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1. 发明授权

US08053477B2 Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same 有权
标题翻译： S100-p53蛋白相互作用的抑制剂和抑制癌症的方法相同
公开(公告)号：US08053477B2
公开(公告)日：2011-11-08
申请号：US10397239
申请日：2003-03-27
申请人： David J. Weber , Joseph Markowitz , France Carrier , Alexander D. MacKerell
发明人： David J. Weber , Joseph Markowitz , France Carrier , Alexander D. MacKerell
IPC分类号： A01N37/52 , A01N31/14 , A61K31/155 , A61K31/075 , G01N33/53
CPC分类号： G01N33/5011 , A61K31/00 , A61K31/12 , A61K31/13 , A61K31/15 , A61K31/155 , A61K31/17 , A61K31/185 , A61K31/27 , A61K31/341 , A61K31/4035 , A61K31/4152 , A61K31/435 , A61K31/4425 , A61K31/47 , A61K31/53 , A61K31/553 , A61K31/635
摘要： Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor suppressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.
摘要翻译：公开了结合S100并抑制S100-p53蛋白质相互作用并激活p53的肿瘤抑制活性，因此具有抗肿瘤作用的化合物，以及鉴定这些化合物的方法，包含它们的组合物和包含其的方法使用它来治疗癌症。

2. 发明申请

US20080181284A1 Hybrid Zero-IF Receiver 有权
标题翻译：混合零中频接收机
公开(公告)号：US20080181284A1
公开(公告)日：2008-07-31
申请号：US12016955
申请日：2008-01-18
申请人： Paul J. Husted , Shahram Abdollahi-Alibeik , David J. Weber , Soner Ozgur
发明人： Paul J. Husted , Shahram Abdollahi-Alibeik , David J. Weber , Soner Ozgur
IPC分类号： H04B1/69
CPC分类号： H04B1/30
摘要： An apparatus for processing a Bluetooth signal advantageously mixes down a received RF signal to an IF signal wherein one band-edge of the spectrum of the IF signal may be approximately 0 Hz. In one embodiment, the IF signal may be digitized, decimated and filtered before being processed into a baseband signal. The baseband signal may be processed by a cordic (COordinate Rotation DIgital Computer) processor to transform the baseband signal from rectangular to polar coordinates. A phase signal from the cordic processor may be used to determine transmitted Bluetooth data symbols. The apparatus may advantageously use less area than traditional Bluetooth receivers.
摘要翻译：用于处理蓝牙信号的装置有利地将所接收的RF信号与IF信号相混合，其中IF信号的频谱的一个带边可以为大约0Hz。在一个实施例中，IF信号可以在被处理成基带信号之前被数字化，抽取和滤波。基带信号可以由Cordic（Coordinate Rotation DIgital Computer）处理器处理，以将基带信号从矩形变换为极坐标。可以使用来自Cordic处理器的相位信号来确定所发送的蓝牙数据符号。该装置可以有利地使用比传统蓝牙接收机更少的面积。

3. 发明授权

US06850117B2 CMOS transceiver having an integrated power amplifier 有权
标题翻译： CMOS收发器具有集成功率放大器
公开(公告)号：US06850117B2
公开(公告)日：2005-02-01
申请号：US10338585
申请日：2003-01-07
申请人： David J. Weber , Patrick Yue , David Su
发明人： David J. Weber , Patrick Yue , David Su
IPC分类号： H01L23/66 , H01L27/088 , H03F1/22 , H03F1/52 , H03F3/195 , H03F3/24 , H03F3/45 , H04B1/04 , H03F3/16
CPC分类号： H01L24/06 , H01L23/66 , H01L24/48 , H01L24/49 , H01L27/088 , H01L2223/6644 , H01L2224/05554 , H01L2224/48247 , H01L2224/48257 , H01L2224/4911 , H01L2224/49171 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01023 , H01L2924/01031 , H01L2924/01051 , H01L2924/01052 , H01L2924/10329 , H01L2924/1305 , H01L2924/13091 , H01L2924/14 , H01L2924/19041 , H01L2924/19042 , H01L2924/19107 , H01L2924/30105 , H01L2924/30107 , H01L2924/3025 , H03F1/223 , H03F3/24 , H03F3/45188 , H03F2200/06 , H03F2203/45638 , H03F2203/45652 , H04B2001/0408 , Y10S977/724 , H01L2924/00 , H01L2224/45099
摘要： The present invention provides a breakdown resistant transistor structure for amplifying communication signals. This structure includes a first NMOS transistor having a source connected to ground and a first gate for receiving the input radio frequency signal. The first gate is disposed above a first insulator and the first NMOS transistor having a first transconductance and a first breakdown voltage associated therewith. Also included is a second NMOS transistor having a source connected to the drain of the first NMOS transistor, a gate connected to the reference DC voltage, and a drain that provides the output for the amplified radio signal, the load being disposed between the reference DC voltage and the drain of the second NMOS transistor. The second gate is disposed above a second insulator, the second NMOS transistor has a second transconductance and a second breakdown voltage associated therewith, and the second insulator may be thicker than the first insulator. This results in the first transconductance being greater than the second transconductance, and the second breakdown voltage being greater than the first breakdown voltage.
摘要翻译：本发明提供一种用于放大通信信号的耐击穿晶体管结构。该结构包括具有连接到地的源极的第一NMOS晶体管和用于接收输入射频信号的第一栅极。第一栅极设置在第一绝缘体之上，并且第一NMOS晶体管具有与之相关联的第一跨导和第一击穿电压。还包括第二NMOS晶体管，其源极连接到第一NMOS晶体管的漏极，连接到参考DC电压的栅极和为放大的无线电信号提供输出的漏极，负载被布置在参考DC 电压和第二NMOS晶体管的漏极。第二栅极设置在第二绝缘体上方，第二NMOS晶体管具有与之相关联的第二跨导和第二击穿电压，并且第二绝缘体可以比第一绝缘体厚。这导致第一跨导大于第二跨导，并且第二击穿电压大于第一击穿电压。

