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1. 发明授权

US4650499A Gas chromatographic apparatus and method 失效
标题翻译：气相色谱仪及方法
公开(公告)号：US4650499A
公开(公告)日：1987-03-17
申请号：US802494
申请日：1985-11-27
申请人： Richard L. Scott
发明人： Richard L. Scott
IPC分类号： G01N30/12 , G01N30/62 , G01N30/88 , B01D15/08 , G01N31/04
CPC分类号： G01N30/88 , G01N2030/125 , G01N2030/625 , G01N2030/626
摘要： A gas chromatographic method and apparatus are provided wherein a reservoir system including at least one reservoir is utilized to collect each component as it elutes from a chromatographic separation column. Immediately after collection of each component, a constant flow of carrier gas is allowed to pass into the reservoir system to carry each component to a detector. According to another aspect of the invention, a method is provided which employs a reference gas mixture in conjunction with the reservoir system to check calibration of a gas chromatography system.
摘要翻译：提供了一种气相色谱方法和装置，其中使用包含至少一个储存器的储存器系统来收集每个组分，当其从色谱分离柱洗脱时。在收集每个组分之后，允许恒定的载气流进入储存器系统以将每个组分携带到检测器。根据本发明的另一方面，提供了一种使用参考气体混合物与储存系统结合来检查气相色谱系统的校准的方法。

2. 发明授权

US4199323A Analytical technique for quantitating acid/salt and base/salt samples for species concentration 失效
标题翻译：用于定量酸/盐和碱/盐样品的物质浓度的分析技术
公开(公告)号：US4199323A
公开(公告)日：1980-04-22
申请号：US913786
申请日：1978-06-08
申请人： Theodore E. Miller, Jr. , Timothy S. Stevens
发明人： Theodore E. Miller, Jr. , Timothy S. Stevens
IPC分类号： G01N27/06 , G01N30/00 , G01N30/02 , G01N30/64 , G01N30/88 , G01N30/96 , G01N31/04 , G01N27/08
CPC分类号： G01N30/00 , G01N27/06 , G01N30/96
摘要： Acid or alternately base species concentration in aqueous and non-aqueous samples is quantitated, in the presence of interfering ionic salts, using most preferably differential conductivity detection combined with ion-exchange derivatization, wherein characteristically the acid or base species is derivatized to water, and blended indistinguishably in a required aqueous carrier phase, and the interfering salt(s) is derivatized to a distinguishable hydroxide or acid derivative(s). Using the preferred mode of detector read-out, the calibrated peak of the conductimetric response of the salt derivative(s) is compared to the peak of the conductimetric response of the sample and the response differential is displayed and used to predict the acid or base species concentration. The salt(s) concentration (with some exceptions) may be simultaneously predicted since it is proportional to the first mentioned peak. The technique has utility with respect to acids and bases broadly, and most advantageously is used with respect to strong and moderately strong acids and bases of a pK.sub.a and pK.sub.b value, respectively, of about 2 or less.
摘要翻译：使用最优选与离子交换衍生化结合的差异电导率检测，在干扰离子盐存在下定量水性和非水性样品中的酸性或交替碱基物质浓度，其中特征性地将酸或碱性物质衍生为水，和在所需的水性载体相中无差别地混合，并且所述干扰的盐被衍生成可区分的氢氧化物或酸衍生物。使用优选的检测器读数模式，将盐衍生物的电导率响应的校准峰与样品的电导响应的峰值进行比较，并显示响应差异并用于预测酸或碱物种集中。盐浓度（有一些例外）可以同时预测，因为它与首先提到的峰成正比。该技术相对于酸和碱广泛使用，并且最有利地分别用于约2或更低的pKa和pKb值的强和中等强酸和碱。

