氧四环素相关的专利数据

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
141	Method for inhibiting expression of inducible nitric oxide synthase with tetracycline	US61286	1998-04-16	US5919775A	1999-07-06	Ashok R. Amin; Steven B. Abramson; Lorne M. Golub; Nungavaram S. Ramamurthy; Thomas F. McNamara; Robert A. Greenwald; Howard Trachtman
The invention is a method of inhibiting the production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo biological system. The method employs a tetracycline compound to inhibit the production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the biological system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.
142	Addition polymers of ethylenically-unsaturated cyclic nitrile sulfites,carbonates and oxalates	US3480595D	1967-11-09	US3480595A	1969-11-25	BURK EMMETT H JR; CARLOS DONALD D

143	Substituted 7-and/or 9-amino-6-deoxytetracyclines	US59815866	1966-12-01	US3341585A	1967-09-12	PANAYOTA BITHA; JOHN HLAVKA JOSEPH; MARTELL JR MICHAEL JOSEPH

144	过氧化物还原酶IV在制备类风湿关节炎体外诊断试剂中的应用	PCT/CN2011/083637	2011-12-07	WO2012100599A1	2012-08-02	吴乔; 吴玉章

145	A new process for the preparation of alpha-6-deoxy-tetracyclines	EP84305623.5	1984-08-17	EP0137661A2	1985-04-17	Page, Philip Ronald
A process for the preparation of α-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, or the simultaneous dehalogenation -and stereo-selective heterogeneous of an 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, characterised by the use of a rhodium salt catalyst, wherein the rhodium is bonded to an aminopolysiloxane, having the following formulae; permitting easy recovery of the rhodium, by simple filtration.
146	TETRACYCLINE RESISTANT EUKARYOTIC CELLS EXPRESSING AN NADP-REQUIRING OXIDOREDUCTASE	US15099227	2016-04-14	US20170015979A1	2017-01-19	Guy A. Cardineau; Sergio Ángel García Echaurri
TETX, a tetracycline degrading enzyme, is provided as a selection marker for eukaryotic cells. Polynucleotide molecules containing tetx and DNA constructs comprising a tetx under the control of a eukaryotic promoter are provided. Additionally, DNA constructs that contain a gene of interest and a tetx, each under the control of an appropriate promoter are provided. Further, methods of expressing tetx in a eukaryotic cell are provided, the method comprising introducing a vector comprising tetx into eukaryotic cells, culturing the eukaryotic cells in the presence of tetracycline, and identifying and isolating the cell that expresses tetx. Furthermore, a method is provided for expressing a gene of interest encoding a protein of interest in a eukaryotic cell by culturing a cell containing a vector comprising a gene of interest and a tetx, each under the control of an appropriate promoter.
147	6-demethyl-6-deoxytetracycline, anti-tumor antibiotic	US41159564	1964-11-16	US3326761A	1967-06-20	KENT ROBERT E

148	7-imidomethyl-6-demethyl-6-deoxytetracyclines	US43570565	1965-02-26	US3345379A	1967-10-03	MARTELL JR MICHAEL JOSEPH; STEPHEN TOMCUFCIK ANDREW

149	2,3-oxidosqualene-lanosterol cyclase inhibitors	US09939872	2001-08-27	US06964974B2	2005-11-15	Jean Ackermann; Johannes Aebi; Alexander Chucholowski; Henrietta Dehmlow; Olivier Morand; Sabine Wallbaum; Thomas Weller
The present invention relates to piperidine derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
150	2,3-oxidosqualene-lanosterol cyclase inhibitors	US09925188	2001-08-09	US20020045777A1	2002-04-18	Jean Ackermann; Johannes Aebi; Denise Blum; Alexander Chucholowski; Henrietta Dehmlow; Hans-Peter Maerki; Olivier Morand; Rene Trussardi; Elisabeth von der Mark; Sabine Wallbaum; Thomas Weller
The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
151	Method of using tetracycline compounds for inhibition of endogenous nitric oxide production	US697815	1996-08-30	US5789395A	1998-08-04	Ashok R. Amin; Steven B. Abramson; Lorne M. Golub; Nungavaram S. Ramamurthy; Thomas F. McNamara; Robert A. Greenwald; Howard Trachtman
A method is disclosed for inhibiting endogenous production of nitric oxide (NO) in an in vivo, in vitro, or ex vivo mammalian system. The method employs a tetracycline compound to inhibit production of NO and/or to inhibit the expression or activity of an inducible isoform of nitric oxide synthase (iNOS). Preferably, the tetracycline compound has inhibitory activity for metalloproteinases. Also it is preferred that the tetracycline compound is provided to the mammalian system in an amount which has little or no antibacterial activity in the system. Accordingly, preferred tetracycline compounds are tetracycline compounds which have be modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by NO production mediated by iNOS, including, for example, inflammatory conditions.
152	5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof	US22186962	1962-09-06	US3145228A	1964-08-18	VON WITTENAU MANFRED SCHACH; STEPHENS JR CHARLES R