4. 发明授权

US06504431B2 CMOS transceiver having an integrated power amplifier 有权
公开(公告)号：US06504431B2
公开(公告)日：2003-01-07
申请号：US10109412
申请日：2002-03-26
申请人： David J. Weber , Patrick Yue , David Su
发明人： David J. Weber , Patrick Yue , David Su
IPC分类号： H03F345
CPC分类号： H01L24/06 , H01L23/66 , H01L24/48 , H01L24/49 , H01L27/088 , H01L2223/6644 , H01L2224/05554 , H01L2224/48247 , H01L2224/48257 , H01L2224/4911 , H01L2224/49171 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01023 , H01L2924/01031 , H01L2924/01051 , H01L2924/01052 , H01L2924/10329 , H01L2924/1305 , H01L2924/13091 , H01L2924/14 , H01L2924/19041 , H01L2924/19042 , H01L2924/19107 , H01L2924/30105 , H01L2924/30107 , H01L2924/3025 , H03F1/223 , H03F3/24 , H03F3/45188 , H03F2200/06 , H03F2203/45638 , H03F2203/45652 , H04B2001/0408 , Y10S977/724 , H01L2924/00 , H01L2224/45099
摘要： The present invention provides a breakdown resistant transistor structure for amplifying communication signals. This structure includes a first NMOS transistor having a source connected to ground and a first gate for receiving the input radio frequency signal. The first gate is disposed above a first insulator and the first NMOS transistor having a first transconductance and a first breakdown voltage associated therewith. Also included is a second NMOS transistor having a source connected to the drain of the first NMOS transistor, a gate connected to the reference DC voltage, and a drain that provides the output for the amplified radio signal, the load being disposed between the reference DC voltage and the drain of the second NMOS transistor. The second gate is disposed above a second insulator, the second NMOS transistor has a second transconductance and a second breakdown voltage associated therewith, and the second insulator may be thicker than the first insulator. This results in the first transconductance being greater than the second transconductance, and the second breakdown voltage being greater than the first breakdown voltage.

5. 外观设计

USD354658S Container for crackers 失效
公开(公告)号：USD354658S
公开(公告)日：1995-01-24
申请号：US10224
申请日：1993-07-02
申请人： Karen S. Weber , David J. Weber
设计人： Karen S. Weber , David J. Weber

6. 发明授权

US08532588B1 Apparatus for signal power loss reduction in RF communication systems 有权
标题翻译： RF通信系统信号功率损耗降低的装置
公开(公告)号：US08532588B1
公开(公告)日：2013-09-10
申请号：US11690784
申请日：2007-03-23
申请人： David J. Weber , Manolis Terrovitis , David K. Su
发明人： David J. Weber , Manolis Terrovitis , David K. Su
IPC分类号： H04B1/02
CPC分类号： H04B7/0814 , H04B7/0608 , Y02D70/444
摘要： Redundancies of power amplifiers (PAs) or low noise amplifiers (LNAs) at the front end of an RF device are used to reduce losses that typically occur at a diversity switch. A signal designator can advantageously be used to select designated signals, which are provided to the PAs for transmitting or provided by the LNAs during receiving.
摘要翻译：在RF设备前端的功率放大器（PA）或低噪声放大器（LNA）的冗余被用于减少通常在分集开关处发生的损耗。信号指示符可以有利地用于选择提供给PA的指定信号，用于在接收期间由LNA发送或提供。

