氧四环素相关的专利数据

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
121	Recovery of 6-deoxy-6-demethyltetracycline	US84335759	1959-09-30	US2999111A	1961-09-05	STEPHENS JR CHARLES R

122	Preparation of alpha-6-deoxy-5-hydroxytetracycline	US47379174	1974-05-28	US3907890A	1975-09-23	SCANIO CHARLES J V
A process for the synthesis of Alpha -6-deoxy-5hydroxytetracycline, a broad spectrum antibiotic, by reduction of 6-methylene-5-hydroxytetracycline using cobalt carbonyl, triphenyl phosphine and hydrochloric acid in a reaction solvent and inert atmosphere.
123	6-deoxy-6-hydroperoxy dehydrotetracyclines and process utilizing the same	US19959062	1962-06-04	US3146265A	1964-08-25	SCOTT ALASTAIR I; BEDFORD COLIN T

124	일산화질소 생산을 억제하기 위한 테트라사이클린 화합물을 포함하는 약제학적 조성물	KR1019997001591	1997-08-21	KR1020000035881A	2000-06-26	아민아쇽알; 아브람슨스티븐비; 골럽론엠; 라마무르씨눈가바람에스; 맥나마라토마스에프; 그린왈드로버트에이; 트라츠먼하워드
PURPOSE: A method for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system, can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions. CONSTITUTION: A method for inhibiting nitric oxide production in a mammal system, comprises of providing to the mammalian system an amount of a tetracycline compound sufficient to cause a decrease in the amount of nitric oxide produced endogenously by the mammalian-system.
125	Combinations of quinoxaline-di-n-oxides and tetracycline antibiotics	US3497594D	1967-06-01	US3497594A	1970-02-24	JOHNSTON JAMES L

126	METHOD OF USING TETRACYCLINE COMPOUNDS FOR INHIBITION OF NITRIC OXIDE PRODUCTION	PCT/US9714723	1997-08-21	WO9808480A2	1998-03-05	AMIN ASHOK R; ABRAMSON STEVEN B; GOLUB LORNE M; RAMAMURTHY NUNGAVARAM S; MCNAMARA THOMAS F; GREENWALD ROBERT A; TRACHTMAN HOWARD
The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform ot nitric oxide synthase (iNOS). Preferably, the tetraclycine compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetraclycine compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.
127	6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines	US7644160	1960-12-19	US2984686A	1961-05-16	BLACKWOOD ROBERT K; RENNHARD HANS H; BEEREBOOM JOHN J; STEPHENS JR CHARLES R

128	Process for the 12a-hydroxylation of 12a-deoxytetracyclines	US6558760	1960-10-28	US3043877A	1962-07-10	HOLMLUND CHESTER E; ANDRES WILLIAM W

129	7-Methoxy-6-thiatetracyclines and their preparation	US600377	1975-07-30	US3988468A	1976-10-26	Werner Rogalski; Richard Kirchlechner; Juergen Seubert; Rudolf Gottschlich; Walter Hameister; Rolf Bergmann; Helmut Wahlig
7-Methoxy-6-thiatetracyclines of the formula ##SPC1##Wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl of 1 to 4 carbon atoms, and the physiologically acceptable acid addition salts thereof.
130	Biological transformation of alpha-6-deoxytetracyclines to tetracyclines	US3433709D	1965-12-07	US3433709A	1969-03-18	MCCORMICK JERRY ROBERT DANIEL; SJOLANDER NEWELL OSCAR

131	製造9–胺基–6–去甲基–6–去氧四環素之新方法	TW081108728	1992-11-03	TW221412B	1994-03-01	非恩.桑
本發明係關於製造〔4S－(4α，12aα)〕－９－胺基－４－（二甲胺基）－１，４－4a，５，5a，６，11，12a－八氫－３，10，12，12a－四羥基－１，11－二氧基－２－羧醯胺的新穎方法，本文後稱為９－胺基－６－去甲基－６－去氧四－環素，該化合物是四環素合成的重要中間物。
132	13-substituted-6-deoxytetracyclines and process utilizing the same	US17823762	1962-03-08	US3165531A	1965-01-12	BLACKWOOD ROBERT K; RENNHARD HANS H; BEEREBOOM JOHN J; STEPHENS JR CHARLES R

133	6-데 옥시- 테트라싸이크린의 수용성 유도체의 제조 방법	KR1019740003789	1974-10-11	KR100008206B1	1980-06-02	지노코티

134	A process for the preparation of 1-alkyl-3-carboxy-4-cinnolones.	EP88105021.5	1988-03-28	EP0287853A3	1990-07-18	Fusco, Raffaello; Piselli, Fulvio L.; Boschi, Pier Marino
A process for the preparation of 1-alkyl-3-carboxy-4-cinnolones of formula I wherein R and R₁ are electron donor groups and R₃ is an alkyl group, starting from an amine of formula II which is subjected to the following transformations; 1) diazotation; 2) coupling with a cyanoacetic ester; 3) alkylation of the arylhydrazone obtained in 2); 4) hydrolysis of the ester and conversion into acyl chloride; 5) intramolecular cyclization; 6) hydrolysis of the nitrile residue.
135	Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines	US443586	1989-11-29	US4987242A	1991-01-22	Jagmohan Khanna; Kiran Bala; Inder P. S. Grover
A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C.sub.1 -C.sub.4 alkyl; and X is chloro, bromo or iodo. This compound is particularly useful as a homogeneous hydrogenation catalyst in the production of alpha-6-deoxytetracyclines, particularly the antibiotic doxycycline. The desired alpha-6-deoxy product is produced in high yields and stereospecificities, the process requiring the use of minimal quantities of rhodium metal in the hydrogenation catalyst per mole of the 6-methylenetetracycline hydrogenated.
136	新穎9–胺基–7–取代–6–去甲基–6–去氧四環素	TW081106574	1992-08-19	TW222616B	1994-04-21	文.傑.李; 宋懷英; 約克.格路曼; 約瑟夫.傑.拉威卡
揭示具有活性的新穎９－胺基－７－取代－６－去甲基－６－去氧四環素以對抗含有會抵抗四環素的有機體之寬譜有機體。也揭示為製備本發明新穎化合物的中間物及方法。
137	4-desdimethylamino-6-deoxy-tetracycline derivatives	US84192959	1959-09-24	US3047626A	1962-07-31	STEPHENS JR CHARLES R; CONOVER LLOYD H

138	New process for the preparation of alpha-6-deoxy-5-hydroxytetracycline	US925109	1986-10-27	US4877559A	1989-10-31	Philip R. Page; Ivan Villax
A homogenous hydrogenation process of preparing 6-demethyl-6-deoxy-6 methylene-5-hydroxytetracycline using a stereospecific tertiary phosphine-hydrozino-rhodium complex catalyst.
139	6–脫甲基–6–脫氧–6–甲︴–四環素之製造法	TW06312025	1974-07-18	TW025656B	1979-07-01	吉諾哥帝

140	α-6-데옥시-5-하이드록시 테트라사이클린염산염의 제조방법	KR1019750001108	1975-05-20	KR100008929B1	1980-11-27	챠아르즈죤빈센트스캐니오

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