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1. 发明授权

US08452402B2 Optical sensing device for use in a medical device 有权
标题翻译：用于医疗设备的光学感测装置
公开(公告)号：US08452402B2
公开(公告)日：2013-05-28
申请号：US12107921
申请日：2008-04-23
申请人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
发明人： Robert M. Ecker , Jonathan L. Kuhn , James D. Reinke , Can Cinbis , Timothy J. Davis , Paul F. Gerrish , Jonathan P. Roberts
IPC分类号： A61B5/1455
CPC分类号： A61B5/0086 , A61B2562/028 , A61N1/3621 , A61N1/36557 , A61N1/375 , A61N1/3956
摘要： A reflectance-type optical sensor includes one or more photodiodes formed in a semiconductor substrate. A well having sidewalls and a bottom is formed in the top surface of the substrate, and a reflective layer is formed on the sidewalls and bottom. A light-emitting diode (LED) is mounted in the well, so that light emitted laterally and rearwardly from the LED strikes the sidewalls or bottom and is redirected in a direction generally perpendicular to the top surface of the substrate. The optical sensor can be fabricated using microelectromechanical systems (MEMS) fabrication techniques.
摘要翻译：反射型光学传感器包括在半导体衬底中形成的一个或多个光电二极管。在衬底的顶表面中形成具有侧壁和底部的阱，并且在侧壁和底部上形成反射层。发光二极管（LED）安装在井中，使得从LED侧向和向后发射的光撞击侧壁或底部，并且在大体上垂直于衬底的顶表面的方向上重定向。光学传感器可以使用微机电系统（MEMS）制造技术来制造。

2. 发明授权

US08396563B2 Clock synchronization in an implantable medical device system 有权
标题翻译：可植入医疗器械系统中的时钟同步
公开(公告)号：US08396563B2
公开(公告)日：2013-03-12
申请号：US12697070
申请日：2010-01-29
申请人： James D. Reinke , Robert M. Ecker , Kaustubh R. Patil , Michael B. Terry , Jonathan P. Roberts , Robert A. Corey
发明人： James D. Reinke , Robert M. Ecker , Kaustubh R. Patil , Michael B. Terry , Jonathan P. Roberts , Robert A. Corey
IPC分类号： A61N1/36 , A61N1/378
CPC分类号： G06F1/12 , A61N1/37288 , G06F1/06
摘要： This disclosure is directed to the synchronization of clocks of a secondary implantable medical device (IMD) to a clock of a primary IMD. The secondary IMD includes a communications clock. The communications clock may be synchronized based on at least one received communications pulse. The secondary IMD further includes a general purpose clock different than the communications clock. The general purpose clock may be synchronized based on at least one received power pulse. The communications clock may also be synchronized based on the at least one received power pulse.
摘要翻译：本公开涉及二次可植入医疗装置（IMD）的时钟与主IMD的时钟的同步。辅助IMD包括通信时钟。通信时钟可以基于至少一个接收到的通信脉冲来同步。次级IMD还包括与通信时钟不同的通用时钟。可以基于至少一个接收的功率脉冲同步通用时钟。通信时钟也可以基于至少一个接收的功率脉冲来同步。

3. 发明申请

US20090156912A1 IMPLANTABLE OPTICAL SENSOR AND METHOD FOR MANUFACTURE 有权
标题翻译：可植入的光学传感器及其制造方法
公开(公告)号：US20090156912A1
公开(公告)日：2009-06-18
申请号：US11955056
申请日：2007-12-12
申请人： Jonathan L. Kuhn , Timothy J. Davis , Can Cinbis , Robert M. Ecker , Shawn D. Knowles
发明人： Jonathan L. Kuhn , Timothy J. Davis , Can Cinbis , Robert M. Ecker , Shawn D. Knowles
IPC分类号： A61B5/1459 , H01L31/18
CPC分类号： A61B5/14542 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B2562/02 , A61B2562/043 , A61B2562/146
摘要： An implantable optical sensor and associated manufacturing method include a sensor housing having an inner surface and an outer surface and a window formed in the housing extending between the housing inner surface and the housing outer surface. An opto-electronic device enclosed within the housing and having a photonic surface is operatively positioned proximate the window for emitting light through the window or detecting light through the window. An optical coupling member is positioned between the opto-electronic device and the window for reducing light reflection at a surface within the implantable optical sensor.
摘要翻译：可植入光学传感器和相关联的制造方法包括具有内表面和外表面的传感器外壳和形成在壳体中的窗口，该壳体在壳体内表面和壳体外表面之间延伸。封闭在壳体内并且具有光子表面的光电器件可操作地定位在窗口附近，用于通过窗口发射光或通过窗口检测光。光耦合构件位于光电器件和窗口之间，用于减少可植入光学传感器内的表面处的光反射。

