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1. 发明授权

US06810279B2 Hyperspectral imaging calibration device 有权
标题翻译：高光谱成像校准装置
公开(公告)号：US06810279B2
公开(公告)日：2004-10-26
申请号：US09986105
申请日：2001-11-07
申请人： James R. Mansfield , Jenny E. Freeman , Michael E. Leventon , Michael J. Hopmeier , Derek Brand
发明人： James R. Mansfield , Jenny E. Freeman , Michael E. Leventon , Michael J. Hopmeier , Derek Brand
IPC分类号： A61B505
CPC分类号： G01J3/2823 , G01J3/28 , G01J2003/2866
摘要： Hyperspectral imaging calibration devices and methods for their use are described that generate images of three dimensional samples. A calibration device may assume the shape of a desired imaging sample such as a body part and may be sterile prior to placement. The calibration device may include openings or may be modified to expose a region of the sample during use. Spectral images, typically obtained at multiple wavelengths, are made of the calibration device. Algorithms are provided that utilize the spectral images of the calibration device to determine the effects of lighting conditions and sample shape on the sample image to form a calibrated image. Calibrated images produced by these devices and methods can provide information, including clinical data that are less sensitive to lighting and sample shape compared to alternative technologies.
摘要翻译：描述了用于生成三维样本图像的高光谱成像校准装置及其使用方法。校准装置可以呈现期望的成像样品的形状，例如身体部位，并且可以在放置之前是无菌的。校准装置可以包括开口，或者可以被修改以在使用期间暴露样品的区域。通常在多个波长下获得的光谱图像由校准装置制成。提供了利用校准装置的光谱图像来确定照明条件和样品形状对样品图像的影响以形成校准图像的算法。通过这些设备和方法生成的校准图像可以提供信息，包括与替代技术相比对照明和样品形状不太敏感的临床数据。

2. 发明授权

US07013172B2 Hyperspectral imaging calibration device 有权
公开(公告)号：US07013172B2
公开(公告)日：2006-03-14
申请号：US10896232
申请日：2004-07-22
申请人： James R. Mansfield , Jenny E. Freeman , Michael E. Leventon , Michael J. Hopmeier , Derek Brand
发明人： James R. Mansfield , Jenny E. Freeman , Michael E. Leventon , Michael J. Hopmeier , Derek Brand
IPC分类号： A61B5/05
CPC分类号： G01J3/2823 , G01J3/28 , G01J2003/2866
摘要： Hyperspectral imaging calibration devices and methods for their use are described that generate images of three dimensional samples. A calibration device may assume the shape of a desired imaging sample such as a body part and may be sterile prior to placement. The calibration device may include openings or may be modified to expose a region of the sample during use. Spectral images, typically obtained at multiple wavelengths, are made of the calibration device. Algorithms are provided that utilize the spectral images of the calibration device to determine the effects of lighting conditions and sample shape on the sample image to form a calibrated image. Calibrated images produced by these devices and methods can provide information, including clinical data that are less sensitive to lighting and sample shape compared to alternative technologies.

3. 发明授权

US08374682B2 Hyperspectral imaging in diabetes and peripheral vascular disease 有权
标题翻译：糖尿病和外周血管疾病中的高光谱成像
公开(公告)号：US08374682B2
公开(公告)日：2013-02-12
申请号：US11396941
申请日：2006-04-04
申请人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Kevin Schomacker , Derek Brand
发明人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Kevin Schomacker , Derek Brand
IPC分类号： A61B6/00
CPC分类号： A61B5/743 , A61B5/0059 , A61B5/145 , A61B5/14551 , A61B5/14552 , A61B5/412 , A61B5/444 , A61B5/445 , A61B5/7275 , G01J3/02 , G01J3/0224 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/12 , G01J3/2823 , G06F19/00 , G06T7/0012
摘要： The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease, that incorporate hyperspectral or multispectral imaging.
摘要翻译：本发明涉及医学组织的高光谱和多光谱成像的方法和系统。特别地，本发明涉及用于检测和评估诸如但不限于糖尿病和外周血管疾病的结合高光谱或多光谱成像的疾病和病症的新装置，工具和方法。

4. 发明授权

US10646109B1 Device and method of balloon endoscopy 有权
公开(公告)号：US10646109B1
公开(公告)日：2020-05-12
申请号：US11184082
申请日：2005-07-19
申请人： Jenny E. Freeman , Derek Brand , Michael J. Hopmeier
发明人： Jenny E. Freeman , Derek Brand , Michael J. Hopmeier
IPC分类号： A61B1/00 , A61B1/06 , A61B1/04
摘要： A medical device is provided that comprises: (i) an expandable capsule that can be swallowed by a patient and positioned to a target tissue within the patient, (ii) an endoscope attached to the capsule for obtaining an image of the target tissue at a wavelength of interest, and (iii) a thin tube or wire configured to position the device to the target tissue. The thin tube or wire is expandable. The capsule can be swallowed in stages to position the device at different locations within the gastrointestinal tract. The thin tube or wire can deliver electromagnetic radiation for visualization of the target tissue. The thin tube or wire can provide a passage of a biopsy device for access to the target tissue. In some instances, the capsule comprises a band which rotates around the capsule to clean the capsule. In some instances, the capsule collects multispectral or hyperspectral information.

