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1. 发明授权

US08788047B2 Systems and methods for the treatment of pain through neural fiber stimulation 有权
标题翻译：通过神经纤维刺激治疗疼痛的系统和方法
公开(公告)号：US08788047B2
公开(公告)日：2014-07-22
申请号：US13309107
申请日：2011-12-01
申请人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021 , A61N1/36057
摘要： Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.
摘要翻译：本发明的实施方案提供了通过激活选择性神经纤维来治疗疼痛的系统和方法。神经纤维可以包含一个或多个传入神经纤维和/或一个或多个传出神经纤维。如果传入纤维被单独或与传出纤维组合刺激，则施用治疗有效量的电刺激以以接近自然传入活性的方式激活传入途径。传入纤维可能与肌肉锭，高尔基体腱器官，肌肉锭子的次要受体，关节受体，触觉受体和其他类型的机械感受器和/或本体感受器的主要受体相关联。如果传出纤维被单独或与传入纤维组合刺激，则施加治疗有效量的电刺激以激活内部和/或外部肌肉纤维，这导致与其相关联的传入纤维的间接活化。

2. 发明申请

US20120310301A1 SYSTEMS AND METHODS FOR THE TREATMENT OF PAIN THROUGH NEURAL FIBER STIMULATION 有权
公开(公告)号：US20120310301A1
公开(公告)日：2012-12-06
申请号：US13309107
申请日：2011-12-01
申请人： MARIA E. BENNETT , JOSEPH W. BOGGS, II , WARREN M. GRILL , JOHN CHAE
发明人： MARIA E. BENNETT , JOSEPH W. BOGGS, II , WARREN M. GRILL , JOHN CHAE
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021 , A61N1/36057
摘要： Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

3. 发明申请

US20120136408A1 WAVEFORM SHAPES FOR TREATING NEUROLOGICAL DISORDERS OPTIMIZED FOR ENERGY EFFICIENCY 有权
标题翻译：用于治疗优化能量效能的神经病变的波形
公开(公告)号：US20120136408A1
公开(公告)日：2012-05-31
申请号：US13118081
申请日：2011-05-27
申请人： WARREN M. GRILL , AMORN WONGSARNPIGOON
发明人： WARREN M. GRILL , AMORN WONGSARNPIGOON
IPC分类号： A61N1/378 , A61N1/36
CPC分类号： A61N1/36146 , A61N1/0529 , A61N1/3606 , A61N1/36175
摘要： Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. The waveform is optimized for energy efficiency.
摘要翻译：用于刺激神经组织的系统和方法应用由开发的遗传算法（GA）导出的刺激波形，其可以耦合到哺乳动物有髓轴突的细胞外刺激的计算模型。该波形针对能量效率进行了优化。

4. 发明申请

US20110301659A1 VAGUS NERVE STIMULATION WITH TARGET EFFECTS CONTROLLED BY ADJUSTING TEMPORAL PARAMETERS 有权
标题翻译： VAGUS神经刺激与调整时间参数控制的目标效应
公开(公告)号：US20110301659A1
公开(公告)日：2011-12-08
申请号：US13114686
申请日：2011-05-24
申请人： Paul B. Yoo , Warren M. Grill , Juan Gabriel Hincapie Ordonez
发明人： Paul B. Yoo , Warren M. Grill , Juan Gabriel Hincapie Ordonez
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0488 , A61B5/4029 , A61B5/4035 , A61N1/0556 , A61N1/18 , A61N1/36 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/36167
摘要： One or more temporal stimulation parameters of vagus nerve stimulation (VNS) are selected to substantially modulate one or more target physiological functions without substantially modulating one or more non-target physiological functions. In one embodiment, a stimulation duty cycle is selected such that VNS is delivered to the cervical vagus nerve trunk to modulate a cardiovascular function without causing laryngeal muscle contractions.
摘要翻译：选择迷走神经刺激（VNS）的一个或多个时间刺激参数以基本上调制一个或多个目标生理功能，而基本上不调制一个或多个非目标生理功能。在一个实施例中，选择刺激占空比使得VNS被递送到子宫颈迷走神经干以调节心血管功能而不引起喉部肌肉收缩。

5. 发明授权

US07623925B2 Methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于选择性刺激阴部神经或其分支中，上或附近的组分以实现选择性生理反应的方法
公开(公告)号：US07623925B2
公开(公告)日：2009-11-24
申请号：US11141457
申请日：2005-05-31
申请人： Warren M Grill , Kenneth J Gustafson , Graham H Creasey
发明人： Warren M Grill , Kenneth J Gustafson , Graham H Creasey
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.
摘要翻译：系统和方法选择性地刺激阴部神经远离骶骨的部分，以在缺乏其他方式产生这些反应的能力的人中引起所需的生理反应 - 例如，保持连续和/或产生排尿和/或提供男性/女性的性行为反应和/或提供肠反应。这些系统和方法使用放置在阴部神经中，外侧或附近的多电极阵列或单个电极。与脉冲发生器相关联的电极阵列或单个电极提供对阴部神经内的各个分支的选择性刺激，以实现不同的生理反应。

