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1. 发明授权

US08716292B2 Riminophenazines with 2-(heteroaryl)amino substituents and their anti-microbial activity 有权
标题翻译：具有2-（杂芳基）氨基取代基的咪唑咪嗪和它们的抗微生物活性
公开(公告)号：US08716292B2
公开(公告)日：2014-05-06
申请号：US13171102
申请日：2011-06-28
申请人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
发明人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
IPC分类号： A61K31/495
CPC分类号： C07D409/14 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/14 , C07D409/12
摘要： The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments. A general representation of the 2-(heteroaryl)amino-riminophenazines is shown below.
摘要翻译：本发明涉及具有杂芳香取代基，包括具有2-杂芳基 - 氨基取代基的那些，其制备方法及其用作治疗结核分枝杆菌和其它微生物感染的药物，其单独使用或与其它抗感染治疗组合。 2-（杂芳基）氨基 - 赖氨酰吩嗪的一般表示如下所示。

2. 发明申请

US20120071472A1 RIMINOPHENAZINES WITH 2-(HETEROARYL)AMINO SUBSTITUENTS AND THEIR ANTI-MICROBIAL ACTIVITY 有权
标题翻译：具有2-（杂芳族）氨基取代基的咪唑啉酮及其抗微生物活性
公开(公告)号：US20120071472A1
公开(公告)日：2012-03-22
申请号：US13171102
申请日：2011-06-28
申请人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
发明人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
IPC分类号： A61K31/498 , A61K31/506 , C07D401/12 , C07D401/14 , A61P31/06 , A61K31/5377 , C07D405/14 , C07D409/14 , A61P31/04 , C07D403/12 , C07D413/14
CPC分类号： C07D409/14 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/14 , C07D409/12
摘要： The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
摘要翻译：本发明涉及具有杂芳香取代基，包括具有2-杂芳基 - 氨基取代基的那些，其制备方法及其用作治疗结核分枝杆菌和其它微生物感染的药物，其单独使用或与其它抗感染治疗组合。

3. 发明授权

US07453917B1 Supersonic all gas-phase iodine laser 失效
标题翻译：超音速全相气相碘激光
公开(公告)号：US07453917B1
公开(公告)日：2008-11-18
申请号：US11179187
申请日：2005-07-12
申请人： Christopher B. Cooper , Gerald C. Manke , Gordon D. Hager , Timothy J. Madden
发明人： Christopher B. Cooper , Gerald C. Manke , Gordon D. Hager , Timothy J. Madden
IPC分类号： H01S3/22
CPC分类号： H01S3/2215 , H01S3/0953
摘要： A continuous wave laser based on the electronic I*(2P½)−I(2P 3/2) transition of atomic iodine at 1.315 microns from the NCl(a1Δ)+I(2P 3/2) energy transfer reaction using a transverse flow device having gas flow from an upstream subsonic combustor section through a converging-diverging supersonic slit nozzle to a downstream supersonic section and an intersecting optical resonator. Laser operation is achieved through the transformation of the gas phase chemical reagents, D2 (deuterium), F2 (fluorine), NF3 (nitrogen trifluoride), DCl (deuterium chloride) HI (hydrogen iodide) in the subsonic section and HN3 (hydrogen azide) in the supersonic section.
摘要翻译：基于电子I *（^{2 P 1/2）的连续波激光器 >）从NCl（α-1 +）+ I（2+ 3/3/2）能量转移反应在1.315微米的原子碘转变使用具有来自上游亚音速燃烧器部分的气流通过会聚发散超音速狭缝喷嘴到下游超音速部分的横向流动装置和相交的光学谐振器。激光操作是通过气相化学试剂D 2（氘），F 2（氟），NF 3 N（Ⅳ）三氟化氮），亚音速部分中的DC1（氘氯化物）HI（碘化氢）和超音速部分中的HN 3（叠氮化氢）。}