5. 发明授权

US08971984B2 Hyperspectral technology for assessing and treating diabetic foot and tissue disease 有权
标题翻译：高光谱技术用于评估和治疗糖尿病足和组织疾病
公开(公告)号：US08971984B2
公开(公告)日：2015-03-03
申请号：US11507043
申请日：2006-08-21
申请人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Derek Brand , Kevin Schomacker
发明人： Jenny E. Freeman , Svetlana V. Panasyuk , Michael J. Hopmeier , Derek Brand , Kevin Schomacker
IPC分类号： A61B5/00 , G01N21/47 , A61B5/103 , A61B5/1455 , G01N21/31 , G01N21/49 , A61B5/026 , G01N21/359
CPC分类号： A61B5/1036 , A61B5/0075 , A61B5/0261 , A61B5/14551 , A61B5/14552 , A61B5/412 , A61B5/445 , A61B5/447 , A61B5/4884 , A61B5/7275 , A61B2562/0233 , A61B2562/046 , G01N21/31 , G01N21/359 , G01N21/474 , G01N21/4795 , G01N21/49 , G01N2021/3144 , G01N2021/4709 , G06F19/00
摘要： This invention relates generally to an index map comprising both pressure and perfusion information from a diabetic patient foot for the purpose of treatment. The index map may also be a map of perfusion and/or metabolism of the tissue (reflecting oxygen delivery and oxygen extraction), obtained by thermal imaging, hyperspectral imaging, or duplex ultrasound, MRA, CT or laser Doppler imaging. This information aids treatment in prevention of diabetic foot ulceration and amputation and in treatment of tissue compromise to prevent tissue loss in other body regions.
摘要翻译：本发明一般涉及包括来自糖尿病患者足部的压力和灌注信息以用于治疗的指标图。索引图还可以是通过热成像，高光谱成像或双相超声，MRA，CT或激光多普勒成像获得的组织的灌注和/或代谢的组合（反射氧气输送和氧气提取）的图。该信息有助于预防糖尿病足部溃疡和截肢并治疗组织妥协以预防其他身体区域的组织损失。

6. 发明授权

US08538507B2 Infrared endoscopic balloon probes 有权
标题翻译：红外内窥镜气球探针
公开(公告)号：US08538507B2
公开(公告)日：2013-09-17
申请号：US13223222
申请日：2011-08-31
申请人： Jenny E. Freeman , Charles R. Lambert , Michael J. Hopmeier , Edgar N. Lewis
发明人： Jenny E. Freeman , Charles R. Lambert , Michael J. Hopmeier , Edgar N. Lewis
IPC分类号： A61B5/05
CPC分类号： A61B1/00082 , A61B1/00009 , A61B1/00135 , A61B1/04 , A61B1/07 , A61B5/0075 , A61B5/0086 , A61B5/6853 , A61B5/6885
摘要： Balloon probes, adapted for use in endoscopy and other medical procedures, are useful to obtain spectroscopic information reflected or emitted from a tissue of interest in the infrared spectral region. The information collected by the probe is useful in the diagnosis and treatment of disease. The invention also relates to methods utilizing these probes to analyze a surface of interest, in a minimally invasive manner, in connection with the diagnosis and treatment of disease.
摘要翻译：适用于内窥镜检查和其他医疗程序的气球探针可用于获得在红外光谱区域中从感兴趣的组织反射或发射的光谱信息。探针收集的信息对疾病的诊断和治疗是有用的。本发明还涉及利用这些探针以微创方式结合疾病的诊断和治疗分析感兴趣的表面的方法。

7. 发明申请

US20120108903A1 INFRARED ENDOSCOPIC BALLOON PROBES 有权
标题翻译：红外内窥镜气囊探查
公开(公告)号：US20120108903A1
公开(公告)日：2012-05-03
申请号：US13223222
申请日：2011-08-31
申请人： Jenny E. Freeman , Charles R. Lambert , Michael J. Hopmeier , Edgar N. Lewis
发明人： Jenny E. Freeman , Charles R. Lambert , Michael J. Hopmeier , Edgar N. Lewis
IPC分类号： A61B1/04
CPC分类号： A61B1/00082 , A61B1/00009 , A61B1/00135 , A61B1/04 , A61B1/07 , A61B5/0075 , A61B5/0086 , A61B5/6853 , A61B5/6885
摘要： Balloon probes, adapted for use in endoscopy and other medical procedures, are useful to obtain spectroscopic information reflected or emitted from a tissue of interest in the infrared spectral region. The information collected by the probe is useful in the diagnosis and treatment of disease. The invention also relates to methods utilizing these probes to analyze a surface of interest, in a minimally invasive manner, in connection with the diagnosis and treatment of disease.
摘要翻译：适用于内窥镜检查和其他医疗程序的气球探针可用于获得在红外光谱区域中从感兴趣的组织反射或发射的光谱信息。探针收集的信息对疾病的诊断和治疗是有用的。本发明还涉及利用这些探针以微创方式结合疾病的诊断和治疗分析感兴趣的表面的方法。

