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1. 发明申请

US20070054916A1 Aryl nitrogen-containing bicyclic compounds and methods of use 审中-公开
标题翻译：芳基含氮双环化合物及其使用方法
公开(公告)号：US20070054916A1
公开(公告)日：2007-03-08
申请号：US11240590
申请日：2005-09-30
申请人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
发明人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
IPC分类号： A61K31/525 , A61K31/519 , A61K31/517
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

2. 发明申请

US20060199817A1 Phthalazine, aza- and diaza-phthalazine compounds and methods of use 有权
标题翻译：酞嗪，氮杂和二氮杂 - 酞嗪化合物及其使用方法
公开(公告)号：US20060199817A1
公开(公告)日：2006-09-07
申请号：US11367123
申请日：2006-03-02
申请人： Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Chakrabarti , James Falsey , Bradley Herberich , Randall Hungate , Liping Pettus , Anthony Reed , Robert Rzasa , Kelvin Sham , Maya Thaman , Shimin Xu
发明人： Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Chakrabarti , James Falsey , Bradley Herberich , Randall Hungate , Liping Pettus , Anthony Reed , Robert Rzasa , Kelvin Sham , Maya Thaman , Shimin Xu
IPC分类号： A61K31/5377 , A61K31/503 , A61K31/53 , C07D487/02
CPC分类号： C07D409/04 , C07D237/30 , C07D237/32 , C07D237/34 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/10
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

3. 发明申请

US20050277631A1 Vanilloid receptor ligands and their use in treatments 有权
公开(公告)号：US20050277631A1
公开(公告)日：2005-12-15
申请号：US11195134
申请日：2005-08-01
申请人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
发明人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
IPC分类号： A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/549 , A61K31/501 , C07D417/02 , C07D43/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

4. 发明申请

US20050272777A1 Vanilloid receptor ligands and their use in treatments 失效
公开(公告)号：US20050272777A1
公开(公告)日：2005-12-08
申请号：US11195159
申请日：2005-08-01
申请人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
发明人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
IPC分类号： A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D417/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

5. 发明授权

US08101612B2 Phthalazine compounds and methods of use 失效
标题翻译：酞嗪化合物及其使用方法
公开(公告)号：US08101612B2
公开(公告)日：2012-01-24
申请号：US11899363
申请日：2007-09-04
申请人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K. C. Sham , Shimin Xu , Partha Chakrabarti
发明人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K. C. Sham , Shimin Xu , Partha Chakrabarti
IPC分类号： C07D237/30 , C07D413/04 , A61K31/502 , A61K31/5355 , A61P29/00 , A61P19/02 , A61P19/10 , A61P17/06 , A61P17/00 , A61P31/00 , A61P31/16 , A61P31/22 , A61P37/08 , A61P21/00 , A61P3/10 , A61P9/10 , A61P33/06
CPC分类号： C07D403/12 , C07D237/30 , C07D237/34 , C07D403/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of p38 kinase mediated diseases and related inflammatory conditions. The compounds have a general Formula II wherein L1, L2, R1a, R1b, R1c, R2, R3, R3a, R4, R5 and p are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of p38 kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗p38激酶介导的疾病和相关炎性病症的化合物。该化合物具有通式II，其中本文定义了L1，L2，R1a，R1b，R1c，R2，R3，R3a，R4，R5和p。本发明还包括包含一种或多种式I化合物的药物组合物，用于治疗p38激酶介导的疾病（包括类风湿性关节炎，牛皮癣和其它炎症疾病）的这些化合物和组合物的用途，以及可用于制备化合物的中间体和方法的式

6. 发明申请

US20080119468A1 Phthalazine, aza-and diaza-phthalazine compounds and methods of use 失效
标题翻译：酞嗪，氮杂和二氮杂 - 酞嗪化合物及其使用方法
公开(公告)号：US20080119468A1
公开(公告)日：2008-05-22
申请号：US11899363
申请日：2007-09-04
申请人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K.C. Sham , Shimin Xu , Partha Chakrabarti
发明人： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K.C. Sham , Shimin Xu , Partha Chakrabarti
IPC分类号： A61K31/502 , C07D403/12 , C07D237/34 , C07D413/02 , C07D471/04 , A61P19/10 , A61P11/00 , A61P9/00 , A61P25/00 , A61P21/00 , A61P35/02 , A61K31/496 , C07D413/14 , A61K31/5377 , C07D237/30
CPC分类号： C07D403/12 , C07D237/30 , C07D237/34 , C07D403/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

