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1. 发明授权

US11369660B2 Method of treating cancer with an HLA-B57 open conformer 有权
公开(公告)号：US11369660B2
公开(公告)日：2022-06-28
申请号：US16083508
申请日：2017-03-07
申请人： UNIVERSITAT ZURICH , UNIVERSITAT BASEL
发明人： Osiris Marroquin Belaunzaran , Ulf Petrausch , Christoph Renner
IPC分类号： A61K38/17 , C07K14/74 , A61P37/02 , A61P35/00
摘要： The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents.
Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

2. 发明申请

US20210045690A1 NEURAL PROBE FOR ELECTROSTIMULATION OR RECORDING AND FABRICATION PROCESS FOR SUCH A PROBE 有权
公开(公告)号：US20210045690A1
公开(公告)日：2021-02-18
申请号：US16976917
申请日：2019-03-01
申请人： Universitat Basel Vizerektorat Forschung
发明人： Bekim OSMANI , Tino TOPPER , Bert MUELLER , Per Magnus KRISTIANSEN , Helmut SCHIFT
IPC分类号： A61B5/00 , H01B1/12 , A61B5/04 , A61N1/05 , A61N1/375
摘要： For improving the electroactivity and long-term stability of a neural interface, a novel neural probe (1) is proposed that is formed from a fiber (6), preferably by thermal imprinting, and wherein a polymer thin film (5) is employed for carrying a conducting thin film to be used as a recording or stimulation electrode (4). Due to this specific choice of materials and design, the electrode (4) is rendered compliant with respect to the fiber (6) on a nanometer to micrometer scale and offers a surface that is tailor-made for adhering to nervous tissue.

3. 发明授权

US09971000B2 Simple microwave field imaging device 有权
公开(公告)号：US09971000B2
公开(公告)日：2018-05-15
申请号：US14387256
申请日：2013-03-23
申请人： UNIVERSITAT BASEL
发明人： Pascal Bohi , Max F. Riedel , Theodor W. Hansch , Philipp Treutlein
IPC分类号： G01V3/00 , G01R33/32 , G01R33/10 , G01R33/12 , G01R33/48
CPC分类号： G01R33/323 , G01R33/10 , G01R33/1284 , G01R33/48
摘要： A device for sensing a microwave magnetic field polarization component (B−, Bπ, B+) of a microwave relative to a static magnetic field B0, comprising a preparation means to prepare atomic vapor (10) comprising thermal atoms in a first hyperfine state, particularly a dark state to applied laser light, which first hyperfine state is split from other hyperfine state due to zero-field hyperfine splitting and/or due to a static magnetic field (B0) generated by preparation means, at least one cell enclosing the thermal atoms (10), the microwave is adapted to drive Rabi oscillations of thermal atoms between first hyperfine state and second hyperfine state, Rabi frequency of Rabi oscillations being proportional to magnetic field polarization component (B−, Bπ, B+) of the microwave, and imaging means to capture state image of plurality of atoms representing spatial atomic density distribution (Ne) as a function of the Rabi frequency (Ωi(r)) of Rabi oscillations.

4. 发明申请

US20170299570A1 METHOD FOR PREDICTING CANCER PROGRESSION BY NANOMECHANICAL PROFILING 审中-公开
公开(公告)号：US20170299570A1
公开(公告)日：2017-10-19
申请号：US15516404
申请日：2015-10-05
申请人： UNIVERSITAT BASEL
发明人： Marko LOPARIC , Marija PLODINEC , Ellen OBERMANN , Christian RAEZ
IPC分类号： G01N33/483 , G01Q60/36
CPC分类号： G01N33/4833 , G01N2800/56 , G01N2800/7028 , G01Q60/366
摘要： The invention relates to a method for staging metastatic potential of a primary tumour sample or related lymph node by nanomechanical measurement and/or for determing the reoccurrence or incidence potential.

