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1. 发明申请

US20120071472A1 RIMINOPHENAZINES WITH 2-(HETEROARYL)AMINO SUBSTITUENTS AND THEIR ANTI-MICROBIAL ACTIVITY 有权
标题翻译：具有2-（杂芳族）氨基取代基的咪唑啉酮及其抗微生物活性
公开(公告)号：US20120071472A1
公开(公告)日：2012-03-22
申请号：US13171102
申请日：2011-06-28
申请人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
发明人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
IPC分类号： A61K31/498 , A61K31/506 , C07D401/12 , C07D401/14 , A61P31/06 , A61K31/5377 , C07D405/14 , C07D409/14 , A61P31/04 , C07D403/12 , C07D413/14
CPC分类号： C07D409/14 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/14 , C07D409/12
摘要： The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
摘要翻译：本发明涉及具有杂芳香取代基，包括具有2-杂芳基 - 氨基取代基的那些，其制备方法及其用作治疗结核分枝杆菌和其它微生物感染的药物，其单独使用或与其它抗感染治疗组合。

2. 发明授权

US08716292B2 Riminophenazines with 2-(heteroaryl)amino substituents and their anti-microbial activity 有权
标题翻译：具有2-（杂芳基）氨基取代基的咪唑咪嗪和它们的抗微生物活性
公开(公告)号：US08716292B2
公开(公告)日：2014-05-06
申请号：US13171102
申请日：2011-06-28
申请人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
发明人： Kai Liu , Christopher B. Cooper , Haihong Huang , Chun Li , Binna Liu , Yang Liu , Zhenkun Ma , Jingbin Wang , Dali Yin , Dongfeng Zhang , Gang Zhang , Hao Zhang
IPC分类号： A61K31/495
CPC分类号： C07D409/14 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/14 , C07D409/12
摘要： The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments. A general representation of the 2-(heteroaryl)amino-riminophenazines is shown below.
摘要翻译：本发明涉及具有杂芳香取代基，包括具有2-杂芳基 - 氨基取代基的那些，其制备方法及其用作治疗结核分枝杆菌和其它微生物感染的药物，其单独使用或与其它抗感染治疗组合。 2-（杂芳基）氨基 - 赖氨酰吩嗪的一般表示如下所示。

3. 发明授权

US06486201B1 Agarofuan derivatives, their preparation, pharmaceutical composition containing them and their use as medicine 失效
标题翻译：琼脂衍生物，它们的制备，含有它们的药物组合物及其作为药物的用途
公开(公告)号：US06486201B1
公开(公告)日：2002-11-26
申请号：US09856125
申请日：2001-05-18
申请人： Jiyu Guo , Weijun Wang , Hongju Fang , Qian Liu , Wuyan Zhang , Dali Yin , Sujuan Sun , Ruiwu Liu , Chun Li , Haifan Liu , Donghui Wang
发明人： Jiyu Guo , Weijun Wang , Hongju Fang , Qian Liu , Wuyan Zhang , Dali Yin , Sujuan Sun , Ruiwu Liu , Chun Li , Haifan Liu , Donghui Wang
IPC分类号： C07D30700
CPC分类号： C07D307/94
摘要： The compound represented by formula (I), in which the substitutes are defined as in the specification and the claims, or their stereoisomers, the process for preparing them, pharmaceutical composition containing them and their use as medicine.
摘要翻译：由式（I）表示的化合物，其中替代物如说明书和权利要求书中所定义，或其立体异构体，其制备方法，含有它们的药物组合物及其作为药物的用途。