4. 发明授权

US06788973B2 Apparatus and method to discriminate between telemetry downlink signals and noise in an implanted device 有权
标题翻译：用于区分遥测下行链路信号和植入设备中的噪声的装置和方法
公开(公告)号：US06788973B2
公开(公告)日：2004-09-07
申请号：US10117550
申请日：2002-04-02
申请人： Timothy J. Davis , Robert M. Ecker , James D. Reinke , John D. Wahlstrand
发明人： Timothy J. Davis , Robert M. Ecker , James D. Reinke , John D. Wahlstrand
IPC分类号： A61N137
CPC分类号： A61N1/37211 , A61N1/3718 , A61N1/37223 , A61N1/37276
摘要： An implanted medical device (IMD) conserves power by discriminating received radio frequency (RF) signals between noise and data based on frequency. Data is processed while noise is attenuated. The IMD operates in a first, relatively low, power mode while not receiving the RF signals, in a second, higher, power mode responsive to receiving RF signals, and operates in still higher power mode when the RF signals' average frequency over a selected period is within a predetermined range. A receiver circuit receives RF signals and discriminates a data signal from noise based on average frequency of the RF signals over selected time periods. The receiver circuit operates in a power-conserving mode unless it receives RF signals, or otherwise operates in a relatively higher-power mode. The receiver transfers signals to a telemetry circuit that operates in a power-conserving mode until it receives a valid data signal to operate in higher power mode.
摘要翻译：植入式医疗设备（IMD）通过基于频率鉴别噪声和数据之间的接收射频（RF）信号来节省功率。在噪声衰减时处理数据。 IMD在第一个相对较低的功率模式下工作，而不响应于接收RF信号而在第二较高功率模式中接收RF信号，并且当RF信号在所选择的频率上的平均频率期间在预定范围内。接收机电路接收RF信号，并根据选定时间段内的RF信号的平均频率，将数据信号与噪声区分开。接收器电路在功率节省模式下工作，除非它接收RF信号，否则以较高功率模式工作。接收机将信号传送到工作在省电模式的遥测电路，直到接收到有效的数据信号以在较高功率模式下工作。

5. 发明申请

US20110190850A1 CLOCK SYNCHRONIZATION IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM 有权
标题翻译：可插入医疗设备系统中的时钟同步
公开(公告)号：US20110190850A1
公开(公告)日：2011-08-04
申请号：US12697070
申请日：2010-01-29
申请人： James D. Reinke , Robert M. Ecker , Kaustubh R. Patil , Michael B. Terry , Jonathan P. Roberts , Robert A. Corey
发明人： James D. Reinke , Robert M. Ecker , Kaustubh R. Patil , Michael B. Terry , Jonathan P. Roberts , Robert A. Corey
IPC分类号： A61N1/08
CPC分类号： G06F1/12 , A61N1/37288 , G06F1/06
摘要： This disclosure is directed to the synchronization of clocks of a secondary implantable medical device (IMD) to a clock of a primary IMD. The secondary IMD includes a communications clock. The communications clock may be synchronized based on at least one received communications pulse. The secondary IMD further includes a general purpose clock different than the communications clock. The general purpose clock may be synchronized based on at least one received power pulse. The communications clock may also be synchronized based on the at least one received power pulse.
摘要翻译：本公开涉及二次可植入医疗装置（IMD）的时钟与主IMD的时钟的同步。辅助IMD包括通信时钟。通信时钟可以基于至少一个接收到的通信脉冲来同步。次级IMD还包括与通信时钟不同的通用时钟。可以基于至少一个接收的功率脉冲同步通用时钟。通信时钟也可以基于至少一个接收的功率脉冲来同步。

