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41. 发明申请

US20050139473A1 Electrode for dielectrophoretic apparatus, dielectrophoretic apparatus, method for manufacturing the same, and method for separating substances using the electrode or dielectrophoretic apparatus 审中-公开
标题翻译：介电泳设备用电极，介电泳设备，其制造方法以及使用电极或介电泳设备分离物质的方法
公开(公告)号：US20050139473A1
公开(公告)日：2005-06-30
申请号：US11064828
申请日：2005-02-25
申请人： Masao Washizu , Tomohisa Kawabata
发明人： Masao Washizu , Tomohisa Kawabata
IPC分类号： B03C5/02 , B01D57/02
CPC分类号： B03C5/026
摘要： To provide an electrode for a dielectrophoretic apparatus in which a background detected by reflecting an excited light on an electrode present under the substance (molecule) is reduced and an S/N ratio is enhanced. Also, there is provided an dielectrophoretic apparatus, in an apparatus in which a liquid containing substances to be separated is present in a non-uniform electric field formed by a dielectrophoretic electrode, and separation is carried out by a dielectrophoretic force exerting on the substances, wherein the collecting ability of substances is enhanced. The present invention is characterized in that a vacant space is provided in an electrode whereby substances subjected to influence by a negative dielectrophoretic force can be concentrated in said vacant space of an electrode, or above or below portion of the space.
摘要翻译：提供一种电介质电泳装置的电极，其中通过在物质（分子）下存在的电极上反射激发光而检测到的背景降低，并且提高S / N比。另外，在由介电泳电极形成的不均匀电场中存在含有待分离物质的液体的设备中，提供了介电泳设备，并且通过对该物质施加的介电电泳力进行分离，其中物质的收集能力得到提高。本发明的特征在于，在电极中设置空白空间，由此受到负介电电泳力的影响的物质可以集中在电极的空间空间中，或者在空间的上方或下方。

42. 发明申请

US20040185512A1 Method for detection of carcinoembryonic antigens having a modified sugar chain structure 审中-公开
标题翻译：检测具有修饰的糖链结构的癌胚抗原的方法
公开(公告)号：US20040185512A1
公开(公告)日：2004-09-23
申请号：US10767718
申请日：2004-01-30
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD.
发明人： Hideaki Hosokawa , Kenji Nakamura , Shinji Satomura
IPC分类号： G01N033/574 , C07K016/30
CPC分类号： G01N33/57473 , G01N2400/02
摘要： The present invention relates to a method for detection of carcinoembryonic antigens (hereinafter abbreviated as CEAs) having a modified sugar chain structure which comprises using an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs, a method for detecting a cancer which comprises using an amount of CEAs having a modified sugar chain structure and a kit for detection of CEAs having a modified sugar chain structure which comprises an antibody against a constant region of CEAs and a protein capable of recognizing a modified sugar chain structure of CEAs. Said method and kit are useful in a separately measurement of the various CEAs, a detection of a cancer and a definition of the kind of a cancer, and, for example, by using in proper combination of the measurement value of various CEAs obtained by the method of the present invention, it becomes possible to detect the cancer or define the kind of the cancer.
摘要翻译：本发明涉及一种检测具有修饰的糖链结构的癌胚抗原（以下简称为CEA）的方法，其包括使用针对恒定区的CEA的抗体和能够识别CEA的修饰的糖链结构的蛋白质，用于检测癌症的方法，其包括使用一定量的具有修饰的糖链结构的CEA和用于检测具有修饰的糖链结构的CEA的试剂盒，其包含针对恒定区的CEA的抗体和能够识别修饰的糖的蛋白质 CEAs的链结构。所述方法和试剂盒可用于各种CEA的单独测量，癌症的检测和癌症种类的定义，并且例如通过以下方式适当地组合各种CEAs的测量值：本发明的方法，可以检测癌症或确定癌症的种类。