4. 发明授权

US09257225B2 Methods and configurations of LC combined transformers and effective utilizations of cores therein 有权
标题翻译： LC组合变压器的方法和配置以及其中的芯的有效利用
公开(公告)号：US09257225B2
公开(公告)日：2016-02-09
申请号：US12166322
申请日：2008-07-02
申请人： Chun Li , Jason (Jian Hao) Li , Ran Ran Li
发明人： Chun Li , Jason (Jian Hao) Li , Ran Ran Li
IPC分类号： H01F21/04 , H01F27/28 , H01F21/02 , H01F27/38 , H01F3/12 , H01F38/16
CPC分类号： H01F27/385 , H01F3/12 , H01F38/16
摘要： The LC combined transformer is a combination of capacitors, inductors and an electrically-isolated mutual inductor, i.e. conventional transformer; which in principle is a unity-coupled mutual capacitor or a cascade connection of an ideal transformer and unity-coupled mutual capacitor(s). To improve the imperfections of widely-used transformers, by employing the simplest passive-circuit design to attain a perfectly-functional match between mutual capacitors and the mutual inductor, this invention achieves optimal features of current or/and voltage transformation, and introduces a new function of waveform conversion from square to quasi-sine. The ideal current transformer herein is suitable for sinusoidal current measurements, the ideal voltage transformer herein suitable for sinusoidal voltage measurements, and they also could be upgraded to ideal transformers for both current and voltage transformations. This transformer can be designed as power transferable as well as waveform convertible, applicable in power systems or power electronics. Herein also states the design approach of integrated inductor and mutual inductor, and the use of push-pull inductor, materials being fully utilized and sizes decreased.
摘要翻译： LC组合变压器是电容器，电感器和电隔离互感器的组合，即常规变压器; 其原理上是单相耦合互电容器或理想变压器和单相耦合互电容器的级联连接。为了改善广泛使用的变压器的缺陷，通过采用最简单的无源电路设计，实现互电容和互感器之间的完美功能匹配，本发明实现了电流或/和电压转换的最佳特性，并引入了新的从正方形到准正弦的波形转换功能。本文中理想的电流互感器适用于正弦电流测量，本文中的理想电压互感器适用于正弦电压测量，并且还可升级为用于电流和电压转换的理想变压器。该变压器可以设计为可转换的以及波形转换，适用于电力系统或电力电子设备。这里还介绍了集成电感和互感器的设计方法，以及推挽式电感器的使用，充分利用材料和尺寸减小。

5. 发明授权

US09089288B2 Apparatus and method for non-invasive diabetic retinopathy detection and monitoring 有权
标题翻译：非侵入性糖尿病视网膜病变检测和监测的装置和方法
公开(公告)号：US09089288B2
公开(公告)日：2015-07-28
申请号：US13436991
申请日：2012-04-01
申请人： Jia You , Qin Li , Zhenhua Guo , Qiang Sun , Chun Li
发明人： Jia You , Qin Li , Zhenhua Guo , Qiang Sun , Chun Li
IPC分类号： G06K9/00 , A61B3/12 , G06K9/46 , G06T7/00 , G06K9/36
CPC分类号： A61B3/12 , G06K9/00597 , G06K9/0061 , G06K9/36 , G06K9/46 , G06K9/4609 , G06K9/4652
摘要： A fundus camera using infrared light sources, which included an imaging optical path and an optical path for focusing and positioning and two optical paths share a common set of retina objective lens, and a computer-assisted method for retinal vessel segmentation in general and diabetic retinopathy (DR) image segmentation in particular. The method is primarily based on Multiscale Production of the Matched Filter (MPMF) scheme, which together the fundus camera, is useful for non-invasive diabetic retinopathy detection and monitoring.
摘要翻译：使用红外光源的眼底照相机，其包括成像光路和用于聚焦和定位的光路，以及两个光路共享一组共同的视网膜物镜，以及用于视网膜血管分割的计算机辅助方法和糖尿病性视网膜病变（DR）图像分割。该方法主要基于多尺度生产匹配滤波器（MPMF）方案，该方案一起使用眼底照相机，可用于非侵入性糖尿病视网膜病变检测和监测。