5. 发明申请

US20150369838A1 METHOD AND DEVICE FOR CONTROLLING A SCANNING PROBE MICROSCOPE 有权
标题翻译：用于控制扫描探针显微镜的方法和装置
公开(公告)号：US20150369838A1
公开(公告)日：2015-12-24
申请号：US14651233
申请日：2013-12-12
申请人： UNIVERSITÄT BASEL
发明人： Roderick LIM , Marija PLODINEC , Marko LOPARIC , Pascal OEHLER , Leon CAMENZIND
IPC分类号： G01Q20/00 , G01Q10/00
CPC分类号： G01Q20/00 , G01Q10/00 , G01Q10/065 , G01Q30/06
摘要： The present invention relates to a method for controlling a scanning probe microscope having a probe (2) with a tip (21) for interacting with a sample (4), and a nanoscanner (1) for retaining the sample (4) or the probe (2), comprising the steps of monitoring the extension of the piezo element (1) along a first direction (R) along which the tip (21) is moved towards the sample (4), and adjusting the level of the probe (2) along the first direction (R) by means of an additional actuator (3), when the nanoscanner (1) exhibits an extension below or above a threshold value. The invention further relates to a device (100) for controlling a scanning probe microscope.
摘要翻译：本发明涉及一种用于控制扫描探针显微镜的方法，所述扫描探针显微镜具有带有用于与样品（4）相互作用的尖端（21）的探针（2）和用于保持样品（4）或探针（2），包括以下步骤：沿尖端（21）朝向样品（4）移动的第一方向（R）监测压电元件（1）的延伸，并且调节探针（2）的水平）当所述纳米扫描仪（1）展现出低于或高于阈值的延伸时，通过附加致动器（3）沿所述第一方向（R）。本发明还涉及一种用于控制扫描探针显微镜的装置（100）。

6. 发明申请

US20150048824A1 SIMPLE MICROWAVE FIELD IMAGING DEVICE 有权
标题翻译：简单的微波场成像装置
公开(公告)号：US20150048824A1
公开(公告)日：2015-02-19
申请号：US14387256
申请日：2013-03-23
申请人： UNIVERSITAT BASEL
发明人： Pascal Bohi , Max F. Riedel , Theodor W. Hansch , Philipp Treutlein
IPC分类号： G01R33/32 , G01R33/48
CPC分类号： G01R33/323 , G01R33/10 , G01R33/1284 , G01R33/48
摘要： The invention relates to a device for sensing a microwave magnetic field polarization component (B−, Bπ, B+,) of a microwave relative to a static magnetic field B0, comprising: a preparation means being designed to prepare an atomic vapor (10) comprising a plurality of thermal atoms in a first hyperfine state, particularly a dark state to applied laser light, which first hyperfine state is split from at least one other hyperfine state due to the zero-field hyperfine splitting and/or due to a static magnetic field (B0) generated by said preparation means, at least one cell (1) enclosing said plurality of thermal atoms (10), wherein said microwave is adapted to drive Rabi oscillations of said plurality of thermal atoms between said first hyperfine state and a second hyperfine state, the Rabi frequency of said Rabi oscillations being proportional to said magnetic field polarization component (B−, Bπ, B+) of said microwave, and an imaging means being designed to capture a state image of said plurality of atoms representing the spatial atomic density distribution (Ne) being a function of the Rabi frequency (Ωi(r)) of said Rabi oscillations. Further, the invention relates to a method for sensing a microwave field.
摘要翻译：本发明涉及一种用于感测微波相对于静态磁场B0的微波磁场偏振分量（B-，B＆Pgr，B +））的装置，包括：制备装置，其被设计成制备原子蒸气（10）包括第一超精细状态的多个热原子，特别是施加激光的暗状态，由于零场超精细分裂和/或由于静态磁场，第一超精细状态从至少一个其他超精细状态分裂由所述制备装置产生的场（B0），包围所述多个热原子（10）的至少一个电池（1），其中所述微波适于驱动所述多个热原子的Rabi振荡在所述第一超精细状态和第二超精细状态之间所述超精细状态，所述Rabi振荡的Rabi频率与所述微波的所述磁场偏振分量（B-，B＆Pgr，B +）成比例，并且成像装置被设计成捕获状态代表所述Rabi振荡的Rabi频率（＆OHgr; i（r））的函数的表示空间原子密度分布（Ne）的所述多个原子的图像。此外，本发明涉及一种用于感测微波场的方法。

7. 发明申请

US20220185865A1 MHC CLASS IA OPEN CONFORMERS 有权
公开(公告)号：US20220185865A1
公开(公告)日：2022-06-16
申请号：US17687732
申请日：2022-03-07
申请人： UNIVERSITAT ZURICH , UNIVERSITAT BASEL
发明人： Osiris MARROQUIN BELAUNZARAN , Christoph RENNER
IPC分类号： C07K14/74 , A61K39/395 , A61K48/00 , A61P31/22 , A61P31/18 , A61P31/16 , A61P35/00
摘要： The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors.
Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.

