2601/16 , C07D211/14 , C07D277/24 , C07D295/088 , C07D295/13 , C07D295/15 , C07D307/52 , C07D307/54
摘要： Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.
摘要翻译：公开了包括通过碳原子或杂原子键合的各种端基的二脱氢愈创木酸衍生物化合物，其中通过醚键或氨基甲酸酯键与各羟基残基O基键合的侧链，药物组合物，制备方法和使用方法它们和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HIV感染或HSV感染引起的或与之相关的疾病，诸如各种类型的关节炎和炎性疾病肠疾病，代谢疾病如糖尿病，血管疾病如高血压和黄斑变性，或增生性疾病，如多种类型的癌症。

6. 发明申请

US20140309273A1 COMPOUNDS AND METHODS OF TREATING OBESITY 审中-公开
标题翻译：化合物和治疗肥胖的方法
公开(公告)号：US20140309273A1
公开(公告)日：2014-10-16
申请号：US14314228
申请日：2014-06-25
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. , AL-QUDS UNIVERSITY
发明人： Jehoshua KATZHENDLER , Meir SAIDIAN , Yousef NAJAJREH , Raphael MEVORACH , Elliot BERRY , Yosefa AVRAHAM
IPC分类号： C07C271/02 , C07C233/22 , C07C233/20 , C07C235/28 , C07D207/08 , C07C53/126
CPC分类号： C07C271/02 , A61K31/164 , A61K31/325 , C07C53/126 , C07C233/20 , C07C233/22 , C07C235/06 , C07C235/08 , C07C235/28 , C07C271/16 , C07D207/08
摘要： Provided are new fatty acid derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, e.g., as agents for the treatment of obesity and related disorders, and for improving cognition.
摘要翻译：提供了新的脂肪酸衍生物，其制备方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物的方法，例如作为治疗肥胖症和相关疾病的药物以及改善认知。

7. 发明授权

US08686032B2 Enzyme inhibitors 有权
标题翻译：酶抑制剂
公开(公告)号：US08686032B2
公开(公告)日：2014-04-01
申请号：US12957829
申请日：2010-12-01
申请人： Alan Hornsby Davidson , Sanjay Ratilal Patel , Francesca Ann Mazzei , Stephen John Davies , Alan Hastings Drummond , David Festus Moffat , Kenneth William John Baker , Alistair David Graham Donald
发明人： Alan Hornsby Davidson , Sanjay Ratilal Patel , Francesca Ann Mazzei , Stephen John Davies , Alan Hastings Drummond , David Festus Moffat , Kenneth William John Baker , Alistair David Graham Donald
IPC分类号： A61K31/381 , A61K31/27 , C07C271/02 , C07C271/06
CPC分类号： C07C237/40 , C07C259/06 , C07C275/24 , C07C311/46 , C07C317/50 , C07C2601/08 , C07C2601/14 , C07D207/416 , C07D209/42 , C07D213/40 , C07D217/02 , C07D217/22 , C07D217/26 , C07D295/185 , C07D295/192 , C07D333/70 , C07D471/04
摘要： Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers:
摘要翻译：式（I）化合物是组蛋白脱乙酰酶活性的抑制剂，可用于治疗例如癌症：