4. 发明授权

US06720427B2 Thiazole derivatives 失效
标题翻译：噻唑衍生物
公开(公告)号：US06720427B2
公开(公告)日：2004-04-13
申请号：US10144403
申请日：2002-05-13
申请人： Mark A. Sanner , Chris J. Helal , Christopher B. Cooper
发明人： Mark A. Sanner , Chris J. Helal , Christopher B. Cooper
IPC分类号： C07D21722
CPC分类号： C07D277/62 , C07D277/42 , C07D277/46 , C07D277/48 , C07D277/64 , C07D417/12 , C07D417/14
摘要： The invention provides compounds of formula 1 wherein R1, R3, and R4 are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission are described. Also described are pharmaceutical compositions and methods comprising compounds of formula 1 for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.
摘要翻译：本发明提供了式1化合物，其中R 1，R 3和R 4如上定义，及其药学上可接受的盐。式1的化合物表示具有抑制cdk5，cdk2和GSK-3的活性。描述了包含式1化合物的药物组合物和方法，用于治疗包括异常细胞生长如癌症和神经变性疾病和病症以及受多巴胺神经传递影响的疾病和病症。还描述了包含用于治疗雄性生育力和精子活力的式1化合物的药物组合物和方法; 糖尿病葡萄糖耐量降低; 代谢综合征或综合征X; 多囊卵巢综合征; 脂肪生成和肥胖; 造血和虚弱，例如年龄相关的身体表现下降; 急性肌肉减少症，例如与烧伤，卧床休息，肢体固定或主要胸部，腹部和/或整形外科手术相关的肌肉萎缩和/或恶病质; 败血症脱发，脱发，秃头; 和免疫缺陷。

5. 发明申请

US20090275279A1 ENERGY EFFICIENT BUILDING 审中-公开
标题翻译：能源效率建筑
公开(公告)号：US20090275279A1
公开(公告)日：2009-11-05
申请号：US12114774
申请日：2008-05-04
申请人： NIcholas Holt , Christopher B. Cooper , Roger Eugene Frechette, III , William F. Baker, JR.
发明人： NIcholas Holt , Christopher B. Cooper , Roger Eugene Frechette, III , William F. Baker, JR.
IPC分类号： F24F7/00
CPC分类号： F24F5/0075 , F03G6/045 , F05B2240/911 , F24F2005/0064 , F24S20/66 , Y02A30/26 , Y02A30/272 , Y02B10/20 , Y02B10/24 , Y02B10/30 , Y02B10/70 , Y02B30/92 , Y02E10/465
摘要： A solar engine, which is vertically aligned along an interior portion of a building, is heated by solar radiation. The solar engine includes a warm air chamber at an upper portion of the solar engine and a hollow core positioned below the warm air chamber. Habitable spaces are positioned around the outside of the core toward an exterior of the building. Solar radiation on the warm air chamber creates a high temperature zone in the warm air chamber that induces a stack effect in which air rises through the core due to the lower temperatures in the core, and results in a negative pressure in the core. Air enters at a lower portion of the building and is pulled through the core by the solar engine. If the windows on the outside of the habitable spaces are opened, the negative pressure in the core causes passive cross ventilation from the outside of the building through the habitable spaces and into the core, where the air rises to the warm air chamber and then out of the building. This allows the habitable spaces to be naturally cooled and ventilated with no energy costs. Solar radiation may be directed into the warm air chamber and core using a reflector at the top of the building. One or more wind turbines and generators positioned around the top of the core convert the moving air from the core into electrical energy to power the building.
摘要翻译：沿着建筑物的内部垂直排列的太阳能发动机被太阳辐射加热。太阳能发动机包括位于太阳能发动机上部的暖空气室和位于暖空气室下方的中空芯。可居住的空间围绕着核心的外部朝向建筑物的外部定位。在暖空气室中的太阳辐射在暖空气室中产生高温区域，其引起堆芯效应，由于芯体中的较低温度，空气通过芯体上升，并且导致芯体中的负压。空气进入建筑物的下部，并被太阳能发动机拉过核心。如果打开可居住的空间外面的窗户，则核心的负压会从建筑物的外部通过可居住的空间进入被动的交叉通风，并进入核心，空气上升到暖空气室，然后出来的建筑物。这使得可居住的空间自然冷却和通风，没有能源成本。可以使用建筑物顶部的反射器将太阳辐射引导到暖空气室和核心中。位于核心顶部周围的一个或多个风力涡轮机和发电机将来自核心的移动空气转换为电能以为建筑物提供动力。

