专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07842003B2 Pulsatile fluid delivery system 有权
标题翻译：脉动流体输送系统
公开(公告)号：US07842003B2
公开(公告)日：2010-11-30
申请号：US11297989
申请日：2005-12-09
申请人： Kenneth A. Jones , Cristo Suresh Corera , Richard S. Hayes
发明人： Kenneth A. Jones , Cristo Suresh Corera , Richard S. Hayes
IPC分类号： A61M37/00 , F04B43/12 , A61N1/362
CPC分类号： F04B49/065
摘要： A system for delivering blood, cardioplegia solution, and other medications or fluids in a pulsatile flow pattern to a patient during cardiopulmonary bypass is disclosed. In a preferred embodiment, a pumping apparatus having at least one chamber is utilized in which a pumping action is achieved by compressing one of the chambers with a piston mechanism, while allowing the other chamber to fill with fluid via retracting its respective piston. The instantaneous flow rate of either of the chambers is determined by the speed of the piston. In a preferred embodiment, a pulsatile flow of fluid is achieved by cyclically alternating the velocity of the piston between two different speeds. A desired average flow rate and/or delivery pressure and/or constant pulse pressure is maintained by adjusting the alternating velocities at the desired frequency and duty cycle. The calculations necessary to obtain a desired average flow rate are performed by a microprocessor, which also controls the movement of the pistons.
摘要翻译：公开了一种用于在体外循环期间向患者输送血液，心麻痹液和脉动流动模式的其它药物或流体的系统。在优选实施例中，使用具有至少一个室的泵送装置，其中通过用活塞机构压缩其中一个室来实现泵送作用，同时允许另一个室通过缩回其相应的活塞来填充流体。任何一个室的瞬时流量由活塞的速度决定。在优选实施例中，通过在两个不同速度之间循环地交替活塞的速度来实现流体的脉动流。通过在所需的频率和占空比下调节交变速度来维持期望的平均流速和/或输送压力和/或恒定脉冲压力。获得所需平均流量所需的计算由微处理器执行，微处理器也控制活塞的运动。

2. 发明申请

US20130190717A1 Cardioplegia Apparatus and Method 有权
标题翻译：心麻痹仪及方法
公开(公告)号：US20130190717A1
公开(公告)日：2013-07-25
申请号：US13613705
申请日：2012-09-13
申请人： Michael L. Dollar , Cristo Suresh Corera , Kenneth A. Jones
发明人： Michael L. Dollar , Cristo Suresh Corera , Kenneth A. Jones
IPC分类号： A61M5/172 , G09B23/28
CPC分类号： A61M5/172 , A61M1/3664 , A61M1/369 , A61M2205/505 , G09B23/285 , G16H40/63
摘要： A microplegia console for controlling the delivery of cardioplegia to a patient, comprising an integrated display/touch screen for displaying cardioplegia information and patient information and allowing inputting of parameters via the display/touch screen into the console for computer-controlled perfusion of cardioplegia into the patient. The invention further comprises a method for delivery of cardioplegia to a patient, including defining and selecting a protocol from a displayed list and sequencing a series of the protocols. The invention also comprises a method for cardioplegia delivery to achieve aortic valve closure. Additionally, the invention comprises a method for activating an icon whereby, upon a first selection of the icon, displaying an indicia indicating that the icon has been first selected; and upon a second selection of the icon, activating the icon.
摘要翻译：一种用于控制对患者的心麻痹递送的微型麻痹控制台，包括用于显示心麻痹信息和患者信息的集成显示/触摸屏，并且允许经由显示/触摸屏将参数输入到控制台中，用于计算机控制的灌注心麻痹进入患者。本发明还包括用于向患者传送心脏停跳症的方法，包括从所显示的列表中定义和选择协议并对一系列协议进行排序。本发明还包括用于实现主动脉瓣闭合的心麻痹输送的方法。此外，本发明包括一种激活图标的方法，其中，在第一次选择图标时，显示指示该图标已被首先选择的标记; 并且在图标的第二选择时，激活图标。

3. 发明授权

US09770554B2 Cardioplegia apparatus and method 有权
公开(公告)号：US09770554B2
公开(公告)日：2017-09-26
申请号：US13613705
申请日：2012-09-13
申请人： Michael L. Dollar , Cristo Suresh Corera , Kenneth A. Jones
发明人： Michael L. Dollar , Cristo Suresh Corera , Kenneth A. Jones
IPC分类号： A61M5/172 , G09B23/28 , A61M1/36 , G06F19/00
CPC分类号： A61M5/172 , A61M1/3664 , A61M1/369 , A61M2205/505 , G09B23/285 , G16H40/63
摘要： A microplegia console for controlling the delivery of cardioplegia to a patient, comprising an integrated display/touch screen for displaying cardioplegia information and patient information and allowing inputting of parameters via the display/touch screen into the console for computer-controlled perfusion of cardioplegia into the patient. The invention further comprises a method for delivery of cardioplegia to a patient, including defining and selecting a protocol from a displayed list and sequencing a series of the protocols. The invention also comprises a method for cardioplegia delivery to achieve aortic valve closure. Additionally, the invention comprises a method for activating an icon whereby, upon a first selection of the icon, displaying an indicia indicating that the icon has been first selected; and upon a second selection of the icon, activating the icon.