3. 发明授权

US4180771A Chemical-sensitive field-effect transistor 失效
标题翻译：化学敏感场效应晶体管
公开(公告)号：US4180771A
公开(公告)日：1979-12-25
申请号：US856935
申请日：1977-12-02
申请人： Henry Guckel
发明人： Henry Guckel
IPC分类号： G01N27/00 , A61B5/00 , G01N27/414 , H01L29/78 , G01N27/56 , A61B5/05 , G01N31/04
CPC分类号： A61B5/14542 , A61B5/1473 , G01N27/414
摘要： The invention relates to an insulated-gate field effect transistor which is adapted for detecting and measuring various chemical properties such as ion activity in a solution. The device has a chemically sensitive layer which overlies a portion of a substrate other than that covered by the gate insulator. When this chemically sensitive layer is exposed to a solution or other substance, the electric field in the substrate is modified which changes the conductance of the channel between a source region and a drain region. The change in conductance is related to the chemical exposure and can be detected with a current meter.
摘要翻译：本发明涉及一种绝缘栅场效应晶体管，适用于检测和测量各种化学性质如溶液中的离子活性。该器件具有化学敏感层，其覆盖除了由栅极绝缘体覆盖的衬底之外的衬底的一部分。当这种化学敏感层暴露于溶液或其他物质时，衬底中的电场被改变，这改变了源极区域和漏极区域之间的沟道的电导。电导率的变化与化学暴露有关，可用电流表检测。

4. 发明授权

US4046634A Assay of isoenzymes by ion exchange chromatography 失效
标题翻译：通过离子交换色谱法测定同工酶
公开(公告)号：US4046634A
公开(公告)日：1977-09-06
申请号：US677553
申请日：1976-04-16
申请人： Donald W. Mercer
发明人： Donald W. Mercer
IPC分类号： C12Q1/00 , G01N30/96 , G01N31/04 , G01N31/08 , G01N31/14
CPC分类号： G01N30/482 , C12Q1/007 , G01N30/96 , B01J2220/54 , Y10S435/815
摘要： A simple, rapid anion-exchange column chromatographic technique is used to determine the presence of fractions of proteins and enzymes in human serum by separating the fractions on the basis of their net electrical charges. Samples of serum of unaltered ionic strength, layered on mini columns of an ion exchange agent previously equilibrated to a low ionic strength similar to blood serum with a buffer solution, are eluted stepwise with an appropriate buffer solution having different ionic strengths at each step. Elution of the samples is without previous dialysis or other ionization treatment. Column effluents are assayed for protein content or enzyme activity by conventional means, e.g., spectrophotometric analysis. Evaluation of sera from patients utilizing these methods reveals protein fractions or isoenzyme patterns which identify specific diseases associated with the protein or isoenzyme pattern.
摘要翻译：使用简单，快速的阴离子交换柱层析技术通过基于其净电荷分离级分来确定人血清中蛋白质和酶的级分的存在。用预先平衡到与缓冲液相似的血清的低离子强度的离子交换剂的微型柱上分层的未改变的离子强度的血清样品在每个步骤中用适当的离子强度缓冲溶液逐步洗脱。样品的洗脱没有以前的透析或其他离子化处理。通过常规方法测定柱流出物的蛋白质含量或酶活性，例如分光光度分析。使用这些方法的患者血清的评估显示蛋白质级分或同工酶模式，其识别与蛋白质或同工酶模式相关的特定疾病。

5. 发明授权

US3996017A Cassette separating column system for chromatography 失效
标题翻译：用于色谱的盒式分离柱系统
公开(公告)号：US3996017A
公开(公告)日：1976-12-07
申请号：US418277
申请日：1973-11-23
申请人： Rudolph E. Kaiser
发明人： Rudolph E. Kaiser
IPC分类号： G01N30/46 , G01N30/60 , G01N30/88 , B01D15/08 , G01N31/04 , G01N31/06
CPC分类号： G01N30/468 , G01N30/60 , G01N30/6034 , G01N2030/8881 , G01N30/461 , G01N30/6091
摘要： A chromatographic system including cassettes, each containing a separating column which is connected at each of its ends to a coupling piece having both of its ends in the form of conical surfaces on the outside of the cassettes. These conical coupling surfaces may be connected to complementary-shaped conical fittings in a fluid-tight manner to connect the inlet and outlet ends of the column of the chromatographic instrument lines such as, for example, the sample injector, stream splitter, backflushing inlet and outlet lines, detector and auxiliary gas flows. A special connection fitting allows the direct connection of the conical coupling surfaces of two column-containing cassettes, as well as connection to other parts of the chromatograph between the columns. Thus, the separating column cassettes may be utilized as components of various relatively simple and complex chromatographic systems.
摘要翻译：一种色谱系统，包括盒，每个盒包含分离柱，每个分离柱的每个端部连接到耦合件，其两端的端部在盒的外侧呈圆锥形表面。这些锥形联接表面可以以流体密封的方式连接到互补形状的锥形配件，以连接色谱仪器管线的柱的入口端和出口端，例如样品注射器，流分离器，反冲入口和出口管路，检测器和辅助气体流。一个特殊的连接配件可以直接连接两个色谱柱盒的锥形耦合表面，以及连接色谱柱的其他部分。因此，分离柱盒可以用作各种相对简单和复杂的色谱系统的组分。