6. 发明授权

US06907293B2 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于选择性刺激阴部神经或其分支中，上或附近的组分的系统和方法以实现选择性生理反应
公开(公告)号：US06907293B2
公开(公告)日：2005-06-14
申请号：US10113828
申请日：2002-03-29
申请人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
发明人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
IPC分类号： A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.
摘要翻译：系统和方法选择性地刺激阴部神经远离骶骨的部分，以在缺乏其他方式产生这些反应的能力的人中引起所需的生理反应 - 例如，保持连续和/或产生排尿和/或提供男性/女性的性行为反应和/或提供肠反应。这些系统和方法使用放置在阴部神经中，外侧或附近的多电极阵列或单个电极。与脉冲发生器相关联的电极阵列或单个电极提供对阴部神经内的各个分支的选择性刺激，以实现不同的生理反应。

7. 发明授权

US08825163B2 Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses 有权
标题翻译：用于选择性刺激阴部神经或其分支中，上或附近的组分的系统和方法以实现选择性生理反应
公开(公告)号：US08825163B2
公开(公告)日：2014-09-02
申请号：US12579581
申请日：2009-10-15
申请人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
发明人： Warren M. Grill , Kenneth J. Gustafson , Graham H. Creasey
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0556 , A61N1/326 , A61N1/36007 , A61N1/36107
摘要： Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persons who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve. The electrode array, or individual electrodes, in association with a pulse generator, provide selective stimulation of individual fascicles within the pudendal nerve, to achieve different physiologic responses.
摘要翻译：系统和方法选择性地刺激阴部神经远离骶骨的部分，以在缺乏其他方式产生这些反应的能力的人中引起所需的生理反应 - 例如，保持连续和/或产生排尿和/或提供男性/女性的性行为反应和/或提供肠反应。系统和方法使用放置在阴部神经上，旁边或附近的多电极阵列或单个电极。与脉冲发生器相关联的电极阵列或单个电极提供对阴部神经内的各个分支的选择性刺激，以实现不同的生理反应。

8. 发明授权

US08892211B2 System and method for selective retinal stimulation 有权
标题翻译：选择性视网膜刺激的系统和方法
公开(公告)号：US08892211B2
公开(公告)日：2014-11-18
申请号：US12789063
申请日：2010-05-27
申请人： Warren M. Grill , Matthew A. Schiefer
发明人： Warren M. Grill , Matthew A. Schiefer
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543
摘要： A method for electrically stimulating a retina of an eye to induce visual perception includes placing an electrode adjacent a retinal ganglion cell (RGC) layer and selectively applying a biphasic asymmetrical waveform (BAW) to a portion of the axon. The BAW includes a pre-pulse phase and a stimulation-pulse phase. The pre-pulse phase has a first polarity, a first amplitude, and a first duration. The first amplitude and the first duration together define a pre-pulse charge having a first magnitude. The stimulation-pulse phase has a second polarity opposite the first polarity, a second amplitude, and a second duration less than the first duration. The second amplitude and the second duration together define a stimulation charge having a second magnitude. Application of the pre-pulse phase and the stimulation-pulse phase effects a change in excitability of the at least one ganglion cell and induces visual perception, respectively.
摘要翻译：用于电刺激眼睛的视网膜以诱导视觉感知的方法包括将电极放置在视网膜神经节细胞（RGC）层附近并选择性地将两相不对称波形（BAW）应用于轴突的一部分。 BAW包括预脉冲相位和刺激脉冲相位。预脉冲相位具有第一极性，第一幅度和第一持续时间。第一幅度和第一持续时间一起限定具有第一幅度的预脉冲电荷。刺激脉冲相位具有与第一极性相反的第二极性，第二幅度和小于第一持续时间的第二持续时间。第二幅度和第二持续时间一起限定具有第二幅度的刺激电荷。预脉冲相位和刺激脉冲相位的应用分别影响至少一个神经节细胞的兴奋性变化并分别诱导视觉感知。

9. 发明授权

US08788046B2 Systems and methods for the treatment of pain through neural fiber stimulation 有权
公开(公告)号：US08788046B2
公开(公告)日：2014-07-22
申请号：US13309024
申请日：2011-12-01
申请人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
发明人： Maria E. Bennett , Joseph W. Boggs, II , Warren M. Grill , John Chae
IPC分类号： A61N1/34 , A61N1/36
CPC分类号： A61N1/36071 , A61N1/36003 , A61N1/36017 , A61N1/36021 , A61N1/36057
摘要： Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

10. 发明授权

US08509919B2 Spatially selective vagus nerve stimulation 有权
公开(公告)号：US08509919B2
公开(公告)日：2013-08-13
申请号：US13114626
申请日：2011-05-24
申请人： Paul B. Yoo , Warren M. Grill , Juan Gabriel Hincapie Ordonez
发明人： Paul B. Yoo , Warren M. Grill , Juan Gabriel Hincapie Ordonez
IPC分类号： A61N1/18
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0488 , A61B5/4029 , A61N1/0556 , A61N1/36114 , A61N1/36167
摘要： By targeting on selected branches or fascicles of a vagus nerve using electrode placement and/or selection, one or more target branches of the vagus nerve are substantially activated by electrical stimulation pulses delivered to a branch without substantially activating one or more non-target branches. In one embodiment, vagus nerve stimulation is delivered through an electrode placed on a thoracic vagus nerve that is separated from a recurrent laryngeal nerve, such that the vagus nerve is stimulated without causing laryngeal muscle contractions. In another embodiment, vagus nerve stimulation is delivered through a multi-contact electrode with one or more contacts selected for delivering the electrical stimulation pulses to stimulate the vagus nerve without causing laryngeal muscle contractions.

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