8. 发明申请

US20140018433A1 METHOD OF TREATING ANDROGEN RECEPTOR (AR) -POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS) 有权
标题翻译：用选择性受体调节剂（SARMS）治疗原始受体（AR） - 乳腺癌的方法
公开(公告)号：US20140018433A1
公开(公告)日：2014-01-16
申请号：US13789005
申请日：2013-03-07
申请人： GTx, Inc.
发明人： James T. Dalton , Mitchell S. Steiner , Ramesh Narayanan , Sunjoo Ahn
IPC分类号： C07C271/02 , A61K45/06 , A61K31/325
CPC分类号： C07C271/02 , A61K31/167 , A61K31/325 , A61K45/06 , Y02A50/395
摘要： This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of: a) treating a subject suffering from breast cancer; b) treating a subject suffering from metastatic breast cancer; c) treating a subject suffering from refractory breast cancer; d) treating a subject suffering from AR-positive breast cancer; e) treating a subject suffering from AR-positive refractory breast cancer; f) treating a subject suffering from AR-positive metastatic breast cancer; g) treating a subject suffering from AR-positive and ER-positive breast cancer; h) treating a subject suffering from triple negative breast cancer; i) treating a subject suffering from advanced breast cancer; j) treating a subject suffering from breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; k) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer; l) prolonging survival of a subject with breast cancer, and/or m) prolonging the progression-free survival of a subject with breast cancer; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound, comprising administering to the subject a therapeutically effective amount of a SARM compound of this invention.
摘要翻译：本发明涉及治疗受试者中雄激素受体阳性乳腺癌，例如女性受试者。因此，本发明提供了以下方法：a）治疗患有乳腺癌的受试者; b）治疗患有转移性乳腺癌的受试者; c）治疗难治性乳腺癌患者; d）治疗患有AR阳性乳腺癌的受试者; e）治疗患有AR阳性难治性乳腺癌的受试者; f）治疗患有AR阳性转移性乳腺癌的受试者; g）治疗患有AR阳性和ER阳性乳腺癌的受试者; h）治疗患有三阴性乳腺癌的受试者; i）治疗晚期乳腺癌患者; j）治疗患有SERM（他莫昔芬，托瑞米芬），芳香酶抑制剂，曲妥珠单抗（赫赛汀，阿霉素，阿曲曲坦），奥妥珠单抗（Perjeta），拉帕替尼，依西美坦（Aromasin），贝伐珠单抗（Avastin） /或氟维司群治疗; k）治疗，预防，抑制或抑制患有乳腺癌患者的转移; l）延长患有乳腺癌的受试者的存活，和/或m）延长乳腺癌患者的无进展生存期; 包括向受试者施用治疗有效量的选择性雄激素受体调节剂（SARM）化合物，其包括向受试者施用治疗有效量的本发明的SARM化合物。

9. 发明申请

US20130165408A1 PHENYL CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING EPILESY 有权
标题翻译：苯甲酸酯化合物，用于预防或治疗皮肤
公开(公告)号：US20130165408A1
公开(公告)日：2013-06-27
申请号：US13727654
申请日：2012-12-27
申请人： Bio-Pharm Solutions Co., Ltd.
发明人： Yong Moon Choi
IPC分类号： C07C271/02
CPC分类号： C07C271/02 , A61K31/047 , A61K31/164 , A61K31/165 , A61K31/325 , C07C33/26 , C07C33/36 , C07C271/12 , C07C271/16 , C07C271/24 , C07C271/28 , C07C2601/02 , C07C2601/14 , C07C2602/42 , C07F7/1804
摘要： A method for treatment or prevention epilepsy comprising administering a phenyl carbamate compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of epilepsy is provided.
摘要翻译：一种用于治疗或预防癫痫的方法，其包括给予需要治疗或预防癫痫的受治疗者有效量的苯基氨基甲酸酯化合物。

10. 发明授权

US08232277B2 Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use 失效
标题翻译：四-O-取代丁烷桥改性NDGA衍生物，其合成和药用
公开(公告)号：US08232277B2
公开(公告)日：2012-07-31
申请号：US12443926
申请日：2007-10-02
申请人： Qingqi Chen , Jonathan Daniel Heller , Rocio Alejandra Lopez , Amanda Jean Morris
发明人： Qingqi Chen , Jonathan Daniel Heller , Rocio Alejandra Lopez , Amanda Jean Morris
IPC分类号： A61K31/495 , A61K31/445 , A61K31/341 , A61K31/426 , A61K31/165 , A61K31/132 , A61K31/085 , C07D277/24 , C07D307/52 , C07D211/06 , C07D241/04 , C07C271/46 , C07C271/02
CPC分类号： C07D295/088 , C07C37/50 , C07C39/21 , C07C39/367 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C47/27 , C07C47/273 , C07C217/20 , C07C217/54 , C07C255/33 , C07D277/24 , C07C39/16
摘要： The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.
摘要翻译：本发明涉及去甲二氢愈创木酸衍生物化合物，即丁烷桥改性的二氢愈创木酸（NDGA）化合物和丁烷桥改性的四-O-取代的NDGA化合物，含有它们的药物组合物，制备它们的方法及其使用方法和试剂盒包括它们用于治疗疾病和病症，特别是由HIV感染，HPV感染或HSV感染引起的或与病毒感染相关的疾病，诸如各种类型的关节炎和炎症性肠病的炎性疾病，代谢疾病，如糖尿病和高血压，或增殖性疾病，如各种类型的癌症。

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