6. 发明申请

US20140301867A1 BALLOON PRESSURE PUMP 有权
标题翻译：气压泵
公开(公告)号：US20140301867A1
公开(公告)日：2014-10-09
申请号：US14124607
申请日：2012-06-06
申请人： Chun Li , Yunxing Liu
发明人： Chun Li , Yunxing Liu
IPC分类号： F04B45/02
CPC分类号： A61M25/10181 , A61M25/1018 , A61M25/10188 , F04B45/02
摘要： A balloon pressure pump comprising a cavity (1) having a distal end and a proximal end; a push rod (2) having a distal end and a proximal end, and provided with an external thread and inserted into the cavity; a handle (3) fixedly connected with the proximal end of the push rod (2); a locking member (4) having a distal end and a proximal end and arranged on the proximal end of the push rod (2) and used to lock same; the distal end of the locking member (4) is fixedly connected with the proximal end of the cavity (1). The handle (3) is internally provided with a sleeve (5) to accommodate the push rod (2); said sleeve (5) is fixedly connected with the proximal end of the locking member (4). The proximal end of the push rod (2) includes a spring (11) which is enclosed within the sleeve. The simple structure of the pump simplifies operations such as pressure application, pressure relief, negative pressure evacuation and the like, and is greatly convenient for a user.
摘要翻译：一种球囊压力泵，包括具有远端和近端的空腔（1）具有远端和近端的推杆（2），并且设置有外螺纹并插入所述空腔中; 与所述推杆（2）的近端固定连接的手柄（3）; 锁定构件（4），其具有远端和近端并且布置在推杆（2）的近端上并且用于将其锁定; 锁定构件（4）的远端与空腔（1）的近端固定连接。手柄（3）内部设置有套筒（5）以容纳推杆（2）; 所述套筒（5）与所述锁定构件（4）的近端固定连接。推杆（2）的近端包括封闭在套筒内的弹簧（11）。泵的简单结构简化了压力施加，减压，负压抽空等操作，并且对用户非常方便。

7. 发明授权

US08546371B2 Nanoparticle formulated glycolipid antigens for immunotherapy 有权
标题翻译：纳米颗粒配制的糖脂抗原用于免疫治疗
公开(公告)号：US08546371B2
公开(公告)日：2013-10-01
申请号：US13188642
申请日：2011-07-22
申请人： Dapeng Zhou , Chun Li
发明人： Dapeng Zhou , Chun Li
IPC分类号： A01N43/00 , A61K31/33
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/55555 , A61K2039/57
摘要： A composition for stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells includes a glycolipid antigen and a nanoparticle conjugated with the glycolipid antigen. The glycolipid antigen and the nanoparticle are not antigenic in mouse and human being. The composition can further include covalent or non-covalent connection between the glycolipid antigen and the nanoparticle. The glycolipid antigen is alpha-galactosylceramide or an analog of that. The nanoparticle can be a polymer. A production method of the composition includes preparing a nanoparticle and a glycolipid antigen and loading the glycolipid antigen to the nanoparticle. The glycolipid antigen can be coated onto the surface of the nanoparticle or encapsulated within the nanoparticle. A method of stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells is also provided.
摘要翻译：用于刺激NKT细胞以产生抗癌和抗病毒细胞因子而不引起NKT细胞的无反应性的组合物包括糖脂抗原和与糖脂抗原缀合的纳米颗粒。糖脂抗原和纳米颗粒在小鼠和人中不是抗原性的。组合物还可以包括糖脂抗原和纳米颗粒之间的共价或非共价连接。糖脂抗原是α-半乳糖神经酰胺或其类似物。纳米颗粒可以是聚合物。组合物的制备方法包括制备纳米颗粒和糖脂抗原并将糖脂抗原加载到纳米颗粒中。糖脂抗原可以涂覆在纳米颗粒的表面上或者包封在纳米颗粒内。还提供了刺激NKT细胞以产生抗癌和抗病毒细胞因子而不引起NKT细胞的无反应性的方法。

8. 发明授权

US08071125B2 Transdermal patch containing isosorbide dinitrate and bisoprolol 有权
标题翻译：透皮贴剂含有硝酸异山梨酯和比索洛尔
公开(公告)号：US08071125B2
公开(公告)日：2011-12-06
申请号：US12096545
申请日：2005-12-09
申请人： Shuming Wang , Li Wang , Xiaoling Fan , Huiyong Xue , Shuang Zhang , Enhong Zhang , Xuying Zhong , Yucheng Lu , Chun Li , Li Song
发明人： Shuming Wang , Li Wang , Xiaoling Fan , Huiyong Xue , Shuang Zhang , Enhong Zhang , Xuying Zhong , Yucheng Lu , Chun Li , Li Song
IPC分类号： A61F13/00
CPC分类号： A61K9/7061 , A61K31/138 , A61K31/724
摘要： This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.
摘要翻译：本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化该补丁仅含有硝酸异山梨酯或比索洛尔。

