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1. 发明授权

US11136606B2 Process for sugar modulation 有权
公开(公告)号：US11136606B2
公开(公告)日：2021-10-05
申请号：US16219110
申请日：2018-12-13
申请人： SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
发明人： Helene Michele Jeanne Chanvrier , Tram Anh Line Do , Jovyn Kye Tyng Frost , Dietmar August Gustav Sievert
IPC分类号： C12P19/14 , C08L3/02 , C12P19/22 , C08B30/18 , A23L29/30 , C12P19/12 , C13K7/00
摘要： The present invention relates to a method for producing a food product comprising hydrolysed starch, as well as to products obtainable by the method. The method has the advantage of reducing the amount of sugar (i.e. maltose) produced by hydrolysis as compared to conventional methods of starch hydrolysis and present the additional advantage of providing good processability for the food product.

2. 发明申请

US20180303139A1 SWEETPOTATO CONDENSED EXTRACT (THAT IS IMO-MITSU) AND METHOD FOR PRODUCING IMO-MITSU 审中-公开
公开(公告)号：US20180303139A1
公开(公告)日：2018-10-25
申请号：US15985174
申请日：2018-05-21
申请人： Mitsuo Kagaya
发明人： Osamu Yamakawa , Makoto Yoshimoto , Hirokazu Beppu
IPC分类号： A23L19/10 , C13K7/00 , A23L29/30 , A23L5/00 , A23L29/00
CPC分类号： A23L5/00 , A23L19/105 , A23L29/06 , A23L29/30 , A23V2002/00 , C13K7/00
摘要： In order to provide sweetpotato condensed extract (that is imo-mitsu) as a dietary supplement having a feeling of high quality with emphasis on nutritional functionality, which is obtained from sweetpotato, does not have extraneous flavors or odor of malt, and also improve taste and flavor enables the setting of a long periods for consumption and storage, a method for producing a imo-mitsu composition adds β-amylase contained in liquid from squeezing sweetpotato or from sweetpotato dry powder as saccharifying enzyme to a raw ingredient derived from sweetpotato by adding water and heating processing, and performs saccharification processing by heating at 60 to 75° C. for 30 to 60 minutes.

3. 发明申请

US20160376546A1 SUGAR MIXTURES AND METHODS FOR PRODUCTION AND USE THEREOF 有权
标题翻译：糖混合物及其生产和使用方法
公开(公告)号：US20160376546A1
公开(公告)日：2016-12-29
申请号：US15191376
申请日：2016-06-23
申请人： Virdia, Inc.
发明人： Aharon Meir Eyal , Robert P. Jansen , Revital Mali , Asher Vitner
IPC分类号： C12N1/22 , C13K7/00 , C13K1/02 , C13K13/00 , C12P19/02 , C12P19/14
CPC分类号： C12N1/22 , A23V2002/00 , C12P7/10 , C12P19/02 , C12P19/14 , C12P2203/00 , C13K1/02 , C13K7/00 , C13K13/00 , Y02E50/13 , Y02E50/16 , Y02E50/17 , A23V2250/60
摘要： A sugar mixture comprising: monosaccharides; oligosaccharides in a ratio ≧0.06 to total saccharides; disaccharides in a ratio to total saccharides ≧0.05; pentose in a ratio to total saccharides ≧0.05; at least one alpha-bonded di-glucose; and at least one beta-bonded di-glucose. Also disclosed are methods to make and/or use such mixtures.
摘要翻译：一种糖混合物，其包含：单糖; 比例≥0.06的寡糖总糖; 二糖与总糖的比例≥0.05; 戊糖与总糖的比例≥0.05; 至少一种α-键合的二葡萄糖; 和至少一种β-键合的二葡萄糖。还公开了制备和/或使用这种混合物的方法。