6. 发明授权

US07493174B2 Implantable medical lead 有权
标题翻译：可植入医用铅
公开(公告)号：US07493174B2
公开(公告)日：2009-02-17
申请号：US10947813
申请日：2004-09-23
申请人： Hugo A. Belalcazar , James D. Reinke , Robert M. Ecker
发明人： Hugo A. Belalcazar , James D. Reinke , Robert M. Ecker
IPC分类号： A61N1/00
CPC分类号： A61N1/36514 , A61B5/02055 , A61B5/145 , A61B5/14532 , A61N1/05 , A61N1/056
摘要： An implantable medical lead includes a device, such as a physiological sensor, that is coupled to one or more stimulation/sensing sensing conductors within the lead. When the implantable medical lead is coupled to an implantable medical device, the device carried by the lead both receives power from, and communicates with the implantable medical device via the one or more stimulation/sensing sensing conductors. Each of the one or more stimulation/sensing sensing conductors is also coupled to an electrode that is exposed to body tissue.
摘要翻译：可植入医疗引线包括耦合到引线内的一个或多个刺激/感测感测导体的装置，例如生理传感器。当可植入医疗引线连接到可植入医疗设备时，由引线承载的设备都经由一个或多个刺激/感测感测导体从可植入医疗设备接收电力并与可植入医疗设备进行通信。一个或多个刺激/感测感测导体中的每一个还耦合到暴露于身体组织的电极。

7. 发明授权

US07139613B2 Implantable medical device communication system with pulsed power biasing 有权
标题翻译：具有脉冲功率偏置的植入式医疗设备通信系统
公开(公告)号：US07139613B2
公开(公告)日：2006-11-21
申请号：US10733000
申请日：2003-12-11
申请人： James D. Reinke , Robert M. Ecker
发明人： James D. Reinke , Robert M. Ecker
IPC分类号： A61N1/36 , A61N1/378
CPC分类号： A61N1/37252 , A61N1/025 , A61N1/372
摘要： An implantable medical device communication system communicates information between an implantable medical device and at least one slave device by way of a two-wire bus. Slave devices may include remote sensors, actuators and other implantable medical devices. The implantable medical device includes a communication unit to output commands and power pulses, and receive information from the slave devices over the two-wire bus. The implantable medical device and slaves communicate over the bus by selectively changing one of the lines of the bus between a first and second voltage, the second voltage substantially equal to a reference voltage of the second line, e.g., zero volts. In some embodiments, the power pulses take the form of bipolar pulse pairs. The slave device includes a recovery unit to recover power from the power pulses.
摘要翻译：可植入医疗装置通信系统通过两线总线在可植入医疗装置与至少一个从属装置之间传送信息。从设备可以包括远程传感器，致动器和其它可植入医疗设备。可植入医疗装置包括通信单元，用于输出命令和功率脉冲，并通过双线总线从从设备接收信息。可植入医疗装置和从动装置通过在第一和第二电压之间选择性地改变总线的一条线，第二电压基本上等于第二条线路的基准电压，例如零伏特，在总线上通信。在一些实施例中，功率脉冲采取双极性脉冲对的形式。从设备包括从功率脉冲恢复功率的恢复单元。

8. 发明授权

US5899927A Detection of pressure waves transmitted through catheter/lead body 失效
标题翻译：检测通过导管/铅体传输的压力波
公开(公告)号：US5899927A
公开(公告)日：1999-05-04
申请号：US953092
申请日：1997-10-17
申请人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
发明人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
IPC分类号： A61B5/0215 , A61B5/08 , A61N1/365 , A61N1/37 , A61B5/00
CPC分类号： A61N1/3702 , A61N1/36514
摘要： In an implanted medical device, a method and apparatus for detecting pressure waves caused by movement of a body organ, muscle group, limb or the like and transmitted through a catheter or lead body to the implanted medical device employing a pressure wave transducer mounted in relation to the proximal end of the catheter or lead to detect the transmitted pressure waves. The system may also include a reference transducer having the same pressure wave response characteristics as the pressure wave transducer but isolated from the proximal connector end for providing a reference signal including common mode pressure wave noise that both transducers are simultaneously subjected to. The pressure wave signal and the reference signal are preferably amplified, bandpass filtered to the body pressure wave of interest and stored, telemetered out or used to trigger a device operation. The pressure and reference wave transducers preferably are piezoelectric crystal transducers or accelerometers in direct or indirect mechanical contact with the proximal connector end of the catheter and is encapsulated from the body within a device connector assembly. Preferably, the catheter is a lead extending into direct or indirect contact with the patient's heart. Cardiac pressure waves and respiration pressure waves are both transmitted proximally through the lead body to the pressure wave transducer. Pressure wave signals may be derived in parallel to detect particular characteristics of the cardiac and/or respiratory cycle to provide timing signal(s) for controlling the device operations.
摘要翻译：在植入式医疗装置中，一种用于检测由身体器官，肌肉群，肢体等的运动引起的透射通过导管或引线体引起的植入医疗装置的压力波的方法和装置，所述压力波换能器安装在关系上到导管的近端或导致检测传输的压力波。该系统还可以包括具有与压力波传感器相同的压力波响应特性但与近端连接器端隔离的参考换能器，用于提供包括两个换能器同时经受的共模压力波噪声的参考信号。压力波信号和参考信号优选被放大，带通滤波到感兴趣的体压波，并被存储，遥测或用于触发装置操作。压力和参考波传感器优选地是与导管的近端连接器端直接或间接机械接触的压电晶体换能器或加速度计，并且在设备连接器组件内从主体封装。优选地，导管是延伸成与患者心脏直接或间接接触的导线。心脏压力波和呼吸压力波都通过引导体向近端传递到压力波传感器。可以并行导出压力波信号以检测心脏和/或呼吸周期的特定特征，以提供用于控制装置操作的定时信号。

