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1. 发明申请

WO2011041463A2 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译：经皮分析传感器
公开(公告)号：WO2011041463A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/050788
申请日：2010-09-29
申请人： DEXCOM, INC. , NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
发明人： NEALE, Paul, V. , BOOCK, Robert , BOHM, Sebastian , SIMPSON, Peter, C. , BRAUKER, James
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供经配置用于连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括被配置用于插入宿主的皮肤180下方的体内部分160和被配置为在传感器插入到主体的传感器之后保持在宿主的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括被配置用于刺穿主体的皮肤180的组织刺穿元件110和包括材料或支撑构件130的传感器主体120，该传感器主体120提供足够的柱强度以允许传感器主体可以在宿主组织中大量屈曲。离体部分170可以被配置成包括（或可操作地连接到）传感器电子单元并且可以包括安装单元150.这里还描述了传感器主体和组织穿透元件的各种配置，其可以用于保护传感器主体的膜。

2. 发明申请

WO2009048462A1 INTEGRATED INSULIN DELIVERY SYSTEM WITH CONTINUOUS GLUCOSE SENSOR 审中-公开
标题翻译：具有连续葡萄糖传感器的集成胰岛素输送系统
公开(公告)号：WO2009048462A1
公开(公告)日：2009-04-16
申请号：PCT/US2007/080848
申请日：2007-10-09
申请人： DEXCOM, INC. , DOBBLES, Mike , KAMATH, Apurv , MAGALINGAM, Aarthi , BRAUKER, James, H.
发明人： DOBBLES, Mike , KAMATH, Apurv , MAGALINGAM, Aarthi , BRAUKER, James, H.
IPC分类号： A61B5/00 , A61M31/00
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61M5/003 , A61M5/14244 , A61M5/14276 , A61M5/178 , A61M5/20 , A61M5/30 , A61M11/00 , A61M15/00 , A61M15/0065 , A61M15/0068 , A61M15/008 , A61M15/0083 , A61M35/00 , A61M2005/14296 , A61M2205/3569 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/587 , A61M2205/8206 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H40/63
摘要： Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.
摘要翻译：提供了用于集成包括接收器14，药物输送装置16，控制器模块和任选的单点葡萄糖监测器18的连续葡萄糖传感器12的系统和方法。集成可以是手动，半自动化和/或完全自动化。

3. 发明申请

WO2006073453A2 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO2006073453A2
公开(公告)日：2006-07-13
申请号：PCT/US2005014696
申请日：2005-05-02
申请人： DEXCOM INC , GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
发明人： GOODE JR PAUL V , HOLMQUIST ARNOLD L , TAPSAK MARK A , SHULTS MARK , CARR-BRENDEL VICTORIA , BRAUKER JAMES H , NEALE PAUL V , MCCLURE JASON D , BRISTER MARK , SIMPSON PETER C , RHODES RATHBUN K
IPC分类号： A61B5/07 , A61B5/00 , A61B5/05 , H04B1/03
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor (12) including a sensor body substantially formed from a water vapor permeable material and electrical components encapsulated within the sensor body, wherein the electrical components comprise RF circuitry (38) and an antenna (42) adapted for RF transmission from the sensor (12) in vivo to a receiver (14) ex vivo, wherein the RF circuitry (38) is spaced a fixed distance from the sensor body so as to support a dielectric constant that enables RF transmission between the sensor (12) in vivo to the receiver (14) ex vivo.
摘要翻译：一种可植入分析物传感器（12），其包括基本由水蒸气可渗透材料形成的传感器主体和封装在传感器主体内的电子部件，其中电子部件包括RF电路（38）和适于从传感器（12）在体内与接收器（14）离体接触，其中所述RF电路（38）与所述传感器主体间隔固定距离，以支持介电常数，所述介电常数使所述传感器（12）能够在体内到体外的接收器（14）。

4. 发明申请

WO2006017359A1 TRANSCUTANEOUS ANALYTE SENSOR WITH VARIABLE STIFFNESS 审中-公开
标题翻译：具有可变刚度的TRANSCUTANEOUS分析仪传感器
公开(公告)号：WO2006017359A1
公开(公告)日：2006-02-16
申请号：PCT/US2005/024994
申请日：2005-07-13
申请人： DEXCOM, INC. , BRISTER, Mark , BRAUKER, James, H.
发明人： BRISTER, Mark , BRAUKER, James, H.
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/14546 , A61B5/1468 , A61B5/14865 , A61B5/150022 , A61B5/6833
摘要： The present invention relates generally to variable stiffness transcutaneous medical devices (34) including a distal tip (30) on a distal portion (28) designed to be more flexible than a proximal portion (24) having a proximal tip (26), wherein the distal portion (28) and the proximal portion (24) are separated by an intermediate portion (32). The variable stiffness can be provided by a variable pitch in one or more wires of the device, a variable cross-section in one or more wires of the device, and/or a variable hardening and/or softening in one or more wires of the device.
摘要翻译：本发明一般涉及可变刚度经皮医疗装置（34），其包括设计成比具有近端（26）的近端部分（24）更柔性的远侧部分（28）上的远侧末端（30），其中远端部分（28）和近端部分（24）由中间部分（32）分开。可变刚度可以通过设备的一个或多个导线中的可变节距，装置的一个或多个导线中的可变横截面和/或一个或多个线中的可变硬化和/或软化来提供设备。