4. 发明申请

US20150353979A1 Preparation Of Malto-Oligosaccharides 审中-公开
标题翻译：麦芽低聚糖的制备
公开(公告)号：US20150353979A1
公开(公告)日：2015-12-10
申请号：US14826354
申请日：2015-08-14
申请人： Grain Processing Corporation
发明人： Steven L. Ramsden , Zachary J. Halloran , Albert J. Pollmeier , Jeff M. Underwood
IPC分类号： C12P19/14 , C12P19/04 , C13K7/00
CPC分类号： C12P19/14 , C08B30/044 , C08B30/18 , C12P19/04 , C12Y302/01001 , C13K7/00
摘要： Disclosed is a method for preparing a mixture of malto-oligosaccharides. Generally, a dry-milled corn fraction, such as a corn flour from which germ and fiber have been removed, is subjected to hydrolysis, typically catalyzed with acid or an enzyme such as an α-amylase enzyme, under conditions suitable to form a mixture of malto-oligosaccharides. A gluten fraction is removed and the enzyme is inactivated, such as with heat. The mixture of malto-oligosaccharides then may be recovered from remaining solids and purified.
摘要翻译：公开了一种制备麦芽低聚糖混合物的方法。一般来说，干法磨碎的玉米级分，例如去除胚芽和纤维的玉米粉，经过水解，通常用酸或酶如α-淀粉酶在适于形成混合物的条件下催化的麦芽寡糖。除去谷蛋白部分，并使酶失活，例如加热。然后可以从剩余的固体中回收麦芽寡糖的混合物并纯化。

5. 发明授权

US07820628B2 Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding 有权
标题翻译：肿瘤病变回归，并通过导致抗Gal抗体结合的组合物原位转化成自体肿瘤疫苗
公开(公告)号：US07820628B2
公开(公告)日：2010-10-26
申请号：US11355804
申请日：2006-02-16
申请人： Uri Galili
发明人： Uri Galili
IPC分类号： A61K31/70 , A61K31/715 , C07H1/00 , C13K5/00 , C13K7/00
CPC分类号： A61K31/739
摘要： The present invention discloses that an intratumoral injection of: i) glycolipids with α-gal epitope; ii) gene vectors comprising an α1,3galactosyltransferase gene; or iii) a mixture of α1,3galactosyltransferase, neuraminidase, and uridine diphosphate galactose results in tumor regression and/or destruction. Binding of the natural anti-Gal antibody to de novo expressed tumoral α-gal epitopes induces inflammation resulting in an anti-Gal antibody mediated opsonization of tumor cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumor specific T cells thereby converting the treated tumor lesions into in situ autologous tumor vaccines. This therapy can be applied to patients with multiple lesions and in neo-adjuvant therapy to patients before tumor resection. In addition to the regression and/or destruction of the treated tumor, such a vaccine will help in the immune mediated destruction of micrometastases that are not detectable during the removal of the treated tumor.
摘要翻译：本发明公开了肿瘤内注射：i）具有α-gal表位的糖脂; ii）包含α1,3半乳糖基转移酶基因的基因载体; 或iii）α1,3半乳糖转移酶，神经氨酸酶和尿苷二磷酸半乳糖的混合物导致肿瘤消退和/或破坏。天然抗-Gal抗体与从头表达的肿瘤α-gal表位的结合诱导炎症，导致抗Gal抗体介导的肿瘤细胞的调理作用及其通过抗原呈递细胞的摄取。这些抗原呈递细胞迁移到引流淋巴结并激活肿瘤特异性T细胞，从而将治疗的肿瘤损伤转化为原位自体肿瘤疫苗。这种治疗方法可以应用于肿瘤切除术前患者多发病灶和新辅助治疗。除了处理的肿瘤的消退和/或破坏之外，这样的疫苗将有助于免疫介导的微转移的破坏，其在去除治疗的肿瘤期间是不可检测的。