8. 发明授权

US06640130B1 Integrated imaging apparatus 有权
标题翻译：集成成像装置
公开(公告)号：US06640130B1
公开(公告)日：2003-10-28
申请号：US09609544
申请日：2000-07-03
申请人： Jenny E. Freeman , Michael J. Hopmeier , M. Leventen , James Mansfield , Edgar Neil Lewis
发明人： Jenny E. Freeman , Michael J. Hopmeier , M. Leventen , James Mansfield , Edgar Neil Lewis
IPC分类号： A61B600
CPC分类号： A61B5/442 , A61B5/0059 , A61B5/0071 , A61B5/0073 , A61B5/0077 , A61B5/015 , A61B5/14535 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/441 , A61B5/444 , A61B5/445
摘要： The invention is directed to imaging methods for performing real-time or near real-time assessment and monitoring. Embodiments of these methods are useful in a plurality of settings including surgery, clinical procedures, tissue assessment, diagnostic procedures, forensic, health monitoring and medical evaluations.
摘要翻译：本发明涉及用于执行实时或接近实时评估和监视的成像方法。这些方法的实施例在多种设置中是有用的，包括手术，临床程序，组织评估，诊断程序，法医，健康监测和医学评估。

9. 发明授权

US09078619B2 Hyperspectral/multispectral imaging in determination, assessment and monitoring of systemic physiology and shock 有权
标题翻译：高光谱/多光谱成像在全身生理和休克的测定，评估和监测中的应用
公开(公告)号：US09078619B2
公开(公告)日：2015-07-14
申请号：US11319225
申请日：2005-12-28
申请人： Svetlana V. Panasyuk , Jenny E. Freeman , Michael J. Hopmeier , Alexander A. Panasyuk , Brian H. Tracey
发明人： Svetlana V. Panasyuk , Jenny E. Freeman , Michael J. Hopmeier , Alexander A. Panasyuk , Brian H. Tracey
IPC分类号： A61B5/05 , A61B5/00 , A61B5/026 , A61B5/1455 , G01J3/02 , G01J3/10 , G01J3/28 , G01J3/32 , G01N21/31 , A61B5/02 , A61B5/029 , G01J5/00
CPC分类号： A61B5/445 , A61B5/0059 , A61B5/0088 , A61B5/02 , A61B5/0261 , A61B5/029 , A61B5/14552 , A61B5/412 , A61B5/416 , A61B5/7264 , G01J3/0224 , G01J3/10 , G01J3/2823 , G01J3/32 , G01J2005/0077 , G01N21/31 , G01N2021/3144 , G01N2021/3155 , G01N2201/0221 , G01N2201/0627 , G06F19/00
摘要： The present invention provides a hyperspectral imaging system which demonstrates changes in tissue oxygen delivery, extraction and saturation during shock and resuscitation including an imaging apparatus for performing real-time or near real-time assessment and monitoring of shock, including hemorrhagic, hypovolemic, cardiogenic, neurogenic, septic or burn shock. The information provided by the hyperspectral measurement can deliver physiologic measurements that support early detection of shock and also provide information about likely outcomes.
摘要翻译：本发明提供了一种高光谱成像系统，其显示了在休克和复苏期间组织氧输送，提取和饱和的变化，包括用于执行实时或接近实时评估和监测休克的成像装置，包括出血性，血容量不足，心源性，神经源性，败血性或烧伤性休克。高光谱测量提供的信息可以提供支持早期检测休克的生理测量，并提供可能的结果信息。

10. 发明授权

US06741884B1 Infrared endoscopic balloon probes 有权
公开(公告)号：US06741884B1
公开(公告)日：2004-05-25
申请号：US09389342
申请日：1999-09-02
申请人： Jenny E. Freeman , Charles R. Lambert , Michael J. Hopmeier
发明人： Jenny E. Freeman , Charles R. Lambert , Michael J. Hopmeier
IPC分类号： A61B500
CPC分类号： A61B5/6885 , A61B5/0075 , A61B5/0086 , A61B5/6853
摘要： Balloon probes, adapted for use in endoscopy and other medical procedures, are useful to obtain spectroscopic information reflected or emitted from a tissue of interest in the infrared spectral region. The information collected by the probe is useful in the diagnosis and treatment of disease. The invention also relates to methods utilizing these probes to analyze a surface of interest, in a minimally invasive manner, in connection with the diagnosis and treatment of disease.

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