氧四环素相关的专利数据

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
161	Method for the production of 9-amino-6-demethyl-6-deoxytetracycline	US928587	1992-08-13	US5248797A	1993-09-28	Phaik-Eng Sum
The invention relates to a novel method for producing [4S-(4alpha, 12aalpha)]-9-amino-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3, 10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, hereinafter called 9-amino-6-demethyl-6-deoxytetracycline, which compound is a valuable intermediate for synthesis of tetracyclines.
162	9-아미노-6-데메틸-6-데옥시테트라시클린 무기산염의 제조 방법	KR1019930015642	1993-08-12	KR100280971B1	2001-02-01	파이크-엥슘
본 발명은 테트라시클린의 합성을 위해 가치있는 중간체인, 이후에 9-아미노-6-데메틸-6-데옥시테트라시클린으로 불리는 [4S-(-알파, 12a알파)]-9-아미노-4-(디메틸아미노)-1,4,4a,5,5a,6,11,12a-옥타히드로-3,10,12,12a-테트라히드록시-1,11-디옥소-2-나프타센카르복사미드의 새로운 제조방법에 관한 것이다.
163	EPOXY RESIN SYSTEM CONTAINING POLYETHYLENE TETRAAMINES FOR RESIN TRANSFER MOLDING PROCESSES	PCT/US2013/069378	2013-11-11	WO2014078219A1	2014-05-22	GRUNDER, Sergio; KOENIGER, Rainer; MORLEY, Timothy A.; JELIC, Nebjosa; REIMERS, Martin; CATE, Peter
A two-component curable epoxy resin system is disclosed. The resin system includes an epoxy resin component containing at least 80% by weight of a polyglycidyl ether of a polyphenol. The system also includes a hardener mixture containing mainly polyethylene tetraamines. The system includes one or more of i) alkali metal salts, ii) carboxylic acid-, carboxylic anhydride- or carboxylic acid ester-substituted phenol compounds, iii) an amino as a catalyst. The system has beneficial curing characteristics that make it useful for producing fiber-reinforced composites in a resin transfer molding process.
164	新穎7–取代–9–取代–胺基–6–去甲基–6–去氧四環素	TW081106768	1992-08-27	TW275616B	1996-05-11	艾德馬.艾.羅斯; 宋泰英; 威.傑.李; 約瑟夫.傑.拉凱; 耶柯夫.格路茲曼
本發明是揭示可拮抗對四環素具性有機體在內之大範圍有機體之新穎的7-經取代-9-(經取代之胺基)-6-去甲基-6-去氧四環素化合物。也揭示製備本發明新穎化合物之中間物及方法。
165	Process for the preparation of 6-demethyl-6-deoxy-6-methylene-tetracyclines	US509054	1974-09-24	US3962330A	1976-06-08	Gino Cotti
The invention relates to the preparation of 6-demethyl-6-deoxy-6-methylene-tetracycline by means of reductive dehalogenation of the corresponding 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline, the reaction being carried out in presence of the stoichiometric quantity of a tertiary phosphine, arsine or stibine and in a polar solvent. The time and temperature of the reaction are controlled within specified limits to obtain a complete conversion.
166	Production of 7-chloro-3-methoxy-2'-N-methyltetracycline with Actinomadura brunnea	US528006	1990-05-23	US5183758A	1993-02-02	Ann C. Horan
An antibiotic complex is produced by the microorganism, Actinomadura brunnea NRRL 15216, ATCC 39216. A novel antibiotic 7-chloro-8-methoxy-2'-N-methyltetracycline, isolated from the antibiotic complex, is active against gram-positive and gram-negative aerobes.
167	EPOXY RESIN SYSTEM CONTAINING POLYETHYLENE TETRAAMINES FOR RESIN TRANSFER MOLDING PROCESSES	US14422021	2013-11-11	US20150240025A1	2015-08-27	Sergio Grunder; Rainer Koeniger; Timothy A. Morley; Nebjosa Jelic; Martin Reimers; Peter Cate
A two-component curable epoxy resin system is disclosed. The resin system includes an epoxy resin component containing at least 80% by weight of a polyglycidyl ether of a polyphenol. The system also includes a hardener mixture containing mainly polyethylene tetraamines. The system includes one or more of i) alkali metal salts, ii) carboxylic acid-, carboxylic anhydride- or carboxylic acid ester-substituted phenol compounds, iii) an amino as a catalyst. The system has beneficial curing characteristics that make it useful for producing fiber-reinforced composites in a resin transfer molding process.
168	Hydrolysis of 2-decarboxamido-2-cyano-6-deoxy-tetracycline derivatives	US13411961	1961-08-28	US3069467A	1962-12-18	BEEREBOOM JOHN J; KENNETH BUTLER

169	Antibacterial compositions comprising a tetracycline-type antibiotic and an alkyl phenoxyethoxyethyl dialkylbenzyl ammonium salt	US58138156	1956-04-30	US2907693A	1959-10-06	PRICE KENNETH E; LUTHER HERBERT G