43. 发明申请

US20020162991A1 Process for producing 9,10-diphenylanthracene 失效
标题翻译：制备9,10-二苯基蒽的方法
公开(公告)号：US20020162991A1
公开(公告)日：2002-11-07
申请号：US09788550
申请日：2001-02-21
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD.
发明人： Kuniaki Okamoto , Tomimasa Kurita , Atsunori Sano
IPC分类号： G03C001/00
CPC分类号： C07C1/327 , C07C1/321 , C07C1/325 , C07C1/326 , C07C1/328 , C07C2603/24 , C07C15/28
摘要： 9,10-Diphenylanthracene, which can be produced applicably for industrial use in one or two process steps by subjecting a 9,10-dihalogenoanthracene and a metal or half-metal phenyl compound to a cross-coupling reaction.
摘要翻译： 9,10-二苯基蒽，其可通过使9,10-二卤代蒽和金属或半金属苯基化合物进行交叉偶联反应而在一个或两个工艺步骤中适用于工业应用。

44. 发明申请

US20010020088A1 Method for separation of isomers of azo compounds 失效
标题翻译：分离偶氮化合物异构体的方法
公开(公告)号：US20010020088A1
公开(公告)日：2001-09-06
申请号：US09756652
申请日：2001-01-10
申请人： Wako Pure Chemical Industries, Ltd.,
发明人： Toshiyasu Ito
IPC分类号： C07C245/14
CPC分类号： C07C253/34 , C07C255/65
摘要： A method for separation of a racemic isomer and a meso isomer from a mixture of a racemic isomer and a meso isomer of a compound shown by the general formula null1null 1 (wherein R1 and R2 are each independently a lower alkyl group or a cyano group, which are different from each other, R3 and R4 are each independently a lower alkyl group, and R5 is a hydrogen atom or a lower alkoxy group), which comprises treating the mixture with a water soluble organic solvent.
摘要翻译：由通式[1]表示的化合物的外消旋异构体和内消旋异构体的混合物分离外消旋异构体和内消旋异构体的方法（其中，R 1和R 2各自独立地为低级烷基或氰基它们彼此不同，R3和R4各自独立地为低级烷基，R5为氢原子或低级烷氧基），其包括用水溶性有机溶剂处理该混合物。

45. 发明授权

US6149818A Method for separating components in liquid specimen and apparatus used in said method 失效
标题翻译：用于分离液体试样中的组分的方法和用于所述方法的装置
公开(公告)号：US6149818A
公开(公告)日：2000-11-21
申请号：US386149
申请日：1999-08-31
申请人： Kenji Nakamura , Shinji Satomura , Masayoshi Hayashi , Hideyoshi Arashima , Tetsushi Okuyama , Nobuhiro Hanafusa , Koji Tanimizu
发明人： Kenji Nakamura , Shinji Satomura , Masayoshi Hayashi , Hideyoshi Arashima , Tetsushi Okuyama , Nobuhiro Hanafusa , Koji Tanimizu
IPC分类号： B01D15/08 , G01N30/16 , G01N30/24 , G01N30/40 , G01N30/88
CPC分类号： G01N30/40 , B01D15/1807 , B01D15/14 , G01N2030/402 , G01N2030/407 , G01N30/16 , G01N30/24 , G01N30/88
摘要： The object of the present invention is to provide a method for separating components in a liquid specimen and an apparatus used in said method, by which it is possible to avoid carryover even when the specimen injector is not washed using washing solution and also to avoid the increase of inner pressure in column of the separation device or ineffective separating operation even when many liquid specimens are separated by many times using the same separation device. In the present invention, the liquid specimen is introduced into the separation device from a direction opposite to eluting direction of the separation device which retains an adsorbent, and by separating and eluting the specimen from eluting outlet together with the eluant, trace quantity of insoluble substances and the specimen remained on the specimen introducing passage can be removed by elution procedure. As a result, it is possible to avoid carryover, to prevent the increase of inner pressure in the column of the separation device and to prevent ineffective separating operation caused by clogging of the column.
摘要翻译：本发明的目的是提供一种用于分离液体试样中的组分和所述方法中使用的装置的方法，即使当使用洗涤溶液不洗涤试样注射器时也可以避免携带，并且避免即使使用相同的分离装置多次分离多个液体样品，分离装置的塔内部压力增加或分离操作无效。在本发明中，将液体试样从与保留吸附剂的分离装置的洗脱方向相反的方向引入分离装置，通过从洗脱液与洗脱液一起分离和洗脱试样，追踪微量的不溶物残留在样品导入通道上的样品可以通过洗脱程序除去。结果，可以避免残留，以防止分离装置的塔中的内压增加，并且防止由于柱的堵塞而导致的无效的分离操作。