6. 发明授权

US3725006A Method for quantitative determination of anions 失效
标题翻译：阴离子定量测定方法
公开(公告)号：US3725006A
公开(公告)日：1973-04-03
申请号：US3725006D
申请日：1971-06-03
申请人： HAESSLE AB
发明人： BRANDSTROM A , MOLNDAL K , JUNGGREN U , KYLBERG K
IPC分类号： G01N30/00 , G01N30/96 , G01N31/00 , B01D11/04 , C02B1/60 , G01N31/04
CPC分类号： G01N30/96 , G01N30/00 , G01N31/00 , Y10T436/18 , Y10T436/193333 , Y10T436/201666 , Y10T436/255
摘要： A METHOD FOR THE DETERMINATION OF ANIONS IN SOLUTION BY MEANS OF ION EXCHANGE COMPRISING ADDING TO A SOLUTION, PREFERABLY AN AQUEOUS SOLUTION CONTAINING AN ANION IN UNKNOWN QUANTITY TO BE ANALYZED, A COMPOUND SELECTED FROM THE GROUP CONSISTING OF QUATERNARY ALIPHATIC AMMONIUM PICRATES HAVING A TOTAL OF AT LEAST 30 CARBON ATOMS, PREFERABLY DISSOLVED IN AN IMMICIBLE ORGANIC SOLVENT, THEREBY TO FORM BY ION EXCHANGE THE CORRESPONDING QUATERNARY AMMONIUM COMPOUND OF SAID ANION TO BE ANALYZED AND TO RELEASE A CORRESPONDING AMOUNT OF PICRATE ANION. SUITABLY TWO LAYERS ARE FORMED UPON MIXING AND THE QUATERNARY AMMONIUM COMPOUND OF SAID UNKNOWN ANION BECOMES DISSOLVED IN THE ORGANIC SOLVENT, WHILE SAID RELEASED PICRATE ION BECOMES DISSOLVED IN THE AQUEOUS PHASE. KNOWN TECHNIQUES SUCH AS OPTICAL METHODS ARE EMPLOYED TO DETERMINE THE AMOUNT OF RELEASED PICRATE ION, WHICH IS A MEASURE OF THE AMOUNT OF ORIGINALLL UNKNOWN ANION TO BE ANALYZED.

7. 发明授权

US3689632A Rheumatoid agglutination test and reagent 失效
标题翻译： RHEUMATOID AGGLUTINATION测试和试剂
公开(公告)号：US3689632A
公开(公告)日：1972-09-05
申请号：US3689632D
申请日：1969-01-06
申请人： KOWA CO
发明人： MIZUSHIMA YUTAKA , NAGAI HIDETAKA
IPC分类号： G01N33/564 , G01N31/00 , G01N31/04 , G01N33/16
CPC分类号： G01N33/564 , G01N2800/102 , Y10S436/805
摘要： A rheumatoid agglutination test reagent, which can be used for detecting rheumatoid factor in whole blood as well as serum, and which demonstrates excellent results with respect to its sensitivity, reproducibility in the detection, comprising a buffered saline of a pH 7.5 + OR - 1.5 wherein are contained proper amounts of gamma -globulin coated resin particles formed by combining an ion-exchange resin with human gamma -globulin in the said solution and one class of assistant selected from the group consisting of hemolytic agent and coloring agent which can color the said gamma -globulin, method for preparation thereof and a diagnostic method of using some.
摘要翻译：一种类风湿凝集试验试剂，可用于检测全血和血清中的类风湿因子，并且其检测灵敏度，再现性方面表现出优异的结果，包括pH 7.5 +/- 1.5的缓冲盐水其中含有通过在所述溶液中混合离子交换树脂与人γ-球蛋白形成的适量的γ-球蛋白包被的树脂颗粒，以及选自溶血剂和着色剂的一类助剂，其可以使所述 γ-球蛋白，其制备方法和使用一些的诊断方法。