5. 发明申请

WO2005057173A2 SYSTEMS AND METHODS FOR IMPROVING ELECTROCHEMICAL ANALYTE SENSORS 审中-公开
标题翻译：改进电化学分析仪传感器的系统和方法
公开(公告)号：WO2005057173A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/040913
申请日：2004-12-07
申请人： DEXCOM, INC. , SIMPSON, Peter, C. , BRAUKER, James, H. , CARR-BRENDEL, Victoria , GOODE, JR., Paul, V. , TAPSAK, Mark
发明人： SIMPSON, Peter, C. , BRAUKER, James, H. , CARR-BRENDEL, Victoria , GOODE, JR., Paul, V. , TAPSAK, Mark
IPC分类号： G01N
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译：提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本无干扰的分析物浓度测量。当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。

6. 发明申请

WO2003011131A2 SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES 审中-公开
标题翻译：传感器头用于可移植设备
公开(公告)号：WO2003011131A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/023903
申请日：2002-07-26
申请人： DEXCOM, INC. , BRAUKER, James, H. , SHULTS, Mark, C. , TAPSAK, Mark, A. , RHODES, Rathbun
发明人： BRAUKER, James, H. , SHULTS, Mark, C. , TAPSAK, Mark, A. , RHODES, Rathbun
IPC分类号： A61B5/00
CPC分类号： G01N27/3272 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/006 , G01N33/48707 , G01N33/48785
摘要： The present invention provides a sensor head (10) for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode (21), a reference electrode (20) and a counter electrode (22), wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode (22) is greater than the surface area of the working electrode (21); and a multi-region membrane having a first region (33), a second region (31), and a third region (32), wherein the membrane is affixed to the nonconductive body and covering the working electrode (21), reference electrode (20) and counter electrode (22). In addition, the present invention provides an implantable device including at least one of the sensor heads (10) of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
摘要翻译：本发明提供一种在可植入装置中使用的传感器头（10），其用于测量生物流体中的分析物的浓度，其包括：非导电体; 工作电极（21），参比电极（20）和对电极（22），其中电极通过非导电体，在身体的一个位置形成电化学反应性表面，并在另一位置形成电子连接其中所述对电极（22）的电化学反应性表面大于所述工作电极（21）的表面积; 以及具有第一区域（33），第二区域（31）和第三区域（32）的多区域膜，其中所述膜固定到所述非导电体并覆盖所述工作电极（21），参考电极 20）和对电极（22）。另外，本发明提供一种可植入装置，其包括至少一个本发明的传感器头（10）和使用本发明的可植入装置监测主机中的葡萄糖水平的方法。

7. 发明申请

WO2011041463A3 TRANSCUTANEOUS ANALYTE SENSOR 审中-公开
标题翻译： TRANSCUTANEOUS分析仪传感器
公开(公告)号：WO2011041463A3
公开(公告)日：2011-07-14
申请号：PCT/US2010050788
申请日：2010-09-29
申请人： DEXCOM INC , NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
发明人： NEALE PAUL V , BOOCK ROBERT , BOHM SEBASTIAN , SIMPSON PETER C , BRAUKER JAMES
IPC分类号： A61B5/151 , A61B5/157
CPC分类号： A61B5/14865 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/1473 , A61B5/1486 , A61B5/6843 , A61B5/6848 , A61B5/6849 , A61B2560/0443 , A61B2562/0209 , A61B2562/04
摘要： A transcutaneous sensor device configured for continuously measuring analyte concentrations in a host is provided. In some embodiments, the transcutaneous sensor device 100 comprises an in vivo portion 160 configured for insertion under the skin 180 of the host and an ex vivo portion 170 configured to remain above the surface of the skin 180 of the host after sensor insertion of the in vivo portion. The in vivo portion may comprise a tissue piercing element 110 configured for piercing the skin 180 of the host and a sensor body 120 comprising a material or support member 130 that provides sufficient column strength to allow the sensor body to be pushable in a host tissue without substantial buckling. The ex vivo portion 170 may be configured to comprise (or operably connect to) a sensor electronics unit and may comprise a mounting unit 150. Also described here are various configurations of the sensor body and the tissue piercing element that may be used to protect the membrane of the sensor body.
摘要翻译：提供了经配置以连续测量宿主中的分析物浓度的经皮传感器装置。在一些实施例中，经皮传感器装置100包括构造成用于插入主体皮肤180下方的体内部分160，以及配置成在传感器插入入口之后保留在主体的皮肤180的表面上方的离体部分170 体内部分。体内部分可以包括构造成用于刺穿主体的皮肤180的组织刺穿元件110和传感器主体120，传感器主体120包括材料或支撑构件130，材料或支撑构件130提供足够的柱强度，以允许传感器主体可在主机组织中推出而不用实质屈曲。离体部分170可以被配置为包括（或可操作地连接）传感器电子单元，并且可以包括安装单元150.此处还描述了传感器主体和组织刺穿元件的各种配置，其可以用于保护传感器体的膜。

