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1. 发明申请

US20170140916A1 Ion Trap with Spatially Extended Ion Trapping Region 审中-公开
公开(公告)号：US20170140916A1
公开(公告)日：2017-05-18
申请号：US15243200
申请日：2016-08-22
申请人： Micromass UK Limited
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/06
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.

2. 发明申请

US20080017789A1 METHOD OF OPERATING A MASS SPECTROMETER TO PROVIDE RESONANT EXCITATION ION TRANSFER 有权
标题翻译：操作质谱仪以提供共振激发离子传输的方法
公开(公告)号：US20080017789A1
公开(公告)日：2008-01-24
申请号：US11778954
申请日：2007-07-17
申请人： Jim Hager , Bruce Thomson
发明人： Jim Hager , Bruce Thomson
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4265 , H01J49/4285
摘要： A method of operating a mass spectrometer having a rod set is provided. The rod set has a first end, a second end opposite to the first end, and a longitudinal axis extending between the first end and the second end. The method comprises a) admitting ions into the rod set; b) trapping at least some of the ions in the rod set by i) producing a first barrier field at a first end member adjacent to the first end of the rod set, ii) producing a second barrier field at a second end member adjacent to the second end of the rod set, and iii) providing an aggregate field comprising an RF field between the rods of the rod set; c) selecting a first selected mass to charge ratio of a first group of ions in the ions; d) determining a first excitement level of a selected characteristic of the aggregate field for the first group of ions; e) adjusting the selected characteristic of the aggregate field to the first excitement level to resonantly excite the first group of ions to mass selectively eject the first group of ions from the rod set past the barrier field; and, f) maintaining the selected characteristic of the aggregate field at the first excitement level during an excitement time interval wherein the excitation time interval is at least 1 millisecond.
摘要翻译：提供了具有棒组的操作质谱仪的方法。杆组具有第一端，与第一端相对的第二端和在第一端和第二端之间延伸的纵向轴线。该方法包括：a）将离子进入棒组; b）通过以下步骤捕获所述棒组中的至少一些离子：i）在与所述棒组的第一端相邻的第一端构件处产生第一屏障场，ii）在邻近所述杆组的第二端构件处产生第二屏障场所述杆组的第二端，以及iii）提供包括所述杆组的杆之间的RF场的聚集场; c）选择离子中的第一组离子的第一选择质量与电荷比; d）确定第一组离子的聚集场的选定特征的第一兴奋度; e）将聚集场的所选特征调整到第一兴奋水平以共振地激发第一组离子以质量选择性地从穿过屏障场的棒组中弹出第一组离子; 以及f）在所述激发时间间隔至少为1毫秒的兴奋时间间隔期间将所述聚集场的选定特性保持在所述第一兴奋度水平。

3. 发明申请

US20020008199A1 Apparatus for mass spectrometry on an ion-trap method 有权
标题翻译：离子阱法质谱仪
公开(公告)号：US20020008199A1
公开(公告)日：2002-01-24
申请号：US09730935
申请日：2000-12-06
发明人： Kiyomi Yoshinari , Yoshiaki Kato , Katsuhiro Nakagawa , Shinji Nagai
IPC分类号： H01J049/30 , B01D059/44
CPC分类号： H01J49/4285 , H01J49/424
摘要： Depending on the RF driving voltage amplitude value and the frequency of each frequency component of wideband auxiliary AC voltages, the wideband auxiliary AC voltage comprising plural different frequency components is optimized so that undesired ions having mass-to-charge ratios within the required range will be resonantly ejected from the ion trap electrodes.
摘要翻译：根据RF驱动电压幅度值和宽带辅助AC电压的每个频率分量的频率，包括多个不同频率分量的宽带辅助AC电压被优化，使得具有所需范围内的质荷比的不期望的离子将是从离子阱电极共振地喷出。

4. 发明授权

US5300772A Quadruple ion trap method having improved sensitivity 失效
标题翻译：具有提高灵敏度的四重离子阱法
公开(公告)号：US5300772A
公开(公告)日：1994-04-05
申请号：US923093
申请日：1992-07-31
申请人： Sidney E. Buttrill, Jr.
发明人： Sidney E. Buttrill, Jr.
IPC分类号： H01J49/42 , B01D59/44 , H01J49/40
CPC分类号： H01J49/424 , H01J49/4285 , H01J49/429
摘要： A method for improving sensivity of a QIT by overcoming deleterious space charge effects on the collection of higher mass ions in a QIT by rejecting residual air gas ions during ionization and by rejecting other ions during ionization employing a 1/m/z weighting of the amplitude of each secular frequency, where m/z is the mass to charge ratio of the ions.
摘要翻译：一种提高QIT灵敏度的方法，通过克服在电离过程中排除残余空气气体离子并通过在采用1 / m / z加权幅度的电离期间排斥其他离子而在QIT中收集较高质量离子的有害空间电荷效应的每个世界频率，其中m / z是离子的质荷比。

