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1. 发明申请

US20130236079A1 METHOD AND DEVICE FOR ANALYSING A REGION OF INTEREST IN AN OBJECT USING X-RAYS 有权
标题翻译：用于分析使用X-RAYS的对象中的兴趣区域的方法和装置
公开(公告)号：US20130236079A1
公开(公告)日：2013-09-12
申请号：US13989507
申请日：2011-12-05
申请人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
发明人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3-dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.
摘要翻译：提出了一种用于分析对象中的感兴趣区域的方法和装置。该方法包括：（a）通过差分相位X射线成像系统提供测量数据，以及（b）分析感兴趣区域中物体的特征。其中，测量数据包括2维或3维像素集合，其中对于每个像素，测量数据包括彼此空间对准的三种类型的图像数据，包括（i）表示图像数据A的吸收，（ii）差分表示图像数据D的相位对比度和（iii）表示图像数据C的相干性。分析步骤基于每个像素，包括在表示图像数据A的吸收中包括的信息中的至少两个信息和差分中包含的信息表示图像数据D的相位对比度和表示图像数据C的相干性中包含的信息。

2. 发明授权

US09767550B2 Method and device for analysing a region of interest in an object using x-rays 有权
公开(公告)号：US09767550B2
公开(公告)日：2017-09-19
申请号：US13989507
申请日：2011-12-05
申请人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
发明人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
IPC分类号： G06K9/00 , G06T7/00 , G01N23/04
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3-dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.

3. 发明授权

US09159462B2 Detection apparatus 有权
标题翻译：检测装置
公开(公告)号：US09159462B2
公开(公告)日：2015-10-13
申请号：US14000414
申请日：2012-02-20
申请人： Ewald Rossl , Thomas Koehler , Roland Proksa
发明人： Ewald Rossl , Thomas Koehler , Roland Proksa
IPC分类号： A61B6/00 , G21K1/00 , A61B6/03 , A61B6/02
CPC分类号： G21K1/00 , A61B6/027 , A61B6/032 , A61B6/4035 , A61B6/4078 , A61B6/4233 , A61B6/482
摘要： The invention relates to a detection apparatus comprising a filter (20) for filtering a conical radiation beam (4) such that at least a first region (22) and a second region (23) of the radiation beam are generated having different energy spectra, wherein the first region of the radiation beam illuminates a first detector area (25) on a detection surface (21) of a detector, thereby generating a first set of detection values, and the second region of the radiation beam illuminates a second detector area (26) on the detection surface, thereby generating a second set of detection values. For example, by using the filter the detection apparatus can be used as dual-energy computed tomography apparatus, wherein, for instance, a standard computed tomography apparatus can be transformed to a dual-energy computed tomography apparatus by adding the filter to the standard computed tomography apparatus, preferentially without modifying the radiation source and the detector.
摘要翻译：本发明涉及一种检测装置，其包括用于过滤锥形辐射束（4）的过滤器（20），使得产生具有不同能谱的辐射束的至少第一区域（22）和第二区域（23）其中辐射束的第一区域照射检测器的检测表面（21）上的第一检测器区域（25），从而产生第一组检测值，并且辐射束的第二区域照亮第二检测器区域 26），从而产生第二组检测值。例如，通过使用滤波器，检测装置可以用作双能计算机断层摄影装置，其中，例如，标准计算机断层摄影装置可以通过将滤波器加到标准计算机断层摄影装置优选不改变辐射源和检测器的断层摄影装置。

4. 发明申请

US20130329851A1 DETECTION APPARATUS 有权
标题翻译：检测装置
公开(公告)号：US20130329851A1
公开(公告)日：2013-12-12
申请号：US14000414
申请日：2012-02-20
申请人： Ewald Rossl , Thomas Koehler , Roland Proksa
发明人： Ewald Rossl , Thomas Koehler , Roland Proksa
IPC分类号： G21K1/00
CPC分类号： G21K1/00 , A61B6/027 , A61B6/032 , A61B6/4035 , A61B6/4078 , A61B6/4233 , A61B6/482
摘要： The invention relates to a detection apparatus comprising a filter (20) for filtering a conical radiation beam (4) such that at least a first region (22) and a second region (23) of the radiation beam are generated having different energy spectra, wherein the first region of the radiation beam illuminates a first detector area (25) on a detection surface (21) of a detector, thereby generating a first set of detection values, and the second region of the radiation beam illuminates a second detector area (26) on the detection surface, thereby generating a second set of detection values. For example, by using the filter the detection apparatus can be used as dual-energy computed tomography apparatus, wherein, for instance, a standard computed tomography apparatus can be transformed to a dual-energy computed tomography apparatus by adding the filter to the standard computed tomography apparatus, preferentially without modifying the radiation source and the detector.
摘要翻译：本发明涉及一种检测装置，其包括用于过滤锥形辐射束（4）的过滤器（20），使得产生具有不同能谱的辐射束的至少第一区域（22）和第二区域（23）其中辐射束的第一区域照射检测器的检测表面（21）上的第一检测器区域（25），从而产生第一组检测值，并且辐射束的第二区域照亮第二检测器区域 26），从而产生第二组检测值。例如，通过使用滤波器，检测装置可以用作双能计算机断层摄影装置，其中，例如，标准计算机断层摄影装置可以通过将滤波器加到标准计算机断层摄影装置优选不改变辐射源和检测器的断层摄影装置。

