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1. 发明申请

US20230133142A1 PATIENT STRATIFICATION AND CLINICAL DECISION SUPPORT ON MECHANICAL VENTILATION SETTINGS FROM SONAR RESPONSES THROUGH AN ENDOTRACHEAL TUBE (ETT) 有权
公开(公告)号：US20230133142A1
公开(公告)日：2023-05-04
申请号：US17960167
申请日：2022-10-05
申请人： Rafael Wiemker , Joerg Sabczynski , Thomas Koehler , Cornelis Petrus Hendriks , Roberto Buizza , Jaap Roger Haartsen , Stefan Winter , Michael Polkey , Rita Priori , Nataly Wieberneit , Kiran Hamilton J. Dellimore
发明人： Rafael Wiemker , Joerg Sabczynski , Thomas Koehler , Cornelis Petrus Hendriks , Roberto Buizza , Jaap Roger Haartsen , Stefan Winter , Michael Polkey , Rita Priori , Nataly Wieberneit , Kiran Hamilton J. Dellimore
IPC分类号： A61M16/00 , A61M16/04
摘要： A respiration monitoring device comprises an electronic controller configured to: receive an audio signal that is acoustically coupled with an airway of a patient receiving mechanical ventilation therapy from a mechanical ventilator; map the audio signal to one or more lung disease or injury condition categories; and at least one of: display the mapped one or more lung disease or injury condition categories on a display device; and determine a recommended adjustment to one or more parameters of the mechanical ventilation therapy delivered to the patient based at least on the mapped lung disease or injury condition categories and displaying the recommended adjustment on the display device.

2. 发明申请

US20130236079A1 METHOD AND DEVICE FOR ANALYSING A REGION OF INTEREST IN AN OBJECT USING X-RAYS 有权
标题翻译：用于分析使用X-RAYS的对象中的兴趣区域的方法和装置
公开(公告)号：US20130236079A1
公开(公告)日：2013-09-12
申请号：US13989507
申请日：2011-12-05
申请人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
发明人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3-dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.
摘要翻译：提出了一种用于分析对象中的感兴趣区域的方法和装置。该方法包括：（a）通过差分相位X射线成像系统提供测量数据，以及（b）分析感兴趣区域中物体的特征。其中，测量数据包括2维或3维像素集合，其中对于每个像素，测量数据包括彼此空间对准的三种类型的图像数据，包括（i）表示图像数据A的吸收，（ii）差分表示图像数据D的相位对比度和（iii）表示图像数据C的相干性。分析步骤基于每个像素，包括在表示图像数据A的吸收中包括的信息中的至少两个信息和差分中包含的信息表示图像数据D的相位对比度和表示图像数据C的相干性中包含的信息。

3. 发明申请

US20110150176A1 IMAGE PROCESSING WITH COMPUTER AIDED DETECTION AND/OR DIAGNOSIS 审中-公开
标题翻译：具有计算机辅助检测和/或诊断的图像处理
公开(公告)号：US20110150176A1
公开(公告)日：2011-06-23
申请号：US12675809
申请日：2008-09-05
申请人： Thomas Koehler , Rafael Wiemker
发明人： Thomas Koehler , Rafael Wiemker
IPC分类号： A61B6/03 , G06T7/00
CPC分类号： G06T7/0012 , G06T11/008 , G06T2207/10072 , G06T2207/30064
摘要： The invention relates to a method and an image processing device (10) for the evaluation of image raw-data of a body region generated with an imaging device like a CT scanner (30). From the image raw-data, a first image (ICAD) is reconstructed with a reconstruction module (12) according to reconstruction parameters (p) set optimally by a computer aided detection and/or diagnosis (CAD) module (13). This module can then evaluate an image (ICAD) that was reconstructed optimally according to its own requirements, for example with respect to image size and/or resolution, to find features of interest.
摘要翻译：本发明涉及一种用于评估由诸如CT扫描仪（30）的成像装置生成的身体区域的图像原始数据的方法和图像处理装置（10）。根据图像原始数据，根据由计算机辅助检测和/或诊断（CAD）模块（13）最佳设置的重建参数（p），利用重建模块（12）重建第一图像（ICAD）。然后，该模块可以根据其自己的要求（例如关于图像尺寸和/或分辨率）评估被最优化地重建的图像（ICAD），以找到感兴趣的特征。

4. 发明授权

US09767550B2 Method and device for analysing a region of interest in an object using x-rays 有权
公开(公告)号：US09767550B2
公开(公告)日：2017-09-19
申请号：US13989507
申请日：2011-12-05
申请人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
发明人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
IPC分类号： G06K9/00 , G06T7/00 , G01N23/04
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3-dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.

