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21. 发明授权

US07513884B2 Branching catheter systems with diagnostic components 有权
标题翻译：具有诊断部件的分支导管系统
公开(公告)号：US07513884B2
公开(公告)日：2009-04-07
申请号：US11112219
申请日：2005-04-22
申请人： Keith A. Miesel , Justin A. Blanco
发明人： Keith A. Miesel , Justin A. Blanco
IPC分类号： A61M31/00
CPC分类号： A61M25/0021 , A61M5/14276 , A61M5/16813 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0043 , A61M25/0068 , A61M25/0071 , A61M25/0075 , A61M27/006 , A61M2025/0073 , A61M2039/1005 , A61M2205/15 , A61M2206/16
摘要： Branching catheter systems with diagnostic components for detecting and isolating fluid flow problems (e.g., leaks, occlusions, etc.) and methods for detecting and isolating fluid flow problems are disclosed. Among the fluid flow problems that may potentially be detected are leaks in the branching catheter systems (e.g., cuts, disconnected components, etc.). Another fluid flow problem that may be detected using the diagnostic systems of the present invention is the presence of occlusions or other blockages that prevent fluid flow within the catheter systems. In addition to identifying that a problem exists, the diagnostic components may preferably also be used to identify the location of the fluid flow problem as discussed herein. Connectors for use in the branching catheter systems are also disclosed. Among the diagnostic components that may be used in branching catheter systems of the present are valves to control fluid flow through the various sections of the branching catheter system, fluid flow detectors to detect flow through the one or more sections of the branching catheter system and a control system for operating the diagnostic components.
摘要翻译：公开了具有用于检测和分离流体流动问题（例如泄漏，闭塞等）的诊断部件的分支导管系统以及用于检测和分离流体流动问题的方法。在可能潜在检测的流体流动问题中，分支导管系统中的泄漏（例如，切割，断开的部件等）。可以使用本发明的诊断系统检测的另一个流体流动问题是存在妨碍导管系统内的流体流动的闭塞或其它阻塞物。除了确定存在问题之外，诊断部件还可以优选地用于识别本文所讨论的流体流动问题的位置。还公开了用于分支导管系统的连接器。在本发明的分支导管系统中可以使用的诊断部件中的阀是控制通过分支导管系统的各个部分的流体流动的流体流动检测器，用于检测通过分支导管系统的一个或多个部分的流动，以及用于操作诊断部件的控制系统。

22. 发明申请

US20090030263A1 SENSITIVITY ANALYSIS FOR SELECTING THERAPY PARAMETER SETS 审中-公开
公开(公告)号：US20090030263A1
公开(公告)日：2009-01-29
申请号：US12248622
申请日：2008-10-09
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61M21/00 , A61N1/36 , A61M37/00
CPC分类号： A61M5/14276 , A61B3/113 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0488 , A61B5/11 , A61B5/1459 , A61B5/4815 , A61B5/4824 , A61B5/4839 , A61B8/06 , A61B8/12 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/08 , A61N1/36071 , A61N1/36135 , A61N1/36146 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/37241
摘要： Techniques for controlling delivery of a therapy to a patient by a medical device, such as an implantable medical device (IMD), involve a sensitivity analysis of a performance metric. The performance metric may relate to efficacy or side effects of the therapy. For example, the performance metric may comprise a sleep quality metric, an activity level metric, a movement disorder metric for patients with Parkinson's disease, or the like. The sensitivity analysis identifies values of therapy parameters that defines a substantially maximum or minimum value of the performance metric. The identified therapy parameters are a baseline therapy parameter set, and a medical device may control delivery of the therapy based on the baseline therapy parameter set.

23. 发明授权

US07447545B2 Collecting posture information to evaluate therapy 有权
标题翻译：收集姿势信息以评估治疗
公开(公告)号：US07447545B2
公开(公告)日：2008-11-04
申请号：US11081872
申请日：2005-03-16
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/362
CPC分类号： A61N1/36071 , A61B5/103 , A61B5/1116 , A61M5/14276 , A61N1/02 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。识别姿势事件，例如，周期性地确定患者的姿势和/或患者的姿势转换，并且每个确定的姿势事件与当前治疗参数组相关联。基于与该治疗参数组相关联的姿势事件，为多个治疗参数组中的每一个确定至少一个姿势度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。可以根据一个或多个姿势度量值对列表进行排序，以帮助评估治疗参数组。在针对多个姿势度量确定值的情况下，可以根据用户选择的姿势度量中的一个排序列表。