46. 发明授权

US6143472A Resist composition and a method for formation of a pattern using the composition 失效
标题翻译：抗蚀剂组合物和使用该组合物形成图案的方法
公开(公告)号：US6143472A
公开(公告)日：2000-11-07
申请号：US195236
申请日：1998-11-18
申请人： Motoshige Sumino , Akiko Katsuyama
发明人： Motoshige Sumino , Akiko Katsuyama
IPC分类号： G03F7/004 , G03F7/039
CPC分类号： G03F7/039 , G03F7/0045
摘要： This invention relates to a resist composition comprising a polymer containing, as a constituent unit, a monomer unit shown by the general formula [1a] ##STR1## (wherein X is a polycyclic hydrocarbon residue which may have a substituent, Z is a spacer or a direct bond, and R is a substituted alkyl or alkenyl group having one or two protected hydroxyl groups as substituent), a photosensitive compound which can generate an acid upon exposure to light and a solvent which can dissolve the polymer and the photosensitive compound, and a method for formation of a pattern using the said resist composition.The said resist composition shows high sensitivity and high resolution ability in which a polymer having high transmittance against deep-ultraviolet lights having a wavelength of 220 nm or less, particularly ArF excimer laser beams. The said resist composition can remarkably advantageously be used as a resist material for ArF excimer laser beams which has been considered to be a valuable technology for exposure belonging to the coming generation.
摘要翻译：本发明涉及一种抗蚀剂组合物，其包含含有由通式[1a]所示的单体单元作为构成单元的聚合物（其中X为可以具有取代基的多环烃残基，Z为间隔基或直接键 R为具有1个或2个被保护的羟基作为取代基的取代的烷基或链烯基），能够在光照下产生酸的光敏化合物和溶解聚合物和感光性化合物的溶剂，以及使用所述抗蚀剂组合物形成图案。所述抗蚀剂组合物显示出高灵敏度和高分辨能力，其中对波长为220nm以下的深紫外光具有高透射率的聚合物，特别是ArF准分子激光束。所述抗蚀剂组合物可以显着有利地用作用于ArF准分子激光束的抗蚀剂材料，其被认为是属于下一代的有意义的曝光技术。

47. 发明授权

US5925534A Method for measuring LDL-cholesterol 失效
标题翻译： LDL胆固醇测定方法
公开(公告)号：US5925534A
公开(公告)日：1999-07-20
申请号：US128930
申请日：1998-08-05
申请人： Yutaka Miki , Isao Koyama , Nobuko Imajo , Masayuki Futatsugi , Toshiro Hanada
发明人： Yutaka Miki , Isao Koyama , Nobuko Imajo , Masayuki Futatsugi , Toshiro Hanada
IPC分类号： G01N33/48 , C12Q1/32 , C12Q1/60 , C12Q1/00
CPC分类号： C12Q1/60 , C12Q1/32
摘要： The amount of cholesterol in low density lipoproteins in a sample can be measured by contacting the sample with one or more reagent solutions to carry out the reaction in the presence of a polyanion and an amphoteric surfactant, followed by optical measurement of the reaction product.
摘要翻译：样品中低密度脂蛋白中胆固醇的量可以通过使样品与一种或多种试剂溶液接触来测量，以在聚阴离子和两性表面活性剂存在下进行反应，随后光学测量反应产物。