5. 发明申请

US20230133142A1 PATIENT STRATIFICATION AND CLINICAL DECISION SUPPORT ON MECHANICAL VENTILATION SETTINGS FROM SONAR RESPONSES THROUGH AN ENDOTRACHEAL TUBE (ETT) 有权
公开(公告)号：US20230133142A1
公开(公告)日：2023-05-04
申请号：US17960167
申请日：2022-10-05
申请人： Rafael Wiemker , Joerg Sabczynski , Thomas Koehler , Cornelis Petrus Hendriks , Roberto Buizza , Jaap Roger Haartsen , Stefan Winter , Michael Polkey , Rita Priori , Nataly Wieberneit , Kiran Hamilton J. Dellimore
发明人： Rafael Wiemker , Joerg Sabczynski , Thomas Koehler , Cornelis Petrus Hendriks , Roberto Buizza , Jaap Roger Haartsen , Stefan Winter , Michael Polkey , Rita Priori , Nataly Wieberneit , Kiran Hamilton J. Dellimore
IPC分类号： A61M16/00 , A61M16/04
摘要： A respiration monitoring device comprises an electronic controller configured to: receive an audio signal that is acoustically coupled with an airway of a patient receiving mechanical ventilation therapy from a mechanical ventilator; map the audio signal to one or more lung disease or injury condition categories; and at least one of: display the mapped one or more lung disease or injury condition categories on a display device; and determine a recommended adjustment to one or more parameters of the mechanical ventilation therapy delivered to the patient based at least on the mapped lung disease or injury condition categories and displaying the recommended adjustment on the display device.

6. 发明申请

US20110150176A1 IMAGE PROCESSING WITH COMPUTER AIDED DETECTION AND/OR DIAGNOSIS 审中-公开
标题翻译：具有计算机辅助检测和/或诊断的图像处理
公开(公告)号：US20110150176A1
公开(公告)日：2011-06-23
申请号：US12675809
申请日：2008-09-05
申请人： Thomas Koehler , Rafael Wiemker
发明人： Thomas Koehler , Rafael Wiemker
IPC分类号： A61B6/03 , G06T7/00
CPC分类号： G06T7/0012 , G06T11/008 , G06T2207/10072 , G06T2207/30064
摘要： The invention relates to a method and an image processing device (10) for the evaluation of image raw-data of a body region generated with an imaging device like a CT scanner (30). From the image raw-data, a first image (ICAD) is reconstructed with a reconstruction module (12) according to reconstruction parameters (p) set optimally by a computer aided detection and/or diagnosis (CAD) module (13). This module can then evaluate an image (ICAD) that was reconstructed optimally according to its own requirements, for example with respect to image size and/or resolution, to find features of interest.
摘要翻译：本发明涉及一种用于评估由诸如CT扫描仪（30）的成像装置生成的身体区域的图像原始数据的方法和图像处理装置（10）。根据图像原始数据，根据由计算机辅助检测和/或诊断（CAD）模块（13）最佳设置的重建参数（p），利用重建模块（12）重建第一图像（ICAD）。然后，该模块可以根据其自己的要求（例如关于图像尺寸和/或分辨率）评估被最优化地重建的图像（ICAD），以找到感兴趣的特征。

7. 发明申请

US20100278409A1 HARDWARE TUMOR PHANTOM FOR IMPROVED COMPUTER-AIDED DIAGNOSIS 审中-公开
标题翻译：硬件肿瘤细胞改进计算机辅助诊断
公开(公告)号：US20100278409A1
公开(公告)日：2010-11-04
申请号：US12746552
申请日：2008-12-12
申请人： Rafael Wiemker , Udo Van Stevendaal , Thomas Koehler , Michael Grass
发明人： Rafael Wiemker , Udo Van Stevendaal , Thomas Koehler , Michael Grass
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B6/03 , A61B6/583 , G06T7/41 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/20104 , G06T2207/30096 , G09B23/30
摘要： An imaging system (1) includes at least one hardware phantom (52, 54, 56, 58) which includes structural features (s, 82, 92) that mimic different structural features of tumors. A scanner (10) acquires image data for a subject (14) in a region of interest (40) and the at least one hardware phantom. A reconstruction processor (32) processes the image data to generate reconstructed image data representative of the region of interest and of the hardware phantom.
摘要翻译：成像系统（1）包括至少一个硬件体模（52,54,56,58），其包括模拟肿瘤的不同结构特征的结构特征（s，82,92）。扫描器（10）获取感兴趣区域（40）中的对象（14）的图像数据和至少一个硬件体模。重建处理器（32）处理图像数据以产生表示感兴趣区域和硬件体模的重建图像数据。