170	9[(經取代胺乙醯基)醯胺基]–6–去甲基–6–去氧四環素	TW081108727	1992-11-03	TW269678B	1996-02-01	非恩.桑; 敏.J.李; 羅蒙.T.提斯塔
本發明提供下式之化合物：CC其中Ｒ，Ｒ1及Ｗ定義於專利說明書中。此合物可充作抗生素。
171	Polymeric resins derived from 1-oxa-3-aza tetraline group-containing compounds and cycloaliphatic epoxides	US21151	1987-03-03	USRE32745E	1988-09-06	Herbert Schreiber
A composition comprising a polymeric resin derived from (A) at least one compound containing an average of more than one 1-oxa-3-aza-tetraline group per molecule with (B) at least one cycloaliphatic epoxide containing at least two epoxide groups, at least one of said epoxide groups being part of said ring, the mole ratio of (b) to (a) .Iadd.epoxide groups to 1-oxa-3-aza-tetraline groups .Iaddend.being in the range of about 0.2 to about 2.
172	Polymeric resins derived from 1-oxa-3-aza tetraline group-containing compounds and cycloaliphatic epoxides	US774433	1985-09-10	US4607091A	1986-08-19	Herbert Schreiber
A composition comprising a polymeric resin derived from (A) at least one compound containing an average of more than one 1-oxa-3-aza-tetraline group per molecule with (B) at least one cycloaliphatic epoxide containing at least two epoxide groups, at least one of said epoxide groups being part of said ring, the mole ratio of (B) to (A) being in the range of about 0.2 to about 2.
173	6-데메틸-6-데옥시-6-메틸렌-5-옥시테트라 싸이클린 및 이의 IIa-클로로 유도체를 제조하는 방법	KR1019840005370	1984-08-31	KR100045947B1	1991-11-12	죠르지루고시; 마리아히마네토츠; 산도르스조케; 마리아바코니

174	SUBSTITUTED TETRACYCLIC OXAZEPINE AND THIAZEPINE DERIVATIVES WITH 5-HT2 RECEPTOR AFFINITY	EP95937007.0	1995-10-25	EP0789702A1	1997-08-20	FERNANDEZ-GADEA, Francisco Javier; SIPIDO, Victor, Karel; ANDRES-GIL, José Ignacio; MEERT, Theo, Frans
This invention concerns the compounds of Formula (I), the pharmaceutically acceptable salts and stereoisomeric forms thereof, and also the N-oxide forms thereof. In said formula, R?1 and R2¿ each independently are hydrogen; C¿1-6? alkyl; C1-6 alkylcarbonyl; trihalomethylcarbonyl; C1-6 alkyl substituted with hydroxy, C1-6alkyloxy, carboxyl, C1-6 alkylcarbonyloxy, C1-6 alkyloxycarbonyl or aryl; or R?1 and R2¿ taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; R?3 to R10¿ each independently are hydrogen, halo, cyano, hydroxy, trifluoromethyl, trifluormethoxy, carboxyl, nitro, amino, mono-or di(C¿1-6?alkyl)amino, C1-6 alkylcarbonylamino, aminosulfonyl, mono-or di(C1-6alkyl)- aminosulfonyl, C1-6 alkyl, C1-6 alkyloxy, C1-6alkylcarbonyl, C1-6 alkyloxycarbonyl; R?11¿ is hydrogen, C¿1-6?alkyl, or trifluoromethyl; R?12¿ is hydrogen, C¿1-6? alkyl, cyano, or trifluorotmethyl; n is zero to 6; and X is O, S, S(=O) or S(=O)2. The compounds of formula (I)may be used as therapeutic agents in the treatment or the prevention of CNS disorders, cardiovascular disorders or gastrointestinal disorders.
175	Tetralins or a combination of tetrlins and organic sulfides as lube oil anti-oxidants	US155407	1993-11-19	US5453211A	1995-09-26	Sandra J. Alward
The oxidation stability of lube base oils is improved by the addition of tetralins or combination of tetralins and organic sulfides. The addition of tetralins or combination of tetralins and organic sulfides to formulated lube oils has also been found to improve the oxidation stability of such formulated oil.
176	9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines	US146666	1993-11-01	US5326759A	1994-07-05	Joseph J. Hlavka; Phaik-Eng Sum; Yakov Gluzman; Ving J. Lee
Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
177	可同時進行光催化產氫及降解環氧四環素之材料的製作方法與其應用	TW108104359	2019-02-11	TW202030019A	2020-08-16	張章堂; CHANG, TANG-CHANG; 田晶晶; TIAN, JING-JING
本發明供了光催化產氫及降解型銅-硫化鉻(Cu-CdS)材料製作方法，並可使用此材料同時光催化產氫及光降解環氧四環素。本發明使用水熱法合成硫化鉻(CdS)奈米材料，然後利用光沉積法合成Cu-CdS，在紫外光下進行光產氫及光降解土黴素oxytetracycline (OTC)，頗具廣泛的應用前景。
178	7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines	US286096	1994-08-04	US5494903A	1996-02-27	Joseph J. Hlavka; Phaik-Eng Sum; Yakov Gluzman; Ving J. Lee; Adma A. Ross
The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula ##STR1## wherein R, X, R.sup.5 and R.sup.6 are defined in the specification. The compounds of the invention are useful as broad spectrum antibiotics.
179	9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines	US771697	1991-10-04	US5281628A	1994-01-25	Joseph J. Hlavka; Phaik-Eng Sum; Yakov Gluzman; Ving J. Lee
9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.
180	9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines	US219568	1994-03-29	US5401863A	1995-03-28	Joseph J. Hlavka; Phaik-Eng Sum; Yakov Gluzman; Ving J. Lee
Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the novel compounds of the present invention.

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