48. 发明授权

US5885788A Method for measuring an amount of LDL-Cholesterol 失效
标题翻译：测定LDL-胆固醇含量的方法
公开(公告)号：US5885788A
公开(公告)日：1999-03-23
申请号：US897954
申请日：1997-07-24
申请人： Yutaka Miki , Nobuko Imajo , Toshiro Hanada
发明人： Yutaka Miki , Nobuko Imajo , Toshiro Hanada
IPC分类号： G01N33/92 , C12Q1/26 , C12Q1/00 , C12Q1/28 , C12Q1/44
CPC分类号： G01N33/92 , G01N2800/044 , Y10S435/975
摘要： The present invention is to provide a method for measuring an amount of cholesterol in low density lipoproteins (LDL-cholesterol) in a sample specifically at high accuracy and a reagent used in this method, and the present invention can attain such effect that direct measuring an amount of LDL-cholesterol by widely used automatic analyzers can be conducted by using the invention, which has not been possible after known methods.
摘要翻译：本发明提供一种以高精度测定样品中低密度脂蛋白（LDL-胆固醇）的胆固醇含量的方法和该方法中使用的试剂，本发明可以获得直接测定通过广泛使用的自动分析仪的LDL-胆固醇的量可以通过使用本发明进行，这在现有方法之后是不可能的。

49. 发明授权

US5677194A Process for rapid measurement of trace components 失效
标题翻译：快速测量微量元素的过程
公开(公告)号：US5677194A
公开(公告)日：1997-10-14
申请号：US309967
申请日：1994-09-20
申请人： Shinji Satomura , Hideo Katoh , Kenji Nakamura , Kazunari Hirayasu
发明人： Shinji Satomura , Hideo Katoh , Kenji Nakamura , Kazunari Hirayasu
IPC分类号： G01N33/537 , G01N33/538 , G01N33/53 , G01N33/536
CPC分类号： G01N33/538 , Y10S436/805 , Y10S436/824 , Y10S436/827
摘要： Trace components in samples can be measured rapidly with high precision by applying interaction between an analyte to be measured and an affinity substance and using a membrane having specific separating capability.
摘要翻译：样品中的痕量组分可以通过应用待测分析物和亲和物质之间的相互作用并使用具有特定分离能力的膜，以高精度快速测量。

50. 发明授权

US5677112A Process for forming a pattern on a semiconductor substrate using a deep ultraviolet absorbent composition 失效
标题翻译：使用深紫外线吸收剂组合物在半导体衬底上形成图案的工艺
公开(公告)号：US5677112A
公开(公告)日：1997-10-14
申请号：US687989
申请日：1996-07-29
申请人： Fumiyoshi Urano , Keiji Oono , Hiroshi Matsuda , Masayuki Endo , Satoshi Kobayashi
发明人： Fumiyoshi Urano , Keiji Oono , Hiroshi Matsuda , Masayuki Endo , Satoshi Kobayashi
IPC分类号： C07C309/75 , G03F7/09 , G03C5/00
CPC分类号： C07C309/75 , G03F7/091
摘要： A deep ultraviolet absorbent comprising at least one compound having one or more glycidyl groups in the molecule and at least one anthracene derivative, and a solvent capable of dissolving these compounds is effective for preventing reflection of deep ultraviolet light from a substrate during formation of resist pattern, resulting in forming ultra-fine patterns without causing notching and halation.
摘要翻译：包含至少一种在分子中具有一个或多个缩水甘油基的化合物和至少一种蒽衍生物和能够溶解这些化合物的溶剂的深紫外线吸收剂在形成抗蚀剂图案期间有效地防止来自基板的深紫外光的反射，导致形成超细图案而不引起开槽和停止。

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