6. 发明申请

US20090203668A1 TRIAZOLOPYRIDINE 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS 有权
标题翻译：三唑基吡啶11-羟基甾体脱氢酶I型抑制剂
公开(公告)号：US20090203668A1
公开(公告)日：2009-08-13
申请号：US12424674
申请日：2009-04-16
申请人： James J. Li , Lawrence G. Hamann , Haixia Wang , Zheming Ruan , Christopher B. Cooper , Jun Li , Jeffrey A. Robi
发明人： James J. Li , Lawrence G. Hamann , Haixia Wang , Zheming Ruan , Christopher B. Cooper , Jun Li , Jeffrey A. Robi
IPC分类号： A61K31/553 , C07D471/02 , A61K31/437 , C07D223/02 , A61K31/55 , C07D413/14 , A61K31/5377 , C07D223/14 , C07D267/08 , A61P3/04 , A61P3/10 , A61P3/00 , A61P37/00 , A61P19/02
CPC分类号： C07D471/04
摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof wherein W, L, R3, R3a, R3b and R4 are defined herein.
摘要翻译：提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。这些新化合物具有以下结构：其中W，L，R 3，R 3a，R 3b和R 4在本文中定义的立体异构体或前药或其药学上可接受的盐。

7. 发明授权

US06552945B2 METHOD FOR STORING A TEMPERATURE THRESHOLD IN AN INTEGRATED CIRCUIT, METHOD FOR STORING A TEMPERATURE THRESHOLD IN A DYNAMIC RANDOM ACCESS MEMORY, METHOD OF MODIFYING DYNAMIC RANDOM ACCESS MEMORY OPERATION IN RESPONSE TO TEMPERATURE, PROGRAMMABLE TEMPERATURE SENSING CIRCUIT AND MEMORY INTEGRATED CIRCUIT 有权
标题翻译：用于在一体化电路中存储温度阈值的方法，用于在动态随机存取存储器中存储温度阈值的方法，在温度，可编程温度感测电路和存储器集成电路中修改动态随机存取存储器操作的方法
公开(公告)号：US06552945B2
公开(公告)日：2003-04-22
申请号：US09768897
申请日：2001-01-23
申请人： Christopher B. Cooper , Ming-Bo Liu , Chris G. Martin , Troy A. Manning , Stephen L. Casper , Charles H. Dennison , Brian M. Shirley , Brian L. Brown , Shubneesh Batra
发明人： Christopher B. Cooper , Ming-Bo Liu , Chris G. Martin , Troy A. Manning , Stephen L. Casper , Charles H. Dennison , Brian M. Shirley , Brian L. Brown , Shubneesh Batra
IPC分类号： G11C704
CPC分类号： G11C7/04 , G11C7/1045 , G11C7/20 , G11C11/4072 , G11C11/4078
摘要： A method for storing a temperature threshold in an integrated circuit includes measuring operating parameters of the integrated circuit versus temperature, calculating a maximum temperature at which the integrated circuit performance exceeds predetermined specifications and storing parameters corresponding to the maximum temperature in a comparison circuit in the integrated circuit by selectively blowing fusable devices in the comparison circuit. The fusable devices may be antifuses. As a result, the integrated circuit is able to provide signals to devices external to the integrated circuit to indicate that the integrated circuit may be too hot to operate properly.
摘要翻译：一种用于在集成电路中存储温度阈值的方法包括：测量集成电路的相对于温度的操作参数，计算集成电路性能超过预定规格的最大温度，并将积分电路性能中最大温度的参数存储在集成电路中的比较电路中通过在比较电路中选择性地吹入可熔设备。可熔断器件可以是反熔丝。因此，集成电路能够向集成电路外部的设备提供信号，以指示集成电路可能太热而无法正常工作。