5. 发明申请

US20100278409A1 HARDWARE TUMOR PHANTOM FOR IMPROVED COMPUTER-AIDED DIAGNOSIS 审中-公开
标题翻译：硬件肿瘤细胞改进计算机辅助诊断
公开(公告)号：US20100278409A1
公开(公告)日：2010-11-04
申请号：US12746552
申请日：2008-12-12
申请人： Rafael Wiemker , Udo Van Stevendaal , Thomas Koehler , Michael Grass
发明人： Rafael Wiemker , Udo Van Stevendaal , Thomas Koehler , Michael Grass
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B6/03 , A61B6/583 , G06T7/41 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/20104 , G06T2207/30096 , G09B23/30
摘要： An imaging system (1) includes at least one hardware phantom (52, 54, 56, 58) which includes structural features (s, 82, 92) that mimic different structural features of tumors. A scanner (10) acquires image data for a subject (14) in a region of interest (40) and the at least one hardware phantom. A reconstruction processor (32) processes the image data to generate reconstructed image data representative of the region of interest and of the hardware phantom.
摘要翻译：成像系统（1）包括至少一个硬件体模（52,54,56,58），其包括模拟肿瘤的不同结构特征的结构特征（s，82,92）。扫描器（10）获取感兴趣区域（40）中的对象（14）的图像数据和至少一个硬件体模。重建处理器（32）处理图像数据以产生表示感兴趣区域和硬件体模的重建图像数据。

6. 发明授权

US09750465B2 Scanning system for differential phase contrast imaging 有权
公开(公告)号：US09750465B2
公开(公告)日：2017-09-05
申请号：US13514312
申请日：2010-12-08
申请人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier , Thomas Koehler
发明人： Klaus Juergen Engel , Dieter Geller , Gereon Vogtmeier , Thomas Koehler
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4291 , A61B6/484 , A61B6/488 , A61B6/5241
摘要： The invention relates to the field of X-ray differential phase contrast imaging. For scanning large objects and for an improved contrast to noise ratio, an X-ray device (10) for imaging an object (18) is provided. The X-ray device (10) comprises an X-ray emitter arrangement (12) and an X-ray detector arrangement (14), wherein the X-ray emitter arrangement (14) is adapted to emit an X-ray beam (16) through the object (18) onto the X-ray detector arrangement (14). The X-ray beam (16) is at least partial spatial coherent and fan-shaped. The X-ray detector arrangement (14) comprises a phase grating (50) and an absorber grating (52). The X-ray detector arrangement (14) comprises an area detector (54) for detecting X-rays, wherein the X-ray device is adapted to generate image data from the detected X-rays and to extract phase information from the X-ray image data, the phase information relating to a phase shift of X-rays caused by the object (18). The object (18) has a region of interest (32) which is larger than a detection area of the X-ray detector (18) and the X-ray device (10) is adapted to generate image data of the region of interest (32) by moving the object (18) and the X-ray detector arrangement (14) relative to each other.