6. 发明申请

US20090036669A1 GLYCOLIPIDS OF BRANCHED CHAIN ALKYL OLIGOSACCHARIDES FOR LIQUID CRYSTAL AND RELATED APPLICATIONS 有权
标题翻译：用于液晶的分支链烷基低聚物的甘氨酸和相关应用
公开(公告)号：US20090036669A1
公开(公告)日：2009-02-05
申请号：US11908791
申请日：2006-02-20
申请人： Rauzah Hashim , Thorsten Heidelberg , Hind Hassan , Nasrul Zamani Mohd Rodzi , Rusnah Syahila Dauli Hussen , Ahmad Sazali Hamzah , Shahidan Radiman , Volkmar Vili , Matthias Wulf , Seiji Ujiie
发明人： Rauzah Hashim , Thorsten Heidelberg , Hind Hassan , Nasrul Zamani Mohd Rodzi , Rusnah Syahila Dauli Hussen , Ahmad Sazali Hamzah , Shahidan Radiman , Volkmar Vili , Matthias Wulf , Seiji Ujiie
IPC分类号： C13K7/00
CPC分类号： C07H15/04 , C09K19/0422
摘要： Glycolipids of branched chain alkyl oligosaccharides according to this patent comprise of a primary alcohol branched in the 2-position and an oligosaccharide, covalently bond to the alcohol in either α- or β-linkage (shown in Formula I and Formula II). These compounds show particularly interesting phase behavior not found for the corresponding straight chain counterparts. The properties involve an ambient temperature liquid crystalline appearance and thermotropic liquid crystal phase polymorphism. Upon the latter, the formation of cubic phases is considered most interesting with respect to life science applications, e.g. liposome for drug delivery. Depending on the choice of sugar head group and alkyl tail, various levels of water miscibility may be adjusted to meet applications requirements (complete solubility for emulsifier applications, e.g. cosmetic creams, to limited water swelling only, e.g. for the preparation of artificial membranes). The closed structural relationship to natural lipids also make branched chain alkyl oligosaccharides valuable subjects for biochemical investigations, e.g. membrane studies. The range of possible applications for glycolipids of branched chain alkyl oligosaccharides involve material science liquid crystal applications, e.g, optical switches, as well as surfactants and the life science applications.
摘要翻译：根据该专利的支链烷基寡糖的糖脂包含在2-位上分支的伯醇和寡糖，以α-或β-键（式I和式II所示）共价键合到醇上。这些化合物表现出对于相应的直链对应物没有发现的特别有趣的相行为。性质包括环境温度液晶外观和热致液晶相多态性。在后者中，立方相的形成在生命科学应用方面被认为是最有趣的。用于药物递送的脂质体。根据糖头基和烷基尾的选择，可以调节不同水平的水混溶性以满足应用要求（对于乳化剂应用（例如化妆品乳液，仅限于有限的水溶胀，例如制备人造膜）的完全溶解度）。与天然脂质的封闭结构关系也使支链烷基寡糖成为生物化学研究的有价值的对象，例如。膜研究。支链烷基寡糖的糖脂的可能应用范围涉及材料科学液晶应用，例如光学开关，以及表面活性剂和生命科学应用。

7. 发明授权

US07087746B2 Functionalised maltosyl fluoride as glycosyl donor in the chemo-enzymatic preparation of ratio of oligo-or polysaccharides 失效
标题翻译：功能化的麦芽糖基氟作为糖基供体在化学酶制剂中的寡糖或多糖的比例
公开(公告)号：US07087746B2
公开(公告)日：2006-08-08
申请号：US10482957
申请日：2002-07-26
申请人： Lionel Greffe , Hugues Driguez
发明人： Lionel Greffe , Hugues Driguez
IPC分类号： C13K7/00 , C12P19/18
CPC分类号： C07H5/02 , C12P19/14 , C12P19/18
摘要： Disaccharides of formula (I) are derived from a-maltosyl fluoride, wherein R1 and R2 are defined. Such disaccharides are useful as glycosyl donors in transglycosylation reactions catalyzed by glycoside-hydrolazes or in transfer reactions catalyzed by transglycosylases during the preparation of oligosaccharides or polysaccharides.
摘要翻译：式（I）的二糖衍生自α-甲苯磺酰氟，其中R 1和R 2定义。这样的二糖可用作由糖苷 - 水溶胶催化的转糖基化反应中的糖基供体，或在制备低聚糖或多糖期间由转糖基酶催化的转移反应中。

