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1. 发明授权

US07449242B2 Durable coating compositions containing novel aspartic amine compounds 有权
标题翻译：含有新型天冬氨酸胺化合物的耐久涂料组合物
公开(公告)号：US07449242B2
公开(公告)日：2008-11-11
申请号：US11300030
申请日：2005-12-14
申请人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
发明人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
IPC分类号： B32B27/26 , B05D1/36
CPC分类号： C08G18/3821 , B05D7/16 , B05D7/532 , C08G18/792 , C09D175/12 , Y10T428/31551
摘要： A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula (I) including isomers and mixtures of isomers thereof: wherein R, R1, R2, X, Y, Z, m, n, p, q, r and s are described in the specification and a two component composition formulated with the above constituents and substrates, such as, automotive and truck bodies and parts coated with the novel composition and novel amine and/or hydroxy amine compounds are also part of the invention.
摘要翻译：一种涂料组合物，其包含a。多异氰酸酯交联剂; b。异氰酸酯反应性组分，其具有至少一种具有下式（I）的化合物，包括异构体及其异构体的混合物：其中R 1，R 2，R 2，X，在说明书中描述了Y，Z，m，n，p，q，r和s，并且用上述组分和底物配制的双组分组合物，例如汽车和卡车体以及涂有新组合物和新型胺的部分和/或羟基胺化合物也是本发明的一部分。

2. 发明授权

US07732018B2 Durable coating compositions containing novel aspartic amine compounds 有权
标题翻译：含有新型天冬氨酸胺化合物的耐久涂料组合物
公开(公告)号：US07732018B2
公开(公告)日：2010-06-08
申请号：US11303083
申请日：2005-12-14
申请人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
发明人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
IPC分类号： C08F218/04 , B32B27/26 , B05D1/36
CPC分类号： C08F220/04 , C08F222/02 , Y10T428/31551
摘要： A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula (I) including isomers and mixtures of isomers thereof: wherein R, R1, R2, X, Y, Z, m, n, p, q, r and s are described in the specification and a two component composition formulated with the above constituents and substrates, such as, automotive and truck bodies and parts coated with the novel composition and novel amine and/or hydroxy amine compounds are also part of the invention.
摘要翻译：一种涂料组合物，其包含a。多异氰酸酯交联剂; b。具有至少一种具有下列通式（I）的化合物的异氰酸酯反应性组分，包括异构体及其异构体的混合物：其中R，R1，R2，X，Y，Z，m，n，p，q，r和s分别为在本说明书中描述的两组分组合物和由上述组分配制的双组分组合物和底物，例如汽车和卡车体以及涂有新组合物和新型胺和/或羟基胺化合物的部分也是本发明的一部分。

3. 发明授权

US07166748B2 Durable coating compositions containing novel aspartic amine compounds 有权
标题翻译：含有新型天冬氨酸胺化合物的耐久涂料组合物
公开(公告)号：US07166748B2
公开(公告)日：2007-01-23
申请号：US11303084
申请日：2005-12-14
申请人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
发明人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
IPC分类号： C07C215/00
CPC分类号： C07C237/06 , C07C2601/14 , C07C2602/42
摘要： A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula (I) including isomers and mixtures of isomers thereof: wherein R, R1, R2, X, Y, Z, m, n, p, q, r and s are described in the specification and a two component composition formulated with the above constituents and substrates, such as, automotive and truck bodies and parts coated with the novel composition and novel amine and/or hydroxy amine compounds are also part of the invention.
摘要翻译：一种涂料组合物，其包含a。多异氰酸酯交联剂; b。异氰酸酯反应性组分，其具有至少一种具有下式（I）的化合物，包括异构体及其异构体的混合物：其中R 1，R 2，R 2，X，在说明书中描述了Y，Z，m，n，p，q，r和s，并且用上述组分和底物配制的双组分组合物，例如汽车和卡车体以及涂有新组合物和新型胺的部分和/或羟基胺化合物也是本发明的一部分。

