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1. 发明申请

US20070054916A1 Aryl nitrogen-containing bicyclic compounds and methods of use 审中-公开
标题翻译：芳基含氮双环化合物及其使用方法
公开(公告)号：US20070054916A1
公开(公告)日：2007-03-08
申请号：US11240590
申请日：2005-09-30
申请人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
发明人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
IPC分类号： A61K31/525 , A61K31/519 , A61K31/517
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

2. 发明申请

US20060241115A1 Compounds and methods of use 有权
公开(公告)号：US20060241115A1
公开(公告)日：2006-10-26
申请号：US11042634
申请日：2005-01-24
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
IPC分类号： A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709 , C07D43/02
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

3. 发明申请

US20070072851A1 Pyrazolopyridine and pyrazolopyrimidine compounds 有权
标题翻译：吡唑并吡啶和吡唑并嘧啶化合物
公开(公告)号：US20070072851A1
公开(公告)日：2007-03-29
申请号：US11506381
申请日：2006-08-18
申请人： John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
发明人： John Buchanan , William Buckner , Mario Cardozo , Erin DiMauro , Jiasheng Fu , Xiaolin Hao , Xian Jiao , Frank Kayser , David Kopecky , Craig Masse , Susan Tomlinson , Ryan White , Xiaotian Zhu
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/519 , A61K31/503 , A61K31/498 , A61K31/497 , A61K31/496 , C07D487/02 , C07D471/02
CPC分类号： C07D403/06 , C07D231/56 , C07D401/14 , C07D405/06 , C07D487/04
摘要： The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.
摘要翻译：本发明涉及式I化合物或立体异构体，互变异构体，溶剂合物，药学上可接受的盐或前药，含有化合物的药物制剂，使用该化合物的治疗方法，例如蛋白质酪氨酸激酶相关诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。

4. 发明申请

US20060040961A1 Furanopyrimidines 有权
标题翻译：呋喃并嘧啶
公开(公告)号：US20060040961A1
公开(公告)日：2006-02-23
申请号：US11169312
申请日：2005-06-29
申请人： John Buchanan , William Buckner , Simon Burkitt , Erin DiMauro , Christopher Farthing , Alexander Frenkel , Martin Harrison , Frank Kayser , Jinqian Liu , Sarah Lively , Teresa Marshall , David McGowan , Rajiv Sharma , Stephen Shuttleworth , Xiaotian Zhu
发明人： John Buchanan , William Buckner , Simon Burkitt , Erin DiMauro , Christopher Farthing , Alexander Frenkel , Martin Harrison , Frank Kayser , Jinqian Liu , Sarah Lively , Teresa Marshall , David McGowan , Rajiv Sharma , Stephen Shuttleworth , Xiaotian Zhu
IPC分类号： A61K31/519 , C07D491/02
CPC分类号： C07D491/04 , C07D495/04
摘要： The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.
摘要翻译：本发明涉及具有通式I的呋喃并嘧啶化合物及其立体异构体，互变异构体，溶剂合物，药用盐和衍生物及其前药。本发明还包括药物组合物，其包含式I化合物，治疗哺乳动物各种疾病和病症的方法，包括炎症，抑制T细胞活化，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹，结肠癌和胸腺瘤，包括向哺乳动物施用治疗有效量的式I化合物。本发明还涉及制备药物的方法，其包含一种或多种式I化合物。

5. 发明申请

US20050026914A1 Substituted heterocyclic compounds and methods of use 失效
标题翻译：取代的杂环化合物及其使用方法
公开(公告)号：US20050026914A1
公开(公告)日：2005-02-03
申请号：US10891636
申请日：2004-07-13
申请人： John Buchanan , Daniel Elbaum , Matthew Martin , David McGowan , Perry Novak , Joseph Nunes
发明人： John Buchanan , Daniel Elbaum , Matthew Martin , David McGowan , Perry Novak , Joseph Nunes
IPC分类号： A61P37/00 , C07D213/75 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/541 , A61K31/506 , A61K31/5377 , C07D413/02 , C07D417/02 , C07
CPC分类号： C04B35/632 , C07D213/75 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, the methods comprising administering a therapeutically-effective amount a compound of Formula I, or a salt or derivative form thereof, as described above.
摘要翻译：本发明涉及具有通式I的嘧啶或吡啶氨基甲酸酯化合物及其药学上可接受的盐或衍生物。还包括治疗各种疾病和病症的方法，包括炎症，T细胞活化和增殖的抑制，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹，癌症，结肠癌，胸腺瘤，仅举几例哺乳动物，所述方法包括给予治疗有效量的如上所述的式I化合物或其盐或衍生物形式。