9. 发明申请

US20110071393A1 LOCKING SYRINGE WITH INTEGRATED BIAS MEMBER 失效
标题翻译：具有集成的偏置构件的锁定注入
公开(公告)号：US20110071393A1
公开(公告)日：2011-03-24
申请号：US12563002
申请日：2009-09-18
申请人： Yunxing Liu , Chun Li
发明人： Yunxing Liu , Chun Li
IPC分类号： A61B6/00 , A61M5/315
CPC分类号： A61M5/31501 , A61B6/481 , A61B6/504 , A61M5/007 , A61M5/20 , A61M5/3129 , A61M5/3148 , A61M5/31505 , A61M5/31511 , A61M2005/3139 , A61M2005/31508
摘要： A locking syringe with an integrated bias member, for delivering medical fluids at high pressure, can include a housing, a shaft, a piston, a cap assembly, a bias member, and a locking member. A distal end of the housing can interface with a patient delivery apparatus. The housing includes an internal cavity into which a distal end of the shaft can be inserted. The piston can be connected to the distal end of the shaft and can include a peripheral sealing surface that can slidably engage the inside surface of the housing to form a movable seal. The cap assembly at the proximal end of the housing can engage the shaft. A base cap can secure the piston within the housing. The bias member can have a distal end coupled to the piston and a proximal end restrained, such as to help pressurize the internal cavity. The user-actuatable locking member can user-selectively engage and inhibit unwanted movement of the shaft.
摘要翻译：具有用于在高压下输送医用流体的集成偏压构件的锁定注射器可以包括壳体，轴，活塞，帽组件，偏置构件和锁定构件。壳体的远端可以与患者输送装置接合。壳体包括内腔，轴的远端可以插入其中。活塞可以连接到轴的远端并且可以包括周边密封表面，其可滑动地接合壳体的内表面以形成可移动的密封。在壳体的近端处的帽组件可以接合轴。底盖可以将活塞固定在壳体内。偏置构件可以具有联接到活塞的远端和约束的近端，例如帮助加压内部空腔。用户可致动的锁定构件可以用户选择性地接合并阻止轴的不期望的运动。

10. 发明申请

US20100145838A1 METHOD, SYSTEM, AND APPARATUS FOR OPENING ACCOUNTING DATA CAPABILITIES 审中-公开
标题翻译：开放会计数据能力的方法，系统和设备
公开(公告)号：US20100145838A1
公开(公告)日：2010-06-10
申请号：US12700528
申请日：2010-02-04
申请人： Xin Shi , Mingjun Shan , Chun Li , Jiao Kang , Zhongjie Guo
发明人： Xin Shi , Mingjun Shan , Chun Li , Jiao Kang , Zhongjie Guo
IPC分类号： G06Q30/00 , G06Q10/00
CPC分类号： H04W4/24 , G06Q30/04 , G06Q40/12 , H04L12/14 , H04L12/1403 , H04L12/1467 , H04M15/00 , H04M15/85 , H04M15/851 , H04M15/852 , H04M15/853 , H04M15/854 , H04M2215/815 , H04M2215/8158 , H04M2215/8162 , H04M2215/8166
摘要： A method for opening accounting data capabilities includes: by a unified accounting data management system, receiving a Balance Control Request (BCR) from a charging system, where the BCR carries a request type; performing an accounting data management operation corresponding to the request type; and returning a Balance Control Answer (BCA) to the charging system, where the BCA carries a result of the accounting data management operation. A system for opening accounting data capabilities is also provided. According to the present invention, the accounting data of the user is sharable between the charging systems, and a specific implementation mode for interactions in the accounting data management is provided.
摘要翻译：一种打开会计数据能力的方法包括：通过统一的会计数据管理系统，从计费系统接收平衡控制请求（BCR），其中BCR携带请求类型; 执行与所述请求类型相对应的计费数据管理操作; 并向平衡控制答复（BCA）返回到计费系统，BCA携带会计数据管理操作的结果。还提供了一种打开会计数据功能的系统。根据本发明，用户的计费数据在充电系统之间是可共享的，并且提供了在会计数据管理中的交互的具体实现模式。

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