氧四环素相关的专利数据

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
101	製備 –6–脫氧四環素之改良方法	TW06310582	1974-03-25	TW018523B	1975-05-01	THOMAS ARTHUR MORRIS, JR.,

102	Fermentative production of nu-ethyloxytetracycline	US44222365	1965-01-21	US3390055A	1968-06-25	DULANEY EUGENE L; IRVING PUTTER

103	Process for the production of alpha-6-deoxytetracyclines	US552839	1990-07-12	US5049683A	1991-09-17	George Krsek
A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The process stereospecifically produces the alpha epimers at higher yields while using lower rhodium metal levels than prior methods.
104	Process for the production of alpha-6-deoxytetracyclines	US337288	1989-04-13	US4997959A	1991-03-05	Jagmohan Khanna; Kiran Bala; Inder P. S. Grover
A process for the hydrogenation of a 6-methylenetetracycline in the production of alpha-6-deoxytetracycline, particularly the antibiotic doxycycline, in the presence of a transition metal complex of the formula MCl.sub.x (PPh.sub.3).sub.y wherein M is Cu, Co or Ni, x is 1 or 2 and y is 1-3, and a trace of rhodium either as the supported metal or as a rhodium salt, as a hydrogenation catalyst. The desired alpha-6-deoxytetracycline product is produced in high yields and stereospecificities. The process requires the use of substantially cheaper transition metal complexes and only traces of rhodium in the hydrogenation catalyst per mole of the 6-methylene tetracycline hydrogenated.
105	Process for the preparation of .alpha.-6-deoxytetracyclines	US458067	1983-01-14	US4500458A	1985-02-19	Ivan Villax; Philip R. Page
An improved process for the preparation of .alpha.-6-deoxytetracyclines and more particularly to the stereo specific hydrogenation of the 6-methylene group of 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracyline and of its 11a-halo-analog, is described in which the catalyst is the reaction product of a rhodium salt or a complex with a hydrazine or salt thereof.
106	7-and 9-alkylamino-6-deoxytetracycline	US28134963	1963-05-17	US3226436A	1965-12-28	JOSEPH PETLSI; HOWARD BOOTHE JAMES

107	옥씨 테트라싸이클린 및 벤지싸이드의 제조 방법	KR1019650000520	1965-07-19	KR1019670000289B1	1967-08-15	애드리아노스피스트루익; 아이알에이졸트에이스디멘

108	Process for the production of alpha-6-deoxytetracyclines	US263728	1988-10-28	US4973719A	1990-11-27	Jagmohan Khanna; Kiran Bala; Inder P. S. Grover
A process for the hydrogenation of a 6-methylenetetracycline in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline, in the presence of hydriodotetrakis (triphenylphosphine) rhodium (I) as a homogenous hydrogenation catalyst. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.
109	Water-soluble derivative of 6-deoxy-tetracyclines	US616830	1975-09-25	US4060605A	1977-11-29	Gino Cotti
This invention relates to a novel water soluble derivatives of 6-deoxy-tetracyclines, particularly of doxycycline, in which a methionine group is linked to the tetracycline group through a methylene bridge, thus obtaining a derivative which is not only water soluble at neutral pH, but also endowed with outstanding properties from the point of view of the therapeutical use.
110	Process for producing oxytetra-cycline antibiotic	US43533665	1965-02-25	US3408258A	1968-10-29	ARPAD GREIN; RICCARDO BARCHIELLI

111	Process for the preparation of .alpha.-6-deoxytetracyclines	US858660	1986-05-01	USRE32535E	1987-10-27	Ivan Villax; Philip R. Page
An improved process for the preparation of .alpha.-6-deoxytetracyclines and more particularly to the stereo specific hydrogenation of the 6-methylene group of 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracyline and of its 11.alpha.-halo-analog, is described in which the catalyst is the reaction product of a rhodium salt or a complex with a hydrazine or salt thereof.
112	Process for the preparation of .alpha.-6-deoxy-tetracyclines	US641607	1984-08-17	US4597904A	1986-07-01	Philip R. Page
A process for the preparation of .alpha.-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, or the simultaneous dehalogenation and stereo-selective heterogeneous hydrogenation of an 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, characterized by the use of a rhodium salt catalysts, wherein the rhodium is bonded to a polysiloxane carrier, having the following formulae:Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.10Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.12Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.15Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.4Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.8permitting easy recovery of the rhodium, by simple filtration.
113	Process for producing .alpha.-6-deoxytetracyclines	US421206	1973-12-03	US3954862A	1976-05-04	Thomas A. Morris, Jr.
The catalytic hydrogenation of 6-methylenetetracyclines, or salts of these compounds, in a reaction-inert solvent medium containing a catalytic amount of rhodium metal to which a phosphine and a promoter is added.
114	Hydroxylating 12alpha-deoxytetracycline with ascomyceteae	US3488660	1960-06-09	US2970087A	1961-01-31	DONALD BECK; SHULL GILBERT M

115	alpha-6-deoxytetracycline derivatives and process	US10614661	1961-05-05	US3200149A	1965-08-10	BLACKWOOD ROBERT K; RENNHARD HANS H; BEEREBOOM JOHN J; STEPHENS JR CHARLES R

116	6–脫氧–四環素的水溶性衍生物之製造方法	TW06312024	1974-09-27	TW024989B	1979-04-01	GINO COTTI

117	Process for the preparation of .alpha.-6-deoxytetracyclines	US509055	1974-09-25	US3962331A	1976-06-08	Gino Cotti
This invention relates to a process for the preparation of .alpha.-6-deoxytetracyclines, by the simultaneous reductive dehalogenation and reduction by hydrogen, in a polar solvent of the corresponding 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline, in presence of a suitable member of the group of the tertiary phosphines, arsines and stibines, as regards the dehalogenation and of a catalyst, selected from amongst the complexes of noble metals with electron-donor ligands, soluble in the reaction medium, whereby the reaction is carried out according to the mechanism of the homogeneous catalysis.
118	Preparation of 7-halo-6-deoxy-tetracyclines	US84530459	1959-10-09	US3036129A	1962-05-22	JOHN HLAVKA JOSEPH; HOWARD BOOTHE JAMES

119	PROCESS FOR THE PRODUCTION OF ALPHA-6-DEOXYTETRACYCLINES	EP90902446.0	1990-01-02	EP0452412A1	1991-10-23	KRSEK, George
L'invention concerne un procédé de préparation d'alpha-6-désoxytétracyclines à partir des 6-méthylènetétracyclines correspondantes, utilisant un catalyseur de rhodium hétérogène à support de silice de formule générale (I), dans laquelle R et R' sont chacun choisis entre l'hydrogène et l'alcoyle contenant 1 à 4 atomes de carbone, x est un nombre entier compris entre 1 et 6, Ph représente phényle, y représente un nombre entier compris entre 1 et 3, et L représente un ligand choisi parmis des phosphines d'aloyldiphényle à substitution alcoxysilyle. Ledit procédé produit stéréospécifiquement les épimères alpha à des rendements supérieurs tout en utilisant des niveaux de rhodium inférieurs à ceux des procédés antérieurs.
120	Therapeutic composition comprising tetracycline and a dioxolane	US80457759	1959-04-07	US3004894A	1961-10-17	JOHNSON RICHARD H; WALLACH DONALD P

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