8. 发明授权

US09066649B2 Apparatus for phase-contrast imaging comprising a displaceable X-ray detector element and method 有权
标题翻译：包括可移位的X射线检测器元件和方法的用于相位对比成像的装置
公开(公告)号：US09066649B2
公开(公告)日：2015-06-30
申请号：US13514383
申请日：2010-12-03
申请人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sebastian Siegmund Schusser , Thomas Koehler
发明人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sebastian Siegmund Schusser , Thomas Koehler
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4021 , A61B6/4092 , A61B6/4291 , A61B6/484
摘要： An X-ray image acquisition apparatus employing phase-contrast imaging with enlarged field of view includes an X-ray source, an X-ray detector element having a detector size, a beam splitter grating and an analyzer grating. An object is arrangeable between the X-ray source and detector. The beam splitter grating and the analyzer grating are arrangeable between the X-ray source and detector. The X-ray source, the beam splitter grating, the analyzer grating and the X-ray detector are operatively coupled such that a phase-contrast image of the object is obtainable. The apparatus is configure to acquire a phase-contrast image having a field of view larger than the detector size. The X-ray detector element is displaceable where, by the displacement of the X-ray detector, a phase-contrast image of the enlarged field of view is obtainable.
摘要翻译：采用具有放大视场的相位对比成像的X射线图像获取装置包括X射线源，具有检测器尺寸的X射线检测器元件，分束器光栅和分析器光栅。 X射线源和检测器之间可以配置一个物体。分束器光栅和分析器光栅可以在X射线源和检测器之间布置。 X射线源，分束器光栅，分析器光栅和X射线检测器可操作地耦合，使得可以获得物体的相差图像。该装置被配置为获取具有大于检测器尺寸的视场的相位对比度图像。 X射线检测器元件可移动，其中通过X射线检测器的位移可以获得放大视场的相位对比图像。

9. 发明申请

US20120008747A1 DIFFERENTIAL PHASE-CONTRAST IMAGING WITH CIRCULAR GRATINGS 有权
标题翻译：具有圆形光栅的差分相位对比成像
公开(公告)号：US20120008747A1
公开(公告)日：2012-01-12
申请号：US13260380
申请日：2010-03-15
申请人： Ewald Roessl , Thomas Koehler , Gerhard Martens
发明人： Ewald Roessl , Thomas Koehler , Gerhard Martens
IPC分类号： G01N23/201 , G01N23/04
CPC分类号： G21K7/00 , A61B6/4291 , A61B6/484 , A61B6/502
摘要： The invention relates to an X-ray differential phase-contrast imaging system which has three circular gratings. The circular gratings are aligned with the optical axis of the radiation beam and a phase stepping is performed along the optical axis with the focal spot, the phase grating and/or the absorber grating. The signal measured is the phase-gradient in radial direction away from the optical axis.
摘要翻译：本发明涉及一种具有三个圆形光栅的X射线差分相位对比成像系统。圆形光栅与辐射束的光轴对准，并且沿着光轴与焦斑，相位光栅和/或吸收光栅一起执行相位步进。测量的信号是远离光轴的径向相位梯度。

10. 发明授权

US09269471B2 Differential phase-contrast imaging with circular gratings 有权
标题翻译：圆形光栅的差分相位对比成像
公开(公告)号：US09269471B2
公开(公告)日：2016-02-23
申请号：US13260380
申请日：2010-03-15
申请人： Ewald Roessl , Thomas Koehler , Gerhard Martens
发明人： Ewald Roessl , Thomas Koehler , Gerhard Martens
IPC分类号： A61B6/03 , G21K7/00 , A61B6/00
CPC分类号： G21K7/00 , A61B6/4291 , A61B6/484 , A61B6/502
摘要： An X-ray differential phase-contrast imaging system has three circular gratings. The circular gratings are aligned with the optical axis of the radiation beam and a phase stepping is performed along the optical axis with the focal spot, the phase grating and/or the absorber grating. The signal measured is the phase-gradient in radial direction away from the optical axis.
摘要翻译： X射线差分相位成像系统具有三个圆形光栅。圆形光栅与辐射束的光轴对准，并且沿着光轴与焦斑，相位光栅和/或吸收光栅一起执行相位步进。测量的信号是远离光轴的径向相位梯度。

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