8. 发明授权

US3600132A Process for the determination of the hydroxyproline content of biological fluids,and diagnostic packs for this determination 失效
标题翻译：用于确定生物流体的羟丙基含量的方法和用于确定的诊断性包装
公开(公告)号：US3600132A
公开(公告)日：1971-08-17
申请号：US3600132D
申请日：1968-12-04
申请人： ORGANON
发明人： GOVERDE BASTIAAN CORNELIS
IPC分类号： B21C23/32 , C07D207/12 , G01N33/68 , C07D27/00 , G01N31/04 , G01N33/16
CPC分类号： C10M7/00 , B21C23/32 , G01N33/6887
摘要： PROCESS FOR THE DETERMINATION OF HYDROXYPROLINE IN BIOLOGICAL FLUIDS, SUCH AS SERUM, URINE, LUMBAR FLUID AND INTERARTICULAR FLUID. IT COMPRISES TREATING A SAMPLE WITH A STRONG ACIDIC CATION EXCHANGE RESIN, WHICH ADSOBS THE FREE AND PEPTIDE-BOUND HYDROXYPROLINE AND HYDROLYZING THE ABSORBED PIPTIDE-BOUND HYDROXYPROLINE BY HEATING, WHEREAFTER THE HYDROXYPROLINE IS ELUTED AND DETERMINED BY MEANS OF A COLOUR REACTION. BESIDES, THE INVENTION COMPRISES A DIAGNOSTIC PACK CHIEFLY COMPRISING A BOTTLE WITH SAID RESIN, A TUBE FOR THE PERFORMANCE OF THE ADSORPTION AND HYDROLYSIS, A BOTTLE WITH A STANDARD QUANTITY OF HYDROXYPROLINE AND A REAGENT FOR THE PERFORMANCE OF A COLOUR REACTION. IN THIS WAY TRACING OF DEVIATIONS IN COLLAGEN METABOLISM CAN EASILY BE PREFORMED.

9. 发明授权

US3426579A Continuous monitor for the rapid detection of hydrogen and oxygen 失效
标题翻译：连续监测氢和氧的快速检测
公开(公告)号：US3426579A
公开(公告)日：1969-02-11
申请号：US3426579D
申请日：1965-09-03
申请人： BOEING CO
发明人： LEBEL STEPHEN J , STROBELT WILLIAM E
IPC分类号： G01N7/10 , G01N31/04
CPC分类号： G01N7/10

10. 发明授权

US4679428A Independent analysis of anions and cations using indirect photometric chromatography 失效
标题翻译：使用间接光度色谱法对阴离子和阳离子进行独立分析
公开(公告)号：US4679428A
公开(公告)日：1987-07-14
申请号：US822188
申请日：1986-01-24
申请人： Theodore E. Miller, Jr. , Ziad Iskandarani
发明人： Theodore E. Miller, Jr. , Ziad Iskandarani
IPC分类号： G01N30/02 , G01N30/96 , G01N31/04
CPC分类号： G01N30/96 , G01N30/02
摘要： An improved technique and apparatus for the independent measurement of anions and cations in solution, wherein the sample ions are chromatographically displaced in a plurality of ion exchange columns by an eluting ion which is or is made light-absorbing and wherein the sample ions are detectable from decrements in absorbance of the eluting ions as revealed by photometric monitoring; and the sample ions, cations and anions, are further detected independently by means for monitoring eluting anion and cation absorbance differences calibrated according to characteristic absorbance ratios of the selected eluting ion species at a plurality of wavelengths.
摘要翻译：一种用于独立测量溶液中阴离子和阳离子的改进的技术和装置，其中样品离子在多个离子交换柱中通过洗光离子进行色谱位移，所述洗脱离子是或被吸收光，并且其中样品离子可从通过光度监测显示洗脱离子的吸光度减少; 并且样品离子，阳离子和阴离子通过监测洗脱阴离子和阳离子吸光度差异的方式被独立地进一步检测，所述洗脱阴离子和阳离子吸光度差异根据在多个波长处选择的洗脱离子种类的特征吸光度比进行校准。

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