8. 发明授权

US06314036B1 Method and apparatus for efficiently testing RAMBUS memory devices 失效
标题翻译：用于有效测试RAMBUS存储器件的方法和装置
公开(公告)号：US06314036B1
公开(公告)日：2001-11-06
申请号：US09708692
申请日：2000-11-07
申请人： Christopher B. Cooper , Brian L. Brown , Thanh K. Mai
发明人： Christopher B. Cooper , Brian L. Brown , Thanh K. Mai
IPC分类号： C13
CPC分类号： G11C7/1072
摘要： A RAMBUS dynamic random access memory includes a test control circuit that selectively couples a row address latch to either a row sense control signal or a CMD control signal. In a normal operating mode, the test control circuit couples the row address latch to the row sense control signal so that the row sense control signal both latches a row address and senses a row of memory cells corresponding to the latched address. Prior to conducting a core noise test, the test control circuit couples the row address latch to the CMD control signal so that the row address is latched by the CMD control signal, and the row sense control signal only functions during the core noise test to sense a row corresponding to the latched row. The memory also includes a multiplexer that receives a time-multiplexed data/address bus and simultaneously couples a first part of the data/address bus to an internal data bus and a second part of the data/address bus to an internal address bus.
摘要翻译： RAMBUS动态随机存取存储器包括选择性地将行地址锁存器耦合到行检测控制信号或CMD控制信号的测试控制电路。在正常操作模式下，测试控制电路将行地址锁存器耦合到行读控制信号，使得行读控制信号都锁存行地址并且感测与锁存地址对应的一行存储单元。在进行核心噪声测试之前，测试控制电路将行地址锁存器耦合到CMD控制信号，使得行地址由CMD控制信号锁存，并且行检测控制信号仅在核心噪声测试期间起作用以感测一行对应于锁存行。存储器还包括多路复用器，其接收时间复用的数据/地址总线，并同时将数据/地址总线的第一部分耦合到内部数据总线以及数据/地址总线的第二部分到内部地址总线。

9. 发明授权

US08148396B2 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors 有权
标题翻译：三唑并吡啶11-β羟基类固醇脱氢酶I型抑制剂
公开(公告)号：US08148396B2
公开(公告)日：2012-04-03
申请号：US12424674
申请日：2009-04-16
申请人： James J. Li , Lawrence G. Hamann , Haixia Wang , Zheming Ruan , Christopher B. Cooper , Jun Li , Jeffrey A. Robl
发明人： James J. Li , Lawrence G. Hamann , Haixia Wang , Zheming Ruan , Christopher B. Cooper , Jun Li , Jeffrey A. Robl
IPC分类号： A01N43/42 , A61K31/44 , C07D513/02
CPC分类号： C07D471/04
摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof wherein W, L, R3, R3a, R3b and R4 are defined herein.
摘要翻译：提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。这些新化合物具有以下结构：其中W，L，R 3，R 3a，R 3b和R 4在本文中定义的立体异构体或前药或其药学上可接受的盐。

10. 发明授权

US07579360B2 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors 有权
标题翻译：三唑并吡啶11-β羟基类固醇脱氢酶I型抑制剂
公开(公告)号：US07579360B2
公开(公告)日：2009-08-25
申请号：US11448947
申请日：2006-06-07
申请人： James J. Li , Lawrence G. Hamann , Haixia Wang , Zheming Ruan , Christopher B. Cooper , Jun Li , Jeffrey A. Robl
发明人： James J. Li , Lawrence G. Hamann , Haixia Wang , Zheming Ruan , Christopher B. Cooper , Jun Li , Jeffrey A. Robl
IPC分类号： A01N43/42 , A61K31/44 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L, R3, R3a, R3b and R4 are defined herein.
摘要翻译：提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。这些新化合物具有以下结构：其立体异构体或前药或其药学上可接受的盐，其中W，L，R3，R3a，R3b和R4如本文所定义。

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