4. 发明授权

US09234514B2 Two-chamber blood pump 有权
标题翻译：双室血泵
公开(公告)号：US09234514B2
公开(公告)日：2016-01-12
申请号：US12199593
申请日：2008-08-27
申请人： Kenneth A. Jones
发明人： Kenneth A. Jones
IPC分类号： F04B1/02 , A61M1/00 , F04B9/04 , F04B43/02 , A61M1/10 , F04B7/00 , F04B23/06 , F04B53/14
CPC分类号： F04B43/02 , A61M1/1006 , A61M1/1037 , A61M1/1046 , A61M1/1081 , A61M1/1086 , A61M2202/047 , A61M2205/12 , F04B7/00 , F04B23/06 , F04B43/026 , F04B53/14
摘要： A fluid pump for medical applications. The pump includes a flexible cassette containing two pump chambers of differing volume, each chamber having a dedicated piston. The first piston pushes fluid from the first chamber to the second, and the second piston pushes fluid from the second chamber and out of the pump. Three valves are coordinated with the action of the pistons to control fluid flow into and out of the pump chambers by applying and releasing pressure to and from specific points of the flexible cassette. A control system controls the operation of the pistons and valves and directs the pistons to be advanced according to a time-varying velocity profile. The first pump chamber passively fills and then rapidly expels the collected fluid into the second chamber at low pressure. The second chamber, once filled, expels the fluid downstream at high pressure, producing a pulsatile pressure profile.
摘要翻译：用于医疗应用的流体泵。该泵包括一个含有两个不同体积的泵室的柔性盒，每个室具有专用的活塞。第一活塞将流体从第一腔室推动到第二活塞，第二活塞将流体从第二腔室推出泵出。三个阀门与活塞的作用协调起来，以通过向和从该软管盒的特定点施加和释放压力来控制流入和流出泵室的流体。控制系统控制活塞和阀的操作，并根据时变速度分布指示要提前的活塞。第一泵室被动填充，然后在低压下将收集的流体快速排出到第二室中。一旦装满了第二个室，高压下排出流体，产生脉动压力分布。

5. 发明授权

US07517658B2 Methods for preparing compositions using a SNORF33 receptor 失效
标题翻译：使用SNORF33受体制备组合物的方法
公开(公告)号：US07517658B2
公开(公告)日：2009-04-14
申请号：US11227855
申请日：2005-09-15
申请人： Beth E. Borowsky , Kristine L. Ogozalek , Kenneth A. Jones
发明人： Beth E. Borowsky , Kristine L. Ogozalek , Kenneth A. Jones
IPC分类号： G01N33/567 , G01N33/53 , C07K14/47
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针，与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。

6. 发明授权

US06709831B1 DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof 失效
标题翻译：编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途
公开(公告)号：US06709831B1
公开(公告)日：2004-03-23
申请号：US09405558
申请日：1999-09-24
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
IPC分类号： G01N33566
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针，与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

7. 发明授权

US06262246B1 DNA encoding mammalian neuropeptides FF (NPFF) receptors and uses thereof 失效
标题翻译：编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途
公开(公告)号：US06262246B1
公开(公告)日：2001-07-17
申请号：US09255368
申请日：1999-02-22
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth Borowsky
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth Borowsky
IPC分类号： C07H2104
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针，与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