5. 发明授权

US5200613A Mass spectrometry method using supplemental AC voltage signals 失效
标题翻译：使用补充交流电压信号的质谱法
公开(公告)号：US5200613A
公开(公告)日：1993-04-06
申请号：US753325
申请日：1991-08-30
申请人： Paul E. Kelley
发明人： Paul E. Kelley
IPC分类号： G01N27/62 , H01J49/42
CPC分类号： H01J49/0063 , H01J49/424 , H01J49/4285
摘要： A mass spectrometry method in which a supplemental AC voltage signal having at least one high power frequency component, and at least one low power frequency component, is applied to an ion trap. Each high power component has an amplitude sufficiently large to eject one or more selected ions from the trap, by resonantly exciting the ions. Each low power component has an amplitude sufficient to induce dissociation (or reaction) of one or more selected ions, but insufficient to resonate the ions for detection. The frequency (or band of frequencies) of each high and low power frequency component is selected to match a resonance frequency of ions having a desired mass-to-charge ratio. Each low power component is applied for the purpose of inducing dissociation or reaction of specific trapped ions, which may be parent, daughter, reagent, or product ions, and each high power component is applied to eject undesired products of each such dissociation or reaction process from the trap. In accordance with the invention, a supplemental voltage signal having appropriately selected high and low power frequency components is applied to a trap during an (MS).sup.n or CI, or combined CI/(MS).sup.n, mass spectrometry operation.
摘要翻译：一种质谱法，其中具有至少一个高功率频率分量和至少一个低功率频率分量的补充AC电压信号被施加到离子阱。每个高功率分量具有足够大的振幅，通过共振地激发离子从捕获器中排出一个或多个选定的离子。每个低功率分量具有足以引起一个或多个选定离子的解离（或反应）的振幅，但不足以共振用于检测的离子。选择每个高和低功率频率分量的频率（或频带）以匹配具有期望质荷比的离子的谐振频率。施加每个低功率组分以诱导特定捕获离子的解离或反应的目的，所述离子可以是亲本，子代，试剂或产物离子，并且每个高功率组分被施加以排出每个这样的解离或反应过程的不需要的产物从陷阱。根据本发明，在（MS）n或CI或组合的CI /（MS）n质谱操作期间，将具有适当选择的高功率和低功率频率分量的补充电压信号施加到陷阱。

6. 发明申请

US20170221695A1 SYSTEMS AND METHODS FOR EJECTION OF IONS FROM AN ION TRAP 有权
公开(公告)号：US20170221695A1
公开(公告)日：2017-08-03
申请号：US15421934
申请日：2017-02-01
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Dalton Snyder
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4285 , H01J49/0013 , H01J49/4225
摘要： The invention generally relates to systems and methods for ejection of ions from an ion trap. In certain embodiments, systems and methods of the invention sum two different frequency signals into a single summed signal that is applied to an ion trap. In other embodiments, an amplitude of a single frequency signal is modulated as the single frequency signal is being applied to the ion trap. In other embodiments, a first alternating current (AC) signal is applied to an ion trap that varies as a function of time, while a constant radio frequency (RF) signal is applied to the ion trap.

7. 发明授权

US09425035B2 Ion trap with spatially extended ion trapping region 有权
标题翻译：离子阱具有空间延伸的离子捕获区域
公开(公告)号：US09425035B2
公开(公告)日：2016-08-23
申请号：US14240586
申请日：2012-08-22
申请人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Raymond Green , Daniel James Kenny , David J. Langridge , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/42 , H01J49/40
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.
摘要翻译：公开了将离子引导到小的喷射区域中的质量或质量比的选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。二次直流势阱用于将离子限制在离子阱内的第三（z）方向。二次直流电势的曲线沿着第二（x）方向逐渐变化。