24. 发明授权

US6077227A Method for manufacture and implant of an implantable blood vessel cuff 有权
标题翻译：可植入血管袖口的制造和植入方法
公开(公告)号：US6077227A
公开(公告)日：2000-06-20
申请号：US221547
申请日：1998-12-28
申请人： Keith A. Miesel , Lee Stylos
发明人： Keith A. Miesel , Lee Stylos
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/022 , A61B5/02 , A61B19/00
CPC分类号： A61B5/02152 , A61B5/022 , A61B5/0031 , A61B5/418
摘要： A method for construction ond delivery of a novel implantable medical device provides for use of a kit having sizeable fixture components for holding a blood vessel and a sensor portion connectable during surgery to the appropriately sized fixture.
摘要翻译：用于构建新型可植入医疗装置的递送方法提供使用具有用于保持血管的相当大的固定部件和在手术期间可连接到适当尺寸的夹具的传感器部分的试剂盒。

25. 发明授权

US08731656B2 Closed-loop therapy adjustment 有权
公开(公告)号：US08731656B2
公开(公告)日：2014-05-20
申请号：US13154309
申请日：2011-06-06
申请人： Duane L. Bourget , Keith A. Miesel
发明人： Duane L. Bourget , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61N1/37211 , A61N1/36071 , A61N1/37247 , A61N1/37252 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H40/63
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.

26. 发明授权

US08554325B2 Therapy control based on a patient movement state 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US08554325B2
公开(公告)日：2013-10-08
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

27. 发明授权

US08308661B2 Collecting activity and sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集活动和睡眠质量信息
公开(公告)号：US08308661B2
公开(公告)日：2012-11-13
申请号：US11691425
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/103 , A61B5/117 , A61B5/04
CPC分类号： A61B5/4815 , A61B5/1116 , A61B5/1118 , A61B5/6814 , A61B5/6823 , A61B5/6825 , A61B5/686 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37247 , G06F19/00 , G06F19/3456 , G06F19/3481 , G06Q50/22 , G16H40/63
摘要： A device, such as an implantable medical device (IMD), programming device, or other computing device determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by a medical device.
摘要翻译：诸如可植入医疗设备（IMD），编程设备或其他计算设备的设备确定患者何时尝试睡眠。当设备确定患者正在尝试睡眠时，设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。当设备确定患者没有尝试睡眠时，设备周期性地确定患者的活动水平。活动度量值可以基于所确定的活动水平来确定。临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息，以例如评估由医疗设备递送给患者的治疗的有效性。

28. 发明申请

US20120108998A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20120108998A1
公开(公告)日：2012-05-03
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/048 , A61B5/0482
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

29. 发明申请

US20120053514A1 DRUG INFUSION DEVICE WITH CONTROLLABLE VALVE 有权
标题翻译：具有可控阀的药物输注装置
公开(公告)号：US20120053514A1
公开(公告)日：2012-03-01
申请号：US13217981
申请日：2011-08-25
申请人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
发明人： Reginald D. Robinson , Mary E. Robischon , Bernard Q. Li , Irfan Z. Ali , Steven R. Christenson , Keith A. Miesel
IPC分类号： A61M5/168 , A61M5/158 , A61M39/22
CPC分类号： A61M5/16827 , A61M5/14276 , A61M5/1684 , A61M39/223 , A61M2205/3523 , A61M2205/3569 , A61M2210/1003
摘要： A therapeutic fluid delivery device that includes at least one controllable valve is generally described. In one example, an implantable therapeutic fluid delivery system includes a first fluid pathway configured to convey a first therapeutic fluid and a second fluid pathway configured to convey a second therapeutic fluid, the second fluid pathway being separate from the first fluid pathway. The therapeutic fluid delivery system includes a valve connected to the first fluid pathway and the second fluid pathway, and a processor configured to control actuation of the value to open and close the first fluid pathway and to open and close the second fluid pathway.
摘要翻译：通常描述包括至少一个可控阀的治疗流体输送装置。在一个示例中，可植入治疗流体递送系统包括构造成输送第一治疗流体的第一流体通路和构造成输送第二治疗流体的第二流体通路，第二流体通路与第一流体通路分离。治疗流体递送系统包括连接到第一流体通路和第二流体通路的阀，以及配置成控制该值的致动以打开和关闭第一流体通路并打开和关闭第二流体通路的处理器。

30. 发明申请

US20120022340A1 DETECTING SLEEP TO EVALUATE THERAPY 有权
标题翻译：检测睡眠以评估治疗
公开(公告)号：US20120022340A1
公开(公告)日：2012-01-26
申请号：US13249862
申请日：2011-09-30
申请人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61B5/0476 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/0476 , A61B5/4809 , A61B5/4815 , A61B5/4818 , A61M5/14276 , A61M2005/1726 , A61M2210/0693 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36067 , A61N1/36082 , A61N1/36135 , A61N1/36585 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep. In addition, an electroencephalogram signal may be used to identify sleep states of the patient.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。此外，可以使用脑波信号来识别患者的睡眠状态。

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