153	2,3-oxidosqualene-lanosterol cyclase inhibitors	US09925188	2001-08-09	US06858651B2	2005-02-22	Jean Ackermann; Johannes Aebi; Denise Blum; Alexander Chucholowski; Henrietta Dehmlow; Hans-Peter Maerki; Olivier Morand; Rene Trussardi; Elisabeth von der Mark; Sabine Wallbaum; Thomas Weller
The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
154	2,3-oxidosqualene-lanosterol cyclase inhibitors	US09939872	2001-08-27	US20020068753A1	2002-06-06	Jean Ackermann; Johannes Aebi; Alexander Chucholowski; Henrietta Dehmlow; Olivier Morand; Sabine Wallbaum; Thomas Weller
The present invention relates to piperidine derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
155	Bromoanhydro-12a-bromo-12a-deoxydedimethylaminotetracycline	US77643558	1958-11-26	US3013075A	1961-12-12	HOWARD BOOTHE JAMES; ARTHUR GREEN

156	可同時進行光催化產氫及降解環氧四環素之材料的製作方法與其應用	TW108104359	2019-02-11	TWI692375B	2020-05-01	張章堂; CHANG, TANG-CHANG; 田晶晶; TIAN, JING-JING

157	신규한9-아미노-7-(치환아미노)-6-데메틸-6-데옥시테트라사이클린 및 그의 생성 방법	KR1019920018123	1992-10-02	KR100261528B1	2000-07-15	조오지프제이라브카; 파이크-엥섬; 야코브글루즈만; 빙제이리이
테트라사이클린에 저항하는 유기체를 포함하는 넓은 스펙트럼의 유기체에 대해 활성을 가지는 신규한 9-아미노-7-(치환 아미노)-6-데메틸-6-데옥시테트라사이클린이 공개된다. 본 발명의 신규한 화합물을 제조하는 중간체 및 방법이 또한 공개된다.
158	6–脫甲基–6–脫氧–6–甲︴–5一氧代四環素及其lla一氯衍生物之製法	TW073104176	1984-10-08	TW066080B	1985-04-01

159	Process for producing 7-amino-6-demethyl-6-deoxytetracycline	US201872	1988-06-03	US4849136A	1989-07-18	Yutaka Saito; Masaji Kasai
This invention provides a new process for producing 7-amino-6-demethyl-6-deoxytetracycline (Compound 3) which is an intermediate for the synthesis of minocycline.Compound 3 can be obtained by reduction of Compound 1 using a dithionite as reducing agent.This invention also provides a method to produce Compound 3 from Compound 2 in one pot. ##STR1## (wherein Ar denotes a substituted aryl group, and X stands for the residue of a mineral acid from which hydrogen atom has been eliminated).
160	일산화질소 생산을 억제하기 위한 테트라사이클린 화합물을 포함하는 약제학적 조성물	KR1019997001591	1997-08-21	KR100554859B1	2006-02-24	아민아쇽알; 아브람슨스티븐비; 골럽론엠; 라마무르씨눈가바람에스; 맥나마라토마스에프; 그린왈드로버트에이; 트라츠먼하워드
본 발명은 생체내, 실험관내 또는 생체외 생물학적 시스템에서 일산화질소(NO)의 생산을 억제하는 방법에 관한 것이다. 본 방법은 NO의 생산을 억제하고/하거나 동형의 유도성 일산화질소 신타제(iNOS)의 발현 또는 활성을 억제하는 테트라사이클린 화합물을 사용한다. 바람직하게는, 테트라사이클린 화합물은 메탈로프로테이나제에 대해 억제 활성을 갖는다. 또한, 생물학적 시스템내에서 항세균 활성을 거의 가지지 않거나 전혀 가지지 않는 양의 테트라사이클린을 상기 생물학적 시스템에 제공하는 것이 바람직하다. 따라서, 바람직한 테트라사이클린 화합물은 자체의 항미생물 활성이 감소되거나 제거되도록 개질된 테트라사이클린 화합물이다. 이 방법은 예를 들어, 염증 상태를 포함하는, iNOS에 의해 중재된 NO 생산으로 특징화되는 포유동물에서의 의학 상태를 치료하는데 사용될 수 있다. 일산화질소 생산 억제, 테트라사이클린

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