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1. 发明申请

US20070054916A1 Aryl nitrogen-containing bicyclic compounds and methods of use 审中-公开
标题翻译：芳基含氮双环化合物及其使用方法
公开(公告)号：US20070054916A1
公开(公告)日：2007-03-08
申请号：US11240590
申请日：2005-09-30
申请人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
发明人： Vinod Patel , Joseph Kim , Stephanie Geuns-Meyer , Stuart Chaffee , Victor Cee , Brian Hodous , Steven Bellon , Jean-Christophe Harmange , Philip Olivieri , Maya Thaman , Erin DiMauro , John Buchanan , David McGowan , Brian Albrecht , Holly Deak , Jean Bemis , Ryan White , Matthew Martin , Gregory Habgood , Paul Tempest , Craig Masse , William Buckner , Bradley Herberich , Russell Graceffa , Dawei Zhang , Shimin Xu , Kelvin Sham , Robert Rzasa , James Falsey , Partha Chakrabarti , Guo-Qiang Cao , Susan Tomlinson , Liping Pettus , Adrian Smith , Nick Paras , Gang Liu , Frenel DeMorin , Andrew Tasker , Anthony Reed
IPC分类号： A61K31/525 , A61K31/519 , A61K31/517
CPC分类号： C07D215/38 , C07C205/37 , C07D215/12 , C07D217/12 , C07D217/22 , C07D217/26 , C07D239/26 , C07D239/84 , C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症，癌症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，A 3，B，R 1， R 2，R 3和R 4在本文中定义。因此，本发明还包括含有本发明化合物的药物组合物，使用本发明化合物和组合物预防和治疗激酶介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

2. 发明申请

US20060199817A1 Phthalazine, aza- and diaza-phthalazine compounds and methods of use 有权
标题翻译：酞嗪，氮杂和二氮杂 - 酞嗪化合物及其使用方法
公开(公告)号：US20060199817A1
公开(公告)日：2006-09-07
申请号：US11367123
申请日：2006-03-02
申请人： Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Chakrabarti , James Falsey , Bradley Herberich , Randall Hungate , Liping Pettus , Anthony Reed , Robert Rzasa , Kelvin Sham , Maya Thaman , Shimin Xu
发明人： Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Chakrabarti , James Falsey , Bradley Herberich , Randall Hungate , Liping Pettus , Anthony Reed , Robert Rzasa , Kelvin Sham , Maya Thaman , Shimin Xu
IPC分类号： A61K31/5377 , A61K31/503 , A61K31/53 , C07D487/02
CPC分类号： C07D409/04 , C07D237/30 , C07D237/32 , C07D237/34 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/10
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备一级方程式

3. 发明申请

US20050277631A1 Vanilloid receptor ligands and their use in treatments 有权
公开(公告)号：US20050277631A1
公开(公告)日：2005-12-15
申请号：US11195134
申请日：2005-08-01
申请人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
发明人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
IPC分类号： A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/549 , A61K31/501 , C07D417/02 , C07D43/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

4. 发明申请

US20050272777A1 Vanilloid receptor ligands and their use in treatments 失效
公开(公告)号：US20050272777A1
公开(公告)日：2005-12-08
申请号：US11195159
申请日：2005-08-01
申请人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
发明人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Hui-Ling Wang , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Celia Dominguez , James Falsey , Christopher Hulme , Jodie Katon , Thomas Nixey , Vassil Ognyanov , Liping Pettus , Robert Rzasa
IPC分类号： A61P29/00 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D417/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

5. 发明授权

US07846944B2 Pyrazolo-pyridinone compounds and methods of use thereof 有权
标题翻译：吡唑并吡啶酮化合物及其使用方法
公开(公告)号：US07846944B2
公开(公告)日：2010-12-07
申请号：US12151478
申请日：2008-05-06
申请人： Liping Pettus , Andrew Tasker , Shimin Xu , Ryan Wurz
发明人： Liping Pettus , Andrew Tasker , Shimin Xu , Ryan Wurz
IPC分类号： C07D487/04 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, A3, A4, B, R1, R2, R3, R4 and R5 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A1，A2，A3，A4，B，R1，R2，R3，R4和R5如本文所定义。本发明还包括药物组合物，其包含一种或多种式I化合物，用于治疗P38地图激酶介导的疾病（包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，疼痛和其它炎症性疾病）的这些化合物和组合物的用途以及中间体和可用于制备式I化合物的方法。