6. 发明授权

US08696903B2 High-pressure tubing 有权
标题翻译：高压管
公开(公告)号：US08696903B2
公开(公告)日：2014-04-15
申请号：US12067216
申请日：2006-09-14
申请人： John Buchanan , Dennis DellaRovere
发明人： John Buchanan , Dennis DellaRovere
IPC分类号： B01D15/08
CPC分类号： G01N30/88 , B01L3/502753 , B01L3/565 , B01L2400/0415 , B01L2400/0487 , B29C63/18 , B29C63/34 , B29L2023/00 , G01N30/32 , G01N30/6052 , G01N30/7233 , G01N2030/324
摘要： A method for making conduits includes inserting an inner tube into an outer tube and melting a portion of the inner tube to form a bond with the outer tube. The inner tube includes a polymeric material and the outer tube includes a material having a greater yield strength than the polymeric material. A conduit includes one or more inner tubes at least one of which is melt-bonded to one or more outer tubes. An analytical instrument includes a separation column, a solvent reservoir and pump, a sample injector, a detector to observe an eluent of the separation column, and tubing to transport fluid between components of the instrument.
摘要翻译：制造管道的方法包括将内管插入外管并熔化内管的一部分以与外管形成结合。内管包括聚合物材料，外管包括具有比聚合材料更高的屈服强度的材料。导管包括一个或多个内管，其中至少一个内管与一个或多个外管熔融粘合。分析仪器包括分离柱，溶剂储存器和泵，样品注射器，用于观察分离柱的洗脱液的检测器和用于在仪器的组件之间输送流体的管道。

7. 发明申请

US20070191664A1 Methane conversion to higher hydrocarbons 有权
标题翻译：甲烷转化为高级烃
公开(公告)号：US20070191664A1
公开(公告)日：2007-08-16
申请号：US11643541
申请日：2006-12-21
申请人： Frank Hershkowitz , John Buchanan , Hary Deckman , Jeffrey Frederick
发明人： Frank Hershkowitz , John Buchanan , Hary Deckman , Jeffrey Frederick
IPC分类号： C07C4/02 , C07C11/00 , C07C2/02 , B01J12/00
CPC分类号： B01J8/02 , B01F3/02 , B01F5/0603 , B01F2215/0431 , B01J4/002 , B01J8/0278 , B01J8/04 , B01J8/0438 , B01J8/0442 , B01J8/0492 , B01J8/0496 , B01J19/2485 , B01J19/26 , B01J2208/00132 , B01J2208/00309 , B01J2208/00504 , B01J2208/0053 , B01J2208/00831 , B01J2208/0084 , B01J2208/00849 , B01J2219/0004 , B01J2219/00081 , B01J2219/00117 , B01J2219/00157 , B01J2219/00159 , B01J2219/182 , B01J2219/1943 , C01B3/46 , C01B2203/0233 , C01B2203/0238 , C01B2203/0244 , C01B2203/0261 , C01B2203/0277 , C01B2203/0811 , C01B2203/0844 , C01B2203/1235 , C01B2203/1241 , C01B2203/142 , C07C2/78 , C07C5/327 , C08G18/10 , C08G18/4825 , C08G18/73 , C08G18/792 , C08G2101/005 , Y02P20/132 , Y10S585/943 , C07C11/24 , C08G18/3203 , C08G18/48
摘要： The present invention provides a process for the manufacture of acetylene and other higher hydrocarbons from methane feed using a reverse-flow reactor system, wherein the reactor system includes (i) a first reactor and (ii) a second reactor, the first and second reactors oriented in a series relationship with respect to each other, the process comprising supplying each of first and second reactant through separate channels in the first reactor bed of a reverse-flow reactor such that both of the first and second reactants serve to quench the first reactor bed, without the first and second reactants substantially reacting with each other until reaching the core of the reactor system.
摘要翻译：本发明提供了使用逆流反应器系统从甲烷进料制造乙炔和其它高级烃的方法，其中反应器系统包括（i）第一反应器和（ii）第二反应器，第一和第二反应器该方法包括通过在逆流反应器的第一反应器床中的单独通道供应第一和第二反应物中的每一个，使得第一和第二反应物都用于使第一反应器骤冷床，没有第一和第二反应物基本上彼此反应直到到达反应器系统的核心。