7. 发明授权

US09105369B2 Differential phase-contrast imaging with improved sampling 有权
标题翻译：差分相位对比成像与改进采样
公开(公告)号：US09105369B2
公开(公告)日：2015-08-11
申请号：US13819764
申请日：2011-08-26
申请人： Thomas Koehler
发明人： Thomas Koehler
IPC分类号： A61B6/00 , G21K1/06 , A61B6/03 , G21K1/02 , G01N23/04
CPC分类号： G21K1/067 , A61B6/032 , A61B6/4035 , A61B6/4291 , A61B6/484 , G01N23/04 , G21K1/02 , G21K2207/005
摘要： The present invention relates to differential phase-contrast imaging of an object. For increasing spatial resolution of an X-ray imaging system (2) the size of a detector pixel element (8) may be considered a limiting factor. Accordingly, it may be beneficial to increase the resolution of an apparatus (38) for phase-contrast imaging without further reducing the area of an individual pixel element (8). Accordingly, an apparatus (38) for phase-contrast imaging with improved sampling is provided, comprising an X-ray source (4), a first grating element G1 (24), a second grating element G2 (26) and an X-ray detector element (6) comprising a plurality of detector pixel elements (8), each detector pixel element (8) having a pixel area A. An object to be imagined (14) is arrangeable between the X-ray source (4) and the X-ray detector element (6). The first grating element G1 (24) as well as the second grating element G2 (26) are arrangeable between the X-ray source (4) and the X-ray detector element (6). The X-ray source (4), the first grating element G1 (24), the second grating element G2 (26) and the X-ray detector (6) are operatively coupled for acquisition of a phase-contrast image of the object (14). At least one of the first grating element G1 (24) and the second grating element G2 (26) comprise a first area A1 having a first grating pitch p1 and a second area A2 having a second grating pitch p2 different from the first grating pitch.
摘要翻译：本发明涉及物体的差分相位对比成像。为了增加X射线成像系统的空间分辨率（2），检测器像素元件（8）的尺寸可以被认为是限制因素。因此，增加用于相位对比成像的装置（38）的分辨率可能是有益的，而不进一步减小单个像素元件（8）的面积。因此，提供了一种用于具有改进采样的相位对比成像的装置（38），包括X射线源（4），第一光栅元件G1（24），第二光栅元件G2（26）和X射线检测器元件（6）包括多个检测器像素元件（8），每个检测器像素元件（8）具有像素区域A.要想象的物体（14）可布置在X射线源（4）和 X射线检测元件（6）。第一光栅元件G1（24）以及第二光栅元件G2（26）可布置在X射线源（X）和X射线探测元件（6）之间。 X射线源（4），第一光栅元件G1（24），第二光栅元件G2（26）和X射线检测器（6）可操作地耦合以获取对象的相位差图像 14）。第一光栅元件G1（24）和第二光栅元件G2（26）中的至少一个包括具有第一光栅间距p1的第一区域A1和具有与第一光栅间距不同的第二光栅间距p2的第二区域A2。

8. 发明授权

US09084528B2 Phase contrast imaging 有权
标题翻译：相位成像
公开(公告)号：US09084528B2
公开(公告)日：2015-07-21
申请号：US13514682
申请日：2010-12-03
申请人： Dieter Geller , Klaus Juergen Engel , Gereon Vogtmeier , Thomas Koehler , Ewald Roessl
发明人： Dieter Geller , Klaus Juergen Engel , Gereon Vogtmeier , Thomas Koehler , Ewald Roessl
IPC分类号： G01N23/04 , A61B6/00
CPC分类号： A61B6/00 , A61B6/4291 , A61B6/4441 , A61B6/484
摘要： X-ray devices for Phase Contrast Imaging (PCI) are often built up with the help of gratings. For large field-of-views (FOV), production cost and complexity of these gratings could increase significantly as they need to have a focused geometry. Instead of a pure PCI with a large FOV, this invention suggests to combine a traditional absorption X-ray-imaging system with large-FOV with an insertable low-cost PCI system with small-FOV, The invention supports the user to direct the PCI system with reduced FOV to a region that he regards as most interesting for performing a PCI scan thus eliminating X-ray dose exposure for scanning regions not interesting for a radiologist. The PCI scan may be generated on the basis of local tomography.
摘要翻译：用于相位对比成像（PCI）的X射线装置通常在光栅的帮助下构建。对于大视野（FOV）来说，这些光栅的生产成本和复杂性可能会因为需要聚焦几何而显着增加。本发明不是采用具有大FOV的纯PCI，而是将传统的吸收X射线成像系统与大型FOV结合，并具有小FOV的可插入低成本PCI系统。本发明支持用户指导PCI 系统将FOV降低到他认为对于执行PCI扫描最有趣的区域，从而消除了用于放射科医生不感兴趣的扫描区域的X射线剂量曝光。可以基于局部断层摄影产生PCI扫描。