8. 发明申请

US20170007328A1 CONTROLLING A SURGICAL INTERVENTION TO A BONE 审中-公开
标题翻译：控制骨科手术干预
公开(公告)号：US20170007328A1
公开(公告)日：2017-01-12
申请号：US15113636
申请日：2015-01-30
申请人： UNIVERSITÄT BASEL , UNIVERSITÄTSSPITAL BASEL
发明人： Philippe Cattin , Gregory Jost , Jonas Walti
IPC分类号： A61B34/10 , G05B15/02 , A61B34/20
CPC分类号： A61B34/10 , A61B34/20 , A61B2017/00221 , A61B2017/564 , A61B2034/107 , A61B2034/2048 , A61B2034/2068 , A61B2090/364 , G05B15/02
摘要： A method of controlling a surgical intervention to a bone (31) comprises: obtaining a three-dimensional image or multiplanar reconstruction of the bone (31), defining a position and an axis of intervention on the three-dimensional image or multi-planar reconstruction of the bone (31), and controlling the orientation of an intervention instrument (1) equipped with an orientation sensor (2) during the surgical intervention by evaluating a signal provided by the orientation sensor (2). The method further comprises referencing the intervention instrument (1) with respect to the bone (31) before the surgical intervention by arranging the intervention instrument (1) along an anatomic landmark (32) being an edge of the bone (31) and rotating the orientation sensor (2) into a predefined position, or by arranging the intervention instrument (1) essentially perpendicular to an anatomic landmark (32) being an essentially flat surface of the bone (31) and rotating the orientation sensor (2) into a predefined position. The method according to the invention allows for efficiently achieving correct orientation and position of the intervention instrument in a bone surgical intervention. Furthermore, the method according to the invention provides an efficient real-time control at comparably low efforts. Still further, with the method according to the invention radiation exposure to the operational staff as well as patients can be reduced.
摘要翻译：控制对骨骼（31）的外科手术的方法包括：获得骨骼（31）的三维图像或多平面重建，在三维图像或多平面重建上定义干涉的位置和轴线，并且通过评估由所述取向传感器（2）提供的信号来控制在手术介入期间配备有方位传感器（2）的介入器械（1）的取向。该方法还包括通过沿着作为骨骼（31）的边缘的解剖标志（32）布置介入器械（1），在外科手术之前相对于骨头（31）参考介入器械（1）或者通过将干涉仪器（1）基本上垂直于作为骨骼（31）的基本上平坦的表面的解剖学标记（32）布置并将定向传感器（2）旋转到预定义的位置位置。根据本发明的方法允许在骨手术介入中有效地实现干预器械的正确取向和位置。此外，根据本发明的方法在相当低的努力下提供了有效的实时控制。此外，根据本发明的方法，可以减少对操作人员以及患者的辐射照射。

9. 发明授权

US09244095B2 Method and device for controlling a scanning probe microscope 有权
公开(公告)号：US09244095B2
公开(公告)日：2016-01-26
申请号：US14364309
申请日：2012-12-12
申请人： UNIVERSITAT BASEL
发明人： Marija Plodinec , Marko Loparic , Roderick Y H Lim
IPC分类号： G01Q10/00 , G01Q10/06 , B82Y35/00
CPC分类号： G01Q10/06 , B82Y35/00 , G01Q10/065
摘要： The present invention relates to a method for controlling a scanning probe microscope having a probe (2) with a tip (21) for interacting with a sample (4), and a nanoscanner (1) for retaining the sample (4) or the probe (2), comprising the steps of monitoring the extension of the piezo element (1) along a first direction (R) along which the tip (21) is moved towards the sample (4), and adjusting the level of the probe (2) along the first direction (R) by means of an additional actuator (3), when the nanoscanner (1) exhibits an extension below or above a threshold value. The invention further relates to a device (100) for controlling a scanning probe microscope.

10. 发明授权

US08993587B2 Combination of syrosingopine and mitochondrial inhibitors for the treatment of cancer and immunosuppression 有权
标题翻译：联合辛伐他汀和线粒体抑制剂治疗癌症和免疫抑制
公开(公告)号：US08993587B2
公开(公告)日：2015-03-31
申请号：US13977811
申请日：2012-01-09
申请人： Don Benjamin , Marco Colombi , Michael Hall , Christoph Moroni
发明人： Don Benjamin , Marco Colombi , Michael Hall , Christoph Moroni
IPC分类号： A61K45/06 , A61K31/155 , A61K31/35 , A61K31/4375 , A61K31/4745 , A61K31/625 , A61K31/7072 , A61K31/365
CPC分类号： A61K31/475 , A61K31/155 , A61K31/35 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/625 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The invention relates to a combination of syrosingopine and a mitochondrial inhibitor, e.g. metformin or oligomycin, and the use of the combination of syrosingopine and a mitochondrial inhibitor for the treatment of cancer and for achieving immunosuppression. The invention also relates to a fluorescence-based method for predicting syrosingopine sensitivity of a cancer cell.
摘要翻译：本发明涉及番茄红素与线粒体抑制剂的组合，例如二甲双胍或寡霉素，以及使用赛罗宁和线粒体抑制剂的组合来治疗癌症和实现免疫抑制。本发明还涉及一种用于预测癌细胞的辛格品素敏感性的基于荧光的方法。

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