4. 发明授权

US09044529B2 Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether 有权
标题翻译：水凝胶组织粘合剂由胺化多糖和醛官能化的多臂聚醚形成
公开(公告)号：US09044529B2
公开(公告)日：2015-06-02
申请号：US13129617
申请日：2009-08-31
申请人： Helen S. M. Lu , Steven Willis Shuey
发明人： Helen S. M. Lu , Steven Willis Shuey
IPC分类号： A61L24/04 , A61L24/00 , A61L24/08 , A61K47/36 , A61K47/34 , A61L26/00
CPC分类号： A61L24/043 , A61K47/34 , A61K47/36 , A61L24/0031 , A61L24/046 , A61L24/08 , A61L26/0019 , A61L26/0023 , C08L71/02
摘要： A hydrogel tissue adhesive formed by reacting an aminated polysaccharide with a water-dispersible, aldehyde-functionalized multi-arm polyether is described. The hydrogel tissue adhesive may be useful as a general tissue adhesive and sealant for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions. Additionally, due to the presence of the aminated polysaccharide, the hydrogel tissue adhesive may also promote wound healing and blood coagulation, and provide antimicrobial properties.
摘要翻译：描述了通过使胺化多糖与水分散性醛官能化的多臂聚醚反应形成的水凝胶组织粘合剂。水凝胶组织粘合剂可用作用于医疗和兽医应用的一般组织粘合剂和密封剂，例如在内部手术过程中的伤口闭合，补充或替换缝合线或缝钉，例如肠吻合和血管吻合，组织修复，眼科手术，药物递送，并防止手术后粘连。此外，由于存在胺化多糖，水凝胶组织粘合剂也可促进伤口愈合和凝血，并提供抗微生物性质。

5. 发明授权

US07601361B2 Process for providing antimicrobial surfaces 失效
标题翻译：提供抗菌表面的方法
公开(公告)号：US07601361B2
公开(公告)日：2009-10-13
申请号：US11242395
申请日：2005-10-03
申请人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
发明人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
IPC分类号： A61K9/00 , A61F13/00 , A61K38/16 , A61K38/10
CPC分类号： C09D5/14 , A61K38/10 , A61K38/16 , A61L29/048 , A61L29/08 , A61L29/16 , A61L31/047 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/606
摘要： Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide. Further embodiments include articles, including medical devices, characterized by a durable antimicrobial surface provided by the processes of the invention.
摘要翻译：公开了用于提供耐久性抗微生物表面的方法，其包括用甲醛处理聚合物底物表面，然后用抗微生物肽处理。其它实施方案包括包括医疗装置的制品，其特征在于由本发明的方法提供的耐久的抗微生物表面。

6. 发明申请

US20090087466A1 PROCESS FOR PROVIDING ANTIMICROBIAL SURFACES 审中-公开
标题翻译：提供抗微生物表面的方法
公开(公告)号：US20090087466A1
公开(公告)日：2009-04-02
申请号：US12261448
申请日：2008-10-30
申请人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
发明人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
IPC分类号： A01N25/34 , A01N37/18 , A01P1/00
CPC分类号： C09D5/14 , A61K38/10 , A61K38/16 , A61L29/048 , A61L29/08 , A61L29/16 , A61L31/047 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/606
摘要： Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide. Further embodiments include articles, including medical devices, characterized by a durable antimicrobial surface provided by the processes of the invention.
摘要翻译：公开了用于提供耐久性抗微生物表面的方法，其包括用甲醛处理聚合物底物表面，然后用抗微生物肽处理。其它实施方案包括包括医疗装置的制品，其特征在于由本发明的方法提供的耐久的抗微生物表面。

7. 发明授权

US06737539B2 Phosphonite ligands and their use in hydrocyanation 失效
标题翻译：膦酸酯配体及其在氢氰化中的应用
公开(公告)号：US06737539B2
公开(公告)日：2004-05-18
申请号：US10454074
申请日：2003-06-04
申请人： Christian P. Lenges , Helen S. M. Lu , Joachim C. Ritter
发明人： Christian P. Lenges , Helen S. M. Lu , Joachim C. Ritter
IPC分类号： C07C25310
CPC分类号： C07C253/30 , C07C253/10 , C07C255/04 , C07C255/07
摘要： Disclosed herein are processes for hydrocyanation and isomerization of olefins by using at least one multidentate phosphonite ligands, including organometallic phosphonite ligands with a Group VIII metal or Group VIII metal compound, and optionally, a Lewis acid promoter.
摘要翻译：本文公开了通过使用至少一个多齿膦酸酯配体，包括具有VIII族金属或VIII族金属化合物的有机金属亚膦酸盐配体和任选的路易斯酸启动子来氢化氰化和异构化烯烃的方法。