8. 发明授权

US5346856A Method of making a selective compositional disordering of a GaAs based heterostructure by the in-diffusion of Au through a single crystal, epitaxially grown Ge film 失效
标题翻译：通过单晶，外延生长的Ge膜通过Au的扩散形成GaAs基异质结构的选择性组成失调的方法
公开(公告)号：US5346856A
公开(公告)日：1994-09-13
申请号：US60073
申请日：1993-05-10
申请人： Kenneth A. Jones , Howard S. Lee
发明人： Kenneth A. Jones , Howard S. Lee
IPC分类号： H01L21/18 , H01S5/042 , H01S5/20 , H01L21/20
CPC分类号： H01L21/182 , H01S5/20 , H01S5/0421 , H01S5/0425 , H01S5/2059
摘要： A method for producing a buried heterostructure active devices and a passive waveguide by providing a heterostructure substrate such as a superlattice having at least one planar GaAs layer and at least one AlGaAs layer adjacent to it. A single crystal germanium layer is epitaxially deposited on the superlattice substrate. A layer of gold is deposited on the germanium layer. The gold and germanium layers are imagewise patterned and selected portions etched away. The patterned substrate is encapsulated in a compatible, heat resistant encapsulating material. The encapsulated substrate is then annealed at a temperature of up to about 350.degree. C.
摘要翻译：通过提供具有至少一个平面GaAs层和与其邻近的至少一个AlGaAs层的超晶格等异质结构衬底来制造掩埋异质结构有源器件和无源波导的方法。单晶锗层外延沉积在超晶格基底上。一层金沉积在锗层上。金和锗层是成像图案的，并且选择的部分被蚀刻掉。图案化衬底被封装在相容的耐热封装材料中。然后将封装的衬底在高达约350℃的温度下退火

9. 发明授权

US5124127A Hollow fiber blood oxygenator 失效
标题翻译：中空纤维血液氧化剂
公开(公告)号：US5124127A
公开(公告)日：1992-06-23
申请号：US302422
申请日：1989-01-26
申请人： Kenneth A. Jones , Francis M. Servas , Timothy C. Ryan , Gregory G. Ulrich
发明人： Kenneth A. Jones , Francis M. Servas , Timothy C. Ryan , Gregory G. Ulrich
IPC分类号： A61M1/14 , A61M1/16 , A61M1/36 , B01D63/02 , F28D7/02 , F28F13/00 , F28F21/06
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/02 , F28D7/024 , F28F13/003 , F28F21/062 , A61M1/3627 , B01D2313/146 , B01D2313/38 , F28F2265/16 , Y10S128/03 , Y10S261/28
摘要： A hollow fiber blood oxygenator is provided having a plurality of enclosed, coaxial heat exchanger coils, having a common header to insure uniform temperature in the coils. An enclosed fiber bundle is concentrically positioned inside the heat exchanger coils to define a flow path around the coils and through the fiber bundle. The heat exchanger coils and the outside of the fiber bundle are tapered to provide a close fit. Gas manifolds direct gas flow to and from the hollow fibers.
摘要翻译：中空纤维血液充氧器（12）设置有多个封闭的同轴热交换器线圈（16），其具有共同的头部（46），以确保线圈中的均匀温度。封闭的纤维束（22）同心地位于热交换器盘管的内部，以限定围绕线圈和通过纤维束的流动路径。热交换器线圈和纤维束的外侧是锥形的以提供紧密配合。气体歧管（32,40）直接将气体流入和流出中空纤维。

10. 发明授权

US08475138B2 Self-adaptive piston blood pump 有权
标题翻译：自适应活塞血泵
公开(公告)号：US08475138B2
公开(公告)日：2013-07-02
申请号：US12199669
申请日：2008-08-27
申请人： Kenneth A. Jones
发明人： Kenneth A. Jones
IPC分类号： F04B49/00
CPC分类号： F04B43/026 , A61M1/1006 , A61M1/1037 , A61M1/1046 , A61M1/1081 , A61M1/1086 , A61M1/3667 , A61M2202/047 , A61M2202/0472 , A61M2205/12 , F04B7/00 , F04B43/04 , F04B53/14
摘要： A self-adjusting fluid pump that includes a piston pump containing at least one piston with a pressure sensor. The fluid pump including at least one fluid-containing pump chamber within the piston pump, adjacent to said piston, wherein advancing the piston causes fluid flow from the pump chamber to a biological destination, and retracting the piston causes fluid to passively till the pump chamber. A microprocessor, senses piston pressure to calculate the rate of fluid input flow into the pump chamber for each pump cycle. If the output flow rate deviates from the input flow rate by a pre-specified value range, the microprocessor adjusts the piston pump to match the output flow rate with the input flow rate by increasing or decreasing stroke rate (piston velocity), stroke volume, or a combination of both.
摘要翻译：一种自调节流体泵，其包括具有至少一个具有压力传感器的活塞的活塞泵。流体泵包括位于活塞泵内的至少一个含有流体的泵室，邻近所述活塞，其中推进活塞导致流体从泵室流向生物目的地，并且缩回活塞导致流体被动填充泵室。微处理器感测活塞压力，以计算每个泵循环进入泵室的流体输入流量。如果输出流量偏离输入流量预先设定的值范围，则微处理器通过增加或减少行程速度（活塞速度），行程体积等来调节活塞泵，使输出流量与输入流量匹配，或两者的组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式