8. 发明授权

US09343281B2 Methods and apparatus for increased ion throughput in tandem mass spectrometers 有权
标题翻译：在串联质谱仪中增加离子通量的方法和装置
公开(公告)号：US09343281B2
公开(公告)日：2016-05-17
申请号：US14470077
申请日：2014-08-27
申请人： Agilent Technologies, Inc.
发明人： Curt A. Flory
IPC分类号： H01J49/00 , H01J49/42 , H01J49/02 , H01J49/06 , H01J49/26
CPC分类号： H01J49/004 , H01J49/0027 , H01J49/025 , H01J49/063 , H01J49/26 , H01J49/4285
摘要： In a tandem mass spectrometry system, a first mass analyzer filters parent ions using a wide mass passband with a narrow rejection notch defined according to a modulation format. A wide mass range of parent ions is transmitted to an ion fragmentation device. Daughter ions produced thereby are transmitted to a second mass analyzer to produce a daughter ion mass spectrum. The modulation of the measured daughter ion mass spectrum, when correlated with the passband modulation of the first mass analyzer (i.e., parent ion spectrum), allows definitive identification of each daughter mass peak with the appropriate parent ion. Due to the wide mass passband, the ion detector signal is in proportion to the increased ion flux passed by the first mass analyzer.
摘要翻译：在串联质谱系统中，第一质量分析器使用具有根据调制格式限定的窄抑制陷波的宽质量通带滤波母离子。母体离子的质量范围很宽，被传送到离子碎片装置。由此产生的子离子传递到第二质量分析器以产生子离子质谱。当与第一质量分析仪的通带调制（即母离子谱）相关时，测量的子离子质谱的调制允许用合适的母离子确定每个子质谱峰。由于宽质量通带，离子检测器信号与通过第一质量分析器的离子通量增加成比例。

9. 发明授权

US08680463B2 Linear ion trap for radial amplitude assisted transfer 有权
标题翻译：线性离子阱用于径向幅度辅助传输
公开(公告)号：US08680463B2
公开(公告)日：2014-03-25
申请号：US13813881
申请日：2011-08-03
申请人： Alexandre Loboda
发明人： Alexandre Loboda
IPC分类号： H01J49/26
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4225 , H01J49/4285
摘要： Systems, methods and apparatus for radial amplitude assisted transfer (RAAT) in mass spectrometers are provided in which ions for RAAT are accelerated along a longitudinal axis of a mass spectrometer in order to decrease the magnitude of excitation energy of radially excited ions in an ion trap that allows the radially excited ions to exit the ion trap. Hence, the radially excited ions exit the ion trap with reduced radial energy thereby decreasing the exit angle of the radially exited ions from the ion trap. Furthermore, combined forces on the ions are such that radially excited ions exit the ion trap while unexcited ions remain in the ion trap.
摘要翻译：提供了用于质谱仪中径向幅度辅助转移（RAAT）的系统，方法和装置，其中RAAT的离子沿着质谱仪的纵轴被加速，以便减小离子阱中径向激发的离子的激发能量的大小这允许径向激发的离子离开离子阱。因此，径向激发的离子以减小的径向能量离开离子阱，从而减小径向排出的离子离离子阱的出射角。此外，离子上的组合力使得径向激发的离子离开离子阱，而未离子离子保留在离子阱中。

10. 发明申请

US20130299689A1 LINEAR ION TRAP FOR RADIAL AMPLITUDE ASSISTED TRANSFER 有权
标题翻译：线性放大器用于辐射放大器辅助传输
公开(公告)号：US20130299689A1
公开(公告)日：2013-11-14
申请号：US13813881
申请日：2011-08-03
申请人： Alexandre Loboda
发明人： Alexandre Loboda
IPC分类号： H01J49/36 , H01J49/00
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4225 , H01J49/4285
摘要： Systems, methods and apparatus for radial amplitude assisted transfer (RAAT) in mass spectrometers are provided in which ions for RAAT are accelerated along a longitudinal axis of a mass spectrometer in order to decrease the magnitude of excitation energy of radially excited ions in an ion trap that allows the radially excited ions to exit the ion trap. Hence, the radially excited ions exit the ion trap with reduced radial energy thereby decreasing the exit angle of the radially exited ions from the ion trap. Furthermore, combined forces on the ions are such that radially excited ions exit the ion trap while unexcited ions remain in the ion trap.
摘要翻译：提供了用于质谱仪中径向幅度辅助转移（RAAT）的系统，方法和装置，其中RAAT的离子沿着质谱仪的纵轴被加速，以便减小离子阱中径向激发的离子的激发能量的大小这允许径向激发的离子离开离子阱。因此，径向激发的离子以减小的径向能量离开离子阱，从而减小径向排出的离子离离子阱的出射角。此外，离子上的组合力使得径向激发的离子离开离子阱，而未离子离子保留在离子阱中。

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