9. 发明授权

US5702427A Verification of capture using pressure waves transmitted through a pacing lead 失效
标题翻译：使用通过起搏引线传输的压力波进行捕获验证
公开(公告)号：US5702427A
公开(公告)日：1997-12-30
申请号：US623443
申请日：1996-03-28
申请人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
发明人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
IPC分类号： A61N1/365 , A61N1/37 , A61N1/375
CPC分类号： A61N1/3702 , A61N1/36542 , A61N1/3712 , A61N1/36578
摘要： A capture verification system for a cardiac pacemaker comprising an implantable pulse generator (IPG) and one or more pacing leads having a proximal end coupled to the IPG and a distal end in contact with a patient's heart. The capture verification system employs a pressure wave sensor mounted in the IPG in relation to the proximal end of the pacing lead for sensing pressure waves transmitted from the distal end of the pacing lead to the proximal end thereof. The pressure waves include characteristic sounds of heart contraction and/or distal end lead motion caused by the contraction motion of the patient's heart that are transmitted along the lead body to the active sensor. A further isolated, reference sensor is also incorporated into the IPG in a similar fashion. Signal processors are coupled to the pressure wave and reference sensors for nulling out common mode noise.
摘要翻译：一种用于心脏起搏器的捕获验证系统，包括可植入脉冲发生器（IPG）和一个或多个起搏引线，其具有耦合到IPG的近端和与患者心脏接触的远端。捕获验证系统使用安装在IPG中的压力波传感器相对于起搏引线的近端，用于感测从起搏引线的远端传递到其近端的压力波。压力波包括由沿着引导体传递到有源传感器的患者心脏的收缩运动引起的心脏收缩和/或远端引导运动的特征性声音。另一个隔离的参考传感器也以类似的方式并入到IPG中。信号处理器耦合到压力波和参考传感器，以消除共模噪声。

10. 发明申请

US20100185262A1 CO-LOCATION OF EMITTERS AND DETECTORS AND METHOD OF OPERATION 有权
标题翻译：发射器和探测器的合作位置及其操作方法
公开(公告)号：US20100185262A1
公开(公告)日：2010-07-22
申请号：US12690957
申请日：2010-01-21
申请人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
发明人： Jonathan L. Kuhn , Jonathan P. Roberts , Andrew J. Ries , James D. Reinke , Jeffrey M. Jelen , Robert M. Ecker , Timothy J. Davis , Can Cinbis , Thomas A. Anderson
IPC分类号： A61N1/08 , A61B5/00
CPC分类号： A61B5/1459 , A61B5/14542 , A61B5/1495 , A61B2562/0233 , A61B2562/046 , A61N1/36557 , G06F19/00 , G16H40/63
摘要： An implantable medical device having an optical sensor selects the function of modular opto-electronic assemblies included in the optical sensor. Each assembly is provided with at least one light emitting device and at least one light detecting device. A device controller coupled to the optical sensor controls the function of each the assemblies. The controller executes a sensor performance test and selects at least one of the plurality of assemblies to operate as a light emitting assembly in response to a result of the performance test. The controller selects at least one other of the plurality of optical sensor assemblies to operate as a light detecting assembly in response to a result of the performance test
摘要翻译：具有光学传感器的可植入医疗装置选择包括在光学传感器中的模块化光电组件的功能。每个组件设置有至少一个发光装置和至少一个光检测装置。耦合到光学传感器的设备控制器控制每个组件的功能。控制器执行传感器性能测试，并且响应于性能测试的结果，选择多个组件中的至少一个作为发光组件进行操作。响应于性能测试的结果，控制器选择多个光学传感器组件中的至少另一个作为光检测组件进行操作

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