7. 发明授权

US08498589B2 Polar modulator with path delay compensation 失效
标题翻译：具有路径延迟补偿的极调制器
公开(公告)号：US08498589B2
公开(公告)日：2013-07-30
申请号：US12172375
申请日：2008-07-14
申请人： Paul J. Husted , William W. Si , David J. Weber , Xiaoru Zhang
发明人： Paul J. Husted , William W. Si , David J. Weber , Xiaoru Zhang
IPC分类号： H04B1/66
CPC分类号： H03C5/00 , H04B2001/0491
摘要： A modulation system comprising a signal processing unit and a modulator. The signal processing unit may generate a low frequency modulator signal, a high frequency modulator signal, and a modulator amplitude control signal. The modulator may generate a modulated signal for transmission via a wireless network based, at least in part, on the low frequency modulator signal, the high frequency modulator signal, and the modulator amplitude control signal. The signal processing unit comprises a delay compensation unit for delaying the generation of the high frequency modulator signal and the modulator amplitude control signal based, at least in part, on signal generation and modulation path delays associated with the low frequency modulator signal to substantially align the modulator signals at the output of the modulation system.
摘要翻译：一种包括信号处理单元和调制器的调制系统。信号处理单元可以生成低频调制器信号，高频调制器信号和调制器幅度控制信号。该调制器可以至少部分地基于低频调制器信号，高频调制器信号和调制器幅度控制信号，经由无线网络生成用于传输的调制信号。信号处理单元包括延迟补偿单元，用于至少部分地基于与低频调制器信号相关联的信号产生和调制路径延迟来延迟高频调制器信号和调制器幅度控制信号的产生，以基本对准调制器信号在调制系统的输出端。

8. 发明申请

US20090311979A1 POLAR MODULATOR WITH PATH DELAY COMPENSATION 失效
标题翻译：具有路径延迟补偿的极性调制器
公开(公告)号：US20090311979A1
公开(公告)日：2009-12-17
申请号：US12172375
申请日：2008-07-14
申请人： Paul J. Husted , William W. Si , David J. Weber , Xiaoru Zhang
发明人： Paul J. Husted , William W. Si , David J. Weber , Xiaoru Zhang
IPC分类号： H04B1/02
CPC分类号： H03C5/00 , H04B2001/0491
摘要： A modulation system comprising a signal processing unit and a modulator. The signal processing unit may generate a low frequency modulator signal, a high frequency modulator signal, and a modulator amplitude control signal. The modulator may generate a modulated signal for transmission via a wireless network based, at least in part, on the low frequency modulator signal, the high frequency modulator signal, and the modulator amplitude control signal. The signal processing unit comprises a delay compensation unit for delaying the generation of the high frequency modulator signal and the modulator amplitude control signal based, at least in part, on signal generation and modulation path delays associated with the low frequency modulator signal to substantially align the modulator signals at the output of the modulation system.
摘要翻译：一种包括信号处理单元和调制器的调制系统。信号处理单元可以生成低频调制器信号，高频调制器信号和调制器幅度控制信号。该调制器可以至少部分地基于低频调制器信号，高频调制器信号和调制器幅度控制信号，经由无线网络生成用于传输的调制信号。信号处理单元包括延迟补偿单元，用于至少部分地基于与低频调制器信号相关联的信号产生和调制路径延迟来延迟高频调制器信号和调制器幅度控制信号的产生，以基本对准调制器信号在调制系统的输出端。

9. 发明授权

US06404289B1 Synthesizer with lock detector, lock algorithm, extended range VCO, and a simplified dual modulus divider 有权
标题翻译：具有锁定检测器，锁定算法，扩展范围VCO和简化双模式分频器的合成器
公开(公告)号：US06404289B1
公开(公告)日：2002-06-11
申请号：US09747778
申请日：2000-12-22
申请人： David K. Su , Chik Patrick Yue , David J. Weber , Masound Zargari
发明人： David K. Su , Chik Patrick Yue , David J. Weber , Masound Zargari
IPC分类号： H03L7095
CPC分类号： H03L7/099 , H03K23/667 , H03L7/089 , H03L7/095 , H03L7/10 , H03L7/193 , Y10S331/02
摘要： The present invention provides a synthesizer having an efficient lock detect signal generator, an extended range VCO that can operate within any one of a plurality of adjacent characteristic curves defined by a plurality of adjacent regions, and a divide circuit implemented using only a single counter along with a decoder. This allows for a method of operating the synthesizer, methods of establishing or reestablishing a lock condition using the extended range VCO, and a method of designing a plurality of divide circuits which each use the same single counter and each use a different decoder.
摘要翻译：本发明提供一种合成器，其具有有效的锁定检测信号发生器，能够在由多个相邻区域限定的多个相邻特性曲线中的任何一个中操作的扩展范围VCO，以及仅使用单个计数器实现的除法电路与解码器。这允许操作合成器的方法，使用扩展范围VCO建立或重新建立锁定条件的方法，以及设计多个除法电路的方法，每个除法电路使用相同的单个计数器并且每个使用不同的解码器。

10. 发明授权

US11510908B2 Protein translation inhibitors and uses thereof 有权
公开(公告)号：US11510908B2
公开(公告)日：2022-11-29
申请号：US16879226
申请日：2020-05-20
申请人： France Carrier , Alexander D. MacKerell , David J. Weber , Wenbo Yu
发明人： France Carrier , Alexander D. MacKerell , David J. Weber , Wenbo Yu
IPC分类号： A61K31/426 , A61P35/00 , A61K31/519 , A61K31/427
摘要： Provided herein are protein translation inhibitors and pharmaceutical compositions thereof that bind to an RNA Recognition motif in heterogeneous ribonucleoprotein A18 to inhibit binding to mRNA transcripts thereby inhibiting protein synthesis. Also provided is a method for treating a cancer by administering a pharmaceutically acceptable amounts of at least one of the protein translation inhibitors.

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