6. 发明申请

US20090012299A1 Pyrazolo-pyridinone compounds and methods of use thereof 有权
标题翻译：吡唑并吡啶酮化合物及其使用方法
公开(公告)号：US20090012299A1
公开(公告)日：2009-01-08
申请号：US12151478
申请日：2008-05-06
申请人： Liping Pettus , Andrew Tasker , Shimin Xu , Ryan Wurz
发明人： Liping Pettus , Andrew Tasker , Shimin Xu , Ryan Wurz
IPC分类号： C07D487/04
CPC分类号： C07D471/04
摘要： The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, A3, A4, B, R1, R2, R3, R4 and R5 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of P38 map kinase mediated diseases including rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disease, pain and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
摘要翻译：本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。化合物具有通式I，其中A1，A2，A3，A4，B，R1，R2，R3，R4和R5如本文所定义。本发明还包括药物组合物，其包含一种或多种式I化合物，用于治疗P38地图激酶介导的疾病（包括类风湿性关节炎，牛皮癣，慢性阻塞性肺病，疼痛和其它炎症性疾病）的这些化合物和组合物的用途以及中间体和可用于制备式I化合物的方法。

7. 发明申请

US20050277646A1 Vanilloid receptor ligands and their use in treatments 失效
公开(公告)号：US20050277646A1
公开(公告)日：2005-12-15
申请号：US11195303
申请日：2005-08-01
申请人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Vassil Ognyanov , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Liping Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
发明人： Elizabeth Doherty , Jiawang Zhu , Markian Stec , Mark Norman , Vassil Ognyanov , Christopher Fotsch , Ning Chen , Partha Chakrabarti , Liping Pettus , Hui-Ling Wang , Xianghong Wang , Premilla Arasasingham
IPC分类号： A61K31/4709 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P9/00 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P27/02 , A61P29/00 , A61P37/08 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/22 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D43/02
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

8. 发明申请

US20050165028A1 Vanilloid receptor ligands and their use in treatments 审中-公开
标题翻译：香草素受体配体及其在治疗中的应用
公开(公告)号：US20050165028A1
公开(公告)日：2005-07-28
申请号：US11040668
申请日：2005-01-21
申请人： Mark Norman , Vassil Ognyanov , Liping Pettus
发明人： Mark Norman , Vassil Ognyanov , Liping Pettus
IPC分类号： A61K31/381 , A61K31/428 , A61K31/4433 , A61K31/452 , A61K31/506 , C07D213/26 , C07D277/82 , C07D319/18 , C07D319/20 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D401/12 , C07D213/26 , C07D277/82 , C07D319/18 , C07D405/12 , C07D409/12
摘要： N-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译： N-双环酰胺及其衍生物和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱疾病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎症性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛和相关的痛觉过敏和异常性疼痛，糖尿病性神经病变疼痛，咳嗽症状，交感神经保持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动性紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，疾病胃溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

9. 发明申请

US20060058308A1 Vanilloid receptor ligands and their use in treatments 失效
标题翻译：香草素受体配体及其在治疗中的应用
公开(公告)号：US20060058308A1
公开(公告)日：2006-03-16
申请号：US11226844
申请日：2005-09-13
申请人： Mark Norman , Liping Pettus , Xianghong Wang , Jiawang Zhu
发明人： Mark Norman , Liping Pettus , Xianghong Wang , Jiawang Zhu
IPC分类号： A61K31/506 , A61K31/505 , C07D239/42 , C07D403/02
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14
摘要： Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：取代的吡啶类和嘧啶类和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，同情维持疼痛，传入综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道内脏运动性紊乱，泌尿生殖道，胃肠道或血管区域，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病严重溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

10. 发明申请

US20050165032A1 Vanilloid receptor ligands and their use in treatments 审中-公开
公开(公告)号：US20050165032A1
公开(公告)日：2005-07-28
申请号：US11041174
申请日：2005-01-21
申请人： Mark Norman , Vassil Ognyanov , Liping Pettus
发明人： Mark Norman , Vassil Ognyanov , Liping Pettus
IPC分类号： A61K31/428 , A61K31/517 , A61K31/519 , C07D401/04 , C07D417/12 , C07D471/04 , C07D487/02
CPC分类号： C07D401/04 , C07D417/12 , C07D471/04
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

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