7. 发明申请

US20050277646A1 Vanilloid receptor ligands and their use in treatments 失效
公开(公告)号：US20050277646A1
公开(公告)日：2005-12-15
申请号：US11195303
申请日：2005-08-01
申请人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Vassil Ognyanov , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Liping Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
发明人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Vassil Ognyanov , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Liping Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
IPC分类号： A61K31/4709 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P27/02 , A61P29/00 , A61P37/08 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D43/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

8. 发明授权

US06869252B1 Taut mooring system for jack-up type mobile offshore platforms 有权
标题翻译：自升式移动式海上平台的紧固系泊系统
公开(公告)号：US06869252B1
公开(公告)日：2005-03-22
申请号：US09473323
申请日：1999-12-28
申请人： Ramesh Maini , Partha Chakrabarti , John S. Laird, II , Kenneth P. Choate
发明人： Ramesh Maini , Partha Chakrabarti , John S. Laird, II , Kenneth P. Choate
IPC分类号： E02B17/08 , B63B21/50
CPC分类号： E02B17/08 , E02B17/021 , E02B2017/006 , E02B2017/0078 , E02B2017/0082
摘要： A taut mooring system for use on a mobile offshore jack-up platform while it is in an elevated operating condition. The elevated operating condition is with the hull jacked up a safe distance above the highest anticipated wave crests, on vertically movable legs which extend to the ocean floor. The mooring system consists of: radially spaced mooring line attachment means on the structure of the platform; suction piles that are radially spaced around the platform, consistent with the radial spacing of the mooring line attachment means; and taut mooring lines which radially connect the suction piles to the attachment means. The flexibility of the taut mooring system provides the ability to coact with the platform's free standing storm resistance capabilities, yielding enhanced capabilities that will enable the platform to safely resist storm induced forces that the platform would not normally be capable of withstanding, and to enable the platform to be used with longer legs in deeper water.
摘要翻译：一个紧凑的系泊系统，用于移动式海上自升式平台，同时处于升高的运行状态。升高的操作条件是，船体在最高预期波峰之上安全距离，延伸到海底的垂直可移动的腿上。系泊系统包括：平台结构上的径向间隔的系泊线连接装置; 与该系泊系连接装置的径向间隔一致的围绕该平台径向隔开的抽吸桩; 以及将抽吸桩径向连接到附接装置的拉紧系泊绳。紧张的系泊系统的灵活性提供了与平台的独立风暴抵抗能力合作的能力，产生增强的功能，使平台能够安全地抵御平台通常不能承受的风暴诱发力，并使在更深的水中使用较长的腿的平台。

9. 发明申请

US20060030618A1 Vanilloid receptor ligands and their use in treatments 审中-公开
公开(公告)号：US20060030618A1
公开(公告)日：2006-02-09
申请号：US11100272
申请日：2005-04-05
申请人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： A61K31/353 , C07D319/08
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

10. 发明申请

US20050272931A1 Vanilloid receptor ligands and their use in treatments 审中-公开
公开(公告)号：US20050272931A1
公开(公告)日：2005-12-08
申请号：US11099978
申请日：2005-04-05
申请人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
发明人： Yunxin Bo , Partha Chakrabarti , Ning Chen , Elizabeth Doherty , Christopher Fotsch , Nianhe Han , Michael Kelly , Qingyian Liu , Mark Norman , Vassil Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号： C07D249/18 , A61K31/17 , A61K31/18 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/443 , A61K31/444 , A61K31/453 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/472 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/5375 , A61K31/538 , A61P1/00 , A61P1/04 , A61P1/12 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/10 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/06 , A61P27/02 , A61P29/00 , A61P31/12 , A61P37/08 , A61P43/00 , C07C233/11 , C07C233/15 , C07C233/33 , C07C233/44 , C07C311/13 , C07C311/16 , C07C317/40 , C07C323/35 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/32 , C07D215/38 , C07D215/40 , C07D215/42 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D235/08 , C07D235/26 , C07D237/20 , C07D239/42 , C07D239/88 , C07D239/90 , C07D241/20 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D311/16 , C07D319/18 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D215/16
CPC分类号： C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

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