8. 发明申请

WO2005051170A3 INTEGRATED RECEIVER FOR CONTINUOUS ANALYTE SENSOR 审中-公开
标题翻译：用于连续分析仪传感器的集成接收器
公开(公告)号：WO2005051170A3
公开(公告)日：2009-04-02
申请号：PCT/US2004038724
申请日：2004-11-17
申请人： DEXCOM INC , RASDAL ANDREW , BRAUKER JAMES , NEALE PAUL , SIMPSON PETER C
发明人： RASDAL ANDREW , BRAUKER JAMES , NEALE PAUL , SIMPSON PETER C
IPC分类号： A61B5/05 , A61B20060101 , A61B5/00 , A61B13/00 , A61K49/00
CPC分类号： A61B5/1495 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B5/7203 , A61B2560/0456 , A61B2562/247
摘要： A system is provided for monitoring glucose in a host, including a continuous glucose sensor (10) that produces a data stream indicative of a host's glucose concentration and an integrated receiver (12) that receives the data stream from the continuous glucose sensor (10) and calibrates the data stream using a single point glucose monitor (14) that is integral with the integrated receiver (12). The integrated receiver (12) obtains a glucose value from the single point glucose monitor (14), calibrates the sensor data stream received from the continuous glucose sensor (10), and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface (16).
摘要翻译：提供了一种用于监测主机中的葡萄糖的系统，包括产生指示宿主葡萄糖浓度的数据流的连续葡萄糖传感器（10）和从连续葡萄糖传感器（10）接收数据流的集成接收器（12）并且使用与集成接收器（12）集成的单点葡萄糖监测器（14）来校准数据流。集成接收器（12）从单点葡萄糖监测器（14）获得葡萄糖值，校准从连续葡萄糖传感器（10）接收的传感器数据流，并显示单点葡萄糖测量值和校准后的一个或两个用户界面上连续的葡萄糖传感器值（16）。

9. 发明申请

WO2007120381A2 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2007120381A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/003881
申请日：2007-02-14
申请人： DEXCOM, INC. , BOOCK, Robert , RIXMAN, Monica , BRAUKER, James, H. , PETISCE, James, R. , SIMPSON, Peter , BRISTER, Mark , TAPSAK, Mark, A. , CARR-BRENDEL, Victoria
发明人： BOOCK, Robert , RIXMAN, Monica , BRAUKER, James, H. , PETISCE, James, R. , SIMPSON, Peter , BRISTER, Mark , TAPSAK, Mark, A. , CARR-BRENDEL, Victoria
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes, for example, a continuous analyte needle-type sensor (34) including a reference electrode (30) helically wound around the working electrode (38), and covered by a membrane system (32) including a silicone-hydrophilic polymer blend membrane.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新颖的硅氧烷亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置，例如连续的分析物针型传感器（34），其包括在工作中螺旋缠绕的参比电极（30）电极（38），并被包括硅氧烷亲水聚合物共混膜的膜系统（32）覆盖。

10. 发明申请

WO2006127694A3 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2006127694A3
公开(公告)日：2007-04-12
申请号：PCT/US2006019889
申请日：2006-05-23
申请人： DEXCOM INC , BRAUKER JAMES H , SIMPSON PETER , BOOCK ROBERT , RIXMAN MONICA
发明人： BRAUKER JAMES H , SIMPSON PETER , BOOCK ROBERT , RIXMAN MONICA
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device. The sensor (34) can incorporate a working electrode (38) and at least one additional electrode (30), and can further incorporate a sensing mechanism (36) comprising a small structure as adapted for insertion under the host's skin.
摘要翻译：本发明一般涉及与可植入装置一起使用的生物界面膜，例如用于检测生物样品中分析物浓度的装置。更具体地，本发明涉及新颖的生物接触膜，包括这些膜的装置和可植入装置，在可植入装置上或周围形成生物接触膜的方法，以及使用可植入分析物检测来监测生物流体样品中的葡萄糖水平的方法设备。传感器（34）可以包括工作电极（38）和至少一个附加电极（30），并且还可以包括感测机构（36），该感测机构包括适于插入主机皮肤下方的小结构。

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