8. 发明授权

US08785013B2 Compositions containing modified fullerenes 有权
标题翻译：含有修饰富勒烯的组合物
公开(公告)号：US08785013B2
公开(公告)日：2014-07-22
申请号：US11205455
申请日：2005-08-17
申请人： Paul J. Krusic , Helen S. M. Lu , Zhen-Yu Yang
发明人： Paul J. Krusic , Helen S. M. Lu , Zhen-Yu Yang
IPC分类号： H01M2/36
CPC分类号： C08K5/02 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B32/152 , C07C23/46 , C08J5/2237 , C08J2327/12 , H01M4/8605 , H01M4/92 , H01M4/921 , H01M4/925 , H01M8/0289 , H01M8/1004 , H01M8/1023 , H01M8/1039 , H01M8/1048 , H01M2004/8684 , H01M2300/0082
摘要： Compositions containing modified fullerenes and their use, for example, as films for membranes in electrode assemblies for electrochemical cells and fuel cells such as fuel cells are described.
摘要翻译：含有改性富勒烯的组合物及其用途，例如作为用于电化学电池的电极组件和燃料电池如燃料电池中的膜的膜。

9. 发明授权

US08551136B2 High swell, long-lived hydrogel sealant 有权
标题翻译：高膨胀，长寿命的水凝胶密封剂
公开(公告)号：US08551136B2
公开(公告)日：2013-10-08
申请号：US12497732
申请日：2009-07-06
申请人： Helen S. M. Lu
发明人： Helen S. M. Lu
IPC分类号： A61B17/03
CPC分类号： A61L24/043 , A61L24/0031 , C08J3/075 , C08J2300/202 , C08J2405/00
摘要： A high swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring high swell and slow degradation, for example, tissue augmentation, both cosmetic and reconstructive; void filling; tissue bulking, for example treatment of urinary incontinence and acid reflux; and embolization. The high swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.
摘要翻译：描述了通过使含有醛基的高度氧化的多糖与多臂胺反应形成的高膨胀，长寿命的水凝胶密封剂。水凝胶密封剂可能特别适用于需要高溶胀和缓慢降解的应用，例如组织增加，包括化妆品和重建; 空隙填充组织膨胀，例如治疗尿失禁和酸反流; 和栓塞。高膨胀，长寿命的水凝胶密封剂也可用作组织密封剂和粘合剂，以及作为抗粘连屏障。

10. 发明授权

US08426492B2 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use 有权
标题翻译：用于医疗用途的氧化阳离子多糖类聚合物组织粘合剂
公开(公告)号：US08426492B2
公开(公告)日：2013-04-23
申请号：US12742457
申请日：2008-11-14
申请人： Helen S. M. Lu
发明人： Helen S. M. Lu
IPC分类号： A61K6/097 , A61K9/00 , A61K31/715
CPC分类号： A61L24/0031 , A61L24/043 , A61L27/26 , A61L27/52 , A61L31/041 , A61L31/145 , C08L71/02 , C08L5/00 , C08L1/02
摘要： A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based polymer tissue adhesive may be useful for medical applications including wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, ophthalmic procedures, drug delivery, anti-adhesive applications and as a bulking agent to treat urinary incontinence. Additionally, due to the presence of the positively charged amine groups on the oxidized polysaccharide, the polymer tissue adhesive disclosed herein may promote wound healing and blood coagulation, and may possess antimicrobial properties.
摘要翻译：描述了通过使包含醛基和胺基的氧化阳离子多糖与多臂胺反应形成的组织粘合剂。氧化的阳离子多糖类聚合物组织粘合剂可用于医学应用，包括在诸如肠内吻合和血管吻合术的内部手术过程中的伤口闭合，补充或替代缝合线或缝钉，眼科手术，药物递送，抗粘连应用和作为填充剂治疗尿失禁。此外，由于在氧化多糖上存在带正电的胺基，本文公开的聚合物组织粘合剂可以促进伤口愈合和凝血，并且可以具有抗微生物性质。

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