8. 发明申请

US20070185364A1 In-line process for generating comonomer 失效
标题翻译：产生共聚单体的在线方法
公开(公告)号：US20070185364A1
公开(公告)日：2007-08-09
申请号：US11346651
申请日：2006-02-03
申请人： John Buchanan , Timothy Shaffer
发明人： John Buchanan , Timothy Shaffer
IPC分类号： C07C2/02
CPC分类号： C07C2/26 , C08F10/02 , C08F210/16 , Y02P20/52 , C08F2/00
摘要： The present invention relates to an in-line method for generating comonomer, such as 1-hexene or 1-octene, from monomer, such as ethylene. The comonomer generated is directly transported, without isolation or storage, to a polyethylene polymerization reactor. The in-line method for generating comonomer includes the steps of providing an in-line comonomer synthesis reactor and a downstream gas/liquid phase separator prior to a polyethylene polymerization reactor; feeding ethylene monomer and a catalyst in a solvent to the comonomer synthesis reactor; reacting the ethylene monomer and the catalyst in solvent under reaction conditions to produce an effluent stream including ethylene monomer and comonomer; passing the effluent stream from the comonomer synthesis reactor to the downstream gas/liquid phase separator to separate a gas stream from a bottom stream, wherein the gas stream is a mixture of ethylene monomer, and comonomer; and passing the gas stream to the polyethylene polymerization reactor to provide the necessary comonomer input. The in-line method is useful in the production of LLDPE, and other branched polyethylene based polymers. Some benefits include process simplification and reduced capital and operating costs.
摘要翻译：本发明涉及从单体如乙烯生成共聚单体如1-己烯或1-辛烯的直列方法。生成的共聚单体直接输送到聚乙烯聚合反应器中，无需隔离或储存。用于生成共聚单体的在线方法包括在聚乙烯聚合反应器之前提供在线共聚单体合成反应器和下游气/液相分离器的步骤; 将乙烯单体和催化剂在溶剂中加入到共聚单体合成反应器中; 在反应条件下使乙烯单体和催化剂在溶剂中反应，以产生包括乙烯单体和共聚单体的流出物流; 将来自共聚单体合成反应器的流出物流输送到下游气/液相分离器以从底部流分离气流，其中气流是乙烯单体和共聚单体的混合物; 并将气流送入聚乙烯聚合反应器以提供所需的共聚单体输入。在线方法可用于生产LLDPE和其他支化聚乙烯基聚合物。一些好处包括流程简化，降低资本和运营成本。

9. 发明申请

US20070090018A1 Hydrocarbon resid processing 有权
标题翻译：烃渣处理
公开(公告)号：US20070090018A1
公开(公告)日：2007-04-26
申请号：US11581882
申请日：2006-10-17
申请人： Paul Keusenkothen , Megan Renstrom , Julian Wolfenbarger , Stephen Brown , John Buchanan
发明人： Paul Keusenkothen , Megan Renstrom , Julian Wolfenbarger , Stephen Brown , John Buchanan
IPC分类号： C10G9/00 , C07C4/02 , C10G15/00
CPC分类号： B01D3/009 , C10G9/007 , C10G9/14 , C10G9/36 , C10G45/00 , C10G45/44 , C10G69/00 , C10G69/06 , C10G2300/107 , C10G2400/20 , C10G2400/30
摘要： The invention concerns integration of hydroprocessing and steam cracking. A feed comprising crude or resid-containing fraction thereof is severely hydrotreated and passed to a steam cracker to obtain an olefins product.
摘要翻译：本发明涉及加氢处理和蒸汽裂化的整合。包含粗制或残留物的级分的进料被严重加氢处理并通入蒸汽裂化器以获得烯烃产物。

10. 发明申请

US20070066860A1 Steam cracking of high tan crudes 有权
标题翻译：蒸汽裂纹高棕褐色原油
公开(公告)号：US20070066860A1
公开(公告)日：2007-03-22
申请号：US11231490
申请日：2005-09-20
申请人： John Buchanan , Paul Keusenkothen , Stephen Brown , Julian Wolfenbarger , James Graham , James McCoy
发明人： John Buchanan , Paul Keusenkothen , Stephen Brown , Julian Wolfenbarger , James Graham , James McCoy
IPC分类号： C07C4/02
CPC分类号： C10G9/00 , C10G2300/1033 , C10G2300/1055 , C10G2300/1059 , C10G2300/107 , C10G2300/1074 , C10G2300/1077 , C10G2300/203 , C10G2300/206 , C10G2300/807 , C10G2400/20 , Y02P30/40
摘要： The invention is directed to a process comprising feeding high TAN feedstreams to a steam cracker, whereby naphthenic acids in the feedstreams are substantially converted to CO, CO2, and low amounts of smaller acids (e.g., formic, acetic, propionic, and butyric acids). The feedstream is preferably a high TAN feedstream comprising crude or high TAN feedstream which has previously been subjected to a refinery process to remove resid.
摘要翻译：本发明涉及一种方法，其包括将高TAN进料流供给蒸汽裂化器，由此进料流中的环烷酸基本上转化为CO，CO 2 CO 2和少量较小的酸（例如甲酸，乙酸，丙酸和丁酸）。进料流优选是高TAN进料流，其包含先前经过炼油方法以除去渣油的粗TAN进料流或高TAN进料流。

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