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    • 4. 发明授权
    • X-ray opaque dental materials
    • X光透镜牙科材料
    • US5780668A
    • 1998-07-14
    • US450812
    • 1995-05-25
    • Volker RheinbergerNorbert MosznerUlrich Salz
    • Volker RheinbergerNorbert MosznerUlrich Salz
    • A61K6/083C07C69/76C07C69/78C07C69/84C07C69/92C07C229/54C07C229/56C07C229/60C07C229/64C07C233/54C07C233/69C07C233/75C08F20/26C08F20/30C08F20/34C08F20/36C08F220/30C08F290/00C08F290/06C07C69/767A61C5/08C07C235/42C07C235/88
    • A61K6/083C07C233/54C07C69/76C08F220/30
    • X-ray opaque esters or amides of iodosubstituted benzoic acid according to formula I and polymers and dental materials produced therefrom. ##STR1## R.sup.1 =hydrogen or C.sub.1 to C.sub.3 alkyl, preferably H or CH.sub.3 ; R.sup.2 =straight-chain or branched C.sub.1 to C.sub.6 alkylene, oxyalkylene or arylene, preferably C.sub.2 to C.sub.4 alkylene and particularly preferably --CH.sub.2 --CH.sub.2 -- and --CH.sub.2 CH(--)CH.sub.2 --; X=O or NH, preferably O; R.sup.3 -R.sup.7 =at least 3 iodine substituents, preferably in R.sup.3, R.sup.4 and R.sup.6 or R.sup.3, R.sup.5 and R.sup.7 position, the other groups are hydrogen, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, --Cl, --Br, --OH, --NH.sub.2, --N(C.sub.1 to C.sub.6 alkyl).sub.2 or --NH--CO--(C.sub.1 to C.sub.6 alkyl), preferably R.sup.3, R.sup.4, and R.sup.6 are=I and R.sup.5 and R.sup.7 =H, or R.sup.3, R.sup.5 and R.sup.7 =I and R.sup.4 and R.sup.6 =--NH(COCH.sub.3); n=1, 2 or 3, preferably 1 or 2. The benzoic acid esters and amides according to the invention can be well polymerized radically or anionically, the polymers are well soluble in the usual dental monomers. Dental materials produced from the monomers or polymers are characterized in that the X-ray opaque component is bonded covalently into the polymeric matrix material and cannot therefore be washed out. Furthermore, excellent X-ray opacity can be achieved without using fillers.
    • 根据式I的碘取代苯甲酸的X-射线不透明酯或酰胺和由其制备的聚合物和牙科材料。 式I R1 =氢或C1至C3烷基,优选H或CH3; R2 =直链或支链C1至C6亚烷基,氧化烯或亚芳基,优选C2至C4亚烷基,特别优选-CH2-CH2-和-CH2CH( - )CH2-; X = O或NH,优选O; R3-R7 =至少3个碘取代基,优选在R3,R4和R6或R3,R5和R7位置,其他基团是氢,C1至C6烷基,C1至C6烷氧基,-Cl,-Br,-OH, -NH 2,-N(C 1至C 6烷基)2或-NH-CO-(C 1至C 6烷基),优选R 3,R 4和R 6为= I且R 5和R 7 = H,或R 3,R 5和R 7 = 和R 4和R 6 = -NH(COCH 3); n = 1,2或3,优选1或2.根据本发明的苯甲酸酯和酰胺可以完全聚合或阴离子聚合,这些聚合物在通常的牙科单体中很好地溶解。 由单体或聚合物生产的牙科材料的特征在于,X射线不透明组分共价键合到聚合物基体材料中,因此不能被洗掉。 此外,可以在不使用填料的情况下实现优异的X射线不透明度。
    • 9. 发明授权
    • Compositions of iodobenzoic acid derivatives for visualization of the
gastrointestinal tract
    • 碘苯甲酸衍生物用于胃肠道可视化的组合物
    • US5344638A
    • 1994-09-06
    • US031384
    • 1993-03-11
    • Carl R. IlligBrent D. Douty
    • Carl R. IlligBrent D. Douty
    • A61K49/04C07C69/76C07C69/767C07C69/773C07C69/78C07C69/82C07C69/92
    • A61K49/0433C07C69/76C07C69/92
    • Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract whereinwhereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-3y is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkylin an aqueous, pharmaceutically acceptable carrier.
    • 公开了含水组合物中含有的式“IMAGE”的造影剂及其用于胃肠道诊断放射学的方法,其中Z = H,卤素,C 1 -C 20烷基,环烷基,低级烷氧基,氰基,其中烷基和 环烷基可以被卤素或卤代低级烷基取代; R = C1-C25烷基,环烷基或卤代低级烷基,任选被卤素,氟 - 低级 - 烷基,芳基,低级烷氧基,羟基,羧基,低级烷氧基羰基或低级 - 烷氧基 - 羰氧基取代,(CR1R2 )p - (CR 3 = CR 4)m Q或(CR 1 R 2) R 1,R 2,R 3和R 4独立地为低级烷基,任选被卤素取代; x为1-3 y为1-4; n为1-5; m为1-15; p为1-10; 并且Q是在水性药学上可接受的载体中的H,低级烷基,低级烯基,低级炔基,低级亚烷基,芳基或芳基 - 低级烷基。