8. 发明授权

US4182634A Process for purifying maltose solution 失效
标题翻译：麦芽糖溶液纯化方法
公开(公告)号：US4182634A
公开(公告)日：1980-01-08
申请号：US898073
申请日：1978-04-20
申请人： Masaru Yamada , Atsushi Mori , Yoshiyasu Sato , Kenichi Terayama , Shogo Miyatani
发明人： Masaru Yamada , Atsushi Mori , Yoshiyasu Sato , Kenichi Terayama , Shogo Miyatani
IPC分类号： C08L5/00 , C13K7/00 , C13D3/12
CPC分类号： C13K7/00
摘要： From a maltose solution of a purity of 75 to 90%, a high-purity maltose solution having a maltose purity of more than 98.5% is obtained in a high yield by preparatorily treating activated carbon with the aqueous solution of an organic solvent, adding the same organic solvent to the maltose solution under treatment until the concentration of the organic solvent equals that in the aqueous solution used for the treatment of the activated carbon, and subsequently bringing the resultant solution into contact with the activated carbon for thereby allowing the activated carbon to adsorb selectively out of the solution only the saccharides such as maltotriose and maltotetraose which are composed of three or more glucoses.
摘要翻译：从纯度为75〜90％的麦芽糖溶液，通过用有机溶剂的水溶液预处理活性炭，以高产率获得麦芽糖纯度高于98.5％的高纯度麦芽糖溶液，加入与处理的麦芽糖溶液相同的有机溶剂，直到有机溶剂的浓度等于用于处理活性炭的水溶液的浓度，随后使所得溶液与活性炭接触，从而使活性炭从溶液中仅选择由三种或更多种葡萄糖组成的糖类如麦芽三糖和麦芽四糖。

9. 发明授权

US3992261A Method for manufacture of maltose from starch by enzymes co-produced by a single microorganism 失效
标题翻译：通过单一微生物共同生产的酶从淀粉制备麦芽糖的方法
公开(公告)号：US3992261A
公开(公告)日：1976-11-16
申请号：US538918
申请日：1975-01-06
申请人： Yoshiyuki Takasaki , Yoshimasa Takahara
发明人： Yoshiyuki Takasaki , Yoshimasa Takahara
IPC分类号： C12P19/22 , C12N9/26 , C12N9/44 , C12R1/07 , C13K7/00 , C12D13/02 , C07G7/02 , C12D13/10
CPC分类号： C13K7/00 , C12N9/2425 , C12N9/2451 , C12Y302/01002 , C12Y302/01033 , Y10S435/832 , Y10S435/834
摘要： A microorganism which simultaneously produces .beta.-amylase and dextrin .alpha.-1,6-glucosidase is cultured. By use of the enzymes thus produced, starch is directly hydrolyzed into maltose in a high yield.
摘要翻译：培养同时产生β-淀粉酶和糊精α-1,6-葡糖苷酶的微生物。通过使用由此产生的酶，淀粉以高产率直接水解成麦芽糖。

10. 发明授权

US3922199A Enzymatic hydrolysis of granular starch 失效
标题翻译：颗粒淀粉的酶水解
公开(公告)号：US3922199A
公开(公告)日：1975-11-25
申请号：US43745274
申请日：1974-01-28
申请人： CPC INTERNATIONAL INC
发明人： HEBEDA RONALD EMIL , HOLIK DENNIS JOHN , LEACH HARRY WOODS
IPC分类号： C08B30/12 , C12P19/14 , C12P19/20 , C13K1/06 , C13K7/00 , C12D13/02
CPC分类号： C13K7/00 , C08B30/12 , C12P19/14 , C12P19/20 , C13K1/06 , Y10S435/832 , Y10S435/836 , Y10S435/839 , Y10S435/917 , Y10S435/939
摘要： A process for converting granular starch to a soluble hydrolysate wherein the unconverted starch retains its granular nature. The conversion is accomplished by means of a bacterial alpha-amylase.
摘要翻译：将颗粒状淀粉转化为可溶性水解产物的方法，其中未转化的淀粉保持其颗粒性质。转化通过细菌α-淀粉酶实现。

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