9. 发明授权

US09066649B2 Apparatus for phase-contrast imaging comprising a displaceable X-ray detector element and method 有权
标题翻译：包括可移位的X射线检测器元件和方法的用于相位对比成像的装置
公开(公告)号：US09066649B2
公开(公告)日：2015-06-30
申请号：US13514383
申请日：2010-12-03
申请人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sebastian Siegmund Schusser , Thomas Koehler
发明人： Ewald Roessl , Klaus Juergen Engel , Gereon Vogtmeier , Dieter Geller , Gerhard Martens , Sebastian Siegmund Schusser , Thomas Koehler
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/00 , A61B6/032 , A61B6/4021 , A61B6/4092 , A61B6/4291 , A61B6/484
摘要： An X-ray image acquisition apparatus employing phase-contrast imaging with enlarged field of view includes an X-ray source, an X-ray detector element having a detector size, a beam splitter grating and an analyzer grating. An object is arrangeable between the X-ray source and detector. The beam splitter grating and the analyzer grating are arrangeable between the X-ray source and detector. The X-ray source, the beam splitter grating, the analyzer grating and the X-ray detector are operatively coupled such that a phase-contrast image of the object is obtainable. The apparatus is configure to acquire a phase-contrast image having a field of view larger than the detector size. The X-ray detector element is displaceable where, by the displacement of the X-ray detector, a phase-contrast image of the enlarged field of view is obtainable.
摘要翻译：采用具有放大视场的相位对比成像的X射线图像获取装置包括X射线源，具有检测器尺寸的X射线检测器元件，分束器光栅和分析器光栅。 X射线源和检测器之间可以配置一个物体。分束器光栅和分析器光栅可以在X射线源和检测器之间布置。 X射线源，分束器光栅，分析器光栅和X射线检测器可操作地耦合，使得可以获得物体的相差图像。该装置被配置为获取具有大于检测器尺寸的视场的相位对比度图像。 X射线检测器元件可移动，其中通过X射线检测器的位移可以获得放大视场的相位对比图像。

10. 发明授权

US08966221B2 Translating translation requests having associated priorities 有权
标题翻译：翻译具有相关优先级的翻译请求
公开(公告)号：US08966221B2
公开(公告)日：2015-02-24
申请号：US13165013
申请日：2011-06-21
申请人： Ute Gaertner , Thomas Koehler
发明人： Ute Gaertner , Thomas Koehler
IPC分类号： G06F12/00 , G06F13/00 , G06F12/10 , G06F12/08
CPC分类号： G06F12/1027 , G06F12/0855
摘要： A lookup operation is performed in a translation look aside buffer based on a first translation request as current translation request, wherein a respective absolute address is returned to a corresponding requestor for the first translation request as translation result in case of a hit. A translation engine is activated to perform at least one translation table fetch in case the current translation request does not hit an entry in the translation look aside buffer, wherein the translation engine is idle waiting for the at least one translation table fetch to return data, reporting the idle state of the translation engine as lookup under miss condition and accepting a currently pending translation request as second translation request, wherein a lookup under miss sequence is performed in the translation look aside buffer based on said second translation request.
摘要翻译：在基于第一翻译请求的翻译旁边缓冲器中执行查找操作作为当前翻译请求，其中相应的绝对地址在命中情况下作为翻译结果返回给第一翻译请求的对应请求者。翻译引擎被激活以执行至少一个转换表提取，以防当前转换请求没有到达翻译旁边缓冲器中的条目，其中翻译引擎空闲等待至少一个转换表提取返回数据，将所述翻译引擎的空闲状态报告为在未命中条件下的查找，并接受当前待处理的转换请求作为第二转换请求，其中在所述翻译旁边缓冲器中基于所述第二翻译请求执行在未命中序列下的查找。

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